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Information on EC 1.1.1.2 - alcohol dehydrogenase (NADP+) and Organism(s) Kluyveromyces lactis and UniProt Accession P49384

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EC Tree
IUBMB Comments
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase), EC 1.1.1.33 [mevaldate reductase (NADPH)] and EC 1.1.1.55 [lactaldehyde reductase (NADPH)]. Re-specific with respect to NADPH.
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Kluyveromyces lactis
UNIPROT: P49384
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Word Map
The taxonomic range for the selected organisms is: Kluyveromyces lactis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
nadph-cytochrome c reductase, aldo-keto reductase, liver alcohol dehydrogenase, adh-1, adh-2, short-chain alcohol dehydrogenase, lbadh, nadph-dependent aldehyde reductase, cbadh, tsadh319, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-DG-reducing enzyme
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-
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ADH
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-
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Alcohol dehydrogenase [NADP+]
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aldehyde reductase
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-
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aldehyde reductase (NADPH2)
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Aldo-keto reductase family 1 member A1
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-
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ALR
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-
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ALR 1
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-
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high-Km aldehyde reductase
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-
-
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low-Km aldehyde reductase
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-
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NADP-alcohol dehydrogenase
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-
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NADP-aldehyde reductase
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NADP-dependent aldehyde reductase
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-
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NADPH-aldehyde reductase
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NADPH-dependent aldehyde reductase
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nonspecific succinic semialdehyde reductase
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
alcohol:NADP+ oxidoreductase
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase), EC 1.1.1.33 [mevaldate reductase (NADPH)] and EC 1.1.1.55 [lactaldehyde reductase (NADPH)]. Re-specific with respect to NADPH.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-12-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
show the reaction diagram
8% of activity with acetaldehyde
-
-
r
butanal + NADPH + H+
1-butanol + NADP+
show the reaction diagram
47% of activity with acetaldehyde
-
-
r
butanol + NADP+
butanal + NADPH
show the reaction diagram
68% of activity with ethanol
-
-
r
cinnamaldehyde + NADPH
cinnamic alcohol + NADP+
show the reaction diagram
5% of activity with acetaldehyde
-
-
r
cyclohexancarbaldehye + NADPH
cyclohexanol + NADP+
show the reaction diagram
3% of activity with acetaldehyde
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-
r
cyclohexanol + NADP+
cyclohexanone + NADPH + H+
show the reaction diagram
14% of activity with ethanol
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-
r
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
show the reaction diagram
-
-
-
r
formaldehyde + NADPH
methanol + NADP+
show the reaction diagram
6% of activity with acetaldehyde
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-
ir
glutaraldehyde + NADPH
? + NADP+
show the reaction diagram
5% of activity with acetaldehyde
-
-
r
hexanol + NADP+
hexanal + NADPH
show the reaction diagram
60% of activity with ethanol
-
-
r
isoamyl alcohol + NADP+
3-methylbutanol + NADPH
show the reaction diagram
18% of activity with ethanol
-
-
r
isopentanol + NADP+
3-methylbutanal + NADPH + H+
show the reaction diagram
9% of activity with ethanol
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-
r
isopropanol + NADP+
acetone + NADPH
show the reaction diagram
2% of activity with ethanol
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-
r
pentanol + NADP+
pentanal + NADPH
show the reaction diagram
75% of activity with ethanol
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-
r
propanal + NADPH + H+
1-propanol + NADP+
show the reaction diagram
49% of activity with acetaldehyde
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r
propanol + NADP+
propanal + NADPH
show the reaction diagram
70% of activity with ethanol
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r
salicylaldehyde + NADPH
salicylalcohol + NADP+
show the reaction diagram
1% of activity with acetaldehyde
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r
additional information
?
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no substrate: methanol, 2-mercaptoethanol
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?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.22 - 2.33
acetaldehyde
0.5 - 1.02
ethanol
0.39 - 1
NAD+
0.025 - 0.07
NADH
2.64 - 6.21
NADP+
0.05 - 0.37
NADPH
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Swissprot
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brisdelli, F.; Saliola, M.; Pascarella, S.; Luzi, C.; Franceschini, N.; Falcone, C.; Martini, F.; Bozzi, A.
Kinetic properties of native and mutagenized isoforms of mitochondrial alcohol dehydrogenase III purified from Kluyveromyces lactis
Biochimie
86
705-712
2004
Kluyveromyces lactis (P49384)
Manually annotated by BRENDA team