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IUBMB CommentsA cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.
The expected taxonomic range for this enzyme is: Eschscholzia californica
Synonyms
Dihydrosanguinarine 10-hydroxylase, EC 1.14.13.56, Oxygenase, dihydrosanguinarine 10-mono, more
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Dihydrosanguinarine 10-hydroxylase
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EC 1.14.13.56
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formerly
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Oxygenase, dihydrosanguinarine 10-mono
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dihydrosanguinarine + [reduced NADPH-hemoprotein reductase] + O2 = 10-hydroxydihydrosanguinarine + [oxidized NADPH-hemoprotein reductase] + H2O
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MetaCyc
sanguinarine and macarpine biosynthesis
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dihydrosanguinarine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.
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dihydrosanguinarine + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxydihydrosanguinarine + [oxidized NADPH-hemoprotein reductase] + H2O
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Substrates: -
Products: -
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cytochrome P450
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dependent on
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CO
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strong inhibition in the dark, effect is partly reversible by illumination
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brenda
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brenda
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associated with
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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De-Eknamkul, W.; Tanahashi, T.; Zenk, M.H.
Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia
Phytochemistry
31
2713-2717
1992
Eschscholzia californica
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brenda
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