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Information on EC 1.14.14.73 - albendazole monooxygenase (sulfoxide-forming)

for references in articles please use BRENDA:EC1.14.14.73

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IUBMB Comments

This is one of the activities carried out by some microsomal cytochrome P-450 monooxygenases. A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32, albendazole monooxygenase (flavin-containing)), but it is estimated that cytochrome P-450s are responsible for 70% of the activity.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
cyp2j2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
albendazole + [reduced NADPH-hemoprotein reductase] + O2 = albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1)
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fenbendazole + [reduced NADPH-hemoprotein reductase] + O2 = fenbendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(2)
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