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Information on EC 1.13.11.26 - peptide-tryptophan 2,3-dioxygenase
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1.13.11.26 peptide-tryptophan 2,3-dioxygenaseIUBMB Comments
Also acts on tryptophan.
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Word Map
- 1.13.11.26
- kynurenine
- indoleamine-2,3-dioxygenase
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hepatocyte-like
-
neuroactive
- 3-hydroxykynurenine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
=
[protein]-N-formyl-L-kynurenine
Synonyms
peptidyltryptophan 2,3-dioxygenase, pyrrolooxygenase, tryptophan pyrrolooxygenase, tryptophan-2,3-dioxygenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
peptidyltryptophan 2,3-dioxygenase
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-
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pyrrolooxygenase
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tryptophan pyrrolooxygenase
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-
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tryptophan-2,3-dioxygenase
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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-
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redox reaction
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-
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reduction
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SYSTEMATIC NAME
IUBMB Comments
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Also acts on tryptophan.
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CAS REGISTRY NUMBER
COMMENTARY
37256-64-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-5-hydroxytryptophan + O2
5-hydroxy-N-formylkynurenine
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very poor substrate activity with molecular form A
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-
?
N-acetyl-5-methyltryptophan + O2
5-methyl-Nalpha-acetyl-Nomega-formylkynurenine
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-
-
-
?
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
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-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
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-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
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-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
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-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
desipramine
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antidepressant, exogenous melatonin counteracts the inhibitory effect
fluoxetine
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antidepressant, exogenous melatonin counteracts the inhibitory effect
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anemia, Hemolytic
[Activity of key enzymes of heme metabolism and cytochrome P-450 content in the rat liver in experimental rhabdomyolysis and hemolytic anemia]
Breast Neoplasms
A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma.
Carcinoma, Hepatocellular
Novel conjugates with dual suppression of glutathione S-transferases and tryptophan-2,3-dioxygenase activities for improving hepatocellular carcinoma therapy.
Encephalitis
Acyclovir inhibits rat liver tryptophan-2,3-dioxygenase and induces a concomitant rise in brain serotonin and 5-hydroxyindole acetic acid levels.
Encephalitis, Herpes Simplex
Acyclovir inhibits rat liver tryptophan-2,3-dioxygenase and induces a concomitant rise in brain serotonin and 5-hydroxyindole acetic acid levels.
Glioblastoma
Hypoxia Inducible Factor 1? Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.
Glioblastoma
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
Glioma
Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBP?.
Glioma
Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.
Glioma
Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.
Hepatitis
The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO).
Infections
The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO).
Liver Diseases
A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases.
Lymphoma, B-Cell
IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era.
Lymphoma, Large B-Cell, Diffuse
IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era.
Multiple Sclerosis
Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.
Neoplasms
Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBP?.
Neoplasms
Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells.
Neoplasms
IDO, TDO, and AHR overexpression is associated with poor outcome in diffuse large B-cell lymphoma patients in the rituximab era.
Neoplasms
Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer.
Neoplasms
Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
Neoplasms
Multifunctional platinum(IV) complexes as immunostimulatory agents to promote cancer immunochemotherapy by inhibiting tryptophan-2,3-dioxygenase.
Neoplasms
Novel conjugates with dual suppression of glutathione S-transferases and tryptophan-2,3-dioxygenase activities for improving hepatocellular carcinoma therapy.
Neoplasms
Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.
Neoplasms
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Neoplasms
Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation.
Neurodegenerative Diseases
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.
Triple Negative Breast Neoplasms
Reversal of Triple-negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immune-Suppression.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, forms A and C stable for at least two weeks, form B activity loss after three days
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Camoretti-Mercado, B.; Frydman, R.B.
Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins
Eur. J. Biochem.
156
317-325
1986
Triticum aestivum
brenda
Sburlati, A.R.; Frydman, R.B.
Changes in the activities of pyrrolooxygenases during the germination of wheat grains
Plant Physiol.
71
822-827
1983
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases from pepper and poinsettia leaves
Phytochemistry
18
1119-1123
1979
Capsicum annuum, Euphorbia pulcherrima
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brenda
Mendy, D.F.; Tomaro, M.L.; Frydman, R.B.
Pyrrolooxygenases from argentine wheat varieties
Phytochemistry
18
1427-1431
1979
Triticum aestivum
-
brenda
Frydman, B.; Frydman, R.B.; Tomaro, M.L.
Pyrrolooxygenases: a new type of oxygenases
Mol. Cell. Biochem.
2
121-135
1973
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases: isolation, properties, and products formed
Biochim. Biophys. Acta
284
63-79
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides
Biochim. Biophys. Acta
284
80-89
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: a new type of target enzyme
FEBS Lett.
15
305-308
1971
Triticum aestivum
brenda
Walsh, H.A.; Daya, S.
Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin
Life Sci.
62
2417-2423
1998
Rattus norvegicus
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