Sequence of DOIS_NIACI
EC Number:4.2.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 4.2.3
EC Number:4.2.3.124
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate
Other sequences found for EC No. 4.2.3.124
General information:
Sequence
0 MTTKQICFAD RCFNFAFGEH VLESVESYIP RDEFDQYIMI SDSGVPDSIV HYAAEYFGKL
60 APVHILRFQG GEEYKTLSTV TNLQERAIAL GANRRTAIVA VGGGLTGNVA GVAAGMMFRG
120 IALIHVPTTF LAASDSVLSI KQAVNLTSGK NLVGFYYPPR FVFADTRILS ESPPRQVKAG
180 MCELVKNMLI LENDNKEFTE DDLNSANVYS PKQLETFINF CISAKMSVLS EDIYEKKKGL
240 IFEYGHTIGH AIELAEQGGI THGEAIAVGM IYAAKIANRM NLMPEHDVSA HYWLLNKIGA
300 LQDIPLKSDP DSIFHYLIHD NKRGYIKLDE DNLGMILLSG VGKPAMYNQT LLTPVRKTLI
360 KEVIREGL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
920203
Kudo F.,Tamegai H.,Fujiwara T.,Tagami U.,Hirayama K.,Kakinuma K.
Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase.
J. Antibiot.
52
559-571
1999
920205
Kudo F.,Numakura M.,Tamegai H.,Yamamoto H.,Eguchi T.,Kakinuma K.
Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.
J. Antibiot.
58
373-379
2005
920206
Kudo F.,Yamauchi N.,Suzuki R.,Kakinuma K.
Kinetic isotope effect and reaction mechanism of 2-deoxy-scyllo-inosose synthase derived from butirosin-producing Bacillus circulans.
J. Antibiot.
50
424-428
1997
920207
Iwase N.,Kudo F.,Yamauchi N.,Kakinuma K.
Substrate specificity of 2-deoxy-scyllo-inosose synthase, the starter enzyme for 2-deoxystreptamine biosynthesis, toward deoxyglucose-6-phosphates and proposed mechanism.
Biosci. Biotechnol. Biochem.
62
2396-2407
1998
920208
Kudo F.,Hosomi Y.,Tamegai H.,Kakinuma K.
Purification and characterization of 2-deoxy-scyllo-inosose synthase derived from Bacillus circulans. A crucial carbocyclization enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics.
J. Antibiot.
52
81-88
1999
920209
Nango E.,Eguchi T.,Kakinuma K.
Active site mapping of 2-deoxy-scyllo-inosose synthase, the key starter enzyme for the biosynthesis of 2-deoxystreptamine. Mechanism-based inhibition and identification of Lysine-141 as the entrapped nucleophile.
J. Org. Chem.
69
593-600
2004
920210
Nango E.,Kumasaka T.,Sato T.,Tanaka N.,Kakinuma K.,Eguchi T.
Crystallization and X-ray analysis of 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics.
Acta Crystallogr. F
61
709-711
2005
920211
Huang Z.,Kakinuma K.,Eguchi T.
Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics.
Bioorg. Chem.
33
82-89
2005
920212
Nango E.,Kumasaka T.,Hirayama T.,Tanaka N.,Eguchi T.
Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+.
Proteins
70
517-527
2008
