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Sequence of HDA10_HUMAN

EC Number:3.5.1.62

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
acetylputrescine deacetylase
Q969S8
Homo sapiens
669
71445
Reaction
N-acetylputrescine + H2O = acetate + putrescine
Other sequences found for EC No. 3.5.1.62

General information:

Sequence
show sequence in fasta format
  0 MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL SAREASEEEL
 60 GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF HCARLAAGAG LQLVDAVLTG
120 AVQNGLALVR PPGHHGQRAA ANGFCVFNNV AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ
180 YLFEDDPSVL YFSWHRYEHG RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA
240 AFLHLLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV
300 LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ APHWKSLQQQ
360 DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD QPCLCPAPSV RTAVALTTPD
420 ITLVLPPDVI QQEASALREE TEAWARPHES LAREEALTAL GKLLYLLDGM LDGQVNSGIA
480 ATPASAAAAT LDVAVRRGLS HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS
540 MFHVSTPLPV MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL
600 AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL RGQLEPQWKM
660 LQCHPHLVA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
301398
Tong J.J.,Liu J.,Bertos N.R.,Yang X.-J.
Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain.
Nucleic Acids Res.
30
1114-1123
2002
301399
Guardiola A.R.,Yao T.-P.
Molecular cloning and characterization of a novel histone deacetylase HDAC10.
J. Biol. Chem.
277
3350-3356
2002
301400
Kao H.-Y.,Lee C.-H.,Komarov A.,Han C.C.,Evans R.M.
Isolation and characterization of mammalian HDAC10, a novel histone deacetylase.
J. Biol. Chem.
277
187-193
2002
301401
Fischer D.D.,Cai R.,Bhatia U.,Asselbergs F.A.M.,Song C.,Terry R.,Trogani N.,Widmer R.,Atadja P.,Cohen D.
Isolation and characterization of a novel class II histone deacetylase, HDAC10.
J. Biol. Chem.
277
6656-6666
2002
301402
Collins J.E.,Wright C.L.,Edwards C.A.,Davis M.P.,Grinham J.A.,Cole C.G.,Goward M.E.,Aguado B.,Mallya M.,Mokrab Y.,Huckle E.J.,Beare D.M.,Dunham I.
A genome annotation-driven approach to cloning the human ORFeome.
Genome Biol.
5
0-0
2004
301404
Dunham I.,Hunt A.R.,Collins J.E.,Bruskiewich R.,Beare D.M.,Clamp M.,Smink L.J.,Ainscough R.,Almeida J.P.,Babbage A.K.,Bagguley C.,Bailey J.,Barlow K.F.,Bates K.N.,Beasley O.P.,Bird C.P.,Blakey S.E.,Bridgeman A.M.,Buck D.,Burgess J.,Burrill W.D.,Burton J.,Carder C.,Carter N.P.,Chen Y.,Clark G.,Clegg S.M.,Cobley V.E.,Cole C.G.,Collier R.E.,Connor R.,Conroy D.,Corby N.R.,Coville G.J.,Cox A.V.,Davis J.,Dawson E.,Dhami P.D.,Dockree C.,Dodsworth S.J.,Durbin R.M.,Ellington A.G.,Evans K.L.,Fey J.M.,Fleming K.,French L.,Garner A.A.,Gilbert J.G.R.,Goward M.E.,Grafham D.V.,Griffiths M.N.D.,Hall C.,Hall R.E.,Hall-Tamlyn G.,Heathcott R.W.,Ho S.,Holmes S.,Hunt S.E.,Jones M.C.,Kershaw J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.F.,Leversha M.A.,Lloyd C.,Lloyd D.M.,Martyn I.D.,Mashreghi-Mohammadi M.,Matthews L.H.,Mccann O.T.,Mcclay J.,Mclaren S.,McMurray A.A.,Milne S.A.,Mortimore B.J.,Odell C.N.,Pavitt R.,Pearce A.V.,Pearson D.,Phillimore B.J.C.T.,Phillips S.H.,Plumb R.W.,Ramsay H.,Ramsey Y.,Rogers L.,Ross M.T.,Scott C.E.,Sehra H.K.,Skuce C.D.,Smalley S.,Smith M.L.,Soderlund C.,Spragon L.,Steward C.A.,Sulston J.E.,Swann R.M.,Vaudin M.,Wall M.,Wallis J.M.,Whiteley M.N.,Willey D.L.,Williams L.,Williams S.A.,Williamson H.,Wilmer T.E.,Wilming L.,Wright C.L.,Hubbard T.,Bentley D.R.,Beck S.,Rogers J.,Shimizu N.,Minoshima S.,Kawasaki K.,Sasaki T.,Asakawa S.,Kudoh J.,Shintani A.,Shibuya K.,Yoshizaki Y.,Aoki N.,Mitsuyama S.,Roe B.A.,Chen F.,Chu L.,Crabtree J.,Deschamps S.,Do A.,Do T.,Dorman A.,Fang F.,Fu Y.,Hu P.,Hua A.,Kenton S.,Lai H.,Lao H.I.,Lewis J.,Lewis S.,Lin S.-P.,Loh P.,Malaj E.,Nguyen T.,Pan H.,Phan S.,Qi S.,Qian Y.,Ray L.,Ren Q.,Shaull S.,Sloan D.,Song L.,Wang Q.,Wang Y.,Wang Z.,White J.,Willingham D.,Wu H.,Yao Z.,Zhan M.,Zhang G.,Chissoe S.,Murray J.,Miller N.,Minx P.,Fulton R.,Johnson D.,Bemis G.,Bentley D.,Bradshaw H.,Bourne S.,Cordes M.,Du Z.,Fulton L.,Goela D.,Graves T.,Hawkins J.,Hinds K.,Kemp K.,Latreille P.,Layman D.,Ozersky P.,Rohlfing T.,Scheet P.,Walker C.,Wamsley A.,Wohldmann P.,Pepin K.,Nelson J.,Korf I.,Bedell J.A.,Hillier L.W.,Mardis E.,Waterston R.,Wilson R.,Emanuel B.S.,Shaikh T.,Kurahashi H.,Saitta S.,Budarf M.L.,McDermid H.E.,Johnson A.,Wong A.C.C.,Morrow B.E.,Edelmann L.,Kim U.J.,Shizuya H.,Simon M.I.,Dumanski J.P.,Peyrard M.,Kedra D.,Seroussi E.,Fransson I.,Tapia I.,Bruder C.E.,O'Brien K.P.,Wilkinson P.,Bodenteich A.,Hartman K.,Hu X.,Khan A.S.,Lane L.,Tilahun Y.,Wright H.
The DNA sequence of human chromosome 22.
Nature
402
489-495
1999
301405
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
301406
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
301407
Hillman R.T.,Green R.E.,Brenner S.E.
An unappreciated role for RNA surveillance.
Genome Biol.
5
0-0
2004
301408
Kotian S.,Liyanarachchi S.,Zelent A.,Parvin J.D.
Histone deacetylases 9 and 10 are required for homologous recombination.
J. Biol. Chem.
286
7722-7726
2011
301409
Oehme I.,Linke J.P.,Boeck B.C.,Milde T.,Lodrini M.,Hartenstein B.,Wiegand I.,Eckert C.,Roth W.,Kool M.,Kaden S.,Groene H.J.,Schulte J.H.,Lindner S.,Hamacher-Brady A.,Brady N.R.,Deubzer H.E.,Witt O.
Histone deacetylase 10 promotes autophagy-mediated cell survival.
Proc. Natl. Acad. Sci. U.S.A.
110
0-0
2013
301410
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
301411
Radhakrishnan R.,Li Y.,Xiang S.,Yuan F.,Yuan Z.,Telles E.,Fang J.,Coppola D.,Shibata D.,Lane W.S.,Zhang Y.,Zhang X.,Seto E.
Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
J. Biol. Chem.
290
22795-22804
2015
301412
Hai Y.,Shinsky S.A.,Porter N.J.,Christianson D.W.
Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.
Nat. Commun.
8
15368-15368
2017
301413
Ridinger J.,Koeneke E.,Kolbinger F.R.,Koerholz K.,Mahboobi S.,Hellweg L.,Gunkel N.,Miller A.K.,Peterziel H.,Schmezer P.,Hamacher-Brady A.,Witt O.,Oehme I.
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
Sci. Rep.
8
10039-10039
2018