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Information on EC 1.14.14.162 - flavanone 2-hydroxylase and Organism(s) Oryza sativa and UniProt Accession Q5VRI5

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IUBMB Comments
A cytochrome P-450 (heme thiolate) plant enzyme that catalyses the 2-hydroxylation of multiple flavanones such as (2S)-naringenin, (2S)-eriodictyol, (2S)-pinocembrin, and (2S)-liquiritigenin. The products are meta-stable and exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione.
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This record set is specific for:
Oryza sativa
UNIPROT: Q5VRI5
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Word Map
The taxonomic range for the selected organisms is: Oryza sativa
The enzyme appears in selected viruses and cellular organisms
Synonyms
cyp93g2, flavanone 2-hydroxylase, (2s)-flavanone 2-hydroxylase, osf2h, os06g01250, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
licodione synthase
-
-
-
-
liquiritigenin,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (licodione-forming)
-
-
-
-
Os06g01250
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
flavanone,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating)
A cytochrome P-450 (heme thiolate) plant enzyme that catalyses the 2-hydroxylation of multiple flavanones such as (2S)-naringenin, (2S)-eriodictyol, (2S)-pinocembrin, and (2S)-liquiritigenin. The products are meta-stable and exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione.
CAS REGISTRY NUMBER
COMMENTARY hide
157972-05-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
eriodictyol + [reduced NADPH-hemoprotein reductase] + O2
2-hydroxyeriodictyol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
naringenin + [reduced NADPH-hemoprotein reductase] + O2
2-hydroxynaringenin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
eriodictyol + [reduced NADPH-hemoprotein reductase] + O2
2-hydroxyeriodictyol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
naringenin + [reduced NADPH-hemoprotein reductase] + O2
2-hydroxynaringenin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P-450
a cytochrome P-450 (heme thiolate) enzyme
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
subsp. japonica
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
knocking down Os06g01250 in rice (Oryza sativa subsp. japonica Zhonghua 11) preferentially depletes the accumulation of C-glycosylapigenin, C-glycosylluteolin, and C-glycosylchrysoeriol but does not affect the levels of tricin
metabolism
the enzyme channels flavanones to C-glycosylflavone biosynthesis in rice
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
transgenic Arabidopsis overexpressing CYP93G2 or coexpressing CYP93G2 and OsCGT accumulates 2-hydroxyflavanone derivatives
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Du, Y.; Chu, H.; Chu, I.K.; Lo, C.
CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice
Plant Physiol.
154
324-333
2010
Oryza sativa (Q5VRI5), Oryza sativa
Manually annotated by BRENDA team