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Information on EC 1.14.99.60 - 3-demethoxyubiquinol 3-hydroxylase and Organism(s) Homo sapiens and UniProt Accession Q99807

for references in articles please use BRENDA:EC1.14.99.60
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IUBMB Comments
The enzyme catalyses the last hydroxylation reaction during the biosynthesis of ubiquinone.
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This record set is specific for:
Homo sapiens
UNIPROT: Q99807
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
clk-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol 5-hydroxylase
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clk-1
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COQ7
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ubiF
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SYSTEMATIC NAME
IUBMB Comments
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol,acceptor:oxygen oxidoreductase (5-hydroxylating)
The enzyme catalyses the last hydroxylation reaction during the biosynthesis of ubiquinone.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the human CLK-1 gene is able to functionally complement Saccharomyces cerevisiae Coq7 deletion mutants
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
COQ7_HUMAN
217
0
24277
Swiss-Prot
Mitochondrion (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vajo, Z.; King, L.M.; Jonassen, T.; Wilkin, D.J.; Ho, N.; Munnich, A.; Clarke, C.F.; Francomano, C.A.
Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human a gene required for ubiquinone biosynthesis with potential implications for aging
Mamm. Genome
10
1000-1004
1999
Homo sapiens (Q99807), Homo sapiens
Manually annotated by BRENDA team