Disease on EC 1.5.3.13 - N1-acetylpolyamine oxidase
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Adenocarcinoma
A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.
Adenocarcinoma
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Adenocarcinoma
The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation.
Brain Edema
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion.
Brain Injuries, Traumatic
Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury.
Brain Ischemia
Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury.
Brain Ischemia
[Changes and significance of PAO activities and polyamine levels at different time of reperfusion after transient focal cerebral ischemia in rats]
Breast Neoplasms
Estrogens and polyamines in breast cancer: their profiles and values in disease staging.
Breast Neoplasms
Inducible expression of maize polyamine oxidase in the nucleus of MCF-7 human breast cancer cells confers sensitivity to etoposide.
Breast Neoplasms
Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
Carcinoma
Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620.
Carcinoma
Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells.
Carcinoma
Inhibition of polyamine oxidase improves the antitumoral effect of ornithine decarboxylase inhibitors.
Carcinoma
Inhibition of polyamine oxidase prevented cyclin-dependent kinase inhibitor-induced apoptosis in HCT 116 colon carcinoma cells.
Carcinoma, Hepatocellular
Expression of spermidine/spermine N1-acetyltransferase in growing Yoshida AH-130 hepatoma cells.
Carcinoma, Lewis Lung
Inhibition of polyamine oxidase improves the antitumoral effect of ornithine decarboxylase inhibitors.
Cataract
Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed ?H-Crystallins Polymerization in Calcium-Induced Experimental Cataract.
Cervical Intraepithelial Neoplasia
Cervical intraepithelial neoplasia is associated with increased polyamine oxidase and diamine oxidase concentrations in cervical mucus.
Colonic Neoplasms
Inhibition of polyamine oxidase enhances the cytotoxicity of polyamine oxidase substrates. A model study with N(1)-(n-octanesulfonyl)spermine and human colon cancer cells.
Colorectal Neoplasms
Polyamine oxidase activity and polyamine levels in human colorectal cancer and in normal surrounding mucosa.
Diabetes Mellitus, Type 1
Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus?
Epilepsy
A barley polyamine oxidase isoform with distinct structural features and subcellular localization.
Glioblastoma
Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation.
Hyperbilirubinemia, Neonatal
Polyamine oxidase activity in peripheral blood of newborn infants with neonatal hyperbilirubinemia: is bilirubin an antioxidant?
Infarction, Middle Cerebral Artery
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion.
Infections
Free polyamine and polyamine regulation during pre?penetration and penetration resistance events in oat against crown rust (Puccinia coronata f. sp. avenae)
Infections
Polyamines as a common source of hydrogen peroxide in host- and nonhost hypersensitive response during pathogen infection.
Kidney Failure, Chronic
[Physiological functions of polyamines and regulation of polyamine content in cells]
Leukemia
Participation of T-lymphocytes in the curative effect of a novel synthetic polyamine analogue, N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine, against L1210 leukemia in vivo.
Lung Neoplasms
Highly expressed N1-acetylpolyamine oxidase detoxifies polyamine analogue N1-cyclopropylmethyl-N11-ethylnorspermine in human lung cancer cell line A549.
Malaria
Polyamine oxidase in human retroplacental serum inhibits the growth of Plasmodium falciparum.
Melanoma
Polyamine oxidase activity and concentration of polyamines in tissues and serum of hamsters with transplantational pigmented melanoma IC-Sofia.
Melanoma, Experimental
Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine.
Neoplasms
Cervical intraepithelial neoplasia is associated with increased polyamine oxidase and diamine oxidase concentrations in cervical mucus.
Neoplasms
Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue.
Neoplasms
Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N1-acetyltransferase activity and cell proliferation.
Neoplasms
Effect of polyamine deprivation on the survival of intracranial glioblastoma bearing rats.
Neoplasms
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Neoplasms
Inhibition of polyamine oxidase activity affects tumor development during the maize-Ustilago maydis interaction.
Neoplasms
Inhibition of polyamine oxidase enhances the cytotoxicity of polyamine oxidase substrates. A model study with N(1)-(n-octanesulfonyl)spermine and human colon cancer cells.
Neoplasms
Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation.
Neoplasms
Microarray analysis uncovers retinoid targets in human bronchial epithelial cells.
Neoplasms
Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells.
Neoplasms
Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity.
Neoplasms
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
Neurodegenerative Diseases
Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration.
Ovarian Neoplasms
Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase.
Pancreatitis
Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase.
Pancreatitis
[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism]
Parasitemia
Trypanosoma brucei: polyamine oxidase mediated trypanolytic activity in the serum of naturally resistant cattle.
Prostatic Neoplasms
A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.
Prostatic Neoplasms
Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.
Stroke
Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke.
Stroke
[Physiological functions of polyamines and regulation of polyamine content in cells]
Ureteral Obstruction
Polyamine oxidase and diamine oxidase activities in acute ureteral obstruction.
Uterine Cervical Neoplasms
Altered urinary profiles of polyamines and endogenous steroids in patients with benign cervical disease and cervical cancer.
Uterine Cervical Neoplasms
Cervical intraepithelial neoplasia is associated with increased polyamine oxidase and diamine oxidase concentrations in cervical mucus.
Vascular System Injuries
Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.
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