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IUBMB Comments The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+ S )-malate and (S )-lactate.
Synonyms
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(R)-sulfolactate dehydrogenase
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(R)-sulfolactate:NAD+ oxidoreductase
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(R)-sulfolactate:NADP+ oxidoreductase
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L-sulfolactate dehydrogenase
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ComC
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(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+
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MetaCyc
sulfolactate degradation I
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(2R)-3-sulfolactate:NADP+ oxidoreductase
The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.
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(S)-3-sulfolactate + NADP+
3-sulfopyruvate + NADPH + H+
Substrates: specific activity for oxidation of sulfolactate is about 5% of the activity for reduction of 3-sulfopyruvate
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3-sulfopyruvate + NADPH + H+
(S)-3-sulfolactate + NADP+
Substrates: specific activity for oxidation of sulfolactate is about 5% of the activity for reduction of 3-sulfopyruvate
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additional information
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Substrates: no substrate: pyruvate, oxaloacetate, (S)-malate, (S)-lactate, (R)-malate, (R)-lactate
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additional information
no cosubstrate: NADH
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19
(S)-3-sulfolactate
pH 9.0, 23°C
0.14
3-sulfopyruvate
pH 9.0, 23°C
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DSM 3043
UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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37000
2 * 37000, SDS-PAGE
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-18°C, stable against freezing and thawing
4°C, stable for several weeks
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expression is induced by growth on sulfolactate
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Denger, K.; Cook, A.M.
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase
Microbiology
156
967-974
2010
Chromohalobacter salexigens (Q1QWN5)
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