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Sequence of TRYB2_HUMAN

EC Number:3.4.21.59

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Tryptase
P20231
Homo sapiens
275
30515
Reaction
Preferential cleavage: Arg-/-, Lys-/-, but with more restricted specificity than trypsin
Other sequences found for EC No. 3.4.21.59

General information:

Sequence
show sequence in fasta format
  0 MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG
 60 GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA
120 DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV
180 PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG
240 VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
112399
Miller J.S.,Moxley G.,Schwartz L.B.
Cloning and characterization of a second complementary DNA for human tryptase.
J. Clin. Invest.
86
864-870
1990
112400
Blom T.,Hellman L.
Characterization of a tryptase mRNA expressed in the human basophil cell line KU812.
Scand. J. Immunol.
37
203-208
1993
112401
Pallaoro M.,Fejzo M.S.,Shayesteh L.,Blount J.L.,Caughey G.H.
Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.
J. Biol. Chem.
274
3355-3362
1999
112403
Trivedi N.N.,Tamraz B.,Chu C.,Kwok P.Y.,Caughey G.H.
Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
J. Allergy Clin. Immunol.
124
1099-1105
2009
112404
Martin J.,Han C.,Gordon L.A.,Terry A.,Prabhakar S.,She X.,Xie G.,Hellsten U.,Chan Y.M.,Altherr M.,Couronne O.,Aerts A.,Bajorek E.,Black S.,Blumer H.,Branscomb E.,Brown N.C.,Bruno W.J.,Buckingham J.M.,Callen D.F.,Campbell C.S.,Campbell M.L.,Campbell E.W.,Caoile C.,Challacombe J.F.,Chasteen L.A.,Chertkov O.,Chi H.C.,Christensen M.,Clark L.M.,Cohn J.D.,Denys M.,Detter J.C.,Dickson M.,Dimitrijevic-Bussod M.,Escobar J.,Fawcett J.J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Goodwin L.A.,Grady D.L.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Hildebrand C.E.,Huang W.,Israni S.,Jett J.,Jewett P.B.,Kadner K.,Kimball H.,Kobayashi A.,Krawczyk M.-C.,Leyba T.,Longmire J.L.,Lopez F.,Lou Y.,Lowry S.,Ludeman T.,Manohar C.F.,Mark G.A.,McMurray K.L.,Meincke L.J.,Morgan J.,Moyzis R.K.,Mundt M.O.,Munk A.C.,Nandkeshwar R.D.,Pitluck S.,Pollard M.,Predki P.,Parson-Quintana B.,Ramirez L.,Rash S.,Retterer J.,Ricke D.O.,Robinson D.L.,Rodriguez A.,Salamov A.,Saunders E.H.,Scott D.,Shough T.,Stallings R.L.,Stalvey M.,Sutherland R.D.,Tapia R.,Tesmer J.G.,Thayer N.,Thompson L.S.,Tice H.,Torney D.C.,Tran-Gyamfi M.,Tsai M.,Ulanovsky L.E.,Ustaszewska A.,Vo N.,White P.S.,Williams A.L.,Wills P.L.,Wu J.-R.,Wu K.,Yang J.,DeJong P.,Bruce D.,Doggett N.A.,Deaven L.,Schmutz J.,Grimwood J.,Richardson P.,Rokhsar D.S.,Eichler E.E.,Gilna P.,Lucas S.M.,Myers R.M.,Rubin E.M.,Pennacchio L.A.
The sequence and analysis of duplication-rich human chromosome 16.
Nature
432
988-994
2004
112405
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
112406
Vanderslice P.,Ballinger S.M.,Tam E.K.,Goldstein S.M.,Craik C.S.,Caughey G.H.
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
Proc. Natl. Acad. Sci. U.S.A.
87
3811-3815
1990
112407
Strik M.C.,Wolbink A.,Wouters D.,Bladergroen B.A.,Verlaan A.R.,van Houdt I.S.,Hijlkema S.,Hack C.E.,Kummer J.A.
Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.
Blood
103
2710-2717
2004
112408
Fukuoka Y.,Schwartz L.B.
Active monomers of human beta-tryptase have expanded substrate specificities.
Int. Immunopharmacol.
7
1900-1908
2007
112409
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
112410
Pereira P.J.B.,Bergner A.,Macedo-Ribeiro S.,Huber R.,Matschiner G.,Fritz H.,Sommerhoff C.P.,Bode W.
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
Nature
392
306-311
1998
112411
Sommerhoff C.P.,Bode W.,Pereira P.J.B.,Stubbs M.T.,Stuerzebecher J.,Piechottka G.P.,Matschiner G.,Bergner A.
The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.
Proc. Natl. Acad. Sci. U.S.A.
96
10984-10991
1999