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Information on EC 1.14.19.1 - stearoyl-CoA 9-desaturase and Organism(s) Plasmodium falciparum and UniProt Accession Q8I0W9

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IUBMB Comments
An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).
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This record set is specific for:
Plasmodium falciparum
UNIPROT: Q8I0W9
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Word Map
The taxonomic range for the selected organisms is: Plasmodium falciparum
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
scd, stearoyl-coa desaturase, fatty acid desaturase, scd-1, stearoyl-coa desaturase 1, stearoyl-coa desaturase-1, stearoyl coa desaturase, stearoyl-coenzyme a desaturase, delta9-desaturase, delta9 desaturase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
stearoyl-CoA desaturase
-
acyl coenzyme A desaturase
-
-
-
-
acyl-CoA desaturase
-
-
-
-
DELTA9-acyl CoA desaturase
-
-
-
-
DELTA9-desaturase
-
-
-
-
eicosatrienoyl-CoA desaturase
-
-
-
-
fatty acid 9-desaturase
-
-
-
-
fatty acid DELTA9-desaturase
-
-
-
-
fatty acid desaturase
-
-
-
-
fatty acyl CoA DELTA9-desaturase
-
-
-
-
fatty acyl DELTA9-desaturase
-
-
-
-
fatty acyl-CoA desaturase
-
-
-
-
long-chain fatty acid DELTA9-desaturase
-
-
-
-
palmitoyl CoA desaturase
-
-
-
-
palmitoyl-CoA desaturase
-
-
-
-
stearoyl coenzyme A desaturase
-
-
-
-
stearoyl-CoA (DELTA8) desaturase
-
-
-
-
stearoyl-CoA desaturase
-
-
-
-
stearyl coenzyme A desaturase
-
-
-
-
stearyl-CoA desaturase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)
An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).
CAS REGISTRY NUMBER
COMMENTARY hide
9014-34-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
stearoyl-CoA + NADPH + H+ + O2
oleoyl-CoA + NADP+ + H2O
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome b5
-
-
NADPH
SCD is mainly dependent on NADPH, no oleic acid is produced in the absence of NADPH
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate
-
methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate
-
methyl malvalate
-
methyl sterculate
inhibits the synthesis of oleic acid both with parasite lysates and infected erythrocytes, most likely by targeting SCD
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0566
stearoyl-CoA
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.041
methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate
Plasmodium falciparum
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C
0.08
methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate
Plasmodium falciparum
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C
0.167
methyl malvalate
Plasmodium falciparum
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C
0.087
methyl sterculate
Plasmodium falciparum
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9.2
calculated from amino acid sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
114000
calculated from amino acid sequence
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
there is a 53fold increase of SCD transcript expression level between 18 and 36 h during the late trophozoite stage
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gratraud, P.; Huws, E.; Falkard, B.; Adjalley, S.; Fidock, D.A.; Berry, L.; Jacobs, W.R.; Baird, M.S.; Vial, H.; Kremer, L.
Oleic acid biosynthesis in Plasmodium falciparum: Characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target
PLoS ONE
4
e6889
2009
Plasmodium falciparum (Q8I0W9), Plasmodium falciparum
Manually annotated by BRENDA team