Sequence of UD17_HUMAN
EC Number:2.4.1.17
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
Other sequences found for EC No. 2.4.1.17
General information:
Sequence
0 MARAGWTGLL PLYVCLLLTC GFAKAGKLLV VPMDGSHWFT MQSVVEKLIL RGHEVVVVMP
60 EVSWQLGRSL NCTVKTYSTS YTLEDQDREF MVFADARWTA PLRSAFSLLT SSSNGIFDLF
120 FSNCRSLFND RKLVEYLKES CFDAVFLDPF DACGLIVAKY FSLPSVVFAR GIFCHYLEEG
180 AQCPAPLSYV PRLLLGFSDA MTFKERVWNH IMHLEEHLFC PYFFKNVLEI ASEILQTPVT
240 AYDLYSHTSI WLLRTDFVLE YPKPVMPNMI FIGGINCHQG KPVPMEFEAY INASGEHGIV
300 VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH
360 PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL
420 ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW
480 YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
498060
Strassburg C.P.,Oldhafer K.,Manns M.P.,Tukey R.H.
Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.
Mol. Pharmacol.
52
212-220
1997
498061
Gong Q.H.,Cho J.W.,Huang T.,Potter C.,Gholami N.,Basu N.K.,Kubota S.,Carvalho S.,Pennington M.W.,Owens I.S.,Popescu N.C.
Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.
Pharmacogenetics
11
357-368
2001
498063
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
498064
Gagne J.F.,Montminy V.,Belanger P.,Journault K.,Gaucher G.,Guillemette C.
Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).
Mol. Pharmacol.
62
608-617
2002
498065
Picard N.,Ratanasavanh D.,Premaud A.,Le Meur Y.,Marquet P.
Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.
Drug Metab. Dispos.
33
139-146
2005
498066
Operana T.N.,Tukey R.H.
Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.
J. Biol. Chem.
282
4821-4829
2007
498067
Joseph T.B.,Wang S.W.,Liu X.,Kulkarni K.H.,Wang J.,Xu H.,Hu M.
Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.
Mol. Pharm.
4
883-894
2007
498068
Girard H.,Levesque E.,Bellemare J.,Journault K.,Caillier B.,Guillemette C.
Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.
Pharmacogenet. Genomics
17
1077-1089
2007
498069
Alonen A.,Finel M.,Kostiainen R.
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan.
Biochem. Pharmacol.
76
763-772
2008
498070
Itaeaho K.,Mackenzie P.I.,Ikushiro S.,Miners J.O.,Finel M.
The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.
Drug Metab. Dispos.
36
2307-2315
2008
498071
Bellemare J.,Rouleau M.,Girard H.,Harvey M.,Guillemette C.
Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.
Drug Metab. Dispos.
38
1785-1789
2010
498072
Rouleau M.,Roberge J.,Falardeau S.A.,Villeneuve L.,Guillemette C.
The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro.
Drug Metab. Dispos.
41
694-697
2013
498073
Guillemette C.,Ritter J.K.,Auyeung D.J.,Kessler F.K.,Housman D.E.
Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene.
Pharmacogenetics
10
629-644
2000
498074
Menard V.,Girard H.,Harvey M.,Perusse L.,Guillemette C.
Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.
Hum. Mutat.
30
677-687
2009
