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EC Tree
IUBMB Comments CYP2C19 is microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the benzene ring of fenbendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. This activity is also carried out by CYP2J2. cf. EC 1.14.14.74, albendazole monooxygenase (hydroxylating). CYP2C19 does not act on albendazole.
The enzyme appears in viruses and cellular organisms
Synonyms
CYP2C19 , CYP2J2,
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CYP2C19
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fenbendazole + [reduced NADPH-hemoprotein reductase] + O2 = 4'-hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
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fenbendazole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (4'-hydroxylating)
CYP2C19 is microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the benzene ring of fenbendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. This activity is also carried out by CYP2J2. cf. EC 1.14.14.74, albendazole monooxygenase (hydroxylating). CYP2C19 does not act on albendazole.
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fenbendazole + [reduced NADPH-hemoprotein reductase] + O2
hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
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fenbendazole + [reduced NADPH-hemoprotein reductase] + O2
hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
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UniProt
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physiological function
fenbendazole hydroxylation correlates with both CYP2C19 and CYP2J2 activities
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CP2CJ_HUMAN
490
0
55931
Swiss-Prot
Secretory Pathway (Reliability: 1 )
A0A6J8AQU6_MYTCO
496
1
56488
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A6J8DYX6_MYTCO
606
0
70289
TrEMBL
other Location (Reliability: 1 )
A0A6J8A0W9_MYTCO
491
1
55977
TrEMBL
Secretory Pathway (Reliability: 2 )
A0A7R8GYT2_LEPSM
527
1
60188
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A6J8E2J7_MYTCO
355
0
41459
TrEMBL
other Location (Reliability: 2 )
A0A7R8D2E2_LEPSM
322
0
37509
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A6J8A1H0_MYTCO
169
0
19077
TrEMBL
other Location (Reliability: 2 )
A0A6J8AEW8_MYTCO
469
0
53374
TrEMBL
other Location (Reliability: 4 )
A0A6J8EKH1_MYTCO
476
0
55398
TrEMBL
other Location (Reliability: 1 )
A0A6J8DXU4_MYTCO
586
0
67596
TrEMBL
Mitochondrion (Reliability: 4 )
A0A6J8E1T3_MYTCO
359
0
41845
TrEMBL
other Location (Reliability: 2 )
A0A6J8A406_MYTCO
488
1
55702
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A6J8A017_MYTCO
502
1
57299
TrEMBL
Secretory Pathway (Reliability: 2 )
CP2J2_HUMAN
502
2
57611
Swiss-Prot
Secretory Pathway (Reliability: 1 )
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Wu, Z.; Lee, D.; Joo, J.; Shin, J.; Kang, W.; Oh, S.; Lee, D.; Lee, S.; Yea, S.; Lee, H.; Lee, T.; Liu, K.
CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems
Antimicrob. Agents Chemother.
57
5448-5456
2013
Homo sapiens (P33261), Homo sapiens (P51589)
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