Information on EC - L-tyrosine reductase

for references in articles please use BRENDA:EC1.2.1.101
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IUBMB Comments
The enzyme, characterized from the ascomycete fungus Aspergillus flavus, is specific for L-tyrosine. It contains three domains - an adenylation domain, a peptidyl-carrier protein (PCP) domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the PCP domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to the aldehyde.
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The expected taxonomic range for this enzyme is: Aspergillus flavus
l-tyrosine reductases lnaa, more
L-tyrosinal + NADP+ + AMP + diphosphate = L-tyrosine + NADPH + H+ + ATP
show the reaction diagram
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