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Information on EC 1.13.11.26 - peptide-tryptophan 2,3-dioxygenase for references in articles please use BRENDA:EC1.13.11.26
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
=
[protein]-N-formyl-L-kynurenine
Synonyms
tryptophan-2,3-dioxygenase, tryptophan pyrrolooxygenase, pyrrolooxygenase,
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peptidyltryptophan 2,3-dioxygenase
-
-
-
-
tryptophan pyrrolooxygenase
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-
-
-
tryptophan-2,3-dioxygenase
-
-
-
-
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[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine
-
-
-
-
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[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Also acts on tryptophan.
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D-tryptophan + O2
formylkynurenine
-
-
-
-
?
DL-5-fluorotryptophan + O2
5-fluoroformylkynurenine
-
-
-
-
?
DL-5-methyltryptophan + O2
5-methyl-N-formylkynurenine
-
-
-
-
?
DL-6-fluorotryptophan + O2
4-fluoro-N-formylkynurenine
-
-
-
-
?
DL-6-methyltryptophan + O2
4-methyl-N-formylkynurenine
-
-
-
-
?
DL-7-methyltryptophan + O2
3-methyl-N-formylkynurenine
-
-
-
-
?
DL-tryptophan + O2
formylkynurenine
-
-
-
-
?
DL-tryptophan methyl ester + O2
formylkynurenine methyl ester
-
-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
L-5-hydroxytryptophan + O2
5-hydroxy-N-formylkynurenine
-
very poor substrate activity with molecular form A
-
-
?
L-tryptophan + O2
2-oxotryptophan
L-tryptophan + O2
formylkynurenine
L-tryptophan methyl ester + O2
N-formylkynurenine methyl ester
-
-
-
-
?
N-acetyl-5-methyltryptophan + O2
5-methyl-Nalpha-acetyl-Nomega-formylkynurenine
-
-
-
-
?
N-acetyl-DL-tryptophan + O2
N-acetylformylkynurenine
-
-
-
-
?
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
tryptophan + O2
L-kynurenine
-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
-
-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
-
-
-
?
L-tryptophan + O2
2-oxotryptophan
-
-
-
?
L-tryptophan + O2
2-oxotryptophan
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
enzyme extract of whole flour
-
-
?
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
-
-
-
-
-
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
-
-
-
-
?
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L-tryptophan + O2
formylkynurenine
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
enzyme extract of whole flour
-
-
?
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Ca2+
-
at 10 mM strong inhibition
Cd2+
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at 10 mM strong inhibition
Cu2+
-
at 10 mM strong inhibition
Sr2+
-
at 10 mM strong inhibition
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alpha,alpha'-dipyridyl
-
-
desipramine
-
antidepressant, exogenous melatonin counteracts the inhibitory effect
dithioerythritol
-
2 mM, total activity loss
fluoxetine
-
antidepressant, exogenous melatonin counteracts the inhibitory effect
p-chloromercuribenzoate
-
-
p-hydroxymercurisulfonate
-
10 mM, activity loss of 60%
Soybean trypsin inhibitor
-
-
-
2-mercaptoethanol
-
2 mM, total activity loss
dithiothreitol
-
2 mM, total activity loss
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0.2
N-acetyltryptophan
-
-
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additional information
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highest in the radicle
additional information
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additional information
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additional information
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8 - 8.5
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Tris-HCl buffer
8
-
sodium sulfate buffer
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22
-
form C with chymotrypsin as substrate
37 - 45
-
form A, tryptophan or gamma-chymotrypsin as substrates
37
-
enzyme assay
37
-
form B, form C with tryptophan as substrate
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field-grown
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brenda
Willd.
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brenda
Wistar, male
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-
brenda
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brenda
different varieties of argentine wheat
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brenda
var Klein Rendidor
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brenda
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-
brenda
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brenda
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brenda
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-
brenda
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embryo, radicle, coleoptile
brenda
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young, senescent
brenda
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young, senescent
brenda
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25000
-
molecular form A, SDS-PAGE
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60
-
70% activity loss after 20 min preincubation
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0-4°C, stable for more than a year, less stable at -15°C
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0-4°C, stable for six months
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4°C, forms A and C stable for at least two weeks, form B activity loss after three days
-
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three molecular forms: A,B,C
-
two forms in the radicle
-
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Camoretti-Mercado, B.; Frydman, R.B.
Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins
Eur. J. Biochem.
156
317-325
1986
Triticum aestivum
brenda
Sburlati, A.R.; Frydman, R.B.
Changes in the activities of pyrrolooxygenases during the germination of wheat grains
Plant Physiol.
71
822-827
1983
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases from pepper and poinsettia leaves
Phytochemistry
18
1119-1123
1979
Capsicum annuum, Euphorbia pulcherrima
-
brenda
Mendy, D.F.; Tomaro, M.L.; Frydman, R.B.
Pyrrolooxygenases from argentine wheat varieties
Phytochemistry
18
1427-1431
1979
Triticum aestivum
-
brenda
Frydman, B.; Frydman, R.B.; Tomaro, M.L.
Pyrrolooxygenases: a new type of oxygenases
Mol. Cell. Biochem.
2
121-135
1973
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases: isolation, properties, and products formed
Biochim. Biophys. Acta
284
63-79
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides
Biochim. Biophys. Acta
284
80-89
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: a new type of target enzyme
FEBS Lett.
15
305-308
1971
Triticum aestivum
brenda
Walsh, H.A.; Daya, S.
Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin
Life Sci.
62
2417-2423
1998
Rattus norvegicus
brenda
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1.13.11.26 peptide-tryptophan 2,3-dioxygenase
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