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Information on EC 1.3.1.20 - trans-1,2-dihydrobenzene-1,2-diol dehydrogenase and Organism(s) Mus musculus and UniProt Accession Q9DBB8

for references in articles please use BRENDA:EC1.3.1.20
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Mus musculus
UNIPROT: Q9DBB8 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dihydrodiol dehydrogenase
-
dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol
-
-
-
-
dihydrodiol dehydrogenase
-
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+
show the reaction diagram
isoform DD3 probably identical with 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 and D-xylose dehydrogenase EC 1.1.1.179
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
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reduction
-
-
-
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dehydrogenation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37255-32-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
camphorquinone + NAD(P)H
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
show the reaction diagram
-
-
-
?
D-xylose + NADP+
D-xylono-1,5-lactone + NADPH + H+
show the reaction diagram
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
catechol + NAD(P)H
show the reaction diagram
-
the reaction produces a ketol which then enolizes to the catechol
-
?
17beta-estradiol + NAD(P)+
?
show the reaction diagram
2-cyclohexen-1-ol + NADP+
2-cyclohexene-1-one + NADPH
show the reaction diagram
-
NAD+
-
-
?
3-keto steroid + NAD(P)H
3alpha-hydroxy steroid + NAD(P)+
show the reaction diagram
-
probably reversible reaction
-
-
?
3alpha-hydroxy steroid + NADP+
3-keto steroid + NADPH
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NAD(P)H
4-nitrobenzylalcohol + NAD(P)+
show the reaction diagram
-
-
-
-
?
alicyclic alcohol + NAD(P)+
?
show the reaction diagram
-
-
-
-
?
camphorquinone + NAD(P)H
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
show the reaction diagram
-
-
-
-
?
cis-1,2-dihydrobenzene-1,2-diol + NAD(P)+
catechol + NAD(P)H
show the reaction diagram
-
-
-
-
r
epitestosterone + NAD(P)+
?
show the reaction diagram
-
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
-
-
?
glycolithocholic acid + NAD(P)+
3-oxo-glycocholanoic acid + NAD(P)H
show the reaction diagram
-
NAD+ preferred as cofactor
-
-
?
naphthalene dihydrodiol + NAD(P)+
?
show the reaction diagram
-
-
-
-
?
testosterone + NADPH + H+
4-androsten-3alpha,17beta-diol + NADP+
show the reaction diagram
-
NAD+
-
-
?
tetrahydrodeoxycorticosterone + NAD(P)+
?
show the reaction diagram
-
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
catechol + NAD(P)H
show the reaction diagram
trans-naphthalene dihydrodiol + NAD(P)+
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
naphthalene dihydrodiol + NAD(P)+
?
show the reaction diagram
-
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
catechol + NAD(P)H
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
dependent on
NADH
-
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17beta-estradiol
-
-
5alpha-Androstan-3-beta-ol-17-one
-
-
5alpha-Pregnan-3beta-21-one
-
-
5beta-androstan-3beta-ol-17-one
-
-
5beta-Pregnan-3beta-ol-20-one
-
-
Dienstrol
-
-
Hexestrol
-
-
Stilbestrol
-
-
testosterone
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.67 - 1.99
cis-benzene dihydrodiol
6.78
Naphthalene dihydrodiol
-
NADP+
0.77
trans-benzene dihydrodiol
-
NADP+, DD1
additional information
additional information
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10.5
-
DD4
9 - 9.5
-
DD2
9.5
-
DD3, DD1
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
low activity
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
additional information
not found in liver and kidney
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DHDH_MOUSE
333
0
36301
Swiss-Prot
Secretory Pathway (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30000
-
DD1, gel filtration
33000
-
2 * 33000 (DD3), 2 * 35000 (DD4), SDS-PAGE
34000
-
DD2, gel filtration
35000
-
2 * 33000 (DD3), 2 * 35000 (DD4), SDS-PAGE
39000
-
1 * 39000, kidney, SDS-PAGE
64000
-
DD3, gel filtration
65000
-
DD4, gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 33000 (DD3), 2 * 35000 (DD4), SDS-PAGE
monomer
-
1 * 39000, kidney, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, 5 min
50
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, all activity lost
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
DD1, DD2, DD3, DD4
-
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
-
enzyme forms: DD1, DD3
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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enzyme may play an important role in benz[a]pyrene carcinogenesis via oxidative DNA damage
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakagawa, M.; Tsukada, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydroxysteroid dehydrogenase activity in mouse kidney
Biochem. J.
106(4)
633-638
1989
Mus musculus
Manually annotated by BRENDA team
Bolcsak, L.E.; Nerland, D.E.
Purification of mouse liver benzene dihydrodiol dehydrogenases
J. Biol. Chem.
258
7252-7255
1983
Mus musculus
Manually annotated by BRENDA team
Seike, K.; Murata, M.; Hirakawa, K.; Deyashiki, Y.; Kawanishi, S.
Oxidative DNA damage induced by benz[a]anthracene dihydrodiols in the presence of dihydrodiol dehydrogenase
Chem. Res. Toxicol.
17
1445-1451
2004
Mus musculus
Manually annotated by BRENDA team
Carbone, V.; Hara, A.; El-Kabbani, O.
Structural and functional features of dimeric dihydrodiol dehydrogenase
Cell. Mol. Life Sci.
65
1464-1474
2008
Bos taurus (Q148L6), Macaca fascicularis, Mus musculus (Q9DBB8), Pongo abelii (Q5R5J5), Sus scrofa
Manually annotated by BRENDA team