Disease on EC 1.1.1.284 - S-(hydroxymethyl)glutathione dehydrogenase
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Aberrant Crypt Foci
Isolation, characterization and identification of antigenotoxic and anticancerous indigenous probiotics and their prophylactic potential in experimental colon carcinogenesis.
Acquired Immunodeficiency Syndrome
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.
Adenocarcinoma
Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy.
Alzheimer Disease
Insight into potent leads for alzheimer's disease by using several artificial intelligence algorithms.
Amyotrophic Lateral Sclerosis
nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis.
Amyotrophic Lateral Sclerosis
S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis.
Anemia
Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.
Anemia, Hypochromic
Overexpression of S-nitrosoglutathione reductase alleviated iron-deficiency stress by regulating iron distribution and redox homeostasis.
Asthma
A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma.
Asthma
Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities.
Asthma
Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases.
Asthma
Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.
Asthma
Exhaled breath condensate formate after inhaled allergen provocation in atopic asthmatics in vivo.
Asthma
Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma.
Asthma
GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.
Asthma
Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice.
Asthma
Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase.
Asthma
Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase.
Asthma
Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation.
Asthma
Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity.
Asthma
Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition.
Asthma
S-nitrosoglutathione Supplementation To Ovalbumin Sensitized and Challenged Mice Ameliorates Methacholine-Induced Bronchoconstriction.
Asthma
Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification.
Atherosclerosis
GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation.
Autoimmune Diseases
Understanding the role of S-nitrosylation/nitrosative stress in inflammation and the role of cellular denitrosylases in inflammation modulation: Implications in health and diseases.
Brain Injuries
Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase.
Brain Ischemia
Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke.
Breast Neoplasms
A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells.
Breast Neoplasms
Altered S-nitrosothiol homeostasis provides a survival advantage to breast cancer cells in HER2 tumors and reduces their sensitivity to trastuzumab.
Breast Neoplasms
Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70.
Breast Neoplasms
Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects.
Bronchial Hyperreactivity
Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.
Carcinogenesis
Cell-free whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic microflora of healthy subjects.
Carcinogenesis
Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans.
Carcinogenesis
Inhibition of Grb2-mediated activation of MAPK signal transduction suppresses NOR1/CB1954-induced cytotoxicity in the HepG2 cell line.
Carcinogenesis
Metabolic reduction of novel 3,4-dichloro-5-nitrofurans in Salmonella typhimurium.
Carcinogenesis
Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice.
Carcinoma
A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.
Carcinoma
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells.
Carcinoma
Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase.
Carcinoma
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.
Carcinoma
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).
Carcinoma, Hepatocellular
Comparative gastrointestinal enzyme activity and activation of the promutagen 2,6-dinitrotoluene in male CD-1 mice and male Fischer 344 rats.
Carcinoma, Hepatocellular
Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma.
Carcinoma, Hepatocellular
Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice.
Carcinoma, Hepatocellular
S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
Carcinoma, Hepatocellular
Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine.
Cardiovascular Diseases
Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase.
Chagas Disease
Putative role of the aldo-keto reductase from Trypanosoma cruzi (TcAKR) in benznidazole metabolism.
Colonic Neoplasms
Comparison of four microbial enzymes in Clostridia and Bacteroides isolated from human feces.
Colonic Neoplasms
Effect of dietary fiber on colonic bacterial enzymes and bile acids in relation to colon cancer.
Colonic Neoplasms
Late Expression of Nitroreductase in an Oncolytic Adenovirus Sensitizes Colon Cancer Cells to the Prodrug CB1954.
Colonic Neoplasms
Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954.
Colonic Neoplasms
Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model.
Colorectal Neoplasms
Galacto-oligosaccharides and Colorectal Cancer: Feeding our Intestinal Probiome.
Coronary Artery Disease
GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation.
Cystic Fibrosis
Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice.
Cystic Fibrosis
Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR.
Cystic Fibrosis
The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy.
Demyelinating Diseases
A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation.
Drug-Related Side Effects and Adverse Reactions
Molecular mechanisms of collateral sensitivity to the antibiotic nitrofurantoin.
Encephalomyelitis
S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis.
Gastrointestinal Diseases
[Frequency of Helicobacter pylori nitroreductase RdxA mutations for metronidazole activation in a population in the Cauca Department, Colombia].
Giardiasis
Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates.
Glioblastoma
Experimental therapy of allogeneic solid tumors induced in athymic mice with suicide gene-transducing replication-competent foamy virus vectors.
Glioma
Anomalous patterns of nitroimidazole binding adjacent to necrosis in human glioma xenografts: possible role of decreased oxygen consumption.
Healthcare-Associated Pneumonia
Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice.
Heart Arrest
Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase.
Heart Failure
Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition.
Herpes Simplex
A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells.
Herpes Simplex
Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo.
Herpes Simplex
Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects.
Herpes Simplex
Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging.
Herpes Simplex
Treatment of thyroid carcinoma cells with four different suicide gene/prodrug combinations in vitro.
Herpes Zoster
A transgenic zebrafish model of targeted oocyte ablation and de novo oogenesis.
Herpes Zoster
Nitroreductase-mediated Gonadal Dysgenesis for Infertility Control of Genetically Modified Zebrafish.
Hypertension
Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo.
Hypertension, Pulmonary
Gender differences in S-nitrosoglutathione reductase activity in the lung.
Hypertension, Pulmonary
Increased Nitrosoglutathione Reductase Activity in Hypoxic Pulmonary Hypertension in Mice.
Hypogonadism
S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism.
Infections
Differential modulation of S-nitrosoglutathione reductase and reactive nitrogen species in wild and cultivated tomato genotypes during development and powdery mildew infection.
Infections
Evaluation of nitrofurantoin combination therapy of metronidazole-sensitive and -resistant Helicobacter pylori infections in mice.
Infections
Exogenous Nitric Oxide Enhances Disease Resistance by Nitrosylation and Inhibition of S-Nitrosoglutathione Reductase in Peach Fruit.
Infections
Identification of a Novel Inhibitor of HRV Replication and Inflammation in Airway Epithelial Cells.
Infections
Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice.
Infections
Involvement of S-nitrosothiols modulation by S-nitrosoglutathione reductase in defence responses of lettuce and wild Lactuca spp. to biotrophic mildews.
Infections
Protein S-nitrosation differentially modulates tomato responses to infection by hemi-biotrophic oomycetes of Phytophthora spp.
Infections
S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.
Infections
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.
Infertility, Male
Inducible Male Infertility by Targeted Cell Ablation in Zebrafish Testis.
Inflammatory Bowel Diseases
Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase.
Leishmaniasis
An Essential Type I Nitroreductase from Leishmania major Can Be Used to Activate Leishmanicidal Prodrugs.
Leishmaniasis, Visceral
Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation.
Liver Neoplasms
Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer.
Liver Neoplasms
Inhibition of Grb2-mediated activation of MAPK signal transduction suppresses NOR1/CB1954-induced cytotoxicity in the HepG2 cell line.
Liver Neoplasms
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
Lung Diseases
A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma.
Lung Diseases
Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD.
Lung Diseases, Interstitial
The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy.
Lymphoma
The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: induction of bystander killing in vitro and in vivo.
Malaria
S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.
Malaria, Cerebral
S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.
Mouth Neoplasms
One step synthesis of red-emitting fluorescence turn-on probe for nitroreductase and its application to bacterial detection and oral cancer cell imaging.
Multiple Sclerosis
Regulation of B cell functions by S-nitrosoglutathione in the EAE model.
Muscular Atrophy
nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis.
Muscular Dystrophies
nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis.
Myocardial Infarction
S-Nitrosoglutathione Reductase Deficiency Enhances the Proliferative Expansion of Adult Heart Progenitors and Myocytes Post Myocardial Infarction.
Myocardial Ischemia
S-Nitrosoglutathione Reductase Is Essential for Protecting the Female Heart From Ischemia-Reperfusion Injury.
Nasopharyngeal Carcinoma
Inhibition of Grb2-mediated activation of MAPK signal transduction suppresses NOR1/CB1954-induced cytotoxicity in the HepG2 cell line.
Nasopharyngeal Carcinoma
Overexpression of oxidored-nitro domain containing protein 1 inhibits human nasopharyngeal carcinoma and cervical cancer cell proliferation and induces apoptosis: Involvement of mitochondrial apoptotic pathways.
Nasopharyngeal Carcinoma
Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma.
Neoplasms
A fluorescent probe for simultaneously sensing NTR and hNQO1 and distinguishing cancer cells.
Neoplasms
A General Approach to Design Dual Ratiometric Fluorescent and Photoacoustic Probe for Quantitatively Visualizing Tumor Hypoxia Levels in Vivo.
Neoplasms
A genetically encoded fluorescent biosensor for detecting nitroreductase activity in living cancer cells.
Neoplasms
A high-selectivity fluorescent probe for hypoxia imaging in cells and a tumor-bearing mouse model.
Neoplasms
A highly sensitive chemiluminescent probe for detecting nitroreductase and imaging in living animal.
Neoplasms
A mitochondria-targeting nitroreductase fluorescent probe with large Stokes shift and long-wavelength emission for imaging hypoxic status in tumor cells.
Neoplasms
A new fluorescent probe with a large turn-on signal for imaging nitroreductase in tumor cells and tissues by two-photon microscopy.
Neoplasms
A new prodrug-derived ratiometric fluorescent probe for hypoxia: high selectivity of nitroreductase and imaging in tumor cell.
Neoplasms
A new tetraphenylethylene derived-fluorescence probe for nitroreductase detection and hypoxic tumor cell imaging.
Neoplasms
A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cells.
Neoplasms
A novel long-wavelength off-on fluorescence probe for nitroreductase analysis and hypoxia imaging.
Neoplasms
A Novel NIR Fluorescent Probe for Highly Selective Detection of Nitroreductase and Hypoxic-Tumor-Cell Imaging.
Neoplasms
A novel off-on fluorescent probe for sensitive imaging of mitochondria-specific nitroreductase activity in living tumor cells.
Neoplasms
A rapid response "Turn-On" fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging.
Neoplasms
A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells.
Neoplasms
Activatable Nanocomposite Probe for Preoperative Location and Intraoperative Navigation for Orthotopic Hepatic Tumor Resection via MSOT and Aggregation-Induced Near-IR-I/II Fluorescence Imaging.
Neoplasms
Activity of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Lung Cancer Cells.
Neoplasms
An upconverting nanotheranostic agent activated by hypoxia combined with NIR irradiation for selective hypoxia imaging and tumour therapy.
Neoplasms
Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment.
Neoplasms
Backbone assignment of E. coli NfsB and the effects of addition of the cofactor analogue nicotinic acid.
Neoplasms
Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.
Neoplasms
Bystander cell killing spreading from endothelial to tumor cells in a three-dimensional multicellular nodule model after Escherichia coli nitroreductase gene delivery.
Neoplasms
Colloidal gold modified with a genetically engineered nitroreductase: toward a novel enzyme delivery system for cancer prodrug therapy.
Neoplasms
Combination of Mesenchymal Stem Cell-Delivered Oncolytic Virus with Prodrug Activation Increases Efficacy and Safety of Colorectal Cancer Therapy.
Neoplasms
Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors.
Neoplasms
Combined antitumor activity of the nitroreductase/CB1954 suicide gene system and ?-rays in HeLa cells in vitro.
Neoplasms
Combretastatin A4 Nanoparticles Combined with Hypoxia-Sensitive Imiquimod: A New Paradigm for the Modulation of Host Immunological Responses during Cancer Treatment.
Neoplasms
Comparative gastrointestinal enzyme activity and activation of the promutagen 2,6-dinitrotoluene in male CD-1 mice and male Fischer 344 rats.
Neoplasms
Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme.
Neoplasms
Delivery of the bacterial nitroreductase gene into endothelial cells prolongs the survival of tumour-bearing mice by bystander mechanisms.
Neoplasms
Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo.
Neoplasms
Dimeric BODIPY-loaded liposomes for dual hypoxia marker imaging and activatable photodynamic therapy against tumors.
Neoplasms
Discovery of a highly efficient nitroaryl group for detection of nitroreductase and imaging of hypoxic tumor cells.
Neoplasms
Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging.
Neoplasms
E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications.
Neoplasms
Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model.
Neoplasms
Efficient Two-Photon Fluorescent Probe for Nitroreductase Detection and Hypoxia Imaging in Tumor Cells and Tissues.
Neoplasms
Endoplasmic reticulum-targeted two-photon turn-on fluorescent probe for nitroreductase in tumor cells and tissues.
Neoplasms
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.
Neoplasms
Experimental therapy of allogeneic solid tumors induced in athymic mice with suicide gene-transducing replication-competent foamy virus vectors.
Neoplasms
Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954.
Neoplasms
Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.
Neoplasms
High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor.
Neoplasms
Hypoxia imaging in cells and tumor tissues using a highly selective fluorescent nitroreductase probe.
Neoplasms
Hypoxia imaging in living cells, tissues and zebrafish with a nitroreductase-specific fluorescent probe.
Neoplasms
Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy.
Neoplasms
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
Neoplasms
Hypoxia-sensitive supramolecular nanogels for the cytosolic delivery of ribonuclease A as a breast cancer therapeutic.
Neoplasms
Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy.
Neoplasms
Increased Hepatocarcinogenesis from GSNOR Deficiency in mice is Prevented by Pharmacological Inhibition of iNOS.
Neoplasms
Inhibition of NF-kappaB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy.
Neoplasms
Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
Neoplasms
Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil.
Neoplasms
Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting.
Neoplasms
Multifunctional Probe Based on Cationic Conjugated Polymers for Nitroreductase-Related Analysis: Sensing, Hypoxia Diagnosis, and Imaging.
Neoplasms
Near-Infrared Fluorescent Probe Activated by Nitroreductase for In Vitro and In Vivo Hypoxic Tumor Detection.
Neoplasms
Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one.
Neoplasms
Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.
Neoplasms
Nitroreductase-Activatable Theranostic Molecules with High PDT Efficiency under Mild Hypoxia Based on a TADF Fluorescein Derivative.
Neoplasms
Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity.
Neoplasms
One step synthesis of red-emitting fluorescence turn-on probe for nitroreductase and its application to bacterial detection and oral cancer cell imaging.
Neoplasms
Overexpression of oxidored-nitro domain containing protein 1 inhibits human nasopharyngeal carcinoma and cervical cancer cell proliferation and induces apoptosis: Involvement of mitochondrial apoptotic pathways.
Neoplasms
Oxygen and nitroreductase-dependent binding of AF-2 in spheroids and murine tumors.
Neoplasms
Oxygen-Dependent Regulation of Excited-State Deactivation Process of Rational Photosensitizer for Smart Phototherapy.
Neoplasms
Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe.
Neoplasms
Prodrugs For Nitroreductase Based Cancer Therapy- 1 Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB.
Neoplasms
PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells.
Neoplasms
Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation.
Neoplasms
Rational design of fluorescent probes for targeted in vivo nitroreductase visualization.
Neoplasms
S-nitrosoglutathione reductase (GSNOR) deficiency-induced S-nitrosylation results in neuromuscular dysfunction.
Neoplasms
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase.
Neoplasms
Self-preparation system using glucose oxidase-inspired nitroreductase amplification for cascade-responsive drug release and multidrug resistance reversion.
Neoplasms
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.
Neoplasms
Sensitive imaging of tumors using a nitroreductase-activated fluorescence probe in the NIR-II window.
Neoplasms
Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.
Neoplasms
Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia.
Neoplasms
Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase.
Neoplasms
Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.
Neoplasms
Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine.
Neoplasms
Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954.
Neoplasms
Targeted nanobody complex enhanced photodynamic therapy for lung cancer by overcoming tumor microenvironment.
Neoplasms
Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.
Neoplasms
The binding mechanism of nitroreductase fluorescent probe: Active pocket deformation and intramolecular hydrogen bonds.
Neoplasms
The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.
Neoplasms
The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy.
Neoplasms
Two-photon fluorescent probe for detection of nitroreductase and hypoxia-specific microenvironment of cancer stem cell.
Neoplasms
Ultrasensitive near-infrared fluorescence-enhanced probe for in vivo nitroreductase imaging.
Neoplasms
Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.
Neoplasms
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
Neoplasms
[Hypoxia in malignant tumors the target for clostridial therapeutic gene strategies]
Neuralgia
S-nitrosoglutathione reductase (GSNOR) deficiency-induced S-nitrosylation results in neuromuscular dysfunction.
Obstetric Labor, Premature
S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor.
Ovarian Neoplasms
Sensitisation of human ovarian cancer cells to killing by the prodrug CB1954 following retroviral or adenoviral transfer of the E. coli nitroreductase gene.
Pancreatic Neoplasms
Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with pancreatic cancer.
Pancreatic Neoplasms
Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.
Pancreatic Neoplasms
Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.
Pancreatitis, Chronic
The Alcohol Dehydrogenase Isoenzyme as a Potential Marker of Pancreatitis.
Parkinson Disease
S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis.
Pneumonia
Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases.
Pneumonia
S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity.
Pouchitis
Azoreductase and nitroreductase activity of bacteria in feces from patients with an ileal reservoir.
Prostatic Neoplasms
A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984.
Prostatic Neoplasms
Antivector and Tumor Immune Responses Following Adenovirus-Directed Enzyme Prodrug Therapy for the Treatment of Prostate Cancer.
Prostatic Neoplasms
Corrigendum to "A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase With CB1984".
Prostatic Neoplasms
Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation.
Prostatic Neoplasms
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.
Pulmonary Disease, Chronic Obstructive
Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD.
Pulmonary Disease, Chronic Obstructive
Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase.
Reperfusion Injury
Pharmacological Inhibition of S-Nitrosoglutathione Reductase Reduces Cardiac Damage Induced by Ischemia-Reperfusion.
Reperfusion Injury
S-Nitrosoglutathione Reductase Is Essential for Protecting the Female Heart From Ischemia-Reperfusion Injury.
Respiratory Insufficiency
S-nitrosoglutathione Supplementation To Ovalbumin Sensitized and Challenged Mice Ameliorates Methacholine-Induced Bronchoconstriction.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Arabidopsis CaM1 and CaM4 Promote Nitric Oxide Production and Salt Resistance by Inhibiting S-Nitrosoglutathione Reductase via Direct Binding.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Increased Hepatocarcinogenesis from GSNOR Deficiency in mice is Prevented by Pharmacological Inhibition of iNOS.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Lymphocyte Development Requires S-nitrosoglutathione Reductase.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Nitroarene reduction and generation of free radicals by cell-free extracts of wild-type, and nitroreductase-deficient and -enriched Salmonella typhimurium strains used in the umu gene induction assay.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Regulation of DNA repair by S-nitrosylation.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Relative refractoriness of guinea pigs to carcinogenesis by 5-nitrofurans.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
S-nitrosoglutathione reductase (GSNOR) deficiency-induced S-nitrosylation results in neuromuscular dysfunction.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
S-Nitrosoglutathione Reductase Deficiency Enhances the Proliferative Expansion of Adult Heart Progenitors and Myocytes Post Myocardial Infarction.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
S-nitrosoglutathione reductase deficiency increases mutagenesis from alkylation in mouse liver.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine.
s-(hydroxymethyl)glutathione dehydrogenase deficiency
Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of human sulfotransferases in the bioactivation of nitro- and aminotoluenes.
Sepsis
Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.
Tuberculosis
3D-QSAR and cell wall permeability of antitubercular nitroimidazoles against Mycobacterium tuberculosis.
Tuberculosis
A putative nitroreductase from the DosR regulon of Mycobacterium tuberculosis induces pro-inflammatory cytokine expression via TLR2 signaling pathway.
Tuberculosis
Bactericidal activity of PA-824 against Mycobacterium tuberculosis under anaerobic conditions and computational analysis of its novel analogues against mutant Ddn receptor.
Tuberculosis
Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver.
Tuberculosis
Comparison of in vitro Susceptibility of Mycobacteria Against PA-824 to Identify Key Residues of Ddn, the Deazoflavin-Dependent Nitroreductase from Mycobacterium tuberculosis.
Tuberculosis
Crystal structure of reduced MsAcg, a putative nitroreductase from Mycobacterium smegmatis and a close homologue of Mycobacterium tuberculosis Acg.
Tuberculosis
Hydrophobic Shielding Drives Catalysis of Hydride Transfer in a Family of F420H2-Dependent Enzymes.
Tuberculosis
Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions.
Tuberculosis
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
Tuberculosis
Mutations in Genes for the F420 Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in Spontaneous In Vitro-Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis.
Tuberculosis
New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053.
Tuberculosis
Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K.
Tuberculosis
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.
Tuberculosis
Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis.
Tuberculosis
Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Tuberculosis
Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824.
Tuberculosis
Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.
Tuberculosis
The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824.
Tuberculosis
The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis.
Urinary Bladder Neoplasms
Enhancing effect of allopurinol on the induction of bladder cancer in rats by n-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
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