Information on EC 1.14.14.75 - fenbendazole monooxygenase (4'-hydroxylating)

for references in articles please use BRENDA:EC1.14.14.75
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The expected taxonomic range for this enzyme is: Homo sapiens

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EC NUMBER
COMMENTARY hide
1.14.14.75
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RECOMMENDED NAME
GeneOntology No.
fenbendazole monooxygenase (4'-hydroxylating)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
fenbendazole + [reduced NADPH-hemoprotein reductase] + O2 = 4'-hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
fenbendazole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (4'-hydroxylating)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
fenbendazole hydroxylation correlates with both CYP2C19 and CYP2J2 activities; fenbendazole hydroxylation correlates with both CYP2C19 and CYP2J2 activities
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
fenbendazole + [reduced NADPH-hemoprotein reductase] + O2
hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
fenbendazole + [reduced NADPH-hemoprotein reductase] + O2
hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
P33261, P51589
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?
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.14.75)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)