Sequence of HDAC6_HUMAN
EC Number:3.5.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 3.5.1
EC Number:3.5.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Other sequences found for EC No. 3.5.1.98
General information:
Sequence
0 MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG
60 QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI
120 QEGLLDRCVS FQARFAEKEE LMLVHSLEYI DLMETTQYMN EGELRVLADT YDSVYLHPNS
180 YSCACLASGS VLRLVDAVLG AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ
240 KHRIRRVLIV DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG
300 QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG DPKGEMAATP
360 AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH TLLGDPCPML ESPGAPCRSA
420 QASVSCALEA LEPFWEVLVR STETVERDNM EEDNVEESEE EGPWEPPVLP ILTWPVLQSR
480 TGLVYDQNMM NHCNLWDSHH PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH
540 SAEYVGHLRA TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN
600 GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQTISGHA LRILIVDWDV HHGNGTQHMF
660 EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT VNVAWNGPRM GDADYLAAWH
720 RLVLPIAYEF NPELVLVSAG FDAARGDPLG GCQVSPEGYA HLTHLLMGLA SGRIILILEG
780 GYNLTSISES MAACTRSLLG DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE
840 DREGPSSSKL VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KVTSASFGEE STPGQTNSET
900 AVVALTQDQP SEAATGGATL AQTISEAAIG GAMLGQTTSE EAVGGATPDQ TTSEETVGGA
960 ILDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME GATLDQTTSE EAPGGTELIQ
1020 TPLASSTDHQ TPPTSPVQGT TPQISPSTLI GSLRTLELGS ESQGASESQA PGEENLLGEA
1080 AGGQDMADSM LMQGSRGLTD QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ
1140 ENWVCLSCYQ VYCGRYINGH MLQHHGNSGH PLVLSYIDLS AWCYYCQAYV HHQALLDVKN
1200 IAHQNKFGED MPHPH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
426740
Grozinger C.M.,Hassig C.A.,Schreiber S.L.
Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Proc. Natl. Acad. Sci. U.S.A.
96
4868-4873
1999
426741
Nagase T.,Ishikawa K.,Suyama M.,Kikuno R.,Hirosawa M.,Miyajima N.,Tanaka A.,Kotani H.,Nomura N.,Ohara O.
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
DNA Res.
5
355-364
1998
426744
Ross M.T.,Grafham D.V.,Coffey A.J.,Scherer S.,McLay K.,Muzny D.,Platzer M.,Howell G.R.,Burrows C.,Bird C.P.,Frankish A.,Lovell F.L.,Howe K.L.,Ashurst J.L.,Fulton R.S.,Sudbrak R.,Wen G.,Jones M.C.,Hurles M.E.,Andrews T.D.,Scott C.E.,Searle S.,Ramser J.,Whittaker A.,Deadman R.,Carter N.P.,Hunt S.E.,Chen R.,Cree A.,Gunaratne P.,Havlak P.,Hodgson A.,Metzker M.L.,Richards S.,Scott G.,Steffen D.,Sodergren E.,Wheeler D.A.,Worley K.C.,Ainscough R.,Ambrose K.D.,Ansari-Lari M.A.,Aradhya S.,Ashwell R.I.,Babbage A.K.,Bagguley C.L.,Ballabio A.,Banerjee R.,Barker G.E.,Barlow K.F.,Barrett I.P.,Bates K.N.,Beare D.M.,Beasley H.,Beasley O.,Beck A.,Bethel G.,Blechschmidt K.,Brady N.,Bray-Allen S.,Bridgeman A.M.,Brown A.J.,Brown M.J.,Bonnin D.,Bruford E.A.,Buhay C.,Burch P.,Burford D.,Burgess J.,Burrill W.,Burton J.,Bye J.M.,Carder C.,Carrel L.,Chako J.,Chapman J.C.,Chavez D.,Chen E.,Chen G.,Chen Y.,Chen Z.,Chinault C.,Ciccodicola A.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Clerc-Blankenburg K.,Clifford K.,Cobley V.,Cole C.G.,Conquer J.S.,Corby N.,Connor R.E.,David R.,Davies J.,Davis C.,Davis J.,Delgado O.,Deshazo D.,Dhami P.,Ding Y.,Dinh H.,Dodsworth S.,Draper H.,Dugan-Rocha S.,Dunham A.,Dunn M.,Durbin K.J.,Dutta I.,Eades T.,Ellwood M.,Emery-Cohen A.,Errington H.,Evans K.L.,Faulkner L.,Francis F.,Frankland J.,Fraser A.E.,Galgoczy P.,Gilbert J.,Gill R.,Gloeckner G.,Gregory S.G.,Gribble S.,Griffiths C.,Grocock R.,Gu Y.,Gwilliam R.,Hamilton C.,Hart E.A.,Hawes A.,Heath P.D.,Heitmann K.,Hennig S.,Hernandez J.,Hinzmann B.,Ho S.,Hoffs M.,Howden P.J.,Huckle E.J.,Hume J.,Hunt P.J.,Hunt A.R.,Isherwood J.,Jacob L.,Johnson D.,Jones S.,de Jong P.J.,Joseph S.S.,Keenan S.,Kelly S.,Kershaw J.K.,Khan Z.,Kioschis P.,Klages S.,Knights A.J.,Kosiura A.,Kovar-Smith C.,Laird G.K.,Langford C.,Lawlor S.,Leversha M.,Lewis L.,Liu W.,Lloyd C.,Lloyd D.M.,Loulseged H.,Loveland J.E.,Lovell J.D.,Lozado R.,Lu J.,Lyne R.,Ma J.,Maheshwari M.,Matthews L.H.,McDowall J.,McLaren S.,McMurray A.,Meidl P.,Meitinger T.,Milne S.,Miner G.,Mistry S.L.,Morgan M.,Morris S.,Mueller I.,Mullikin J.C.,Nguyen N.,Nordsiek G.,Nyakatura G.,O'dell C.N.,Okwuonu G.,Palmer S.,Pandian R.,Parker D.,Parrish J.,Pasternak S.,Patel D.,Pearce A.V.,Pearson D.M.,Pelan S.E.,Perez L.,Porter K.M.,Ramsey Y.,Reichwald K.,Rhodes S.,Ridler K.A.,Schlessinger D.,Schueler M.G.,Sehra H.K.,Shaw-Smith C.,Shen H.,Sheridan E.M.,Shownkeen R.,Skuce C.D.,Smith M.L.,Sotheran E.C.,Steingruber H.E.,Steward C.A.,Storey R.,Swann R.M.,Swarbreck D.,Tabor P.E.,Taudien S.,Taylor T.,Teague B.,Thomas K.,Thorpe A.,Timms K.,Tracey A.,Trevanion S.,Tromans A.C.,d'Urso M.,Verduzco D.,Villasana D.,Waldron L.,Wall M.,Wang Q.,Warren J.,Warry G.L.,Wei X.,West A.,Whitehead S.L.,Whiteley M.N.,Wilkinson J.E.,Willey D.L.,Williams G.,Williams L.,Williamson A.,Williamson H.,Wilming L.,Woodmansey R.L.,Wray P.W.,Yen J.,Zhang J.,Zhou J.,Zoghbi H.,Zorilla S.,Buck D.,Reinhardt R.,Poustka A.,Rosenthal A.,Lehrach H.,Meindl A.,Minx P.J.,Hillier L.W.,Willard H.F.,Wilson R.K.,Waterston R.H.,Rice C.M.,Vaudin M.,Coulson A.,Nelson D.L.,Weinstock G.,Sulston J.E.,Durbin R.M.,Hubbard T.,Gibbs R.A.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence of the human X chromosome.
Nature
434
325-337
2005
426746
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
426747
Amann J.M.,Nip J.,Strom D.K.,Lutterbach B.,Harada H.,Lenny N.,Downing J.R.,Meyers S.,Hiebert S.W.
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Mol. Cell. Biol.
21
6470-6483
2001
426748
Gao L.,Cueto M.A.,Asselbergs F.,Atadja P.
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.
J. Biol. Chem.
277
25748-25755
2002
426749
Kirsh O.,Seeler J.-S.,Pichler A.,Gast A.,Mueller S.,Miska E.,Mathieu M.,Harel-Bellan A.,Kouzarides T.,Melchior F.,Dejean A.
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
EMBO J.
21
2682-2691
2002
426750
Hook S.S.,Orian A.,Cowley S.M.,Eisenman R.N.
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.
Proc. Natl. Acad. Sci. U.S.A.
99
13425-13430
2002
426751
Hubbert C.,Guardiola A.,Shao R.,Kawaguchi Y.,Ito A.,Nixon A.,Yoshida M.,Wang X.-F.,Yao T.-P.
HDAC6 is a microtubule-associated deacetylase.
Nature
417
455-458
2002
426752
North B.J.,Marshall B.L.,Borra M.T.,Denu J.M.,Verdin E.
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
Mol. Cell
11
437-444
2003
426753
Pugacheva E.N.,Jablonski S.A.,Hartman T.R.,Henske E.P.,Golemis E.A.
HEF1-dependent Aurora A activation induces disassembly of the primary cilium.
Cell
129
1351-1363
2007
426754
Ohoka N.,Hattori T.,Kitagawa M.,Onozaki K.,Hayashi H.
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.
J. Biol. Chem.
282
35687-35694
2007
426755
Olzmann J.A.,Li L.,Chudaev M.V.,Chen J.,Perez F.A.,Palmiter R.D.,Chin L.S.
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
J. Cell Biol.
178
1025-1038
2007
426756
Nahhas F.,Dryden S.C.,Abrams J.,Tainsky M.A.
Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.
Mol. Cell. Biochem.
303
221-230
2007
426757
Loktev A.V.,Zhang Q.,Beck J.S.,Searby C.C.,Scheetz T.E.,Bazan F.,Slusarski D.C.,Sheffield V.C.,Jackson P.K.,Nachury M.V.
A BBSome subunit links ciliogenesis, microtubule stability and acetylation.
Dev. Cell
15
854-865
2008
426758
Kalveram B.,Schmidtke G.,Groettrup M.
The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.
J. Cell Sci.
121
4079-4088
2008
426759
Zhuang Y.,Nguyen H.T.,Lasky J.A.,Cao S.,Li C.,Hu J.,Guo X.,Burow M.E.,Shan B.
Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation.
Biochem. Biophys. Res. Commun.
392
608-613
2010
426760
Wickstrom S.A.,Masoumi K.C.,Khochbin S.,Fassler R.,Massoumi R.
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.
EMBO J.
29
131-144
2010
426761
Tokesi N.,Lehotzky A.,Horvath I.,Szabo B.,Olah J.,Lau P.,Ovadi J.
TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.
J. Biol. Chem.
285
17896-17906
2010
426762
Schofield A.V.,Steel R.,Bernard O.
Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration.
J. Biol. Chem.
287
43620-43629
2012
426763
Simon D.,Laloo B.,Barillot M.,Barnetche T.,Blanchard C.,Rooryck C.,Marche M.,Burgelin I.,Coupry I.,Chassaing N.,Gilbert-Dussardier B.,Lacombe D.,Grosset C.,Arveiler B.
A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia.
Hum. Mol. Genet.
19
2015-2027
2010
426764
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
426765
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
426766
Kang H.J.,Lee M.H.,Kang H.L.,Kim S.H.,Ahn J.R.,Na H.,Na T.Y.,Kim Y.N.,Seong J.K.,Lee M.O.
Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.
Cancer Res.
74
1484-1494
2014
426767
Balasubramanian A.,Kawahara G.,Gupta V.A.,Rozkalne A.,Beauvais A.,Kunkel L.M.,Gussoni E.
Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.
FASEB J.
28
2955-2969
2014
426768
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
426769
Theng S.S.,Wang W.,Mah W.C.,Chan C.,Zhuo J.,Gao Y.,Qin H.,Lim L.,Chong S.S.,Song J.,Lee C.G.
Disruption of FAT10-MAD2 binding inhibits tumor progression.
Proc. Natl. Acad. Sci. U.S.A.
111
0-0
2014
426770
Olah J.,Szunyogh S.,Szenasi T.,Szaniszlo T.,Szabo A.,Lehotzky A.,Berki T.,Nyitray L.,Ovadi J.
Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.
Biochim. Biophys. Acta
2019
118556-118556
2019
426771
Wang R.,Tan J.,Chen T.,Han H.,Tian R.,Tan Y.,Wu Y.,Cui J.,Chen F.,Li J.,Lv L.,Guan X.,Shang S.,Lu J.,Zhang Z.
ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion.
J. Cell Biol.
218
267-284
2019
