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Information on EC - 5a,11a-dehydrotetracycline 5-monooxygenase

for references in articles please use BRENDA:EC1.14.13.234
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IUBMB Comments
The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalysing two successive monooxygenation reactions. It starts by catalysing the stereospecific hydroxylation of anhydrotetracycline at C-6 (EC If the released product is captured by EC, 5a,11a-dehydrotetracycline dehydrogenase (OxyR), it is reduced to tetracycline. However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C-5, producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR, becomes oxytetracycline.
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The enzyme appears in viruses and cellular organisms
12-dehydrotetracycline 5-monooxygenase, anhydrotetracycline oxygenase, OtcC, oxyS, more
5a,11a-dehydrotetracycline + NADPH + H+ + O2 = 5a,11a-dehydrooxytetracycline + NADP+ + H2O
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