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Information on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+) and Organism(s) Macaca fascicularis and UniProt Accession Q8MI29

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IUBMB Comments
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
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This record set is specific for:
Macaca fascicularis
UNIPROT: Q8MI29
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Word Map
The taxonomic range for the selected organisms is: Macaca fascicularis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
prostaglandin e 9-ketoreductase, 9-ketoprostaglandin reductase, nadp-dependent 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin dehydrogenase (nadp+), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NADP-dependent 15-hydroxyprostaglandin dehydrogenase
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-
-
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NADP-linked 15-hydroxyprostglandin dehydrogenase
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-
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NADP-specific 15-hydroxyprostaglandin dehydrogenase
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-
-
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type II 15-hydroxyprostaglandin dehydrogenase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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-
-
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oxidation
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-
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reduction
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
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SYSTEMATIC NAME
IUBMB Comments
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
CAS REGISTRY NUMBER
COMMENTARY hide
54989-39-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acid form of latanoprost + NADP+
? + NADPH
show the reaction diagram
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-
-
?
latanoprost + NADP+
? + NADPH
show the reaction diagram
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-
-
?
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
show the reaction diagram
-
-
-
?
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0012
substrate latanoprost, pH 7.0, 25°C
0.0022
substrate acid form of latanoprost, pH 7.0, 25°C
0.0061
substrate prostaglandin F2alpha, cosubstrate NAD+, pH 7.0, 25°C
0.0098
substrate prostaglandin E2, cosubstrate NADP+, pH 7.0, 25°C
0.0243
substrate prostaglandin F2alpha, cosubstrate NADP+, pH 7.0, 25°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Swissprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
epithelial cells of cornea
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CBR1_MACFA
277
0
30473
Swiss-Prot
Mitochondrion (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30500
x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE
31000
x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis (Q8MI29)
Manually annotated by BRENDA team