We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 1.13.11.26 - peptide-tryptophan 2,3-dioxygenase for references in articles please use BRENDA:EC1.13.11.26
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
=
[protein]-N-formyl-L-kynurenine
Synonyms
peptidyltryptophan 2,3-dioxygenase, pyrrolooxygenase, tryptophan pyrrolooxygenase, tryptophan-2,3-dioxygenase,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
peptidyltryptophan 2,3-dioxygenase
-
-
-
-
tryptophan pyrrolooxygenase
-
-
-
-
tryptophan-2,3-dioxygenase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Also acts on tryptophan.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
D-tryptophan + O2
formylkynurenine
-
-
-
-
?
DL-5-fluorotryptophan + O2
5-fluoroformylkynurenine
-
-
-
-
?
DL-5-methyltryptophan + O2
5-methyl-N-formylkynurenine
-
-
-
-
?
DL-6-fluorotryptophan + O2
4-fluoro-N-formylkynurenine
-
-
-
-
?
DL-6-methyltryptophan + O2
4-methyl-N-formylkynurenine
-
-
-
-
?
DL-7-methyltryptophan + O2
3-methyl-N-formylkynurenine
-
-
-
-
?
DL-tryptophan + O2
formylkynurenine
-
-
-
-
?
DL-tryptophan methyl ester + O2
formylkynurenine methyl ester
-
-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
L-5-hydroxytryptophan + O2
5-hydroxy-N-formylkynurenine
-
very poor substrate activity with molecular form A
-
-
?
L-tryptophan + O2
2-oxotryptophan
L-tryptophan + O2
formylkynurenine
L-tryptophan methyl ester + O2
N-formylkynurenine methyl ester
-
-
-
-
?
N-acetyl-5-methyltryptophan + O2
5-methyl-Nalpha-acetyl-Nomega-formylkynurenine
-
-
-
-
?
N-acetyl-DL-tryptophan + O2
N-acetylformylkynurenine
-
-
-
-
?
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
tryptophan + O2
L-kynurenine
-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
-
-
-
-
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
-
-
-
?
L-tryptophan + O2
2-oxotryptophan
-
-
-
?
L-tryptophan + O2
2-oxotryptophan
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
enzyme extract of whole flour
-
-
?
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
-
-
-
-
-
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-tryptophan + O2
formylkynurenine
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
-
-
-
?
L-tryptophan + O2
formylkynurenine
-
enzyme extract of whole flour
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ca2+
-
at 10 mM strong inhibition
Cd2+
-
at 10 mM strong inhibition
Cu2+
-
at 10 mM strong inhibition
Sr2+
-
at 10 mM strong inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
alpha,alpha'-dipyridyl
-
-
desipramine
-
antidepressant, exogenous melatonin counteracts the inhibitory effect
dithioerythritol
-
2 mM, total activity loss
fluoxetine
-
antidepressant, exogenous melatonin counteracts the inhibitory effect
p-chloromercuribenzoate
-
-
p-hydroxymercurisulfonate
-
10 mM, activity loss of 60%
Soybean trypsin inhibitor
-
-
-
2-mercaptoethanol
-
2 mM, total activity loss
dithiothreitol
-
2 mM, total activity loss
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.2
N-acetyltryptophan
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
highest in the radicle
additional information
-
-
additional information
-
-
additional information
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
8 - 8.5
-
Tris-HCl buffer
8
-
sodium sulfate buffer
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
22
-
form C with chymotrypsin as substrate
37 - 45
-
form A, tryptophan or gamma-chymotrypsin as substrates
37
-
enzyme assay
37
-
form B, form C with tryptophan as substrate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
field-grown
-
-
brenda
Willd.
-
-
brenda
Wistar, male
-
-
brenda
-
-
-
brenda
different varieties of argentine wheat
-
-
brenda
var Klein Rendidor
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
embryo, radicle, coleoptile
brenda
-
young, senescent
brenda
-
young, senescent
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
25000
-
molecular form A, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
60
-
70% activity loss after 20 min preincubation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0-4°C, stable for more than a year, less stable at -15°C
-
0-4°C, stable for six months
-
4°C, forms A and C stable for at least two weeks, form B activity loss after three days
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
three molecular forms: A,B,C
-
two forms in the radicle
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Camoretti-Mercado, B.; Frydman, R.B.
Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins
Eur. J. Biochem.
156
317-325
1986
Triticum aestivum
brenda
Sburlati, A.R.; Frydman, R.B.
Changes in the activities of pyrrolooxygenases during the germination of wheat grains
Plant Physiol.
71
822-827
1983
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases from pepper and poinsettia leaves
Phytochemistry
18
1119-1123
1979
Capsicum annuum, Euphorbia pulcherrima
-
brenda
Mendy, D.F.; Tomaro, M.L.; Frydman, R.B.
Pyrrolooxygenases from argentine wheat varieties
Phytochemistry
18
1427-1431
1979
Triticum aestivum
-
brenda
Frydman, B.; Frydman, R.B.; Tomaro, M.L.
Pyrrolooxygenases: a new type of oxygenases
Mol. Cell. Biochem.
2
121-135
1973
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases: isolation, properties, and products formed
Biochim. Biophys. Acta
284
63-79
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides
Biochim. Biophys. Acta
284
80-89
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: a new type of target enzyme
FEBS Lett.
15
305-308
1971
Triticum aestivum
brenda
Walsh, H.A.; Daya, S.
Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin
Life Sci.
62
2417-2423
1998
Rattus norvegicus
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
1.13.11.26 peptide-tryptophan 2,3-dioxygenase
more
top
Information
