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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
21-hydroxy steroid (NADP) dehydrogenase, 21-hydroxy steroid dehydrogenase, 21-hydroxy steroid dehydrogenase (NADP), NADP-21-hydroxysteroid dehydrogenase,
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21-hydroxy steroid (NADP) dehydrogenase
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21-hydroxy steroid dehydrogenase
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21-hydroxy steroid dehydrogenase (NADP)
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NADP-21-hydroxysteroid dehydrogenase
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pregnan-21-ol + NADP+ = pregnan-21-al + NADPH + H+
Acts on a number of 21-hydroxycorticosteroids
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21-hydroxysteroid:NADP+ 21-oxidoreductase
Acts on a number of 21-hydroxycorticosteroids.
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11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione + NADPH
11beta,17,21-trihydroxy-pregn-4,11-diene-3,20-dione + NADP+
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i.e. 21-dehydro-delta1-cortisol
21-hydroxy-delta1-cortisol
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11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
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i.e. 21-dehydrocortisol
i.e. cortisol
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11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADPH
11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NADP+
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i.e. 21-dehydrocorticosterone
21-hydroxycorticosterone
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17-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADPH + H+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADP+
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r
17-hydroxy-pregn-4-ene-3,20,21-trione + NADPH
17,21-dihydroxy-pregn-4-ene-3,20-dione + NADP+
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i.e. 21-dehydro-11-deoxycortisol
i.e. 21-hydroxy-11-deoxycortisol
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17alpha-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADPH
17alpha,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADP+
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i.e. 21-dehydrocortisone, marked dependence on the nature of steroids
i.e. cortisone
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pregn-4-ene-3,20,21-trione + NADPH
21-hydroxy-pregn-4-ene-3,20-dione + NADP+
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i.e. 21-dehydro-11-deoxy-corticosterone
21-hydroxy-11-deoxy-corticosterone
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Ag+
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complete inhibition at 0.004 mM
Hg2+
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53% inhibition at 0.002 mM
NADH
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competitive inhibition
NADPH
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competitive inhibition
p-mercuribenzoate
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55% inhibition at 0.014 mM
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0.137
11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione
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0.177
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione
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0.233
11beta-hydroxy-pregn-4-ene-3,20,21-trione
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0.461
17-hydroxy-pregn-4-ene-3,11,20,21-tetraone
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0.137
17-hydroxy-pregn-4-ene-3,20,21-trione
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0.118
pregn-4-ene-3,20,21-trione
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sheep
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brenda
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brenda
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56
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80% loss of activity in 5 min
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not sensitive against repeated freezing and thawing
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-10°C, 0.01 M sodium phosphate , pH 6-7.4, 1 year
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to homogeneity, Sephadex G-100, starch block elelctrophoresis
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Monder, C.; White, A.
The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases
J. Biol. Chem.
240
71-77
1965
Ovis aries aries
brenda
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