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Information on EC 1.13.11.26 - peptide-tryptophan 2,3-dioxygenase
for references in articles please use BRENDA:EC1.13.11.26
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EC Tree 1 Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.26 peptide-tryptophan 2,3-dioxygenase
IUBMB Comments
Also acts on tryptophan.
The enzyme appears in viruses and cellular organisms
- 1.13.11.26
- kynurenine
- indoleamine-2,3-dioxygenase
-
hepatocyte-like
-
neuroactive
- 3-hydroxykynurenine
Reaction Schemes
show+
=
[protein]-N-formyl-L-kynurenine
Synonyms
tryptophan pyrrolooxygenase, pyrrolooxygenase, more
top
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
peptidyltryptophan 2,3-dioxygenase
-
-
-
-
pyrrolooxygenase
-
-
-
-
tryptophan pyrrolooxygenase
-
-
-
-
tryptophan-2,3-dioxygenase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Also acts on tryptophan.
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CAS REGISTRY NUMBER
COMMENTARY
37256-64-7
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-tryptophan + O2
formylkynurenine
-
Substrates: -
Products: -
Products: -
?
DL-5-fluorotryptophan + O2
5-fluoroformylkynurenine
-
Substrates: -
Products: -
Products: -
?
DL-5-methyltryptophan + O2
5-methyl-N-formylkynurenine
-
Substrates: -
Products: -
Products: -
?
DL-6-fluorotryptophan + O2
4-fluoro-N-formylkynurenine
-
Substrates: -
Products: -
Products: -
?
DL-6-methyltryptophan + O2
4-methyl-N-formylkynurenine
-
Substrates: -
Products: -
Products: -
?
DL-7-methyltryptophan + O2
3-methyl-N-formylkynurenine
-
Substrates: -
Products: -
Products: -
?
DL-tryptophan methyl ester + O2
formylkynurenine methyl ester
-
Substrates: -
Products: -
Products: -
?
ethyl N-acetyl-L-tryptophan + O2
ethyl 2-acetamido-3-2'-formimidobenzoyl propionate
-
Substrates: -
Products: -
Products: -
?
L-5-hydroxytryptophan + O2
5-hydroxy-N-formylkynurenine
-
Substrates: very poor substrate activity with molecular form A
Products: -
Products: -
?
L-tryptophan methyl ester + O2
N-formylkynurenine methyl ester
-
Substrates: -
Products: -
Products: -
?
N-acetyl-5-methyltryptophan + O2
5-methyl-Nalpha-acetyl-Nomega-formylkynurenine
-
Substrates: -
Products: -
Products: -
?
N-acetyl-DL-tryptophan + O2
N-acetylformylkynurenine
-
Substrates: -
Products: -
Products: -
?
N-acetyltryptophan + O2
Nalpha-acetyl-Nomega-formylkynurenine
-
Substrates: -
Products: -
Products: -
?
L-tryptophan + O2
formylkynurenine
-
Substrates: -
Products: -
Products: -
?
L-tryptophan + O2
formylkynurenine
-
Substrates: enzyme extract of whole flour
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-tryptophan + O2
formylkynurenine
-
Substrates: -
Products: -
Products: -
?
L-tryptophan + O2
formylkynurenine
-
Substrates: enzyme extract of whole flour
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
desipramine
-
antidepressant, exogenous melatonin counteracts the inhibitory effect
fluoxetine
-
antidepressant, exogenous melatonin counteracts the inhibitory effect
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, forms A and C stable for at least two weeks, form B activity loss after three days
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Camoretti-Mercado, B.; Frydman, R.B.
Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins
Eur. J. Biochem.
156
317-325
1986
Triticum aestivum
brenda
Sburlati, A.R.; Frydman, R.B.
Changes in the activities of pyrrolooxygenases during the germination of wheat grains
Plant Physiol.
71
822-827
1983
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases from pepper and poinsettia leaves
Phytochemistry
18
1119-1123
1979
Capsicum annuum, Euphorbia pulcherrima
-
brenda
Mendy, D.F.; Tomaro, M.L.; Frydman, R.B.
Pyrrolooxygenases from argentine wheat varieties
Phytochemistry
18
1427-1431
1979
Triticum aestivum
-
brenda
Frydman, B.; Frydman, R.B.; Tomaro, M.L.
Pyrrolooxygenases: a new type of oxygenases
Mol. Cell. Biochem.
2
121-135
1973
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenases: isolation, properties, and products formed
Biochim. Biophys. Acta
284
63-79
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides
Biochim. Biophys. Acta
284
80-89
1972
Triticum aestivum
brenda
Frydman, R.B.; Tomaro, M.L.; Frydman, B.
Pyrrolooxygenase: a new type of target enzyme
FEBS Lett.
15
305-308
1971
Triticum aestivum
brenda
Walsh, H.A.; Daya, S.
Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin
Life Sci.
62
2417-2423
1998
Rattus norvegicus
brenda
EXTERNAL LINKS (specific for EC-Number 1.13.11.26)
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