Information on EC 3.4.21.59 - Tryptase

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The expected taxonomic range for this enzyme is: Eutheria

EC NUMBER
COMMENTARY hide
3.4.21.59
-
RECOMMENDED NAME
GeneOntology No.
Tryptase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Preferential cleavage: Arg-/-, Lys-/-, but with more restricted specificity than trypsin
show the reaction diagram
preferential cleavage: Arg-, Lys-, but with more restricted specificity than trypsin
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
97501-93-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
pig
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
tryptase deficiency results in defective proteolytic modification of core histones
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ac-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate
-
-
?
Ac-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate
-
-
?
Ac-PANKAAC + H2O
Ac-PANK + Ala-Ala-Cys
show the reaction diagram
-
betaI and betaII tryptase
-
?
Ac-PRNKAAC + H2O
Ac-PRNK + Ala-Ala-Cys
show the reaction diagram
-
betaI and betaII tryptase
-
?
Ac-PRNRAAC + H2O
Ac-PRNR + Ala-Ala-Cys
show the reaction diagram
-
betaI and betaII tryptase
-
?
Ac-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate, best peptide substrate
-
-
?
Ac-PRTKAAC + H2O
Ac-PRTK + Ala-Ala-Cys
show the reaction diagram
-
betaI and betaII tryptase
-
?
Ac-Ser-Ile-Gln-Ser-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 51.2%
-
?
Ala-Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate, high activity
-
-
?
Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate
-
-
?
alpha2-antiplasmin + H2O
?
show the reaction diagram
-
substrate binding and interaction with the enzyme, overview
-
-
?
Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate
-
-
?
benzoyl-Arg 4-nitroanilide + H2O
benzoyl-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
-
Benzoyl-L-Lys-Gly-L-Arg 4-nitroanilide + H2O
Benzoyl-L-Lys-Gly-L-Arg + 4-nitroaniline
show the reaction diagram
benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O
benzoyl-L-Phe-L-Val-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Benzyloxycarbonyl-Ala-Ala-Lys 4-methoxy-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-Ala-Arg-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Ala-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarine
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-Arg 4-nitroanilide + H2O
Benzyloxycarbonyl-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
Benzyloxycarbonyl-Glu-Phe-Arg 4-nitroanilide + H2O
Benzyloxycarbonyl-Glu-Phe-Arg + 4-nitroaniline
show the reaction diagram
-
best substrate for lung enzyme
-
-
-
Benzyloxycarbonyl-Gly-Arg 4-trifluoromethylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Gly-Arg + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-Gly-Pro-Arg 4-nitroanilide + H2O
Benzyloxycarbonyl-Gly-Pro-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-Lys-Arg 4-trifluoromethylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Lys-Arg + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
-
Benzyloxycarbonyl-Lys-Arg-S-CH2(CH3)2 + H2O
Benzyloxycarbonyl-Lys-Arg + S-CH2(CH3)2
show the reaction diagram
-
best substrate for skin enzyme
-
-
-
Boc-Phe-Ser-Arg-methyl-coumarin + H2O
?
show the reaction diagram
-
synthetic substrate
-
?
Bz-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
complement component 3 + H2O
?
show the reaction diagram
-
digestion
-
-
?
D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
D-Ile-Pro-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
D-Phe-Pip-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
D-Phe-piperocolyl-L-Arg 4-nitroanilide + H2O
D-Phe-piperocolyl-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
-
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
D-phenylalanyl-pipecolyl-L-arginine-4-nitroaniline
show the reaction diagram
-
-
-
-
?
D-Pro-Phe-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
D-Val-Leu-Arg 4-methoxy-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
-
D-Val-Leu-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
fibrinogen + H2O
fibrin + ?
show the reaction diagram
-
-
-
?
fibrinogen + H2O
fibrinogen fragments
show the reaction diagram
Fibronectin + H2O
?
show the reaction diagram
Gelatinase + H2O
?
show the reaction diagram
-
digestion of the 72000 MW form to a 62000 MW form
-
-
-
Glu-Gly-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
Glu-Pro-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
High-molecular mass kininogen + H2O
?
show the reaction diagram
-
-
-
-
-
high-molecular-weight kininogen + H2O
?
show the reaction diagram
-
-
-
-
?
histone 2B + H2O
?
show the reaction diagram
-
-
-
-
?
histone 3 + H2O
?
show the reaction diagram
-
-
-
-
?
human influenza virus HA + H2O
HA1 + HA2
show the reaction diagram
-
-
-
?
Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate
-
-
?
L-pyroGlu-Gly-Arg 4-nitroanilide + H2O
L-pyroGlu-Gly-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
-
LL-37 + H2O
LL-37 fragments
show the reaction diagram
-
the platelet-derived chemokine CXCL4 protects LL-37 from cleavage by beta-tryptase
-
-
?
MeOCO-Nle-Gly-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
N-(p-tosyl)-Gly-Pro-Arg-4-nitroanilide + H2O
N-(p-tosyl)-Gly-Pro-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-(p-tosyl)-Gly-Pro-Lys-4-nitroanilide + H2O
N-(p-tosyl)-Gly-Pro-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-Benzoyl-Arg ethyl ester + H2O
?
show the reaction diagram
-
-
-
-
-
N-benzoyl-DL-Arg-p-nitroanilide + H2O
N-benzoyl-DL-Arg + p-nitroaniline
show the reaction diagram
-
measurements of tryptase activity in sputum of chronic obstructive pulmonary disease patiens
-
-
?
N-benzoyl-DL-arginine-4-nitroanilide + H2O
N-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
N-Carbobenzoxy-Arg-Arg 4-methylcoumarin 7-amide + H2O
N-Carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
N-carbobenzoxy-GPR-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
N-Carbobenzoxy-Phe-Arg 4-methylcoumarin 7-amide + H2O
N-Carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
?
show the reaction diagram
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
N-p-tosyl-Gly-Pro-Arg + p-nitroaniline
show the reaction diagram
-
-
-
-
?
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
show the reaction diagram
N-tert-Butyloxycarbonyl-Ile-Glu-Gly-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Ile-Glu-Gly-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
rapid hydrolysis by free enzyme, scarcely hydrolyzed by the enzyme associated with trypstatin
-
-
-
N-tert-Butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-tert-Butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
Nalpha-benzoyl-L-arginine-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
neurotensin + H2O
?
show the reaction diagram
-
-
-
-
-
Oxidized B-chain of insulin + H2O
?
show the reaction diagram
-
cleavage at Arg8-Gly9-NH2, Arg8-Arg9- and Arg22-Gly23-bonds
-
-
-
Precursor of matrix metalloproteinase 1 + H2O
?
show the reaction diagram
-
conversion of the 52000 MW precursor into a 41000 MW protein, generation of new N-termini, namely Gln80 and Val82
-
-
-
Precursor of matrix metalloproteinase 3 + H2O
?
show the reaction diagram
-
conversion of the 57000 MW precursor to a 45000 MW polypeptide, N-terminal amino acid is Phe83
-
-
-
Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
show the reaction diagram
-
chromogenic substrate, best peptide substrate
-
-
?
pro-interleukin-6 + H2O
interleukin-6 + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease-3 + H2O
?
show the reaction diagram
-
digestion
-
-
?
pro-matrix metalloproteinase-2 + H2O
matrix metalloproteinase-2 + ?
show the reaction diagram
-
-
-
-
?
pro-nerve growth factor + H2O
mature nerve growth factor and smaller fragments
show the reaction diagram
-
-
analyzed by MS/MS
-
?
pro-nuclear factor-kappa B + H2O
nuclear factor-kappa B + ?
show the reaction diagram
-
-
-
-
?
Pro-Phe-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 3.9%
-
?
pro-proteinase-activated receptor 2 + H2O
proteinase-activated receptor 2 + ?
show the reaction diagram
-
-
-
-
?
pro-tissue necrosis factor + H2O
tissue necrosis factor + ?
show the reaction diagram
-
-
-
-
?
Pro-urokinase + H2O
?
show the reaction diagram
-
digestion
-
-
?
protease-activated receptor 2 + H2O
fibrin + ?
show the reaction diagram
-
-
-
-
?
protease-activated receptor-2 + H2O
?
show the reaction diagram
-
digestion
-
-
?
proteinase-activated receptor 2 + H2O
?
show the reaction diagram
-
-
-
-
?
proteinase-activated receptor-2 + H2O
?
show the reaction diagram
-
tryptase may contribute to cyclooxygenase-2 upregulation by epithelial proteinase-activated receptor-2 activation during early lip carcinogenesis
-
-
?
prothrombin + H2O
thrombin + ?
show the reaction diagram
S2366 + H2O
?
show the reaction diagram
-
-
-
?
t-butyloxycarbonyl-Gln-Ala-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 100%
-
?
t-butyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 26.0%
-
?
t-butyloxycarbonyl-Gln-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 63.3%
-
?
t-butyloxycarbonyl-Glu(OBzl)-Ala-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 67.3%
-
?
t-butyloxycarbonyl-Glu(OBzl)-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 26.3%
-
?
t-butyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 1.6%
-
?
t-butyloxycarbonyl-Gly-Lys-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 10.9%
-
?
t-butyloxycarbonyl-Ile-Glu-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 3.5%
-
?
t-butyloxycarbonyl-Leu-Arg-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 5.9%
-
?
t-butyloxycarbonyl-Leu-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 30.0%
-
?
t-butyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 14.4%
-
?
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
t-butyloxycarbonyl-Val-Pro-Arg-4-methyl-coumarin 7-amide + H2O
?
show the reaction diagram
-
synthetic substrate, relative activity 6.1%
-
?
tert-butyloxycarbonyl-Gly-Lys-Arg 4-methylcoumarin 7-amide + H2O
tert-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
TGFbeta + H2O
activated TGFbeta + ?
show the reaction diagram
Tos-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
Tos-Gly-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Tosyl-Arg methyl ester + H2O
?
show the reaction diagram
-
-
-
-
-
Tosyl-Gly-L-Pro-Arg 4-nitroanilide + H2O
Tosyl-Gly-L-Pro-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
tosyl-Gly-L-Pro-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
Tosyl-Gly-Pro-Lys 4-nitroanilide + H2O
Tosyl-Gly-Pro-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
-
-
tosyl-Gly-Pro-Lys-4-nitroanilide + H2O
tosyl-Gly-Pro-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
tosyl-glycine-L-proline-L-arginine-4-nitroanilide + H2O
tosyl-glycine-L-proline-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
tosyl-GPK-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
tosyl-GPR-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
Vasoactive intestinal peptide + H2O
?
show the reaction diagram
-
-
-
-
-
Z-D-Arg-Gly-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
[Arg8]vasopressin + H2O
?
show the reaction diagram
-
-
-
-
-
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
complement component 3 + H2O
?
show the reaction diagram
-
digestion
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
-
digestion
-
-
?
fibrinogen + H2O
fibrin + ?
show the reaction diagram
Q7YS62
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
-
digestion
-
-
?
histone 2B + H2O
?
show the reaction diagram
-
-
-
-
?
histone 3 + H2O
?
show the reaction diagram
-
-
-
-
?
pro-interleukin-6 + H2O
interleukin-6 + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease-3 + H2O
?
show the reaction diagram
-
digestion
-
-
?
pro-matrix metalloproteinase-2 + H2O
matrix metalloproteinase-2 + ?
show the reaction diagram
-
-
-
-
?
pro-nerve growth factor + H2O
mature nerve growth factor and smaller fragments
show the reaction diagram
-
-
analyzed by MS/MS
-
?
pro-nuclear factor-kappa B + H2O
nuclear factor-kappa B + ?
show the reaction diagram
-
-
-
-
?
pro-proteinase-activated receptor 2 + H2O
proteinase-activated receptor 2 + ?
show the reaction diagram
-
-
-
-
?
pro-tissue necrosis factor + H2O
tissue necrosis factor + ?
show the reaction diagram
-
-
-
-
?
Pro-urokinase + H2O
?
show the reaction diagram
-
digestion
-
-
?
protease-activated receptor 2 + H2O
fibrin + ?
show the reaction diagram
-
-
-
-
?
protease-activated receptor-2 + H2O
?
show the reaction diagram
-
digestion
-
-
?
proteinase-activated receptor 2 + H2O
?
show the reaction diagram
-
-
-
-
?
proteinase-activated receptor-2 + H2O
?
show the reaction diagram
-
tryptase may contribute to cyclooxygenase-2 upregulation by epithelial proteinase-activated receptor-2 activation during early lip carcinogenesis
-
-
?
TGFbeta + H2O
activated TGFbeta + ?
show the reaction diagram
-
tryptase activates TGFbeta, a key remodelling factor in asthma, in human airway smooth muscle cells via direct proteolysis in a PAR2-independent manner, TGFbeta is produced as a latent complex and the main limiting step in TGFb bioavailability is its activation, overview
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CaCl2
-
tryptase free from trypstatin is activated by 10 mM CaCl2, but tryptase associated with trypstatin is not
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2,5-azetidinearboxamide
-
-
-
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2-pyrrolidinecarboxamide
-
-
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-4-methylpentanamide
-
-
-
(Arg-Trp-Lys-Gly)4(Lys)2Lys-NH2
-
noncompetitive
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2
-
noncompetitive
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 4-[[(phenylmethoxy)carbonyl]amino]-benzoate
-
-
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 5-[[(phenylmethoxy)carbonyl]amino]-pentanoate
-
-
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl N-[(phenylmethoxy)carbonyl]-beta-alanate
-
-
1,2,5-thiadiazolidin-3-one 1,1-dioxide
-
1,2,5-zhiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors
1,2-benzisothiazol-3-one 1,1-dioxide
-
-
1-acetyl-N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]prolinamide
-
-
1-methylethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
2-methoxyethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-diethylurea
-
-
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-dimethylurea
-
-
4',6-Diamidino-2-phenylindole
-
-
4'-[[5-(phenylethynyl)furan-2-yl]carbonyl]spiro[1-benzofuran-3,1'-cyclohexane]-5-carboxamide
-
-
4'-[[5-(phenylethynyl)furan-2-yl]carbonyl]spiro[1-benzofuran-3,1'-cyclohexane]-5-carboximidamide
-
-
4-Amidinophenylpyruvic acid
-
-
4-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]butanamide
-
-
4-aminobenzamidine
-
-
4-Methylumbelliferyl 4-guanidinobenzoate
-
-
4-Nitrophenyl 4-guanidinobenzoate
-
-
5-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]pentanamide
-
-
6-amidino-2-naphthyl p-guanidinobenzoate dimethane sulfonate
-
nafamostat mesilate
6-amino-N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
6-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
7-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]heptanamide
-
-
acetyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
acetyl-PRNK-chloromethylketone
-
-
Alpha1-antitrypsin
antipain
antithrombin III
-
-
-
APC 366
-
-
APC-1167
-
-
-
APC-366
APC366
Aprotinin
Arg-Trp-Lys-Gly-NH2
-
noncompetitive
BABIM
-
-
benzamidine
benzyl 4-[(3-[N2-[(benzyloxy)carbonyl]-L-lysyl]-1,2,4-oxadiazol-5-yl)methyl]piperazine-1-carboxylate
-
-
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-1-(1H-indol-2-ylmethyl)-2-oxoethyl]carbamate
-
-
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)ethyl]carbamate
-
-
benzyl [(1S)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-(benzylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-([2-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-([2-[4-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(2-thiophen-2-ylethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(3,4-dimethylbenzyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(3-methylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(3-phenylpropyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(4-phenylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-1-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-2-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-methoxybenzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[(2E)-3-phenylprop-2-en-1-yl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,4-dichlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate10n
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,5-difluorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(4-fluorophenoxy)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[4-(2-fluorobenzyl)piperazin-1-yl]carbonyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S,3E)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pent-3-en-1-yl]carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(2,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dimethoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(4-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(4-fluorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(4-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-benzyl-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((benzyl ((1S)-5-amino-1-[(5-(4-[(3,4-dimethoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate1S)-5-amino-1-[(5-(4-[(3-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[3-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[3-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(cyclohexylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-1-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-2-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
BMS-262084
-
-
Bovine pancreatic trypsin inhibitor
CaCl2
-
-
Calcium
-
5 mM is needed to cause an irreversible 50% loss of activity after 60 min at room temperature
ck-MCoEeTI
-
-
-
CRA-2059
cyclotheonamide E4
-
-
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
-
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
-
c[-Pro-beta3hPhe(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
-
c[-Pro-beta3Lys(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
-
D-Tyr-Glu-Phe-Lys-Arg-CH2Cl
-
-
Dansyl-L-glutamyl-glycyl-L-arginine chloromethyl ketone
-
-
diisopropyl fluorophosphate
diisopropylfluorophosphate
DTNB
-
-
ethyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
ethyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
ethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
ethyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
ferritin
-
ferritin can retard the cleavage of both native oxidized high-molecular-weight kininogen by tryptase, initial rates of cleavage are reduced 45-75% in the presence of ferritin
-
FUT175
-
a selective tryptase inhibitor
gabexate mesilate
-
-
histamine
-
-
JNJ-27390467
-
-
leech-derived tryptase inhibitor
-
nanomolar inhibitor
-
Leupeptin
Lys-Lys-Phe-Gly-NH2
-
noncompetitive
M58539
-
i.e. N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(1-chloronaphthalen-2-yl)sulfanyl]ethane-1,2-diamine, a highly selective inhibitor
MCoEeTI
-
-
-
MCoEeTI[K10R]
-
-
-
MCoTI-I
-
-
-
MCoTI-II
-
-
-
MCoTI-II derived miniprotein
-
nanomolar inhibitor
-
MCoTI-II-DELTA[DG]
-
-
-
MCoTI-II-DELTA[GSDGV]
-
-
-
MCoTI-II-DELTA[SDGGV]
-
-
-
MCoTI-II-DELTA[SDGG]
-
-
-
MCoTI-II-DELTA[SDGG][K10R]
-
-
-
MCoTI-II[K10A]
-
-
-
MCoTI-II[K10F]
-
-
-
MCoTI-II[K10Q]
-
-
-
MCoTI-II[K10R]
-
-
-
MCoTI-II[K10V]
-
-
-
MCoTI-II[K10V]-[I11P]
-
-
-
MCoTI-II[PKI]-[AVP]
-
-
-
methyl 4'-[3-([(6-chloronaphthalen-2-yl)sulfonyl][2-[(2-hydroxyethyl)(methyl)amino]-2-oxoethyl]amino)-2-oxopiperidin-1-yl]-3'-fluorobiphenyl-2-sulfinate
-
-
methyl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
methyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
MOL 6131
-
developed against mast cell beta-tryptase and studied in ovalbumin-induced allergic airway inflammation
mucus protease inhibitor
-
-
-
N-tosyl-L-Lys chloromethyl ketone
N-tosyl-L-Phe chloromethyl ketone
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-piperidin-4-ylpropyl]-3,4-difluorobenzamide
-
-
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]-3,4-difluorobenzamide
-
-
N-[(1S)-3-azetidin-3-yl-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)propyl]-3,4-difluorobenzamide
-
-
N-[(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]-3,4-difluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-1,3-benzodioxole-5-carboxamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,4-difluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,5-difluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3-fluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-chlorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-fluorobenzamide
-
-
N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
N-[2-(3-chlorophenyl)ethyl]-4-([3-[N2-(2,2-dimethylpropanoyl)-L-lysyl]-1,2,4-oxadiazol-5-yl]methyl)benzamide
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1,2,3,4-tetrahydroisoquinolin-7-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-2-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-5-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(2,3-dihydro-1H-inden-5-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(naphthalen-2-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(phenylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(2-methyl-1,3-benzothiazol-6-yl)sulfanyl]ethane-1,2-diamine
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2,2-trifluoroacetamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2-dimethylpropanamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,4-difluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,5-dimethylfuran-3-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-fluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methoxyacetamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methylpropanamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3,4-difluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3-fluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-chlorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-fluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopentanecarboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopropanecarboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]furan-2-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]hexanamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]morpholine-4-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]piperidine-1-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]pyrrolidine-1-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]tetrahydrofuran-3-carboxamide
-
-
Nafamostat
-
complete inhibition at 0.1 mM
nafamostat mesilate
-
-
neutrophil myeloperoxidase
-
important component of the neutrophil response to microbial infection, high concentrations of heparin can prevent the inhibition of tryptase by MPO
-
p-Aminophenylmethanesulfonyl fluoride
-
lung enzyme is inhibited over 3times faster than the skin enzyme
p-chloromercuribenzoate
-
-
Pentamidine
-
nonselective inhibitor
Peptide chloromethyl ketone inhibitors
-
-
-
polybrene
prop-2-en-1-yl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
protamine
rLDTI
-
recombinant leech-derived tryptase inhibitor
-
RWJ-56423
-
-
RWJ-58643
-
-
SBTII
-
-
Soybean trypsin inhibitor
Sulfonyl fluoride inhibitors
-
-
trans-4-(Guanidinomethyl)cyclohexanecarboxylic acid esters
-
most effective: trans-4-(guanidinomethyl)cyclohexanecarboxylic acid butylphenyl ester
Trypstatin
Tryptase inhibitor
-
derived from the medical leech Hirudo medicinalis
-
ZnSO4
-
-
[1'-(acetyloxy)-5'-(aminomethyl)-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5'-(aminomethyl)-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5'-(aminomethyl)-1'-[(methylsulfinyl)oxy]-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5'-(aminomethyl)-1'-[(phenylsulfinyl)oxy]-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl](5-benzylfuran-2-yl)methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(2-phenylethyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylsulfanyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-chlorophenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-fluorophenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-methoxyphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-methylphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-hydroxyphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-methylphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-tert-butylphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-[(1E)-1-aminoprop-1-en-1-yl]spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[6'-(aminomethyl)-2',3'-dihydrospiro[cyclohexane-1,1'-inden]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
heparin
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05
Ac-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.062
Ac-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.1105 - 0.1333
Ac-PANK-AAC
0.0089 - 0.0145
Ac-PRNK-AAC
0.0165 - 0.0186
Ac-PRNR-AAC
0.071
Ac-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.0147 - 0.0234
Ac-PRTK-AAC
0.04
Ala-Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.053
Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.1
Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.0002
Benzyloxycarbonyl-Ala-Arg-Arg 4-methylcoumarin 7-amide
-
-
0.0231
benzyloxycarbonyl-Arg 4-methylcoumarin 7-amide
-
-
0.0409
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg 4-methylcoumarin 7-amide
-
-
0.323
benzyloxycarbonyl-L-Ala-L-Leu-L-Lys 4-methylcoumarin 7-amide
-
-
0.0138
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg 4-methylcoumarin 7-amide
-
-
0.0148
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys 4-methylcoumarin 7-amide
-
-
0.0023
bovine prothrombin
-
-
-
0.3 - 5
Bz-Arg-p-nitroanilide
0.062 - 0.081
D-Ile-Pro-Arg-4-nitroanilide
0.4 - 8.2
D-Ile-Pro-Arg-p-nitroanilide
0.7 - 0.79
D-Phe-Pip-Arg-p-nitroanilide
1.64 - 13.5
D-Pro-Phe-Arg-p-nitroanilide
1.12 - 3.49
D-Val-Leu-Arg-p-nitroanilide
5.03 - 10.5
Glu-Gly-Arg-p-nitroanilide
0.37 - 0.64
Glu-Pro-Arg-p-nitroanilide
0.111
Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.58 - 1.16
MeOCO-Nle-Gly-Arg-p-nitroanilide
0.922
N-(p-tosyl)-Gly-Pro-Arg-4-nitroanilide
pH 8.0, 22C
2.849
N-(p-tosyl)-Gly-Pro-Lys-p-nitroanilide
pH 8.0, 22C
0.049 - 0.12
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
0.19 - 4.2
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
0.044
Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.043
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide
-
pH 8.0, 30C
0.0046
Tert-Butyloxycarbonyl-Gly-Lys-Arg 4-methylcoumarin 7-amide
-
-
0.029
tert-butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide
-
-
0.031
tert-butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide
-
-
0.35 - 0.49
tosyl-Gly-Pro-Lys-p-nitroanilide
0.04 - 0.36
Z-D-Arg-Gly-Arg-p-nitroanilide
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
141
Ac-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
367
Ac-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
1.1 - 3.5
Ac-PANK-AAC
0.97 - 0.99
Ac-PRNK-AAC
3.8 - 21.8
Ac-PRNR-AAC
378
Ac-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
0.99 - 1.1
Ac-PRTK-AAC
187
Ala-Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
233
Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
159
Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
0.8
Benzyloxycarbonyl-Ala-Arg-Arg 4-methylcoumarin 7-amide
Bos taurus
-
-
0.05
benzyloxycarbonyl-Arg 4-methylcoumarin 7-amide
Bos taurus
-
-
5.35 - 5.52
benzyloxycarbonyl-Arg 4-nitroanilide
104 - 107
Benzyloxycarbonyl-Gly-Arg 4-trifluoromethylcoumarin 7-amide
551 - 553
Benzyloxycarbonyl-Gly-Pro-Arg 4-nitroanilide
2040
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg 4-methylcoumarin 7-amide
Homo sapiens
-
-
1870
benzyloxycarbonyl-L-Ala-L-Leu-L-Lys 4-methylcoumarin 7-amide
Homo sapiens
-
-
3290
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg 4-methylcoumarin 7-amide
Homo sapiens
-
-
1520
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys 4-methylcoumarin 7-amide
Homo sapiens
-
-
45.7
Benzyloxycarbonyl-Lys-Arg 4-trifluoromethylcoumarin 7-amide
Homo sapiens
-
skin and lung enzyme
46.3
bovine prothrombin
Rattus norvegicus
-
-
-
0.03 - 8.9
Bz-Arg-p-nitroanilide
97 - 170
D-Ile-Pro-Arg-4-nitroanilide
3 - 40
D-Ile-Pro-Arg-p-nitroanilide
24.1 - 59.5
D-Phe-Pip-Arg-p-nitroanilide
2.8 - 5.3
D-Pro-Phe-Arg-p-nitroanilide
0.833 - 31
D-Val-Leu-Arg-p-nitroanilide
9 - 183
Glu-Gly-Arg-p-nitroanilide
1.5 - 56.9
Glu-Pro-Arg-p-nitroanilide
199
Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
15.2 - 2630
MeOCO-Nle-Gly-Arg-p-nitroanilide
23.5
N-(p-tosyl)-Gly-Pro-Arg-4-nitroanilide
Equus caballus
Q7YS62
pH 8.0, 22C
12
N-(p-tosyl)-Gly-Pro-Lys-p-nitroanilide
Equus caballus
Q7YS62
pH 8.0, 22C
1.9 - 21
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
0.74 - 540
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
435
Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
Homo sapiens
-
-
7
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide
Bos taurus
-
pH 8.0, 30C
0.5
Tert-Butyloxycarbonyl-Gly-Lys-Arg 4-methylcoumarin 7-amide
Bos taurus
-
-
1.4
tert-butyloxycarbonyl-L-Val-L-Pro-L-Arg-4-methylcoumarin 7-amide
Bos taurus
-
-
2.2
tert-butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide
Bos taurus
-
-
27.9 - 75.5
tosyl-Gly-Pro-Lys-p-nitroanilide
1.9 - 10.3
Z-D-Arg-Gly-Arg-p-nitroanilide
additional information
additional information
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00017
(Arg-Trp-Lys-Gly)4(Lys)2Lys-NH2
-
22C, pH not specified in the publication
0.000323 - 0.00063
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2
0.000006
1-acetyl-N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]prolinamide
-
-
0.000005
1-methylethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
0.000018
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-diethylurea
-
-
0.0000096
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-dimethylurea
-
-
0.001
4-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]butanamide
-
-
0.05697
4-aminobenzamidine
-
22C, pH not specified in the publication
0.000012
5-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]pentanamide
-
-
0.0000000953
6-amidino-2-naphthyl p-guanidinobenzoate dimethane sulfonate
-
pH 7.8, 37C
0.000007
6-amino-N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
0.000016
6-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
0.000023
7-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]heptanamide
-
-
0.000003
acetyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.0092 - 0.0097
APC-1167
0.00053 - 0.25
APC-366
0.25 - 0.369
Aprotinin
0.3058
Arg-Trp-Lys-Gly-NH2
-
22C, pH not specified in the publication
0.0025 - 0.0046
BABIM
0.00047
benzyl 4-[(3-[N2-[(benzyloxy)carbonyl]-L-lysyl]-1,2,4-oxadiazol-5-yl)methyl]piperazine-1-carboxylate
-
-
0.012
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-1-(1H-indol-2-ylmethyl)-2-oxoethyl]carbamate
-
-
0.045
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)ethyl]carbamate
-
-
0.0073
benzyl [(1S)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pentyl]carbamate
-
-
0.0000037
benzyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.000037
benzyl [(1S)-5-amino-1-([5-[4-(benzylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.000012
benzyl [(1S)-5-amino-1-([5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.0000082
benzyl [(1S)-5-amino-1-([5-[4-([2-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.00022
benzyl [(1S)-5-amino-1-([5-[4-([2-[4-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.0000024
benzyl [(1S)-5-amino-1-[(5-[4-[(2-thiophen-2-ylethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000039
benzyl [(1S)-5-amino-1-[(5-[4-[(3,4-dimethylbenzyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0000099
benzyl [(1S)-5-amino-1-[(5-[4-[(3-methylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000003 - 0.0000032
benzyl [(1S)-5-amino-1-[(5-[4-[(3-phenylpropyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
0.00006
benzyl [(1S)-5-amino-1-[(5-[4-[(4-phenylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000013
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-1-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000011
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-2-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.00023
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000011
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000034
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0000058
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.00077
benzyl [(1S)-5-amino-1-[[5-(4-methoxybenzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000036
benzyl [(1S)-5-amino-1-[[5-(4-[[(2E)-3-phenylprop-2-en-1-yl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.000016
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,4-dichlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000035
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,5-difluorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000018
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000029
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(4-fluorophenoxy)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.00014
benzyl [(1S)-5-amino-1-[[5-(4-[[4-(2-fluorobenzyl)piperazin-1-yl]carbonyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.025
benzyl [(1S,3E)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pent-3-en-1-yl]carbamate
-
-
0.000096
benzyl((1S)-5-amino-1-[(5-(4-[(2,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.00001
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000024
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dimethoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000013
benzyl((1S)-5-amino-1-[(5-(4-[(3-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000041
benzyl((1S)-5-amino-1-[(5-(4-[(3-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000014
benzyl((1S)-5-amino-1-[(5-(4-[(4-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000016
benzyl((1S)-5-amino-1-[(5-(4-[(4-fluorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000019
benzyl((1S)-5-amino-1-[(5-(4-[(4-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.0027
benzyl((1S)-5-amino-1-[(5-benzyl-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.00036
benzyl[(1S)-5-amino-1-((5-[3-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.00012
benzyl[(1S)-5-amino-1-((5-[3-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000012
benzyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000025
benzyl[(1S)-5-amino-1-((5-[4-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.00018
benzyl[(1S)-5-amino-1-((5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.0011
benzyl[(1S)-5-amino-1-((5-[4-(cyclohexylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000078
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-1-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000027
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-2-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.00011
ck-MCoEeTI
-
-
-
0.00000062
CRA-2059
-
pH 8.0, 25C, tryptase-beta
0.04
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.000007
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.000025
c[-Pro-beta3hPhe(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.38
c[-Pro-beta3Lys(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.0000028
ethyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.0000019
ethyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000047
ethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0000054
ethyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.0000951
gabexate mesilate
-
pH 7.8, 37C
0.4717
Lys-Lys-Phe-Gly-NH2
-
22C, pH not specified in the publication
0.000005
M58539
-
-
0.000033
MCoEeTI
-
-
-
0.000028
MCoEeTI[K10R]
-
-
-
0.0016
MCoTI-I
-
-
-
0.0006
MCoTI-II, MCoTI-II-DELTA[DG]
-
-
-
0.002
MCoTI-II-DELTA[GSDGV]
-
Ki above 0.002 mM
-
0.003
MCoTI-II-DELTA[SDGGV]
-
Ki above 0.003 mM
-
0.000009
MCoTI-II-DELTA[SDGG]
-
-
-
0.00001
MCoTI-II-DELTA[SDGG][K10R]
-
-
-
0.05
MCoTI-II[K10A], MCoTI-II[K10F], MCoTI-II[K10Q]
-
IC50 above 0.05 mM
-
0.085
MCoTI-II[K10R]
-
-
-
0.05
MCoTI-II[K10V], MCoTI-II[K10V]-[I11P], MCoTI-II[PKI]-[AVP]
-
IC50 above 0.05 mM
-
0.000011
methyl 4'-[3-([(6-chloronaphthalen-2-yl)sulfonyl][2-[(2-hydroxyethyl)(methyl)amino]-2-oxoethyl]amino)-2-oxopiperidin-1-yl]-3'-fluorobiphenyl-2-sulfinate
-
-
0.00013
methyl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
0.000017
methyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.00045
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-piperidin-4-ylpropyl]-3,4-difluorobenzamide
-
-
0.000021
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]-3,4-difluorobenzamide
-
-
0.00059
N-[(1S)-3-azetidin-3-yl-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)propyl]-3,4-difluorobenzamide
-
-
0.000004
N-[(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]-3,4-difluorobenzamide
-
-
0.0000021
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-1,3-benzodioxole-5-carboxamide
-
-
0.0000017
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,4-difluorobenzamide
-
-
0.0000015
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,5-difluorobenzamide
-
-
0.0000017
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3-fluorobenzamide
-
-
0.0000019
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-chlorobenzamide
-
-
0.0000018
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-fluorobenzamide
-
-
0.04
N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
0.38
N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
0.000002
N-[2-(3-chlorophenyl)ethyl]-4-([3-[N2-(2,2-dimethylpropanoyl)-L-lysyl]-1,2,4-oxadiazol-5-yl]methyl)benzamide
-
-
0.00019
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1,2,3,4-tetrahydroisoquinolin-7-ylsulfanyl)ethane-1,2-diamine
-
-
0.00013
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-2-ylsulfanyl)ethane-1,2-diamine
-
-
0.00021
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-5-ylsulfanyl)ethane-1,2-diamine
-
-
0.0002
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(2,3-dihydro-1H-inden-5-ylsulfanyl)ethane-1,2-diamine
-
-
0.000073
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(naphthalen-2-ylsulfanyl)ethane-1,2-diamine
-
-
0.00076
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(phenylsulfanyl)ethane-1,2-diamine
-
-
0.00027
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(2-methyl-1,3-benzothiazol-6-yl)sulfanyl]ethane-1,2-diamine
-
-
0.0000029
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2,2-trifluoroacetamide
-
-
0.0000038
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2-dimethylpropanamide
-
-
0.0000033
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,4-difluorobenzamide
-
-
0.000046
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,5-dimethylfuran-3-carboxamide
-
-
0.0000062
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-fluorobenzamide
-
-
0.0000037
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methoxyacetamide
-
-
0.0000068
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methylpropanamide
-
-
0.0000076
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3,4-difluorobenzamide
-
-
0.0000058
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3-fluorobenzamide
-
-
0.0000066
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-chlorobenzamide
-
-
0.0000025
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-fluorobenzamide
-
-
0.0000065
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopentanecarboxamide
-
-
0.0000046
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopropanecarboxamide
-
-
0.0000023
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]furan-2-carboxamide
-
-
0.0000098
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]hexanamide
-
-
0.0000057
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]morpholine-4-carboxamide
-
-
0.0000092
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]piperidine-1-carboxamide
-
-
0.000032
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]pyrrolidine-1-carboxamide
-
-
0.000022
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]tetrahydrofuran-3-carboxamide
-
-
0.0023 - 0.0028
Pentamidine
0.000025
prop-2-en-1-yl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
0.0000012
rLDT1
-
pH 7.6, 25C
-
0.000001
RWJ-56423
-
pH 7.4, 37C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00078
4'-[[5-(phenylethynyl)furan-2-yl]carbonyl]spiro[1-benzofuran-3,1'-cyclohexane]-5-carboximidamide
Homo sapiens
-
pH 7.4, 37C
0.0000051
cyclotheonamide E4
Homo sapiens
-
-
0.0000036
JNJ-27390467
Homo sapiens
-
pH 7.4, 37C
0.000015
[1'-(acetyloxy)-5'-(aminomethyl)-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.000023
[5'-(aminomethyl)-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000018
[5'-(aminomethyl)-1'-[(methylsulfinyl)oxy]-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000057
[5'-(aminomethyl)-1'-[(phenylsulfinyl)oxy]-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.000028
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl](5-benzylfuran-2-yl)methanone
Homo sapiens
-
pH 7.4, 37C
0.000082
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(2-phenylethyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000045
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylethynyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.00009
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylsulfanyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000052
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-chlorophenyl)ethynyl]furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000043
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-fluorophenyl)ethynyl]furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.000013
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-methoxyphenyl)ethynyl]furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000012
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-methylphenyl)ethynyl]furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0032
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-hydroxyphenyl)ethynyl]furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000083
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-methylphenyl)ethynyl]furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0007
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-tert-butylphenyl)ethynyl]furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.000059
[5-[(1E)-1-aminoprop-1-en-1-yl]spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylethynyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
0.0000031
[6'-(aminomethyl)-2',3'-dihydrospiro[cyclohexane-1,1'-inden]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
Homo sapiens
-
pH 7.4, 37C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000000055
-
substrate tosyl-Gly-Pro-Lys-4-nitroanilide, pH not specified in the publication, temperature not specified in the publication
1000
-
purified commercial preparation from lung
3930
-
-
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 8.5
-
in complex with heparin
6
-
assay at
7.4
-
assay at
7.5 - 8
7.5
-
tryptase associated with trypstatin
7.5 - 8
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 10
-
-
6 - 9
-
-
6 - 8.5
-
no activity below pH 6 or above pH 8.5
6
-
no activity below
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
assay at room temperature
37
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.1
-
isoelectric focusing
5.7
-
lung mast cell lysate and lung tryptase, isoelectric focusing
5.8
-
skin mast cell lysate, isoelectric focusing
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
significantly more tryptase in peritumoral tissue than in normal breast tissue
Manually annotated by BRENDA team
-
connective tissues of adult mice, MCP-7
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
tryptase is not cleared by the kidneys into the urine
Manually annotated by BRENDA team
additional information
-
mMCP-6, mMCP-7 can be detected in plasma as early as 20 min after mast cell degranulation
Manually annotated by BRENDA team