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Information on EC 1.14.14.56 - 1,8-cineole 2-exo-monooxygenase

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IUBMB Comments
A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase).
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The enzyme appears in viruses and cellular organisms
Synonyms
CYP3A4, CYP3A5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1,8-cineole + [reduced NADPH-hemoprotein reductase] + O2 = 2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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