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Information on EC 1.6.2.4 - NADPH-hemoprotein reductase and Organism(s) Schizosaccharomyces pombe and UniProt Accession P36587

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EC Tree
     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.2 With a heme protein as acceptor
                1.6.2.4 NADPH-hemoprotein reductase
IUBMB Comments
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b5 and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
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Schizosaccharomyces pombe
UNIPROT: P36587
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The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
nadph-cytochrome p-450 reductase, cytochrome p450 reductase, p450 reductase, p-450 reductase, nadph-p450 reductase, p450 bm3, p450 oxidoreductase, nadph cytochrome p450 reductase, cytochrome p450 oxidoreductase, cypor, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cytochrome P450 reductase
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aldehyde reductase (NADPH-dependent)
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CPR
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cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
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dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
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FAD-cytochrome c reductase
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ferrihemprotein P450 reductase
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NADP-cytochrome c reductase
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NADP-cytochrome reductase
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NADPH-cytochrome c oxidoreductase
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NADPH-cytochrome c reductase
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NADPH-cytochrome p-450 reductase
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NADPH-cytochrome P450 (CYP) oxidoreductase
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NADPH-dependent cytochrome c reductase
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NADPH-ferricytochrome c oxidoreductase
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P450R
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reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
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reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
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TPNH-cytochrome c reductase
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TPNH2 cytochrome c reductase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
NADPH:hemoprotein oxidoreductase
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b5 and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-03-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lah, L.; Krasevec, N.; Trontelj, P.; Komel, R.
High diversity and complex evolution of fungal cytochrome P450 reductase: cytochrome P450 systems
Fungal Genet. Biol.
45
446-458
2008
Eremothecium gossypii, Aspergillus fumigatus, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Aspergillus terreus, Botrytis cinerea, Saccharomyces cerevisiae, Candida albicans, Debaryomyces hansenii, [Candida] glabrata, Yarrowia lipolytica, Chaetomium globosum, Coccidioides immitis, Fusarium graminearum, Kluyveromyces lactis, Pyricularia grisea, Neurospora crassa, Phytophthora sojae, Rhizopus arrhizus, Sclerotinia sclerotiorum, Ustilago maydis, Parastagonospora nodorum, Phytophthora ramorum, Schizosaccharomyces pombe (P36587), Phanerodontia chrysosporium (Q9HDG2)
Manually annotated by BRENDA team