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Information on EC 1.13.11.65 - carotenoid isomerooxygenase

for references in articles please use BRENDA:EC1.13.11.65
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IUBMB Comments
The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including beta-carotene, alpha-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
carotenoid cleavage oxygenase, CCO, NinaB, ppsir_15490, Rv0654, sala_1698, SIR-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
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PATHWAY SOURCE
PATHWAYS
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