Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.14.14.49 - 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase

for references in articles please use BRENDA:EC1.14.14.49

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

A cytochrome P450 (heme thiolate) enzyme found in plants. The enzyme acts on jasmonoyl-L-amino acid conjugates that have been hydroxylated at the C-12 position of jasmonic acid by EC 1.14.14.48, jasmonoyl-L-amino acid 12-hydroxylase, further oxidizing that position to a carboxylate via an aldehyde intermediate. While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.

The expected taxonomic range for this enzyme is: Arabidopsis thaliana

Synonyms
CYP94C1, CYP94C3, jasmonoyl-L-isoleucine-12-hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 12-hydroxyjasmonoyl-L-amino acid + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = a 12-hydroxy-12-oxojasmonoyl-L-amino acid + 2 [oxidized NADPH-hemoprotein reductase] + 3 H2O
show the reaction diagram
overall reaction
-
-
-
a 12-hydroxyjasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2 = a 12-oxojasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
(1a)
-
-
-
a 12-oxojasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2 = a 12-hydroxy-12-oxojasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1b)
-
-
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links