Information on EC 2.4.1.17 - glucuronosyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

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2.4.1.17

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glucuronosyltransferase

GO:0015020

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UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

6 entries

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hexosyl group transfer

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Ascorbate and aldarate metabolism

00053

Biosynthesis of secondary metabolites

01110

Drug metabolism - cytochrome P450

00982

Drug metabolism - other enzymes

00983

melatonin degradation I

PWY-6398

Metabolic pathways

01100

Metabolism of xenobiotics by cytochrome P450

00980

nicotine degradation IV

PWY66-201

nicotine degradation V

PWY66-221

Pentose and glucuronate interconversions

00040

Porphyrin and chlorophyll metabolism

00860

Retinol metabolism

00830

saponin biosynthesis II

PWY-5756

serotonin degradation

PWY-6313

Steroid hormone biosynthesis

00140

thyroid hormone metabolism II (via conjugation and/or degradation)

PWY-6261

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UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)

This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

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Show Synonyms (318 entries)

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37205-52-0

37277-52-4

37277-66-0

61969-98-0

62213-43-8

62213-47-2

9030-08-4

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Bos taurus

488800

Canis lupus familiaris

6 entries

Cavia porcellus

domestic guinea pig

488729, 488741, 488744, 488747, 488748, 488750

rhesus monkey

overview

UGT1A6; C57BL/6 crossed with DBA/2, gene UGT1A6

UniProt

rainbow trout

Oryctolagus cuniculus

Pleuronectes platessa

plaice

488702, 488757

Rattus norvegicus

24 entries

Rattus norvegicus Gunn

5 entries

Rattus norvegicus R/A Pfd

R/A Pfd strain

488710, 488716

Rattus norvegicus Wistar

Wistar strain

488695, 488697, 488698, 488701, 488703, 488706, 488707, 488711, 488712, 488715, 488717, 488719, 488720, 488721, 488723, 488724, 488730, 488734, 488735, 488736, 488737, 488739, 488740, 488746, 488750, 488752, 488762, 488792

Sphingomonas paucimobilis

produces gellan gum

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evolution

10 entries

malfunction

2 entries

metabolism

3 entries

physiological function

15 entries

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution

735649

Homo sapiens

O60656, P19224, P22309, P22310

UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview

735776

metabolism

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. In the intestine, L-thyroxine is conjugated by UGT1A8 and UGT1A10 suggesting first-pass metabolism of oral L-thyronine, although UGT1A1 and UGT1A3 are the major UGTs glucuronidating T4 at the hydroxyl and carboxyl groups, respectively; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. In the intestine, L-thyroxine is conjugated by UGT1A8 and UGT1A10 suggesting first-pass metabolism of oral L-thyronine, although UGT1A1 and UGT1A3 are the major UGTs glucuronidating T4 at the hydroxyl and carboxyl groups, respectively; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops, proposed feedback loop between bilirubin, AhR and AhR-controlled UGT1A1. UGT1A1 is the sole enzyme conjugating bilirubin. AhR- and Nrf2-binding domains, termed XRE (xenobiotic responsive element) and ARE (antioxidant responsive element), respectively, are identified in the regulatory region of UGT1A1 and UGT1A6; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. The family 2 member UGT2B7 is regulated by Nrf2, but not by the AhR. UGT1A9- and UGT2B7-mediated detoxification of 20-hydroxyeicosatetraenoic acid to prevent hypertension. UGT1A9 and UGT2B7 appear to be major UGT enzymes responsible for 20-hydroxyeicosatetraenoic acid and leukotriene B4 glucuronidation; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. UGT1A9- and UGT2B7-mediated detoxification of 20-hydroxyeicosatetraenoic acid to prevent hypertension. UGT1A9 and UGT2B7 appear to be major UGT enzymes responsible for 20-hydroxyeicosatetraenoic acid and leukotriene B4 glucuronidation; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. UGT2B28 is involved in estradiol and testosterone glucuronidation in a variety of tissues including breast cells

735649

O60656, P16662, P22309, P22310

metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues; metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues; metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues; metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues

737080

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(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate

? + UDP

Homo sapiens

substrate for isoforms UGT1A9 and UGT1A10

703407

(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate

? + UDP

Homo sapiens

substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10

703407

(-)-borneol + UDP-glucuronate

UDP + (-)-borneol-O-alpha-D-glucuronide

Rattus norvegicus

P08541, P20720, Q62789, Q64638

676310

(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP

Homo sapiens

720303

(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP

Homo sapiens

720303

(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP

Homo sapiens

720303

(R)-propanolol + UDP-glucuronate

UDP + (R)-propanolol O-glucuronide

Homo sapiens

706097

(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP

Homo sapiens

720303

(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP

Homo sapiens

720303

(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP

Homo sapiens

720303

(S)-naproxen + UDP-alpha-D-glucuronate

beta-D-glucuronosyl (S)-naproxen + UDP

Homo sapiens

718805

(S)-naproxen + UDP-alpha-D-glucuronate

UDP + beta-D-glucuronosyl (S)-naproxen

Homo sapiens

703410

(S)-propanolol + UDP-glucuronate

UDP + (S)-propanolol O-glucuronide

Homo sapiens

706097

1-hydroxy-benzo(a)pyrene + UDP-glucuronate

1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP

Homo sapiens

720625

1-hydroxybenzo(a)pyrene + UDP-glucuronate

2 entries

1-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-1-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

1-hydroxypyrene + UDP-glucuronate

1-hydroxypyrene 1-O-glucuronate + UDP

Homo sapiens

720625

1-hydroxypyrene + UDP-glucuronate

Homo sapiens

P35504

675594

1-hydroxy[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide

Homo sapiens

675319

1-naphthol + UDP-alpha-D-glucuronate

1-naphthyl O-glucuronide + UDP

Rattus norvegicus

721077

1-naphthol + UDP-alpha-D-glucuronate

1-naphthyl-O-glucuronide + UDP

Homo sapiens

720115

1-naphthol + UDP-glucuronate

1-naphthyl 1-O-glucuronate + UDP

Homo sapiens

720625

1-naphthol + UDP-glucuronate

1-naphthyl-O-glucuronide + UDP

Homo sapiens

O75795, P16662, P22309, P35503, P54855

673300

1-naphthol + UDP-glucuronate

Homo sapiens

P22310, P35503, Q9HAW7

671661

1-naphthol + UDP-glucuronate

naphth-1-yl-beta-D-glucuronide + UDP

36 entries

1-naphthol + UDP-glucuronate

UDP + naphth-1-yl-beta-D-glucuronide

2 entries

10-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-10-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

11-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-11-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

11alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 11alpha-hydroxyprogesterone-11-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

12-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-12-yl-beta-D-glucuronide

2 entries

12-hydroxyeicosatetraenoic acid + UDP-glucuronate

Homo sapiens

O75310, P06133, P36537

673353

13-hydroxyoctadecadienoic acid + UDP-glucuronate

Homo sapiens

O75310, P06133, P36537

673353

16alpha-hydroxyprogesterone + UDP-glucuronate

2 entries

16alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 16alpha-hydroxyprgesterone-16-O-alpha-D-glucuronate

Homo sapiens

P54855

UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation

673304

16alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 16alpha-hydroxyprogesteron-16-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

17-epiestriol + UDP-glucuronate

Homo sapiens

673582

17-epiestriol + UDP-glucuronate

UDP + ?

Homo sapiens

702049

17alpha-estradiol + UDP-alpha-D-glucuronate

? + UDP

Homo sapiens

720334

17alpha-ethynylestradiol + UDP-glucuronate

UDP + 17alpha-ethynylestradiol 3-O-beta-D-glucuronide

Macaca mulatta

488797

17beta-estradiol + UDP-alpha-D-glucuronate

? + UDP

Homo sapiens

720334

17beta-estradiol + UDP-glucuronate

2 entries

17beta-ethynylestradiol + UDPglucuronate

Rattus norvegicus

P70624, Q64634

673292

17beta-hydroxy-5alpha-androstan-3-one + UDPglucuronate

UDP + 17beta-hydroxy-5alpha-androstan-3-one 17O-glucuronide

Rattus norvegicus

488718

2 UDP-D-glucuronate + 2 dexmedetomidine

2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside

3 entries

2 UDP-D-glucuronate + 2 levomedetomidine

2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside

3 entries

2',4,4'-trihydroxychalcone + UDP-glucuronate

UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside

Homo sapiens

i.e. isoliquiritigenin

703403

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate

3 entries

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate

Homo sapiens

glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans

673310

2-aminobenzoate + UDPglucuronate

UDP + ?

Cavia porcellus

488748

2-aminobiphenyl + UDP-glucuronate

Homo sapiens

P22310, P35503, Q9HAW7

671661

2-aminophenol + UDPglucuronate

UDP + (2-aminophenyl)-O-glucuronide

9 entries

2-hydroxy-2',3',4',5'-tetrachlorobiphenyl + UDPglucuronate

UDP + 2',3',4',5'-tetrachlorobiphenyl 2-O-glucuronate

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

2-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-2-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

2-hydroxyestradiol + UDP-glucuronate

Homo sapiens

677147

2-hydroxyestradiol + UDPglucuronate

UDP + 2-hydroxyestradiol O-glucuronide

2 entries

2-hydroxyestrone + UDP-glucuronate

Homo sapiens

677147

2-hydroxyestrone + UDPglucuronate

2-hydroxyestrone 2-O-glucuronide + UDP

5 entries

2-methoxy-4-(2-propenyl)phenol + UDPglucuronate

UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide

2 entries

21-hydroxyprogesterone + UDP-glucuronate

UDP + 21-hydroxyprogesterone-21-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate

3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP

Homo sapiens

substrate of isoform UGT2B7

720509

3'-azido-3'-deoxythymidine + UDPglucuronate

3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP

4 entries

3,5-dinitrocatechol + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

3-azido-4-chlorobenzoic acid + UDP-glucuronate

Homo sapiens

Q9HAW8, Q9HAW9

672123

3-azidobenzoic acid + UDP-glucuronate

Homo sapiens

Q9HAW8, Q9HAW9

672123

3-hydroxy-benzo(a)pyrene + UDP-glucuronate

3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP

Homo sapiens

720625

3-hydroxybenzo(a)pyrene + UDP-glucuronate

2 entries

3-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-3-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

3-hydroxybenzo[a]pyrene + UDPglucuronate

UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide

4 entries

3-hydroxydesloratadine + UDP-glucuronate

UDP + 3-hydroxydesloratadinyl-O-glucuronide

2 entries

4-aminobiphenyl + UDP-glucuronate

UDP + 4-aminobiphenyl N-glucuronide

Homo sapiens

706582

4-aminobiphenyl + UDPglucuronate

UDP + ?

Homo sapiens

catalyzed by isozyme 1 but not by isozyme 2

488761

4-azido-2-hydroxybenzoic acid + UDPglucuronate

Homo sapiens

Q9HAW8, Q9HAW9

672123

4-azidobenzoic acid + UDP-glucuronate

Homo sapiens

Q9HAW8, Q9HAW9

672123

4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl + UDPglucuronate

UDP + 2,3,3',4',5'-pentachlorobiphenyl 4-O-glucuronate

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

4-hydroxy-2',3,3',4',5,5'-heptachlorobiphenyl + UDPglucuronate

UDP + 2',3,3',4',5,5'-hexachlorobiphenyl 4-O-glucuronate

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl + UDPglucuronate

UDP + 2',3,4',5,6'-pentachlorobiphenyl 4-O-glucuronate

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

4-hydroxy-2',3,4',6'-tetrachlorobiphenyl + UDP-glucuronate

UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

4-hydroxy-2',4',6'-trichlorobiphenyl + UDP-glucuronate

UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

4-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-4-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

4-hydroxybiphenyl + UDP-glucuronate

UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide

12 entries

4-hydroxybiphenyl + UDPglucuronate

UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide

2 entries

4-hydroxyestradiol + UDP-glucuronate

Homo sapiens

677147

4-hydroxyestradiol + UDPglucuronate

UDP + 4-hydroxyestradiol O-glucuronide

2 entries

4-hydroxyestrone + UDP-glucuronate

Homo sapiens

673582, 677147

4-hydroxyestrone + UDP-glucuronate

UDP + 4-hydroxyestrone 4-O-glucuronide

4 entries

4-hydroxyestrone + UDP-glucuronate

UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide

Homo sapiens

659571

4-methylumbeliferone + UDP-alpha-D-glucuronate

4-methylumbelliferyl-7-O-alpha-D-glucuronide

Homo sapiens

718805

4-methylumbeliferone + UDP-glucuronate

4-methylumbelliferyl-7-O-alpha-D-glucuronide

2 entries

4-methylumbeliferone + UDP-glucuronate

4-methylumbelliferyl-7-O-beta-D-glucuronide

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

4-methylumbelliferone + UDP-glucuronate

UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide

23 entries

4-n-octylgallate + UDPglucuronate

UDP + 4-n-octylgallate 3-O-glucuronide

Oryctolagus cuniculus

highly specific for UGT1A71

488782

4-nitrophenol + UDP-glucuronate

4-nitrophenyl beta-D-glucuronide + UDP

66 entries

4-nitrothiophenol + UDP-glucuronate

4-nitrothiophenyl thio-beta-D-glucuronide + UDP

5 entries

5-diethylaminoethylamino-8-hydroxyimidazoacridinone + UDP-alpha-D-glucuronate

5-{[2-(diethylamino)ethyl]amino}-6-oxo-6H-imidazo[4,5,1-de]acridin-8-yl beta-D-glucuronide + UDP

Homo sapiens

i.e. antitumor agent C-1311, NSC-645809

719349

5-dimethylaminopropylamino-8-hydroxytriazoloacridinone + UDP-alpha-D-glucuronate

5-dimethylaminopropylamino-8-hydroxytriazoloacridinone-8-D-glucuronide + UDP

Homo sapiens

i.e. antitumor agent C-1305

719349

5-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-5-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

5-hydroxybenzo[a]pyrene + UDPglucuronate

UDP + 5-hydroxybenzo[a]pyrene O-glucuronide

Homo sapiens

glucuronidated by UGT1A3

488781

5-methylchrysene-1,2-diol + UDP-glucuronate

? + UDP

Homo sapiens

720625

5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate

Homo sapiens

O75310, P06133, P36537

673353

5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate

UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide

3 entries

5beta-androstane-3alpha,17beta-diol + UDP-glucuronate

UDP + 5beta-androstane-3alpha,17beta-diol O-glucuronide

Macaca fascicularis

488786

6-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-6-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

6-hydroxywarfarin + UDP-glucuronate

? + UDP

Homo sapiens

703404

6alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

7,7,7-triphenylheptanoic acid + UDPglucuronate

UDP + 7,7,7-triphenylheptanoic acid glucuronide

4 entries

7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate

UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate

2 entries

7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate

UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate

2 entries

7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate

7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP

2 entries

7-hydroxy benzo(a)pyrene + UDP-glucuronate

2 entries

7-hydroxy-4-(trifluoromethyl)-coumarin + UDPglucuronate

UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide

Macaca mulatta

488797

7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate

7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP

2 entries

7-hydroxy-benzo(a)pyrene + UDP-glucuronate

7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP

Homo sapiens

720625

7-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-7-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

7-hydroxycoumarin + UDP-glucuronate

UDP + coumarin-7-yl-alpha-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

7-hydroxywarfarin + UDP-glucuronate

? + UDP

Homo sapiens

703404

8-hydroxy-benzo(a)pyrene + UDP-glucuronate

8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP

Homo sapiens

720625

8-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-8-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

8-hydroxyquinoline + UDPglucuronate

UDP + 8-hydroxyquinoline 8-O-glucuronide

Rattus norvegicus

488745

8-hydroxywarfarin + UDP-glucuronate

? + UDP

Homo sapiens

703404

9-hydroxybenzo(a)pyrene + UDP-glucuronate

2 entries

9-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-9-yl-beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

acetaminophen + UDP-glucuronate

4 entries

alpha-naphthylamine + UDPglucuronate

UDP + ?

2 entries

alprazolam + UDP-alpha-D-glucuronate

alprazolam D-glucuronate + UDP

Homo sapiens

719348

amitriptyline + UDP-glucuronate

Homo sapiens

673312

androstane-3alpha,17beta diol + UDPglucuronate

UDP + androstane-3alpha,17beta diol O-glucuronide

Macaca fascicularis

488786

androsterone + UDP-glucuronate

Rattus norvegicus

P08541, P20720, Q62789, Q64638

676310

androsterone + UDPglucuronate

UDP + androsterone O-glucuronide

10 entries

anthraflavic acid + UDPglucuronate

UDP + ?

3 entries

apigenin + UDPglucuronate

UDP + apigenin O-glucuronide

2 entries

benzo(a)pyrene-7,8-diol + UDP-glucuronate

? + UDP

Homo sapiens

720625

benzo[a]pyrene 3,6-diphenol + UDP-glucuronate

Rattus norvegicus

converted readily to mono- and diglucuronides

675803

benzo[a]pyrene 3,6-quinone + UDPglucuronate

benzo[a]pyrene 3,6-quinol glucuronide + UDP

Rattus norvegicus

488733

no information to which positions 3-, 6-, or both the glucuronate is attached

488733

benzo[a]pyrene-3,6-quinol + UDPglucuronate

benzo[a]pyrene 3,6-quinol mono- and diglucuronide + UDP

Rattus norvegicus

488758

benzo[a]pyrene-7,8(+)-diol + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

benzo[a]pyrene-7,8(-)diol + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

beta-estradiol + UDP-alpha-D-glucuronate

beta-estradiol-3-glucuronide + UDP

Homo sapiens

720115

beta-estradiol + UDPglucuronate

beta-estradiol-3-glucuronide + UDP

3 entries

bifonazole + UDP-alpha-D-glucuronate

bifonazole D-glucuronate + UDP

Homo sapiens

719348

bilirubin + UDP-glucuronate

Homo sapiens

P22310, P35503, Q9HAW7

671661

bilirubin + UDP-glucuronate

bilirubin D-glucuronate + UDP

Homo sapiens

719760

bilirubin + UDP-glucuronate

bilirubin glucuronoside + UDP

Homo sapiens

UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein)

673306

bilirubin + UDPglucuronate

bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP

58 entries

bilirubin + UDPglucuronate

UDP + bilirubin O-glucuronide

5 entries

bilirubin monoglucuronide + UDPglucuronate

bilirubin diglucuronide + UDP

5 entries

bisphenol A + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

borneol + UDPglucuronate

UDP + borneol O-glucuronide

3 entries

buprenorphine + UDPglucuronate

UDP + buprenorphine O-glucuronide

4 entries

cannabinol + UDP-glucuronate

? + UDP

Homo sapiens

substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10

703407

carvacrol + UDP-glucuronate

caervcrol O-glucuronate + UDP

Homo sapiens

isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes

721114

chenodeoxycholic acid + UDP-glucuronate

UDP + ?

4 entries

chenodeoxycholic acid + UDPgalacturonate

UDP + chenodeoxycholic acid O-galacturonide

Rattus norvegicus

488727

chloramphenicol + UDPglucuronate

UDP + chloramphenicol O-glucuronide

3 entries

cholic acid + UDPglucuronate

cholic acid O-glucuronide

Homo sapiens

488772

chrysin + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

clofibrate + UDPglucuronate

UDP + ?

2 entries

codeine + UDPglucuronate

codeine-6-glucuronide + UDP

Homo sapiens

glucuronidated by HGT2B7H and HGT2B7Y

488794

deferiprone + UDP-glucuronate

deferiprone 3-O-glucuronide + UDP

Homo sapiens

703415

deoxycholic acid + UDPglucuronate

UDP + deoxycholic acid O-glucuronide

Homo sapiens

488763

dibenzo(a,l)pyrene-11,12-diol + UDP-glucuronate

? + UDP

Homo sapiens

720625

diclofenac + UDP-alpha-D-glucuronate

diclofenac D-glucuronide + UDP

Homo sapiens

720115

diclofenac + UDPalpha-D-glucuronate

UDP + ?

2 entries

digitoxigenin + UDPglucuronate

UDP + digitoxigenin O-glucuronide

Rattus norvegicus

488780

dihydromorphine + UDPglucuronate

UDP + dihydromorphine O-glucuronide

Macaca fascicularis

488783

dihydromorphone + UDPglucuronate

UDP + dihydromorphone O-glucuronide

Macaca fascicularis

488783

dihydrotestosterone + UDP-alpha-D-glucuronate

dihydrotestosterone D-glucuronate + UDP

Homo sapiens

719346

dihydrotestosterone + UDPglucuronate

UDP + dihydrotestosterone O-glucuronide

Macaca fascicularis

488783

econazole + UDP-alpha-D-glucuronate

econazole D-glucuronate + UDP

Homo sapiens

719348

edaravone + UDP-alpha-D-glucuronate

edaravone beta-D-glucuronate + UDP

Homo sapiens

i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7

719352

epicatechin + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

epitestosterone + UDP-glucuronate

UDP + epitestosterone 17-O-glucuronide

2 entries

epitestosterone + UDP-glucuronate

UDP + epitestosterone O-glucuronide

Homo sapiens

glucuronidated by HGT2B7H and HGT2B7Y

488794

estradiol + UDP-alpha-D-glucuronate

estradiol 3-O-glucuronate + UDP

Macaca fascicularis

Q9TSL7

sigmoidal kinetics with n of 1.7

720355

estradiol + UDP-alpha-D-glucuronate

UDP + estradiol 3-O-glucuronide

Homo sapiens

substrate of isoform UGT1A1

720509

estradiol + UDP-glucuronate

2 entries

estradiol + UDP-glucuronate

estradiol 3-O-glucuronate + UDP

Homo sapiens

P22309

sigmoidal kinetics with n of 1.7

720355

estradiol + UDPglucuronate

UDP + estradiol O-glucuronide

Platyrrhini

488795

estradiol-17alpha + UDPglucuronate

UDP + 17-alpha-estradiol O-glucuronide

Sus scrofa

488755

estradiol-17beta + UDPglucuronate

estradiol-17beta-3-monoglucuronide + UDP

4 entries

estriol + UDP-glucuronate

3 entries

estriol + UDPglucuronate

UDP + estriol-16 alpha-glucuronide

7 entries

estrogen + UDP-glucuronate

2 entries

estrone + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

estrone + UDPglucuronate

UDP + estrone 3-O-glucuronide

14 entries

ethinylestradiol + UDPglucuronate

UDP + ethinylestradiol-3-glucuronide

Macaca mulatta

488797

etiocholanone + UDPglucuronate

UDP + etiocholanone O-glucuronide

2 entries

etoposide + UDP-glucuronate

Homo sapiens

673312

etoposide + UDP-glucuronate

UDP + etoposide glucuronide

4 entries

eugenol + UDP-glucuronate

Homo sapiens

676792

eugenol + UDP-glucuronate

UDP + eugenol-O-alpha-D-glucuronide

Homo sapiens

676792

fluconazole + UDP-alpha-D-glucuronate

fluconazole D-glucuronate + UDP

Homo sapiens

719348

flurbiprofen + UDP-glucuronate

Homo sapiens

metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7

676792

frusemide + UDP-alpha-D-glucuronate

frusemide D-glucuronide

Homo sapiens

718805

glycolithocholic acid + UDPglucuronate

UDP + glycolithocholic acid O-glucuronide

Homo sapiens

lowest activity among five bile acids studied

488763

hyodeoxycholic acid + UDP-glucuronate

2 entries

hyodeoxycholic acid + UDPglucuronate

UDP + hyodeoxycholic acid O-glucuronide

2 entries

ibuprofen + UDPglucuronate

UDP + ?

2 entries

imipramine + UDPglucuronate

UDP + ?

2 entries

itraconazole + UDP-alpha-D-glucuronate

Homo sapiens

719348

ketoconazole + UDP-alpha-D-glucuronate

Homo sapiens

719348

lamotrigine + UDP-alpha-D-glucuronate

lamotrigine D-glucuronate + UDP

Homo sapiens

719346

lamotrigine + UDP-glucuronate

UDP + ?

Homo sapiens

703410

lithocholic acid + UDPglucuronate

UDP + ?

3 entries

lorazepam + UDP-glucuronate

Homo sapiens

673312

miconazole + UDP-alpha-D-glucuronate

miconazole D-glucuronate + UDP

Homo sapiens

719348

midazolam + UDP-alpha-D-glucuronate

midazolam D-glucuronide + UDP

Homo sapiens

720115

milnacipran + UDP-glucuronate

Homo sapiens

673312

morphine + UDP-glucuronate

Rattus norvegicus

P08541, P20720, Q62789, Q64638

676310

morphine + UDP-glucuronate

UDP + morphine 3,6-diglucuronide

24 entries

morphine + UDP-glucuronate

UDP + morphine 3-glucuronide + morphine 6-glucuronide

Homo sapiens

673312

mycophenolate + UDP-glucuronate

Homo sapiens

673312

mycophenolic acid + UDP-alpha-D-glucuronate

mycophenolic acid D-glucuronide

Homo sapiens

718805

N-hydroxy-2-acetylaminofluorene + UDPglucuronate

UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide

Homo sapiens

glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives

488781

N-hydroxy-2-naphthylamine + UDPglucuronate

UDP + N-hydroxy-2-naphthylamine-O-glucuronide

4 entries

nalorphine + UDPglucuronate

UDP + nalorphine O-glucuronate

Macaca fascicularis

488783

naloxone + UDPglucuronate

UDP + naloxone O-glucuronide

Macaca fascicularis

488783

naltrexone + UDPglucuronate

UDP + naltrexone O-glucuronide

Macaca fascicularis

488783

octylgallate + UDPglucuronate

Homo sapiens

P22310, P35503, Q9HAW7

671661

olanzapine + UDP-glucuronate

Homo sapiens

673312

opiates + UDPglucuronate

opiates 6-O-glucuronides + UDP

Homo sapiens

substrate for UGT2B7

488793

oxazepam + UDP-glucuronate

Homo sapiens

673312

oxymorphone + UDPglucuronate

UDP + oxymorphone O-glucuronide

Macaca fascicularis

488783

p,p'-biphenyl + UDPglucuronate

UDP + ?

Macaca fascicularis

488786

p-ethoxyphenylurea + UDP-glucuronate

Homo sapiens

P22310, P35503, Q9HAW7

671661

phenolphthalein + UDPglucuronate

UDP + phenolphthalein O-glucuronide

5 entries

planar phenols + UDPglucuronate

UDP + phenylglucuronides

Rattus norvegicus

expressed before birth

488777

profen + UDPglucuronate

UDP + ?

2 entries

propofol + UDP-alpha-D-glucuronate

propofol D-glucuronide

Homo sapiens

718805

propofol + UDP-alpha-D-glucuronate

UDP + estradiol O-glucuronide

Homo sapiens

substrate of isoform UGT1A9

720509

propofol + UDP-glucuronate

UDP + propofyl beta-D-glucuronide

Rattus norvegicus

P70624, Q64634

673292

quercetin + UDPglucuronate

UDP + quercetin O-glucuronide

2 entries

retigabine + UDP-alpha-D-glucuronate

retigabine D-glucuronide

Homo sapiens

718805

retigabine + UDP-glucuronate

UDP + retigabine N-glucuronide

Homo sapiens

706582

scopoletin + UDP-glucuronate

Homo sapiens

P22310, P35503, Q9HAW7

671661

scopoletin + UDP-glucuronate

UDP + scopoletin O-glucoside

Homo sapiens

P35504

very low rate of glucuronidation

675594

scopoletin + UDP-glucuronate

UDP + scopoletin O-glucuronide

Homo sapiens

706582, 675319

scopoletin + UDPglucuronate

UDP + scopoletin O-glucuronide

5 entries

senecionine + UDP-alpha-D-glucuronate

senecionine N-glucuronide + UDP

Homo sapiens

senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics

719347

serotonin + UDP-glucuronate

Rattus norvegicus

P70624, Q64634

673292

serotonin + UDP-glucuronate

UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide

5 entries

serotonin + UDPglucuronate

tryptamine 5-O-beta-D-glucuronide + UDP

5 entries

sulconazole + UDP-alpha-D-glucuronate

sulconazole D-glucuronate + UDP

Homo sapiens

719348

sulfinpyrazone + UDP-alpha-D-glucuronate

sulfinpyrazone D-glucuronide

Homo sapiens

718805

tamoxifen + UDP-alpha-D-glucuronate

tamoxifen-N-glucuronate + UDP

Homo sapiens

719346

tamoxifen + UDP-glucuronate

UDP + ?

Homo sapiens

703017

testosterone + UDP-glucuronate

2 entries

testosterone + UDP-glucuronate

UDP + testosterone 17-O-glucuronide

Homo sapiens

isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics

703416

testosterone + UDP-glucuronate

UDP + testosterone-17-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

testosterone + UDP-glucuronate

UDP + testosterone-17alpha-glucuronide

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

673287

testosterone + UDPglucuronate

UDP + testosterone O-glucuronide

31 entries

thiophenol + UDPglucuronate

thiophenyl thio-beta-D-glucuronide + UDP

3 entries

tioconazole + UDP-alpha-D-glucuronate

tioconazole D-glucuronate + UDP

Homo sapiens

719348

tranilast + UDP-glucuronate

tranilast glucuronoside + UDP

Homo sapiens

673306

trans-4-hydroxytamoxifen + UDP-glucuronate

UDP + ?

Homo sapiens

703017

trans-androsterone + UDP-alpha-D-glucuronate

trans-androsterone D-glucuronate + UDP

Homo sapiens

719346

trans-endoxifen + UDP-glucuronate

UDP + ?

Homo sapiens

703017

trifluoperazine + UDP-glucuronate

UDP + ?

Homo sapiens

substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P

703410

troglitazone + UDPglucuronate

UDP + troglitazone 6-O-glucuronide

5 entries

UDP-alpha-D-glucuronate + (S)-naproxen

UDP + beta-D-glucuronosyl (S)-naproxen

2 entries

UDP-alpha-D-glucuronate + 3-hydroxyflavone

UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone

Homo sapiens

P22309

isozyme UGT1A1

691934

UDP-alpha-D-glucuronate + diclofenac

UDP + diclofenac O-beta-D-glucuronide

Homo sapiens

O75795

658529

UDP-alpha-D-glucuronate + dopamine

UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid

Homo sapiens

substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested

703419

UDP-alpha-D-glucuronate + dopamine

UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid

Homo sapiens

703419

substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested

UDP-alpha-glucuronate + diclofenac

UDP + beta-D-glucuronosyl-diclofenac

Homo sapiens

657879

UDP-D-glucuronate + 1-naphthol

UDP + 1-naphthyl beta-D-glucuronoside

3 entries

UDP-D-glucuronate + 11alpha-hydroxyprogesterone

UDP + 11alpha-hydroxyprogesterone 11-O-beta-D-glucuronoside

Homo sapiens

P54855

an UGT2B7 substrate

690847

UDP-D-glucuronate + 17beta-estradiol

UDP + 17beta-estradiol 3-O-beta-D-glucuronoside

Homo sapiens

P36537

695149

UDP-D-glucuronate + 17beta-estradiol

UDP + 17beta-estradiol-3-O-beta-D-glucuronoside

Homo sapiens

694249

UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3

UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside

Homo sapiens

P22310

among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview

690850

UDP-D-glucuronate + 2-hydroxyestradiol

UDP + 2-hydroxyestradiol beta-D-glucuronoside

Homo sapiens

P19224, P22310

isozyme UGT1A1

693017

UDP-D-glucuronate + 2-hydroxyestrone

UDP + 2-hydroxyestrone beta-D-glucuronoside

Homo sapiens

P19224, P22310

isozyme UGT1A1

693017

UDP-D-glucuronate + 2-naphthol

UDP + 2-naphthyl beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 3'-azido-3'-deoxythymidine

UDP + 3'-azido-3'-deoxythymidine 5'-O-beta-D-glucuronoside

Homo sapiens

P16662

model substrate for determination of glucuronidation with respect to specificity, linearity, detection limit, recovery, stability, precision and accuracy, method development and validation for assay and chromatographic determination of reaction products, overview

693343

UDP-D-glucuronate + 3-hydroxydesloratadine

UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside

Homo sapiens

specific substrate of isozyme UGT1A8

692047

UDP-D-glucuronate + 4'-hydroxy-warfarin

UDP + 4'-hydroxy-warfarin beta-D-glucuronoside

Homo sapiens

Q9HAW9

substrate of isozyme UGT1A10

693817

UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone

UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside

Homo sapiens

694249

UDP-D-glucuronate + 4-hydroxy-estrone

UDP + ?

Homo sapiens

P36537

695149

UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen

UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferone beta-D-glucuronoside

3 entries

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferonyl beta-D-glucuronoside

Homo sapiens

694261

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl beta-D-glucuronoside

6 entries

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl beta-O-glucuronoside

Homo sapiens

692047

UDP-D-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl beta-O-D-glucuronoside

Homo sapiens

692047

UDP-D-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl O-beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol

UDP + ?

Homo sapiens

693111

UDP-D-glucuronate + 6-hydroxy-warfarin

UDP + 6-hydroxy-warfarin beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 7-hydroxy-warfarin

UDP + 7-hydroxy-warfarin beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 8-hydroxy-warfarin

UDP + 8-hydroxy-warfarin beta-D-glucuronoside

3 entries

UDP-D-glucuronate + acacetin

UDP + acacetin 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + acceptor

UDP + acceptor beta-D-glucuronoside

38 entries

UDP-D-glucuronate + androstane-3alpha,17beta-diol

UDP + ?

9 entries

UDP-D-glucuronate + androsterone

UDP + androsterone 3-O-beta-D-glucuronoside

8 entries

UDP-D-glucuronate + anthraflavic acid

UDP + ?

Homo sapiens

693111

UDP-D-glucuronate + apigenin

UDP + apigenin 7-O-beta-D-glucuronoside

Homo sapiens

692786, 693111

UDP-D-glucuronate + beta-D-estradiol

UDP + beta-estradiol 3-O-beta-D-glucuronoside

Homo sapiens

P19224, P22310

isozyme UGT1A1

693017

UDP-D-glucuronate + beta-estradiol

UDP + beta-estradiol 3-O-beta-D-glucuronoside

Homo sapiens

692044

UDP-D-glucuronate + bilirubin

UDP + ?

Homo sapiens

693111

UDP-D-glucuronate + bilirubin

UDP + bilirubin beta-D-glucuronoside

Homo sapiens

P22309

isozyme UGT1A1

691934

UDP-D-glucuronate + bisdemethoxy-curcumin

UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide

Homo sapiens

694249

UDP-D-glucuronate + candesartan

UDP + candesartan beta-D-glucuronoside

Homo sapiens

isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, also isozyme UGT2B7 glucuronidates candesartan at the tetrazole-N2 position, whereas isozymes UGT1A7, UGT1A8, UGT1A9, and UGT1A10 mainly yield candesartan O-glucuronide

690857

UDP-D-glucuronate + capsaicin

UDP + capsaicin beta-D-glucuronoside

Homo sapiens

693111

UDP-D-glucuronate + chenodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

Homo sapiens

Q6UWM9

isozyme UGT2A3

694264

UDP-D-glucuronate + cis-4-hydroxytamoxifen

UDP + 4-hydroxytamoxifen beta-D-glucuronoside

2 entries

UDP-D-glucuronate + cotinine

UDP + ?

3 entries

UDP-D-glucuronate + curcumin

UDP + curcumin beta-D-glucuronoside

Homo sapiens

low activity, can reverse the inhibtory effect of curcumin on UGTs

693111

UDP-D-glucuronate + curcumin

UDP + curcumin phenolic beta-D-monoglucuronide

2 entries

UDP-D-glucuronate + dehydrotestosterone

UDP + dehydrotestosterone 17-O-beta-D-glucuronoside

6 entries

UDP-D-glucuronate + demethoxy-curcumin

UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide

Homo sapiens

694249

UDP-D-glucuronate + deoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

Homo sapiens

Q6UWM9

isozyme UGT2A3

694264

UDP-D-glucuronate + dihydrotestosterone

UDP + dihydrotestosterone 17-O-beta-D-glucuronoside

2 entries

UDP-D-glucuronate + eriodictyol

UDP + eriodictyol 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + estradiol

UDP + estradiol 3-O-beta-D-glucuronoside

4 entries

UDP-D-glucuronate + estradiol

UDP + estradiol-3-beta-D-glucuronoside

3 entries

UDP-D-glucuronate + estriol

UDP + ?

Homo sapiens

691811

UDP-D-glucuronate + estriol

UDP + estriol 3-O-beta-D-glucuronoside

Homo sapiens

693111

UDP-D-glucuronate + estriol

UDP + estriol glucuronoside

Homo sapiens

691812

UDP-D-glucuronate + eugenol

UDP + eugenol beta-D-glucuronoside

2 entries

UDP-D-glucuronate + flurbiprofen

UDP + flurbiprofen beta-D-glucuronoside

Homo sapiens

isozyme UGT2B7

692034

UDP-D-glucuronate + frusemide

UDP + frusemide beta-D-glucuronoside

2 entries

UDP-D-glucuronate + gemfibrozil

UDP + gemfibrozil beta-D-glucuronoside

2 entries

UDP-D-glucuronate + hesperetin

UDP + hesperetin 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + homoeriodictyol

UDP + homoeriodictyol 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 24-carboxy-glucuronoside

Homo sapiens

Q6UWM9

recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation

694264

product formation depends on the isozyme, overview

UDP-D-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 3-O-glucuronoside

Homo sapiens

Q6UWM9

recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation

694264

product formation depends on the isozyme, overview

UDP-D-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

2 entries

UDP-D-glucuronate + imipramine

UDP + imipramine N-beta-D-glucuronoside

Homo sapiens

reaction of isozyme UGT1A4

692043

UDP-D-glucuronate + isolongifolol

UDP + isolongifolol beta-D-glucuronoside

Homo sapiens

the compound is substrate and competitive inhibitor

691811

UDP-D-glucuronate + kaempferol

UDP + kaempferol 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + labetalol

UDP + ?

3 entries

UDP-D-glucuronate + longifolol

UDP + longifolol beta-D-glucuronoside

Homo sapiens

the compound is substrate and competitive inhibitor

691811

UDP-D-glucuronate + losartan

UDP + losartan beta-D-glucuronoside

Homo sapiens

no O-glucuronide is generated by any isozyme, while isozymes UGT1A1, UGT1A3, 1A10, UGT2B7, and UGT2B17 glucuronidate losartan at the tetrazole-N2, isozyme UGT1A10 also yields the respective N1-glucuronide, isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring

690857

UDP-D-glucuronate + luteolin

UDP + luteolin 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + menadiol

UDP + mendadiol 1-O-beta-D-glucuronoside

Homo sapiens

702016

isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1

UDP-D-glucuronate + menadiol

UDP + mendadiol 4-O-beta-D-glucuronoside

Homo sapiens

702016

isoform UGT1A10, preferential formation of 4-menadiol glucuronoside, isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1

UDP-D-glucuronate + morphine

UDP + morphine 3-beta-D-glucuronoside

Homo sapiens

activity of isozyme UGT1A8

692045

UDP-D-glucuronate + morphine

UDP + morphine 3-O-beta-D-glucuronoside

5 entries

UDP-D-glucuronate + morphine

UDP + morphine 6-beta-D-glucuronoside

3 entries

UDP-D-glucuronate + morphine

UDP + morphine 6-O-beta-D-glucuronoside

Papio anubis

D2SML9, D2SMM0, D2SMM1, D2SMM2, D2SMM3, D2SMM4, D2SMM5, D2SMM6

703422

UDP-D-glucuronate + mycophenolate

UDP + ?

2 entries

UDP-D-glucuronate + mycophenolic acid

UDP + mycophenolic acid beta-D-glucuronoside

Homo sapiens

K314 and K404m are determined binding sites required for UDP-glcA binding to isozyme UGT1A10, overview

690975

UDP-D-glucuronate + myricetin

UDP + myricetin 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + naringenin

UDP + naringenin 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + nicotine

UDP + ?

3 entries

UDP-D-glucuronate + octylgallate

UDP + octylgallate beta-D-glucuronoside

3 entries

UDP-D-glucuronate + phenolphthalein

UDP + phenolphthalein beta-D-glucuronoside

Homo sapiens

P54855

an UGT2B15 substrate

690847

UDP-D-glucuronate + phenolphthalein

UDP + phenolphthalein beta-D-monoglucuronoside

Homo sapiens

693111

UDP-D-glucuronate + phloretin

UDP + ?

Homo sapiens

693111

UDP-D-glucuronate + propofol

UDP + propofol beta-D-glucuronoside

3 entries

UDP-D-glucuronate + protocatechuic aldehyde

UDP + ?

2 entries

UDP-D-glucuronate + quercetin

UDP + quercetin 7-O-beta-D-glucuronoside

Homo sapiens

692786

UDP-D-glucuronate + scopoletin

UDP + scopoletin beta-D-glucuronoside

3 entries

UDP-D-glucuronate + serotonin

UDP + serotonin beta-D-glucuronoside

Homo sapiens

P19224

isozyme UGT1A6

692114

UDP-D-glucuronate + serotonin

UDP + serotonin O-beta-D-glucuronoside

Homo sapiens

reaction of isozyme UGT1A6

692043

UDP-D-glucuronate + tamoxifen + H+

UDP + tamoxifen beta-D-glucuronoside

2 entries

UDP-D-glucuronate + testosterone

UDP + testosterone 17-O-beta-D-glucuronoside

Homo sapiens

P54855

an UGT2B15 substrate

690847

UDP-D-glucuronate + thyroxine

UDP + thyroxine beta-D-glucuronoside

2 entries

UDP-D-glucuronate + trans-4-hydroxytamoxifen

UDP + 4-hydroxytamoxifen beta-D-glucuronoside

3 entries

UDP-D-glucuronate + trifluoperazine

UDP + trifluoperazine beta-D-glucuronoside

Homo sapiens

692044

UDP-D-glucuronate + umbelliferone

UDP + umbelliferyl beta-D-glucuronoside

Homo sapiens

694254

UDP-D-glucuronate + ursodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

Homo sapiens

Q6UWM9

isozyme UGT2A3

694264

UDP-D-glucuronate + zidovudine

UDP + zidovudine beta-D-glucuronoside

2 entries

UDP-D-glucuronate + zolarsartan

UDP + zolarsartan beta-D-glucuronoside

Homo sapiens

isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, the tetrazole-N1 of this aglycone is accessible to other enzymes, including isozyme UGT1A5, zolarsartan O-glucuronide is mainly produced by isozyme UGT1A10 and isozyme UGT2B7

690857

UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime

UDP + 1-O-[(Z)-(2,4-dimethoxy-6[(E)-2-(4-methoxyphenyl)ethenyl]methylidene)amino]-beta-D-glucuronate

2 entries

UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid

UDP + ?

Homo sapiens

i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9

735944

UDP-glucuronate + (R)-propranolol

UDP + (R)-propranolol beta-D-glucuronoside

3 entries

UDP-glucuronate + (S)-propranolol

UDP + (S)-propranolol beta-D-glucuronoside

3 entries

UDP-glucuronate + 1,25-dihydroxyergocalciferol

UDP + 1,25-dihydroxyergocalciferol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 1-hydroxypyrene

UDP + 1-hydroxypyrene beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 1-naphthol

UDP + 1-naphthol beta-D-glucuronide

9 entries

UDP-glucuronate + 1-naphthol

UDP + beta-D-glucuronosyl-(1-naphthol)

3 entries

UDP-glucuronate + 10-gingerol

UDP + 10-gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 10-gingerol

UDP + 10-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 10-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 12-hydroxyeicosatetraenoic acid

UDP + 12-hydroxyeicosatetraenoyl beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 12-hydroxyeicosatetraenoic acid

UDP + 12-hydroxyeicosatetraenoyl-beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 15-hydroxyeicosatetraenoic acid

UDP + 15-hydroxyeicosatetraenoyl beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 15-hydroxyeicosatetraenoic acid

UDP + 15-hydroxyeicosatetraenoyl-beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 17-alpha-estradiol

UDP + 17-alpha-estradiol beta-D-glucuronoside

8 entries

UDP-glucuronate + 17-beta-estradiol

UDP + 17-beta-estradiol 3-beta-D-glucuronoside

6 entries

UDP-glucuronate + 17-beta-estradiol

UDP + 17-beta-estradiol beta-D-glucuronoside

5 entries

UDP-glucuronate + 17beta-estradiol

UDP + 17beta-estradiol 3-O-glucuronide

Homo sapiens

Q9HAW8

658519

UDP-glucuronate + 17beta-estradiol

UDP + estradiol 17-beta-D-glucuronide

Homo sapiens

O60656, P16662, P22309, P35503, P54855

657537

UDP-glucuronate + 2',4'-hydroxychalcone

UDP + 2'-hydroxychalcone 4'-O-beta-D-glucuronoside

Homo sapiens

glucuronidation at the OH-4' position by UGT1A1 and UGT1A10 isoforms, both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide

736672

UDP-glucuronate + 2',4'-hydroxychalcone

UDP + 4'-hydroxychalcone 2'-O-beta-D-glucuronoside

Homo sapiens

glucuronidation at the OH-2' position with low activity by UGT1A7, UGT1A6, and UGT1A10 isoforms, and with high activity by isozyme UGT1A9. Both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide

736672

UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone

3 entries

UDP-glucuronate + 2'-hydroxychalcone

UDP + chalcone 2'-O-beta-D-glucuronoside

Homo sapiens

glucuronidation at the OH-2' position by UGT1A9 isoform

736672

UDP-glucuronate + 2-hydroxyestrone

UDP + 2-hydroxyestrone beta-D-glucuronide

Homo sapiens

659571

UDP-glucuronate + 2-methoxyestrone

UDP + 2-methoxyestrone beta-D-glucuronide

Homo sapiens

659571

UDP-glucuronate + 20-hydroxyeicosatetraenoic acid

UDP + 20-hydroxyeicosatetraenoyl beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 25-hydroxyergocalciferol

UDP + 25-hydroxyergocalciferol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 3'-azido-3'-deoxythymidine

UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide

Homo sapiens

isozymes UGT2B4, UGT2B7, and UGT2B17

658516

UDP-glucuronate + 3'-azido-3'-deoxythymidine

UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside

6 entries

UDP-glucuronate + 3,17-estradiol

UDP + 17-estradiol 3-O-glucuronide

Homo sapiens

isozyme UGT1A1

658522

UDP-glucuronate + 3,17-estradiol

UDP + 3-estradiol 17-O-glucuronide

Homo sapiens

isozyme UGT1A1

658522

UDP-glucuronate + 3,2'-dihydroxychalcone

UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside

Homo sapiens

very low activity with isozyme UGT1A6

736672

UDP-glucuronate + 3,2'-hydroxychalcone

UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside

Homo sapiens

glucuronidation at the OH-2' position by UGT1A8 isoform

736672

UDP-glucuronate + 3-epideacetycinobufagin

UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside

2 entries

UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone

UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide

Homo sapiens

P16662

high activity

658558

UDP-glucuronate + 4,2'-hydroxychalcone

UDP + 4-hydroxychalcone 2'-O-beta-D-glucuronoside

Homo sapiens

glucuronidation at the OH-2' position by UGT1A8, UGT1A1, and UGT1A3 isoforms. The A-ring OH-4 group promotes glucuronidation at the 2' position for the reaction of the exclusive substrate 4,2'-dihydroxychalcone of UGT1A1 and 1A3

736672

UDP-glucuronate + 4-aminobiphenyl

Homo sapiens

674230

UDP-glucuronate + 4-ethylphenol

UDP + beta-D-glucuronosyl-(4-ethylphenol)

2 entries

UDP-glucuronate + 4-hydroxy-estrone

UDP + ?

Homo sapiens

P36537

glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy

695149

UDP-glucuronate + 4-hydroxyestradiol

UDP + 4-hydroxyestradiol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 4-hydroxyretinoic acid

UDP + 4-hydroxyretinoic acid beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

mainly conjugated by UGT2B7

735649

UDP-glucuronate + 4-methoxyestrone

UDP + 4-methoxyestrone beta-D-glucuronide

Homo sapiens

659571

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferone beta-D-glucuronide

11 entries

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl beta-D-glucuronoside

5 entries

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl-beta-D-glucuronide

Homo sapiens

all isozymes, nonselective substrate

658515

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl-beta-D-glucuronoside

Homo sapiens

736961

UDP-glucuronate + 4-methylumbelliferone

UDP + beta-D-glucuronosyl-(4-methylumbelliferone)

3 entries

UDP-glucuronate + 4-nitrophenol

UDP + 4-nitrophenol beta-D-glucuronide

Homo sapiens

659971

UDP-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl beta-D-glucuronide

2 entries

UDP-glucuronate + 4-nitrophenol

UDP + beta-D-glucuronosyl-(4-nitrophenol)

2 entries

UDP-glucuronate + 5-hydroxytryptophol

UDP + 5-hydroxy-tryptophol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + 5-hydroxytryptophol

UDP + 5-hydroxytryptophol beta-D-glucuronide

Homo sapiens

P19224

isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity

658527

UDP-glucuronate + 5-hydroxytryptophol

UDP + 5-hydroxytryptophol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

mucosal serotonin and its metabolite 5-hydroxytryptophol are solely conjugated by UGT1A6

735649

UDP-glucuronate + 5alpha-dihydroaldosterone

UDP + 5alpha-dihydroaldosterone beta-D-glucuronide

Homo sapiens

P16662

658558

UDP-glucuronate + 5alpha-tetrahydrocortisone

UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide

Homo sapiens

P16662

658558

UDP-glucuronate + 5beta-tetrahydrocortisone

UDP + 5beta-tetrahydrocortisone beta-D-glucuronide

Homo sapiens

P16662

658558

UDP-glucuronate + 6-gingerol

UDP + 6-gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 6-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 6-hydroxymelatonin

UDP + 6-hydroxymelatonin beta-D-glucuronide

Homo sapiens

P19224

658527

UDP-glucuronate + 7-ethyl-10-hydroxy-camptothecin

UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

i.e. SN-38, an active metabolite of irinotecan

735649

UDP-glucuronate + 7-ethyl-10-hydroxycampothecin

UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide

Homo sapiens

O60656

i.e. SN-38, isozymes UGT1A1, UGT1A7, and UGT1A9

659783

UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin

UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside

Homo sapiens

O60656, P16662, P22309, P22310

i.e. SN-38, an active metabolite of irinotecan

737080

UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin

UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide

Homo sapiens

O75795

658529

UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin

UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide

Homo sapiens

Q9HAW8

658519

UDP-glucuronate + 7-hydroxyflavanone

UDP + flavanone 7-O-beta-D-glucuronoside

Homo sapiens

736672

UDP-glucuronate + 8-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 8-gingerol

UDP + 8-gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 8-gingerol

UDP + 8-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 8-hydroxyquinoline

UDP + 8-hydroxyquinoline beta-D-glucuronide

Homo sapiens

O60656, P16662, P22309, P35503, P54855

657537

UDP-glucuronate + acceptor

UDP + acceptor beta-D-glucuronoside

2 entries

UDP-glucuronate + acceptor

UDP + acceptor beta-glucuronoside

3 entries

UDP-glucuronate + aldosterone

UDP + aldosterone beta-D-glucuronide

Homo sapiens

P16662

658558

UDP-glucuronate + all-trans-retinoic acid

UDP + all-trans-retinoic acid beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

mainly conjugated by UGT2B7

735649

UDP-glucuronate + Aloe-emodin

UDP + Aloe-emodin beta-D-glucuronide

Homo sapiens

O60656, P22309, Q9HAW7, Q9HAW9

isozyme UGT1A7

659315

UDP-glucuronate + alpinetin

UDP + alpinetin beta-D-glucuronoside

Homo sapiens

736672

UDP-glucuronate + amitriptyline

UDP + amitriptyline beta-D-glucuronoside

Homo sapiens

736005

UDP-glucuronate + amitryptiline

UDP + amitryptiline beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + androstane-3,17-diol

UDP + androstane-3,17-diol 17-O-beta-D-glucuronide

Homo sapiens

isozyme UGT2B15

658522

UDP-glucuronate + androstane-3,17-diol

UDP + beta-D-glucuronosyl-androstane-3,17-diol

2 entries

UDP-glucuronate + androstanediol

UDP + androstanediol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + anthraflavic acid

UDP + anthraflavic acid 2-glucuronide

Homo sapiens

isozyme UGT1A1

658522

UDP-glucuronate + anthraflavic acid

UDP + anthraflavic acid 2-O-beta-D-glucuronide

3 entries

UDP-glucuronate + apigenin

UDP + apigenin beta-D-glucuronide

3 entries

UDP-glucuronate + asialo-orosomucoid

UDP + asialo-orosomucoid beta-D-glucuronide

Homo sapiens

acceptor is a glycoprotein, preferred substrate

660431

UDP-glucuronate + beta-estradiol

UDP + estradiol 3-beta-D-glucuronide

Homo sapiens

658531

UDP-glucuronate + bilirubin

Homo sapiens

671843

UDP-glucuronate + bilirubin

UDP + bilirubin beta-D-glucuronoside

4 entries

UDP-glucuronate + biochanin A

UDP + biochanin A beta-D-glucuronide

3 entries

UDP-glucuronate + buprenorphine

UDP + buprenorphine glucuronide

2 entries

UDP-glucuronate + capsaicin

UDP + capsaicin beta-D-glucuronide

3 entries

UDP-glucuronate + cardamonin

UDP + cardamonin beta-D-glucuronoside

Homo sapiens

UGT1A9 is the only isoform to glucuronidate cardamonin at the OH-2' position, lower activity with isozyme UGT1A7

736672

UDP-glucuronate + carvedilol

UDP + carvedilol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + chenodeoxycholic acid

UDP + chenodeoxycholic acid 24-beta-D-glucuronoside

3 entries

UDP-glucuronate + chloramphenicol

UDP + ?

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + cholic acid

UDP + cholic acid 24-beta-D-glucuronoside

2 entries

UDP-glucuronate + chrysin

UDP + chrysin beta-D-glucuronide

5 entries

UDP-glucuronate + citronellol

UDP + citronellol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + clozapine

UDP + clozapine beta-D-glucuronide

Homo sapiens

658530

UDP-glucuronate + codeine

UDP + beta-D-glucuronosyl-codeine

Homo sapiens

low activity

657879

UDP-glucuronate + codeine

UDP + codeine beta-D-glucuronide

Homo sapiens

isozymes UGT2B4 and UGT2B7

658516

UDP-glucuronate + cotinine

UDP + cotinine N-beta-D-glucuronoside

Homo sapiens

P36537

cotinine is a highly selective substrate of human liver microsomal UGT2B10

736012

UDP-glucuronate + curcumin

UDP + curcumin beta-D-glucuronide

4 entries

UDP-glucuronate + cyproheptadine

UDP + cyproheptadine beta-D-glucuronide

Homo sapiens

658530

UDP-glucuronate + deferiprone

UDP + deferiprone beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + denopamine

UDP + denopamine beta-D-glucuronide

5 entries

UDP-glucuronate + deoxycholic acid

UDP + deoxycholic acid 24-beta-D-glucuronoside

Homo sapiens

Q6UWM9, Q9Y4X1

736006

UDP-glucuronate + desmethylnaproxen

6 entries

UDP-glucuronate + dexmedetomidine

UDP + dexmedetomidine beta-D-glucuronoside

2 entries

UDP-glucuronate + diclofenac

UDP + diclofenac beta-D-glucuronoside

7 entries

UDP-glucuronate + dihydrotestosterone

UDP + dihydrotestosterone beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + diphenhydramine

UDP + diphenhydramine beta-D-glucuronoside

2 entries

UDP-glucuronate + dopamine

UDP + dopamine beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + entacapone

UDP + entacapone beta-D-glucuronide

2 entries

UDP-glucuronate + entacapone

UDP + entacapone beta-D-glucuronoside

6 entries

UDP-glucuronate + epirubicin

UDP + epirubicin beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + epitestosterone

UDP + epitestosterone beta-D-glucuronoside

2 entries

UDP-glucuronate + estradiol

UDP + estradiol beta-D-glucuronide

Homo sapiens

659571

UDP-glucuronate + estradiol

UDP + estradiol beta-D-glucuronoside

2 entries

UDP-glucuronate + estriol

UDP + estriol beta-D-glucuronoside

Homo sapiens

P16662

735648

UDP-glucuronate + estrone

UDP + estrone beta-D-glucuronide

Homo sapiens

659571

UDP-glucuronate + estrone

UDP + estrone beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + ethanol

UDP + ethyl beta-D-glucuronoside

3 entries

UDP-glucuronate + ethinylestradiol

UDP + ethinylestradiol beta-D-glucuronoside

6 entries

UDP-glucuronate + ethinylestradiol

UDP + ethinylestradiol glucuronide

Homo sapiens

isozyme UGT1A1

658522

UDP-glucuronate + etoposide

UDP + etoposide beta-D-glucuronide

Homo sapiens

P22309

isozyme UGT1A1 is specific for etoposide

658521

UDP-glucuronate + etoposide

UDP + etoposide beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + eugenol

UDP + beta-D-glucuronosyl-eugenol

2 entries

UDP-glucuronate + eugenol

UDP + eugenol beta-D-glucuronide

2 entries

UDP-glucuronate + fenofibrate

UDP + fenofibrate beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + flavopiridol

UDP + flavopiridol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + flufenamic acid

Homo sapiens

P16662

671924

UDP-glucuronate + gemfibrozil

UDP + beta-D-glucuronosyl-gemfibrozil

2 entries

UDP-glucuronate + genistein

UDP + genistein beta-D-glucuronide

3 entries

UDP-glucuronate + genistein

UDP + genistein beta-D-glucuronoside

Homo sapiens

O60656, P16662, P22309, P22310

737080

UDP-glucuronate + gingerol

UDP + gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + grepafloxacin

UDP + grepafloxacin beta-D-glucuronide

4 entries

UDP-glucuronate + hydromorphone

UDP + beta-D-glucuronosyl-hydromorphone

Homo sapiens

657879

UDP-glucuronate + hyocholic acid

UDP + hyocholic acid 24-beta-D-glucuronoside

Homo sapiens

Q6UWM9, Q9Y4X1

736006

UDP-glucuronate + hyodeoxycholic acid

UDP + beta-D-glucuronosyl-hyodeoxycholic acid

Homo sapiens

high activity

657879

UDP-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 24G-beta-D-glucuronoside

Homo sapiens

Q6UWM9, Q9Y4X1

736006

UDP-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholoyl beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + ibuprofen

UDP + beta-D-glucuronosyl-ibuprofen

Homo sapiens

657879

UDP-glucuronate + imipramine

UDP + imipramine beta-D-glucuronide

Homo sapiens

658530

UDP-glucuronate + imipramine

UDP + imipramine beta-D-glucuronoside

2 entries

UDP-glucuronate + imipramine

UDP + imipramine N-beta-D-glucuronoside

2 entries

UDP-glucuronate + indomethacin

UDP + indomethacin beta-D-glucuronoside

6 entries

UDP-glucuronate + ketoconazole

UDP + ketoconazole beta-D-glucuronoside

Homo sapiens

736005

UDP-glucuronate + ketoprofen

UDP + beta-D-glucuronosyl-ketoprofen

2 entries

UDP-glucuronate + ketotifen

UDP + ketotifen beta-D-glucuronoside

Homo sapiens

736005

UDP-glucuronate + ketotifen

UDP + ketotifenbeta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + L-thyroxine

UDP + L-thyroxyl beta-D-glucuronoside

2 entries

UDP-glucuronate + lamotrigine

UDP + lamotrigine beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + leukotriene B4

UDP + leukotriene B4 beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + levofloxacin

UDP + levofloxacin beta-D-glucuronide

4 entries

UDP-glucuronate + levomedetomidine

UDP + levomedetomidine beta-D-glucuronoside

2 entries

UDP-glucuronate + lithocholic acid

UDP + lithocholic acid 3-beta-D-glucuronoside + lithocholic acid 24G-beta-D-glucuronoside

Homo sapiens

Q6UWM9, Q9Y4X1

736006

UDP-glucuronate + lorazepam

UDP + beta-D-glucuronosyl-lorazepam

Canis lupus familiaris

Q6K1J1

657879

UDP-glucuronate + lorazepam

UDP + lorazepam beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + mefenamic acid

Homo sapiens

P16662

671924

UDP-glucuronate + midazolam

UDP + midazolam beta-D-glucuronoside

Homo sapiens

736005

UDP-glucuronate + morphine

UDP + morphine 3-beta-D-glucuronoside

7 entries

UDP-glucuronate + morphine

UDP + morphine 3-glucuronide

5 entries

UDP-glucuronate + morphine

UDP + morphine 6-glucuronide

3 entries

UDP-glucuronate + morphine

UDP + morphine beta-D-glucuronoside

2 entries

UDP-glucuronate + morphine

UDP + morphine-3-beta-D-glucuronide

Homo sapiens

736681

UDP-glucuronate + morphine

UDP + morphine-6-beta-D-glucuronide

Homo sapiens

736681

UDP-glucuronate + morphine 3-glucuronide

UDP + ?

Homo sapiens

P19224

658527

UDP-glucuronate + morphine 3-glucuronide

UDP + morphine 3,6-diglucuronide

2 entries

UDP-glucuronate + moxifloxacin

UDP + moxifloxacin beta-D-glucuronide

4 entries

UDP-glucuronate + mycophenolic acid

UDP + mycophenolic acid beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + mycophenolic acid

UDP + mycophenolic acid-acyl-glucuronide

2 entries

UDP-glucuronate + mycophenolic acid

UDP + mycophenolic acid-phenyl-glucuronide

2 entries

UDP-glucuronate + mycophenolic acid

UDP + mycophenoloyl beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + N-acetylserotonin

UDP + N-acetylserotonin beta-D-glucuronide

Homo sapiens

P19224

658527

UDP-glucuronate + naphthol

UDP + naphthol glucuronide

Homo sapiens

isozyme UGT1A6

658522

UDP-glucuronate + naproxen

2 entries

UDP-glucuronate + naproxen

UDP + naproxen beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + naringenin

UDP + naringenin beta-D-glucuronide

3 entries

UDP-glucuronate + nicotine

UDP + nicotine beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + niflumic acid

Homo sapiens

P16662

671924

UDP-glucuronate + olanzapine

UDP + olanzapine beta-D-glucuronoside

2 entries

UDP-glucuronate + p-nitrophenol

UDP + 4-nitrophenyl-alpha-D-glucuronide

Rattus norvegicus

675741

UDP-glucuronate + paracetamol

UDP + paracetamol beta-D-glucuronide

Homo sapiens

O60656, P16662, P22309, P35503, P54855

657537

UDP-glucuronate + paracetamol

UDP + paracetamol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + paragloboside

UDP + paragloboside beta-D-glucuronide

Homo sapiens

acceptor is a glycolipid, activity requires phosphatidylinositol

660431

UDP-glucuronate + phenylbutazone

Homo sapiens

O60656

among 16 UDP-glucuronosyltransferase isoforms investigated, only UGT1A9 catalyzes PB C-glucuronidation

671611

UDP-glucuronate + phloretin

UDP + phloretin beta-D-glucuronide

3 entries

UDP-glucuronate + pizotifen

UDP + pizotifen beta-D-glucuronoside

Homo sapiens

736005

UDP-glucuronate + pregnan-3,17-diol

UDP + pregnan-3,17-diol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + propofol

UDP + propofol alpha-D-glucuronide

Homo sapiens

isozyme UGT1A9

658522

UDP-glucuronate + propofol

UDP + propofol beta-D-glucuronide

Homo sapiens

658531

UDP-glucuronate + propofol

UDP + propofol beta-D-glucuronoside

9 entries

UDP-glucuronate + quercetin

UDP + quercetin beta-D-glucuronide

3 entries

UDP-glucuronate + quercetin

UDP + quercetin beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + quinazarin

UDP + quinazarin beta-D-glucuronide

3 entries

UDP-glucuronate + quinizarin

UDP + quinizarin beta-D-glucuronide

Homo sapiens

O60656, P22309, Q9HAW7, Q9HAW9

isozyme UGT1A7

659315

UDP-glucuronate + R-propranolol

UDP + R-propranolol beta-D-glucuronoside

Canis lupus familiaris

F1PJF0, P56592, Q29476, Q95M37, Q9N280

736010

UDP-glucuronate + S-oxazepam

UDP + S-oxazepam beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + S-propranolol

UDP + S-propranolol beta-D-glucuronoside

2 entries

UDP-glucuronate + scopoletin

UDP + scopoletin beta-D-glucuronide

Homo sapiens

659971

UDP-glucuronate + serotonin

2 entries

UDP-glucuronate + serotonin

UDP + serotonin beta-D-glucuronide

2 entries

UDP-glucuronate + serotonin

UDP + serotonin beta-D-glucuronoside

7 entries

UDP-glucuronate + serotonin

UDP + serotonin beta-glucuronoside

Homo sapiens

P19224

isozyme UGT2B7

691935

UDP-glucuronate + sitafloxacin

UDP + sitafloxacin beta-D-glucuronide

4 entries

UDP-glucuronate + sorafenib

UDP + sorafenib beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + tacrolimus

UDP + tacrolimus beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + tamoxifen

UDP + tamoxifen beta-D-glucuronoside

2 entries

UDP-glucuronate + tamoxifen

UDP + tamoxifen N-beta-D-glucuronoside

Homo sapiens

O60656, P16662, P22309, P22310

737080

UDP-glucuronate + Telmisartan

UDP + Telmisartan beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + testosterone

UDP + testosterone beta-D-glucuronoside

3 entries

UDP-glucuronate + thymol

UDP + thymol beta-D-glucuronide

2 entries

UDP-glucuronate + thymol

UDP + thymol beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + tigogenin

UDP + tigogenin beta-D-glucuronide

Homo sapiens

658530

UDP-glucuronate + tolcapone

UDP + tolcapone beta-D-glucuronide

Homo sapiens

O60656, P16662, P22309, P35503, P54855

657537

UDP-glucuronate + trans-androsterone

UDP + trans-androsterone beta-D-glucuronide

Homo sapiens

658530

UDP-glucuronate + trans-resveratrol

UDP + trans-resveratrol beta-D-glucuronoside

Homo sapiens

735944

UDP-glucuronate + trifluoperazine

UDP + trifluoperazine beta-D-glucuronide

Homo sapiens

O75795

isozyme UGT1A4

658529

UDP-glucuronate + trifluoroperazine

UDP + trifluoroperazine beta-D-glucuronide

Homo sapiens

658531

UDP-glucuronate + trifluperazine

UDP + trifluperazine

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + umbelliferone

UDP + umbelliferone beta-D-glucuronide

2 entries

UDP-glucuronate + valproic acid

UDP + beta-D-glucuronosyl-valproic acid

Homo sapiens

657879

UDP-glucuronate + vorinostat

UDP + vorinostat beta-D-glucuronoside

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

UDP-glucuronate + zidovudine

UDP + zidovudine beta-D-glucuronoside

3 entries

UDP-glucuronate + zidovudine

UDP + zidovudine O-beta-D-glucuronoside

Homo sapiens

P16662

735648

UDP-glucuronic acid + 7-hydroxy-4-(trifluoromethyl)-coumarin

UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide

Homo sapiens

UGT1A6, UGT1A9, and UGT2B7

673288

UDP-glucuronic acid + beta-estradiol

UDP + beta-estradiol 3-O-beta-D-glucuronide

Homo sapiens

UGT1A3

673288

UDP-glucuronic acid + bilirubin

bilirubin glucuronoside + UDP

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

676313

UDP-glucuronic acid + bilirubin

UDP + bilirubin-glucuronoside

2 entries

UDP-glucuronic acid + diclofenac

UDP + diclofenac O-glucuronide

Homo sapiens

692032

UDP-glucuronic acid + imipramine

UDP + imipramine N-glucuronide

Homo sapiens

692032

UDP-glucuronic acid + serotonin

UDP + serotonin O-glucuronide

Homo sapiens

692032

UDP-glucuronic acid + trifluoperazine

UDP + ?

Homo sapiens

UGT1A4

673288

UDP-glucuronic acid + trifluoperazine

UDP + trifluoperazine N-glucuronide

Homo sapiens

692032

UDPglucuronate + bilirubin

Rattus norvegicus

675741

UDPglucuronate + naproxen

Homo sapiens

UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug

672823

ursodeoxycholic acid + UDPglucuronate

UDP + ursodeoxycholic acid O-glucuronide

2 entries

valproic acid + UDPglucuronate

UDP + ?

3 entries

vanillin + UDP-glucuronate

UDP + vanillin O-glucuronide

Homo sapiens

other 7 phenolic compounds show substrate activity on hUGT2A1

488788

voriconazole + UDP-alpha-D-glucuronate

voriconazole D-glucuronate + UDP

Homo sapiens

719348

additional information

249 entries

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11alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 11alpha-hydroxyprogesterone-11-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

16alpha-hydroxyprogesterone + UDP-glucuronate

Homo sapiens

P54855

UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation

673304

16alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 16alpha-hydroxyprgesterone-16-O-alpha-D-glucuronate

Homo sapiens

P54855

UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation

673304

16alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 16alpha-hydroxyprogesteron-16-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

2 UDP-D-glucuronate + 2 dexmedetomidine

2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside

Homo sapiens

P36537

the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides

692037

2 UDP-D-glucuronate + 2 levomedetomidine

2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside

Homo sapiens

P36537

the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide

692037

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate

2 entries

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate

Homo sapiens

glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans

673310

21-hydroxyprogesterone + UDP-glucuronate

UDP + 21-hydroxyprogesterone-21-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

6alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate

Homo sapiens

P54855

673304

bilirubin + UDPglucuronate

UDP + bilirubin O-glucuronide

5 entries

estrogen + UDP-glucuronate

Homo sapiens

UDP-glucuronosyltransferase 1A10 has been identified as the major isoform involved in the biotransformation of a wide range of phenolic substrates, including native estrogens and their oxidized metabolites

677147

etoposide + UDP-glucuronate

UDP + etoposide glucuronide

Homo sapiens

UGT1A1 is principally responsible for the formation of etoposide glucuronides, mainly in the form of phenolic glucuronide

673305

testosterone + UDP-glucuronate

Homo sapiens

P54855

UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation

673304

UDP-alpha-D-glucuronate + (S)-naproxen

UDP + beta-D-glucuronosyl (S)-naproxen

Homo sapiens

693814

UDP-alpha-D-glucuronate + 3-hydroxyflavone

UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone

Homo sapiens

P22309

isozyme UGT1A1

691934

UDP-D-glucuronate + 17beta-estradiol

UDP + 17beta-estradiol 3-O-beta-D-glucuronoside

Homo sapiens

P36537

695149

UDP-D-glucuronate + 3-hydroxydesloratadine

UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside

Homo sapiens

specific substrate of isozyme UGT1A8

692047

UDP-D-glucuronate + 4'-hydroxy-warfarin

UDP + 4'-hydroxy-warfarin beta-D-glucuronoside

Homo sapiens

Q9HAW9

substrate of isozyme UGT1A10

693817

UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen

UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside

Homo sapiens

O75795, P22309, Q9HAW9

the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview

692033

UDP-D-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl O-beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 6-hydroxy-warfarin

UDP + 6-hydroxy-warfarin beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 7-hydroxy-warfarin

UDP + 7-hydroxy-warfarin beta-D-glucuronoside

2 entries

UDP-D-glucuronate + 8-hydroxy-warfarin

UDP + 8-hydroxy-warfarin beta-D-glucuronoside

3 entries

UDP-D-glucuronate + acceptor

UDP + acceptor beta-D-glucuronoside

29 entries

UDP-D-glucuronate + androstane-3alpha,17beta-diol

UDP + ?

4 entries

UDP-D-glucuronate + androsterone

UDP + androsterone 3-O-beta-D-glucuronoside

4 entries

UDP-D-glucuronate + bilirubin

UDP + bilirubin beta-D-glucuronoside

Homo sapiens

P22309

isozyme UGT1A1

691934

UDP-D-glucuronate + bisdemethoxy-curcumin

UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide

Homo sapiens

694249

UDP-D-glucuronate + chenodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

Homo sapiens

Q6UWM9

isozyme UGT2A3

694264

UDP-D-glucuronate + cis-4-hydroxytamoxifen

UDP + 4-hydroxytamoxifen beta-D-glucuronoside

Homo sapiens

O75795, P22309, Q9HAW9

692033

UDP-D-glucuronate + cotinine

UDP + ?

Homo sapiens

P36537

isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes

694256

UDP-D-glucuronate + curcumin

UDP + curcumin phenolic beta-D-monoglucuronide

Homo sapiens

glucuronidation is an important pathway in the metabolism of curcumin

694249

UDP-D-glucuronate + dehydrotestosterone

UDP + dehydrotestosterone 17-O-beta-D-glucuronoside

3 entries

UDP-D-glucuronate + demethoxy-curcumin

UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide

Homo sapiens

694249

UDP-D-glucuronate + deoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

Homo sapiens

Q6UWM9

isozyme UGT2A3

694264

UDP-D-glucuronate + dihydrotestosterone

UDP + dihydrotestosterone 17-O-beta-D-glucuronoside

Homo sapiens

in epithelial cells of the human prostate

693011

UDP-D-glucuronate + estradiol

UDP + estradiol 3-O-beta-D-glucuronoside

3 entries

UDP-D-glucuronate + estradiol

UDP + estradiol-3-beta-D-glucuronoside

Homo sapiens

liver microsomes

690683

UDP-D-glucuronate + flurbiprofen

UDP + flurbiprofen beta-D-glucuronoside

Homo sapiens

isozyme UGT2B7

692034

UDP-D-glucuronate + frusemide

UDP + frusemide beta-D-glucuronoside

Homo sapiens

690855

UDP-D-glucuronate + gemfibrozil

UDP + gemfibrozil beta-D-glucuronoside

Homo sapiens

gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver

692034

UDP-D-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

Homo sapiens

Q6UWM9

isozyme UGT2A3

694264

UDP-D-glucuronate + labetalol

UDP + ?

3 entries

UDP-D-glucuronate + morphine

UDP + morphine 3-O-beta-D-glucuronoside

4 entries

UDP-D-glucuronate + morphine

UDP + morphine 6-beta-D-glucuronoside

Homo sapiens

the metabolic conversion of morphine to morphine-6-glucuronide plays a significant role in mediation of the clinical effect of morphine because of the superior analgesic effect of morphine-6-glucuronide

692045

UDP-D-glucuronate + mycophenolate

UDP + ?

2 entries

UDP-D-glucuronate + nicotine

UDP + ?

Homo sapiens

P36537

isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes

694256

UDP-D-glucuronate + propofol

UDP + propofol beta-D-glucuronoside

Homo sapiens

isozymes UGT1A1 and UGT1A9

692034

UDP-D-glucuronate + protocatechuic aldehyde

UDP + ?

Homo sapiens

692038

UDP-D-glucuronate + serotonin

UDP + serotonin beta-D-glucuronoside

Homo sapiens

P19224

isozyme UGT1A6

692114

UDP-D-glucuronate + tamoxifen + H+

UDP + tamoxifen beta-D-glucuronoside

Homo sapiens

O75795, P22309, Q9HAW9

692033

UDP-D-glucuronate + thyroxine

UDP + thyroxine beta-D-glucuronoside

Homo sapiens

glucuronidation of the thyroid hormone thyroxine, T4, in the human liver, the T4 glucuronidation activities of recombinant human UGT isoforms and microsomes

692044

UDP-D-glucuronate + trans-4-hydroxytamoxifen

UDP + 4-hydroxytamoxifen beta-D-glucuronoside

Homo sapiens

O75795, P22309, Q9HAW9

692033

UDP-D-glucuronate + ursodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

Homo sapiens

Q6UWM9

isozyme UGT2A3

694264

UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime

UDP + 1-O-[(Z)-(2,4-dimethoxy-6[(E)-2-(4-methoxyphenyl)ethenyl]methylidene)amino]-beta-D-glucuronate

Homo sapiens

i.e. NI-ST-05, low activity, NI-ST-05 forms a distinct N-O-glucuronide. NI-ST-05 is primarily metabolized by an extrahepatic enzyme, UGT1A10

735944

UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid

UDP + ?

Homo sapiens

i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9

735944

UDP-glucuronate + 10-gingerol

UDP + 10-gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 10-gingerol

UDP + 10-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 10-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 3-epideacetycinobufagin

UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside

Homo sapiens

3-epideacetycinobufagin is a highly isoform-specific probe substrate for 3-glucuronidation mediated by UDP-glucuronosyltransferase 2B7 determined in recombinant UGT supersomes, overview

737232

UDP-glucuronate + 4-hydroxy-estrone

UDP + ?

Homo sapiens

P36537

glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy

695149

UDP-glucuronate + 6-gingerol

UDP + 6-gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 6-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin

UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside

Homo sapiens

O60656, P16662, P22309, P22310

i.e. SN-38, an active metabolite of irinotecan

737080

UDP-glucuronate + 8-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 8-gingerol

UDP + 8-gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + 8-gingerol

UDP + 8-gingerol 5-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + acceptor

UDP + acceptor beta-D-glucuronoside

Homo sapiens

O75795, P16662, P22309, P35503, P54855

UGT1A10 is an important detoxifier of polycyclic aromatic hydrocarbons

673300

UDP-glucuronate + acceptor

UDP + acceptor beta-glucuronoside

2 entries

UDP-glucuronate + estriol

UDP + estriol beta-D-glucuronoside

Homo sapiens

P16662

735648

UDP-glucuronate + ethanol

UDP + ethyl beta-D-glucuronoside

Homo sapiens

O60656, P16662, P19224, P22309, P22310, P35503, P36537, P54855

735425

UDP-glucuronate + genistein

UDP + genistein beta-D-glucuronoside

Homo sapiens

O60656, P16662, P22309, P22310

737080

UDP-glucuronate + gingerol

UDP + gingerol 4'-O-beta-D-glucuronoside

Homo sapiens

736680

UDP-glucuronate + morphine

UDP + morphine 3-glucuronide

Homo sapiens

regioselectivity of activity is altered by cytochrome P450 enzyme CYP3A4 so that the ratio of morphine activation/detoxification is increased

659973

UDP-glucuronate + morphine

UDP + morphine beta-D-glucuronoside

Homo sapiens

P16662

735648

UDP-glucuronate + morphine

UDP + morphine-3-beta-D-glucuronide

Homo sapiens

736681

UDP-glucuronate + morphine

UDP + morphine-6-beta-D-glucuronide

Homo sapiens

736681

UDP-glucuronate + mycophenolic acid

UDP + mycophenolic acid-acyl-glucuronide

Homo sapiens

mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil

658528

UDP-glucuronate + mycophenolic acid

UDP + mycophenolic acid-phenyl-glucuronide

Homo sapiens

mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil

658528

UDP-glucuronate + propofol

UDP + propofol beta-D-glucuronoside

2 entries

UDP-glucuronate + serotonin

UDP + serotonin beta-glucuronoside

Homo sapiens

P19224

isozyme UGT2B7

691935

UDP-glucuronate + tamoxifen

UDP + tamoxifen N-beta-D-glucuronoside

Homo sapiens

O60656, P16662, P22309, P22310

737080

UDP-glucuronate + trans-resveratrol

UDP + trans-resveratrol beta-D-glucuronoside

Homo sapiens

735944

UDP-glucuronate + zidovudine

UDP + zidovudine beta-D-glucuronoside

2 entries

UDP-glucuronic acid + bilirubin

UDP + bilirubin-glucuronoside

2 entries

UDPglucuronate + naproxen

Homo sapiens

UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug

672823

additional information

70 entries

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Ca2+

Co2+

Cu2+

Hg2+

activation of bilirubin UDP-glucuronyltransferase

Mg2+

Mn2+

Zn2+

additional information

3 entries

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((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid

Homo sapiens

691811

((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid

Homo sapiens

691811

((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid

Homo sapiens

691811

((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid

Homo sapiens

691811

(+)-longifolol

Homo sapiens

a tricyclic sesquiterpenol

(-)-nicotine

(1R)-1-cyclopropyl-2-methylpropan-1-ol

Homo sapiens

IC50: 0.0004 mM

675319

(1R)-1-cyclopropylbut-3-en-1-ol

Homo sapiens

IC50: 0.0004 mM; IC50: 0.0009 mM

675319

(1R)-1-cyclopropylbut-3-ene-1,3-diol

Homo sapiens

IC50: 0.0004 mM

675319

(1R)-1-cyclopropylethanol

Homo sapiens

IC50: 0.0005 mM

675319

(1R)-1-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0003 mM

675319

(1R)-1-cyclopropylpropan-1-ol

Homo sapiens

IC50: 0.0002 mM

675319

(1R)-1-cyclopropylpropane-1,3-diol

Homo sapiens

IC50: 0.0002 mM

675319

(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol

Homo sapiens

691811

(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol

Homo sapiens

691811

(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol

Homo sapiens

691811

(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1R)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol

Homo sapiens

691811

(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol

Homo sapiens

691811

(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethan

Homo sapiens

691811

(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol

Homo sapiens

691811

(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1R)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol

Homo sapiens

691811

(1R)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1R)-2-chloro-1-cyclopropylethanol

Homo sapiens

IC50: 0.0002 mM

675319

(1R)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol

Homo sapiens

691811

(1R)-2-methyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1R)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1S)-1-cyclopropyl-2,2-dimethylpropan-1-ol

Homo sapiens

IC50: 0.0002 mM

675319

(1S)-1-cyclopropyl-2-methylpropan-1-ol

Homo sapiens

IC50: 0.0004 mM

675319

(1S)-1-cyclopropylbut-3-en-1-ol

Homo sapiens

IC50: 0.0002 mM

675319

(1S)-1-cyclopropylethanol

Homo sapiens

IC50: 0.0007 mM

675319

(1S)-1-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0006 mM

675319

(1S)-1-cyclopropylpropan-1-ol

Homo sapiens

IC50: 0.0005 mM

675319

(1S)-1-cyclopropylpropane-1,3-diol

Homo sapiens

IC50: 0.0003 mM

675319

(1S)-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol

Homo sapiens

691811

(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-1-ol

Homo sapiens

691811

(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol

Homo sapiens

691811

(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]prop-2-en-1-ol

Homo sapiens

691811

(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1S)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propane-1,3-diol

Homo sapiens

691811

(1S)-2,2-dimethyl-1-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1S)-2,2-dimethyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(1S)-2-chloro-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol

Homo sapiens

691811

(1S)-2-methyl-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

(2-cyclopropylethyl)phosphonic acid

Homo sapiens

IC50: 0.012 mM

675319

(2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonic acid

Homo sapiens

691811

(2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol

Homo sapiens

691811

(2E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid

Homo sapiens

691811

(2E)-3-cyclopropylacrylic acid

Homo sapiens

IC50: 0.003 mM

675319

(2E)-3-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0008 mM

675319

(2R)-3,3-dimethyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol

Homo sapiens

691811

(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]but-3-en-2-ol

Homo sapiens

691811

(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol

Homo sapiens

691811

(2S)-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]pent-4-en-2-ol

Homo sapiens

691811

(2S)-3-methyl-2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-2-ol

Homo sapiens

691811

(2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-en-1-ol

Homo sapiens

691811

(2Z)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-2-enoic acid

Homo sapiens

691811

(2Z)-3-cyclopropylacrylic acid

Homo sapiens

IC50: 0.003 mM

675319

(2Z)-3-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0007 mM

675319

(3-(dimethylamino)-1-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid

Homo sapiens

691811

(3-cyclopropylpropyl)phosphonic acid

Homo sapiens

IC50: 0.032 mM

675319

(3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonic acid

Homo sapiens

691811

(3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid

Homo sapiens

691811

(3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid

Homo sapiens

691811

(3S)-3-cyclopropyl-3-hydroxypropanoic acid

Homo sapiens

IC50: 0.001 mM

675319

(3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid

Homo sapiens

691811

(3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoic acid

Homo sapiens

691811

(4-(dimethylamino)-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butyl)phosphonic acid

Homo sapiens

691811

(4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one

Homo sapiens

i.e. atractylenolide II, one of two important efficient herbal ingredients isolated from Atractylodes macrocepha exhibits specific inhibition towards UGT2B7, with negligible influence towards other UGT isoforms

736961

(5alpha)-17-allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one

Homo sapiens

IC50 for morphine 3-glucuronide formation: 0.412 mM (noncompetitive), IC50 for morphine 3-glucuronide formation: 0.429 mM (competitive)

673312

(8aS)-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one

Homo sapiens

i.e. atractylenolide I, one of two important efficient herbal ingredients isolated from Atractylodes macrocephala, exhibits specific competitive inhibition towards UGT2B7, with negligible influence towards other UGT isoforms

736961

(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid

Homo sapiens

691811

(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulene-9-carboxylic acid

Homo sapiens

691811

(R)-7-hydroxywarfarin

Homo sapiens

substrate (S)-7-hydroxywarfarin, noncompetitive

720303

(R)-8-hydroxywarfarin

Homo sapiens

substrate (S)-6-hydroxywarfarin, noncompetitive

720303

(R)-chloro(cyclopropyl)methanol

Homo sapiens

IC50: 0.0002 mM

675319

(R)-cyclopropyl(phenyl)methanol

Homo sapiens

IC50: 0.00007 mM

675319

(R)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol

Homo sapiens

691811

(S)-8-hydroxywarfarin

Homo sapiens

substrate (R)-8-hydroxywarfarin, noncompetitive

720303

(S)-cyclopropyl(phenyl)methanol

Homo sapiens

IC50: 0.0009 mM

675319

(S)-phenyl[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol

Homo sapiens

691811

(S)-phenyl[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol

Homo sapiens

691811

1-cyclopropyl-2,2-dimethylpropan-1-ol

Homo sapiens

IC50: 0.0008 mM

675319

1-naphthol

2 entries

1-naphthol O-glucuronide

Homo sapiens

inhibitory effects on different isozymes with different substrates, overview; inhibitory effects on different isozymes with different substrates, overview; inhibitory effects on different isozymes with different substrates, overview

692043

17alpha-ethinylestradiol

Homo sapiens

strongly inhibits the formation of etoposide alcoholic glucuronide EAG2 (IC50: 0.0 42 mM) but shows very similar and moderate inhibition on etoposide phenolic glucuronide (IC50: 0.2 mM) and etoposide alcoholic glucuronide EAG1 (IC50: 0.21 mM)

673305

17alpha-ethynylestradiol

Homo sapiens

slightly activates the 3-beta-glucuronidation of estradiol to 116% at 0.005 mM, but inhibits it at 0.1 mM by 23%, inhibits glucuronidation of 4-methylumbelliferone at all concentration of 0.1 mM

690683

17beta-estradiol

Homo sapiens

720334

2,2,2-(Triphenyl)ethyl-UDP

2,2,2-triphenyl-UDP

selective inhibitor

2,5-Dichlorophenyl-UDP

Rattus norvegicus

488706

2,6-Dimethoxyphenyl-UDP

Rattus norvegicus

488706

2-(1-Naphthyl)ethyl-UDP

Rattus norvegicus

488706

2-(1-Naphthyl)ethyl-UMP

Rattus norvegicus

488706

2-(2-Naphthyl)ethyl-UDP

Rattus norvegicus

488706

2-(2-Naphthyl)ethyl-UMP

Rattus norvegicus

488706

2-(4-Bromophenyl)ethyl-UDP

Rattus norvegicus

488706

2-(4-Bromophenyl)ethyl-UMP

Rattus norvegicus

488706

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid

Homo sapiens

673310

2-(4-Nitrophenyl)ethyl-UDP

2-Bromophenyl-UDP

2-Chlorophenyl-UDP

2-cyclopropyl-N,N-dimethylethanamine

IC50: 0.005 mM

2-cyclopropylethanol

IC50: 0.0005 mM

2-hydroxy-estradiol

38.5% inhibition at 0.1 mM, UGT1A3

673288

2-hydroxyestradiol

Homo sapiens

inhibits 4-hydroxyestradiol glucuronidation catalyzed by UGT2B7Y

488785

2-phenyl-4H-benzo[h]chromen-4-one

Homo sapiens

720115

2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol

Homo sapiens

691811

2-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-2-ol

Homo sapiens

691811

2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethanol

Homo sapiens

691811

3'-azido-3'-deoxythymidin

Homo sapiens

slight inhibition

737232

3,3,3-Triphenylpropionic acid

Rattus norvegicus

competitive to bilirubin

488711

3-cyclopropylpropan-1-ol

Homo sapiens

IC50: 0.0009 mM

675319

3-cyclopropylpropanoic acid

IC50: 0.002 mM

3-demethyltranilast

3-hydroxyflavone

three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview

691934

3-Methyl-2-nitrobenzyl-UDP

Rattus norvegicus

488706

3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propan-1-ol

Homo sapiens

691811

4,4,4-Triphenylbutanoic acid

Rattus norvegicus

competitive to bilirubin

488711

4-azido-2-hydroxybenzoic acid

Homo sapiens

inhibition of UGT1A10 catalyzed glucuronidation of 4-nitrophenol

4-Bromophenyl-UDP

4-Chlorophenyl-UDP

4-cyclopropylbutan-1-ol

Homo sapiens

IC50: 0.003 mM

675319

4-cyclopropylbutanoic acid

Homo sapiens

IC50: 0.016 mM

675319

4-demethyltranilast

Homo sapiens

bilirubin glucuronosyltransferase activity, tranilast glucuronosyltransferase activity

673306

4-hydroxyestradiol

Homo sapiens

inhibits 2-hydroxyestradiol glucuronidation catalyzed by UGT1A1

488785

4-Iodophenyl-UDP

Rattus norvegicus

488706

4-Isopropylphenyl-UDP

Rattus norvegicus

488706

4-Methylumbelliferone

2 entries

4-nitrophenol

3 entries

4-nitrophenol glucuronide

Rattus norvegicus

inhibits 4-nitrophenol glucuronidation

488768

4-tert-Butylphenyl-UDP

Rattus norvegicus

488706

4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol

Homo sapiens

691811

4-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid

Homo sapiens

691811

4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butan-1-ol

Homo sapiens

691811

4-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]butanoic acid

Homo sapiens

691811

5,5,5-Triphenylpentanoic acid

Rattus norvegicus

competitive to bilirubin

488711

5-diethylaminoethylamino-8-hydroxyimidazoacridinone

Homo sapiens

substrate inhibition with isoform UGT1A9

719349

5-dimethylaminopropylamino-8-hydroxytriazoloacridinone

Homo sapiens

substrate inhibition with isoform UGT1A9

719349

5-hydroxytryptophol

Homo sapiens

P19224

competitive inhibition of serotonin glucuronidation

658527

6,6,6-Triphenylhexanoic acid

Rattus norvegicus

competitive to bilirubin

488711

6-hydroxywarfarin

Homo sapiens

competitive

703404

7,7,7-Triphenylheptanoic acid

Rattus norvegicus

competitive to bilirubin

488711, 488777

7,7,7-triphenylheptyl-UDP

Rattus norvegicus

488701

7-hydroxy-4-trifluoromethylcoumarin

2 entries

7-hydroxywarfarin

Homo sapiens

competitive

703404

8,8,8-Triphenyloctanoic acid

Rattus norvegicus

competitive to bilirubin

488711

9,9,9-Triphenylnonanoic acid

Rattus norvegicus

non-competitive to bilirubin

488711

acetone

Homo sapiens

30% and 40% inhibition of isozyme UGT2B15 at 1%, respectively; 30% and 40% inhibition of isozyme UGT2B17 at 1%, respectively

658524

acetonitrile

Homo sapiens

50% inhibition of isozyme UGT2B15 at 1%

658524

ADP

Rattus norvegicus

markedly reduces 4-methylumbelliferone UGT activity only when detergent-treated rat liver microsomes are used as the enzyme source, inhibits UGT activity non-competitively without competing with either 4-methylumbelliferone or UDP-D-glucuronic acid

691045

amitriptyline

3 entries

AMP

Rattus norvegicus

inhibits exclusively the estradiol 17-glucuronidation activity

androsterone

aripiprazole

asialo-orosomucoid

inhibits activity with paragloboside

660431

atazanavir

Homo sapiens

a HIV protease inhibitor, linear mixed-type inhibition mechanism, UGT1A1, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7

673288

ATP

3 entries

azidothymidine

Homo sapiens

selective for isozyme UGT2B7

658528

beta-estradiol

3 entries

beta-phenyllongifolol

2 entries

bilirubin

9 entries

bilirubin diglucuronides

Rattus norvegicus

competitive inhibitors

488700

bilirubin monoglucuronides

Rattus norvegicus

competitive inhibitors

488700

bisphenol A

Homo sapiens

P19224

i.e. BPA, inhibits glucuronidation of serotonin and 4-methylumbelliferone

bupropion

calphostin-C

carbamazepine

IC50 for morphine 3-glucuronide formation: 0.431 mM (mixed type inhibition), IC50 for morphine 3-glucuronide formation: 0.456 mM (mixed type inhibition)

673312

Cd2+

Sus scrofa

complete inactivation at 10 mM

488742

chenodeoxycholic acid

Homo sapiens

inhibits glucuronidation of bilirubin

chlorpromazine

clomipramine

codeine

competitive inhibitor to morphine-UDPGT

488762, 488768

CTP

Rattus norvegicus

no inhibition of UGT by other cytosine-related nucleotides but CTP

691045

Cu2+

Sus scrofa

10 mM, complete inactivation

488742

curcumin

2 entries

cyclopropanecarboxylic acid

IC50: 0.001 mM

cyclosporine A

cyproheptadine

desipramine

desloratadine

desmethylcycloheptadine

Rattus norvegicus

488768

desmethylnortriptyline

desvenlafaxine

dextromethorphan

diazepam

IC50 for morphine 3-glucuronide formation: 0.057 mM (noncompetitive), IC50 for morphine 3-glucuronide formation: 0.053 mM (noncompetitive)

673312

diclofenac

7 entries

didesmethylimipramine

Homo sapiens

P36537

736012

diethyl ((2R)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate

Homo sapiens

691811

diethyl ((2S)-2-hydroxy-2-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]ethyl)phosphonate

Homo sapiens

691811

diethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate

Homo sapiens

691811

diethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate

Homo sapiens

691811

diethyl [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonate

Homo sapiens

IC50: 0.01 mM

675319

diethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate

Homo sapiens

IC50: 0.005 mM

675319

diethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate

Homo sapiens

IC50: 0.004 mM

675319

diethyl [(R)-cyclopropyl(hydroxy)methyl]phosphonate

Homo sapiens

IC50: 0.01 mM

675319

Diethyldicarbamate

Rattus norvegicus

irreversible inhibitor

Digitonin

Dihydrocodeine

dilauroylphosphatidylcholine

Rattus norvegicus

activity towards 4-methylumbelliferone: decreased kidney enzyme activity

488704

dimethyl ((3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate

Homo sapiens

691811

dimethyl ((3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propyl)phosphonate

Homo sapiens

691811

dimethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate

Homo sapiens

IC50: 0.003 mM

675319

dimethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate

IC50: 0.004 mM

DMSO

doxepin

duloxetine

EDTA

estradiol

estriol

linear noncompetitive inhibition towards estrone

488742

estrone

Sus scrofa

competitive to estradiol-17beta

488753, 488755

ethanol

Homo sapiens

50% inhibition of isozyme UGT2B17 at 1%

658524

ethyl (3R)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate

Homo sapiens

691811

ethyl (3R)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate

Homo sapiens

691811

ethyl (3S)-3-cyclopropyl-3-hydroxypropanoate

Homo sapiens

IC50: 0.0003 mM

675319

ethyl (3S)-3-hydroxy-3-[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate

Homo sapiens

691811

ethyl (3S)-3-hydroxy-3-[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]propanoate

Homo sapiens

691811

Eugenol

Homo sapiens

UGT2B7, 54.5% inhibition at 0.1 mM

Fe2+

fluconazole

Flufenamic acid

0.02-0.5 mM, completely inhibits glucuronidation of 4-methylumbelliferone; 0.02-0.5 mM, inhibits glucuronidation of 4-methylumbelliferone

flunitrazepam

fluoxetine

fluphenazine

fluvoxamine

genistein

0.003 mM, 25.4% inhibition. 0.03 mM, 79.5% inhibition; 0.003 mM, 38.8% inhibition. 0.03 mM, 97.6% inhibition; weak; weak

673310

gossypol

Homo sapiens

noncompetitive inhibitin of estradiol-3-glucuronidation and propofol O-glucuronidation, competitive inhibition towards 3'-azido-3'-deoxythymidine glucuronidation

720509

GTP

Rattus norvegicus

weak inhibition, no inhibition of UGT by other guanosine-related nucleotides but GTP

haloperidol

hecogenin

Hg2+

hyodeoxycholic acid

imipramine

indinavir

a HIV protease inhibitor, linear mixed-type inhibition mechanism, UGT1A1, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7

isolongifolol

itraconazole

kaempferol

the formation of ethylglucuronoside is inhibited by the flavonoids for all enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition

ketoconazole

lacto-N-biose

22% inhibition of recombinant GlcAT-P and 77.3% of recombinant GlcAT-S at 5 mM

660431

lactose

Homo sapiens

24.5% inhibition of recombinant GlcAT-S at 5 mM, no inhibition of recombinant GlcAT-P

660431

lamotrigen

Homo sapiens

low-affinity substrate of isoform UGT1A4, noncompetitively inhibits dihydrotestosterone and trans-androsterone glucuronidation

719346

lithocholic acid

Rattus norvegicus

inhibition at high concentration, other bile acids and bile acids glucuronides also inhibit

488798

long-chain unsaturated fatty acids

Homo sapiens

O60656

selective inhibition of some UGT isozymes

692035

longifolol

Homo sapiens

and derivatives of primary alcohol series or carboxylic/phosphonic acids and amines, inhibitory potency, overview

691811

lopinavir

Homo sapiens

a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7

673288

lorazepam

Homo sapiens

IC50 for morphine 3-glucuronide formation: 0.065 mM (mixed type inhibition), IC50 for morphine 3-glucuronide formation: 0.056 mM (mixed type inhibition)

loxapine

Lubrol 12A9

Mefenamic acid

menthol

Gunn rat, non-competitive inhibition of troglitazone glucuronidation

mianserin

midazolam

mirtazapine

morphine

morphine 3-glucuronide

Rattus norvegicus

inhibits morphine glucuronidation

488768

mycophenolate

Homo sapiens

IC50 for morphine 3-glucuronide formation: 0.341 mM (noncompetitive), IC50 for morphine 3-glucuronide formation: 0.389 mM (noncompetitive)

673312

N-acetyllactosamine

Homo sapiens

87.4% inhibition of recombinant GlcAT-P and 83.7% of recombinant GlcAT-S at 5 mM

660431

NAD+

Rattus norvegicus

inhibits UGT activity non-competitively without competing with either 4-methylumbelliferone or UDP-D-glucuronic acid

NADP+

Naphthol

UGT1A6, 87.0% inhibition at 0.05 mM

673288

nelfinavir

Homo sapiens

a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7

Ni2+

Nicotine

niflumic acid

norclomipramine

nordihydroguaiaretic acid

Homo sapiens

O60656, P22309, Q9HAW7, Q9HAW9

nortriptyline

oitalopram

olanzapine

oleandomycin

olozapine

omega,omega,omega-triphenylalkyl-UDP derivatives

Rattus norvegicus

e.g. 7,7,7-triphenylheptyl-UDP

Omeprazole

oratadine

oxazepam

IC50 for morphine 3-glucuronide formation: 0.109 mM (competitive), IC50 for morphine 3-glucuronide formation: 0.119 mM (mixed type inhibition)

673312

p-chloromercuribenzoate

Sus scrofa

488742

p-[di-n-Propylsulfamoyl]benzoic acid

paclitaxel

paroxetine

perphenazine

Phenelzine

Phenolphthalein

Phenylbutazone

Phospholipase A

potentiates end-product inhibition in whole microsomes: inhibition of glucuronidation of testosterone, stimulation of glucuronidation of estradiol and estrone

probenecid

propofol

protriptyline

quercetin

quetiapine

quinidine

ritonavir

a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7

673288

saquinavir

Homo sapiens

a HIV protease inhibitor, inhibition of isozymes UGT1A1, 1A3, 1A4, low inhibition of isozymes UGT1A6, 1A9, and 2B7

selegiline

sertraline

silibinin-glucuronide

Rattus norvegicus

cmpetitive; competitive

silymarin

competitive

sulfinpyrazone

a UGT1A selective inhibitor

690855

tacrolimus

Homo sapiens

IC50 for morphine 3-glucuronide formation: 0.384 mM (mixed type inhibition), IC50 for morphine 3-glucuronide formation: 0.488 mM (mixed type inhibition)

tamoxifen

testosterone

thioridazine

Tolbutamide

tranilast

bilirubin glucuronosyltransferase activity, activity in human jejunum microsomes is strongly inhibited (0.0753 mM)

673306

trans-androsterone

Homo sapiens

uncompetitive substrate inhibition

Tranylcypromine

trimipramine

Triphenylacetic acid

Triton X-100

troglitazone

inhibition of bilirubin glucuronidation by UGT1A1

488792

UDP

6 entries

UDP-glucose

Homo sapiens

competitive inhibition, predicted binding sites in isozyme UGT1A10 are sites N292, K314, K315, and K404, overview

690975

UDP-hexanol amine

Homo sapiens

competitive inhibition, predicted binding sites in isozyme UGT1A10 are sites N292, K314, K315, and K404

690975

UDP-N-acetylglucosamine

3 entries

UDPgalactose

Rattus norvegicus

inhibition or chenodeoxycholic acid and testosterone glucuronidation

UDPgalacturonic acid

UDPglucose

slight effect

UDPxylose

inhibition or chenodeoxycholic acid and testosterone glucuronidation

UMP

UTP

venlafaxine

zidovudine

Zn2+

[(1E)-3-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)prop-1-en-1-yl]phosphonic acid

Homo sapiens

691811

[(1E)-3-cyclopropylprop-1-en-1-yl]phosphonic acid

Homo sapiens

IC50: 0.041 mM

675319

[(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonic acid

Homo sapiens

IC50: 0.013 mM

675319

[(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid

Homo sapiens

IC50: 0.028 mM

675319

[(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid

Homo sapiens

IC50: 0.018 mM

675319

[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid

Homo sapiens

691811

[(9R)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol

Homo sapiens

691811

[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]acetic acid

Homo sapiens

691811

[(9S)-4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl]methanol

Homo sapiens

691811

[(E)-2-(4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)ethenyl]phosphonic acid

Homo sapiens

691811

[(E)-2-cyclopropylvinyl]phosphonic acid

Homo sapiens

IC50: 0.008 mM

675319

[(R)-cyclopropyl(hydroxy)methyl]phosphonic acid

Homo sapiens

IC50: 0.018 mM

675319

additional information

23 entries

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17alpha-ethynylestradiol

Homo sapiens

slightly activates the 3-beta-glucuronidation of estradiol to 116% at 0.005 mM, but inhibits it at 0.1 mM by 23%

3-methylcholanthrene

alamethicin

Alkyl ketones

activation

bilirubin

stimulates the glucoronidation of 4-nitrophenol and morphine

488768

bovine serum albumin

Homo sapiens

O60656

activates isozyme UGT1A9 by reducing the Km of the substrates, overview

Brij58

cholate

activation

choline

Oryctolagus cuniculus

required as phospholipid with a polar head group for maximal activity

488765

Clofibrate

3 entries

cysteine

Sus scrofa

10 mM, slight activation

488753

Diethylnitrosamine

4 entries

Digitonin

5 entries

dilauroylphosphatidylcholine

Rattus norvegicus

activity towards 4-methylumbelliferone: increased liver enzyme activity

488704

fatty acid-free human serum albumin

Homo sapiens

O60656

activates isozyme UGT1A9 by reducing the Km of the substrates, overview

692035

Lecithins

Oryctolagus cuniculus

activation, unsaturated lecithins are more efficient than saturated restoring estrone-UDPG activity whereas saturated lecithins are more efficient than unsaturated in restoring 4-nitrophenol-UDPG activity

488765

lysophosphatidylcholine

2 entries

Mersalyl

Cavia porcellus

maximal activation towards estrone, estradiol and testosterone at 1 mM

488741

Nicotine

Homo sapiens

slightly activating with substrate amitriptyline

736005

Phenobarbital

7 entries

phosphate

Homo sapiens

activity in phosphate buffer is higher than in Tris/malate buffer containing 5 mM sucrose

658522

phosphatidylcholine

3 entries

phosphatidylinositol

Homo sapiens

highly required for activity of GlcAT-P and GlcAT-S with paraglobosid and other glycolipids

Phospholipase A

Phospholipase C

Phospholipids

polycyclic aromatic hydrocarbons

Rattus norvegicus

induce activity towards simple phenols such as 1-naphthol, 2-aminophenol and mitoxantrone

488767

propofol

Homo sapiens

activates the glucuronidation of 4-methylumbelliferone at 0.2 mM leading to 1.5fold increased Vmax and 0.53fold reduced Km, overview

690683

sphingomyelin

Homo sapiens

almost indispensable activator of GlcAT-P as to glycoprotein acceptors

660431

Src

Homo sapiens

overexpression of regular or active Src, but not dominant-negative Src, in UGT2B7-transfected COS-1 cells increases UGT2B7 activity and phospho-Y438-2B7 by 50%. UGT2B7 and regular SrcTK are co-localized in COS-1

Triton X-100

UDP-GlcNAc

stimulates

UDP-N-acetylglucosamine

11 entries

additional information

8 entries

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0.0073 - 0.072

(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol

2 entries

0.068 - 0.17

(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol

2 entries

0.0062

(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime

Homo sapiens

pH 7.4, 37°C

735944

0.063 - 0.24

(E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid

Homo sapiens

pH 7.4, 37°C, isozyme-dependent

735944

0.21

(R)-6-hydroxywarfarin

Homo sapiens

isoform UGT1A10, pH 7.6, 37°C

720303

0.044 - 0.13

(R)-7-hydroxywarfarin

2 entries

0.105

(R)-8-hydroxywarfarin

Homo sapiens

isoform UGT1A10, pH 7.6, 37°C

720303

0.16 - 1.21

(R)-propanolol

3 entries

0.36

(S)-6-hydroxywarfarin

Homo sapiens

isoform UGT1A10, pH 7.6, 37°C

720303

0.16 - 0.23

(S)-7-hydroxywarfarin

2 entries

0.139

(S)-8-hydroxywarfarin

Homo sapiens

isoform UGT1A10, pH 7.6, 37°C

720303

0.507 - 1.013

(S)-naproxen

5 entries

0.135 - 0.515

(S)-propanolol

3 entries

0.247 - 0.263

1-hydroxy-benzo(a)pyrene

2 entries

0.0113 - 2.869

1-hydroxybenzo(a)pyrene

9 entries

0.091 - 0.111

1-hydroxypyrene

2 entries

0.00246 - 27

1-naphthol

16 entries

0.0178 - 0.0353

10-gingerol

6 entries

0.0069 - 0.093

11alpha-hydroxyprogesterone

2 entries

0.073 - 0.211

16alpha-hydroxyprogesterone

2 entries

0.042 - 0.159

17-epiestriol

6 entries

0.00192 - 0.0975

17beta-estradiol

7 entries

0.0073 - 0.0112

1alpha,25-dihydroxyvitamin D3

2 entries

0.00298 - 0.0258

2',4,4'-trihydroxychalcone

4 entries

0.0119 - 0.293

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid

4 entries

0.014 - 5

2-hydroxyestradiol

6 entries

0.0102 - 6

2-hydroxyestrone

10 entries

0.551 - 13.4

3'-azido-3'-deoxythymidine

4 entries

0.0444

3-epideacetycinobufagin

Homo sapiens

pH and temperature not specified in the publication

737232

0.271 - 0.278

3-hydroxy-benzo(a)pyrene

2 entries

0.0097 - 0.583

3-hydroxybenzo(a)pyrene

9 entries

0.00197 - 0.0047

3alpha,5beta-tetrahydroaldosterone

2 entries

0.0588 - 0.286

4-aminobiphenyl

5 entries

0.26

4-Hydroxybiphenyl

Rattus norvegicus

488756

0.006 - 0.292

4-hydroxyestradiol

7 entries

0.014 - 0.1182

4-hydroxyestrone

6 entries

0.011 - 1.621

4-methylumbeliferone

5 entries

0.00012 - 4.204

4-Methylumbelliferone

43 entries

0.0102 - 2

4-nitrophenol

20 entries

0.0293 - 0.149

5-diethylaminoethylamino-8-hydroxyimidazoacridinone

4 entries

0.0289 - 0.0706

5-dimethylaminopropylamino-8-hydroxytriazoloacridinone

3 entries

0.135 - 3.674

5-hydroxytryptophol

2 entries

0.27 - 0.381

5-methylchrysene-1,2-diol

2 entries

0.016

5alpha-androstane-3alpha,17beta diol

Homo sapiens

P19224

apparent Km for UGT1A4

488790

0.00023 - 0.00036

5alpha-dihydroaldosterone

2 entries

0.0646 - 0.0647

5beta-tetrahydrocortisone

2 entries

0.0253 - 0.404

6-gingerol

8 entries

0.48 - 0.72

6-hydroxywarfarin

3 entries

0.003 - 0.055

6alpha-hydroxyprogesterone

2 entries

19.3 - 44.4

7-ethyl-10-hydroxycampothecin

2 entries

0.0098 - 1.588

7-hydroxy benzo(a)pyrene

9 entries

0.044

7-hydroxy-4-(trifluoromethyl)-coumarin

Macaca mulatta

apparent Km for microsomal preparation

488797

0.00418 - 0.198

7-hydroxy-4-trifluoromethylcoumarin

5 entries

0.261 - 0.334

7-hydroxy-benzo(a)pyrene

2 entries

0.17 - 0.56

7-hydroxywarfarin

2 entries

0.0132 - 0.0314

8-gingerol

5 entries

0.308 - 0.368

8-hydroxy-benzo(a)pyrene

2 entries

0.00048 - 0.494

8-hydroxyquinoline

5 entries

0.19 - 0.39

8-hydroxywarfarin

3 entries

0.0301 - 0.615

9-hydroxybenzo(a)pyrene

9 entries

acetaminophen

Homo sapiens

675803

0.00036 - 0.00076

aldosterone

2 entries

0.261

alprazolam

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.0075 - 0.49

amitriptyline

3 entries

0.0011

androstane-3alpha,17beta diol

Macaca fascicularis

apparent Km for UGT2B20

488786

0.013 - 0.0175

androstanediol

2 entries

0.006 - 0.12

androsterone

5 entries

0.01

anthraflavic acid

Homo sapiens

O60656, P22309, Q9HAW7, Q9HAW9

isozyme UGT1A1, pH 6.4 or pH 7.6, 37°C; isozyme UGT1A1, pH 6.4 or pH 7.6, 37°C; isozyme UGT1A9, pH 7.6, 37°C

659315

0.397 - 0.426

benzo(a)pyrene-7,8-diol

2 entries

0.035

beta estradiol

Macaca mulatta

apparent Km for microsomal preparation

488797

0.021

beta-estradiol

Homo sapiens

isoform UGT1A1, pH 7.4, 37°C

720115

0.028

bifonazole

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.004 - 0.064

bilirubin

8 entries

0.0034 - 0.059

cannabinol

4 entries

0.071 - 0.368

carvacrol

5 entries

0.083

chenodeoxycholic acid

Homo sapiens

488772

0.004 - 0.005

chrysin

2 entries

0.0074 - 0.193

cis-4-hydroxytamoxifen

10 entries

0.025 - 0.049

clozapine

2 entries

0.156 - 0.4

codeine

3 entries

0.0278

cotinine

Homo sapiens

P36537

pH 7.4, 37°C, recombinant isozyme UGT2B10

736012

0.1

curcumin

Homo sapiens

O60656, P22309, Q9HAW7, Q9HAW9

isozymes UGT1A1 and UGT1A10, pH 6.4, 37°C; isozyme UGT1A1, pH 6.4, 37°C; isozyme UGT1A7, pH 7.6, 37°C; isozyme UGT1A7, pH 7.6, 37°C; isozyme UGT1A8, pH 7.0, 37°C; isozyme UGT1A8, pH 7.0, 37°C

659315

0.086 - 0.228

cyproheptadine

2 entries

7.4 - 19.3

deferiprone

4 entries

0.0018 - 10.18

denopamine

9 entries

3.133 - 7.724

desmethylnaproxen

3 entries

0.284 - 0.307

dibenzo(a,l)pyrene-11,12-diol

2 entries

0.007 - 0.069

diclofenac

8 entries

0.98

dihydromorphine

Macaca fascicularis

apparent Km for UGT1B9

488783

1.39

dihydromorphone

Macaca fascicularis

apparent Km for UGT1B9

488783

0.0196

dihydrotestosterone

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719346

0.0023

Dihydroxytestosterone

Macaca fascicularis

apparent Km for UGT2B20

488786

0.037 - 0.47

diphenhydramine

2 entries

1.89 - 3.11

dopamine

10 entries

0.115

econazole

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.021 - 0.294

entacapone

2 entries

0.0017 - 0.0116

Epitestosterone

2 entries

0.0049 - 13

estradiol

6 entries

0.046

estradiol-17beta

Sus scrofa

range between 0.045 mM and 0.047 mM

488753, 488755

0.0388 - 0.0467

estriol

2 entries

0.0035 - 0.0421

estrone

4 entries

8.03 - 40.04

ethanol

8 entries

0.028

ethinylestradiol

Macaca mulatta

apparent Km for microsomal preparation

488797

0.44 - 0.5

etoposide

2 entries

0.0084 - 0.0257

Eugenol

4 entries

1.667

fluconazole

Homo sapiens

isoform UGT2B7, pH 7.4, 37°C

719348

0.048

Flufenamic acid

Homo sapiens

671924

0.0209 - 0.229

frusemide

5 entries

0.0022 - 0.139

gemfibrozil

3 entries

2.1 - 5.2

grepafloxacin

3 entries

0.011 - 0.27

hyodeoxycholic acid

9 entries

0.0072 - 1.442

imipramine

12 entries

0.007

ketoconazole

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.48 - 1.695

Ketoprofen

2 entries

0.368 - 0.956

labetalol

3 entries

0.774 - 3.812

lamotrigine

4 entries

2.6 - 10

levofloxacin

3 entries

0.449

Mefenamic acid

Homo sapiens

671924

0.059

miconazole

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.013

midazolam

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

720115

0.0355 - 37.4

morphine

22 entries

1.15 - 1.425

morphine 3-glucuronide

2 entries

1.9 - 3.4

moxifloxacin

3 entries

0.34 - 1.272

mycophenolate

2 entries

0.046 - 0.336

Mycophenolic acid

7 entries

0.06 - 0.065

nalorphine

2 entries

0.045 - 0.048

naloxone

2 entries

0.05 - 0.067

Naltrexone

2 entries

0.072 - 4.375

naproxen

5 entries

0.135 - 7.344

niflumic acid

2 entries

0.702 - 0.775

oxymorphone

2 entries

5.06 - 6.99

p-ethoxyphenylurea

2 entries

0.0198 - 0.1951

Phenylbutazone

2 entries

0.0068 - 0.0964

phloretin

3 entries

0.0072 - 0.17

propofol

9 entries

0.211 - 0.627

Protocatechuic aldehyde

8 entries

0.032 - 0.099

retigabine

7 entries

0.034 - 0.045

S-naproxen

2 entries

0.061 - 7.64

scopoletin

11 entries

0.51

senecionine

Homo sapiens

pH 7.4, 37°C

719347

3.7 - 55.9

serotonin

12 entries

1.9 - 6.3

Sitafloxacin

3 entries

0.035

sulconazole

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.014 - 0.053

sulfinpyrazone

5 entries

0.0009

tamoxifen

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719346

0.0038 - 0.0387

testosterone

9 entries

0.007 - 0.008

tigogenin

2 entries

0.124

tioconazole

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.0506 - 0.0515

tranilast

2 entries

0.0037 - 0.319

trans-4-hydroxytamoxifen

13 entries

0.008 - 0.255

trans-androsterone

3 entries

0.013 - 0.135

trans-endoxifen

5 entries

0.0197 - 0.305

Trifluoperazine

5 entries

0.136

troglitazone

2 entries

0.00025

UDP-D-glucuronate

Homo sapiens

P19224, P22310

pH 7.4, 37°C, recombinant wild-type isozyme UGT1A6

693017

0.138 - 0.184

UDP-glucuronate

4 entries

0.229 - 0.704

UDP-glucuronic acid

3 entries

0.3 - 1.06

UDPglucuronate

8 entries

0.0036 - 5.4

UDPglucuronic acid

9 entries

0.111 - 0.339

umbelliferone

3 entries

1.13

voriconazole

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719348

0.508 - 0.841

zidovudine

11 entries

additional information

62 entries

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0.533 - 1.547

17beta-estradiol

2 entries

1.56

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid

Homo sapiens

673310

0.09

3-hydroxyflavone

Homo sapiens

P22309

isozyme UGT1A1

691934

0.23 - 3.73

4-Methylumbelliferone

7 entries

23.4 - 51.2

4-nitrophenol

2 entries

1.651

5-diethylaminoethylamino-8-hydroxyimidazoacridinone

Homo sapiens

isoform UGT1A9, pH not specified in the publication, temperature not specified in the publication

719349

0.958

5-dimethylaminopropylamino-8-hydroxytriazoloacridinone

Homo sapiens

isoform UGT1A9, pH not specified in the publication, temperature not specified in the publication

719349

0.2 - 0.29

5-hydroxytryptophol

2 entries

0.82 - 1.1

6-hydroxywarfarin

2 entries

0.03

7,7,7-triphenylheptyl-UDP

Rattus norvegicus

apparent Ki for the inhibition of 1-naphthol glucuronidation

488701

0.0996 - 0.161

7-hydroxy-4-trifluoromethylcoumarin

2 entries

1.1

7-hydroxywarfarin

Homo sapiens

mutant V92A, pH 7.4, 37°C

703404

0.03 - 0.248

amitriptyline

4 entries

0.009 - 0.149

androsterone

2 entries

0.0019

atazanavir

Homo sapiens

pH 7.5, 37°C, UGT1A1

673288

0.00000091

beta-phenyllongifolol

Homo sapiens

691812

0.0005 - 0.28

bilirubin

2 entries

0.0723 - 0.085

bisphenol A

4 entries

0.047 - 0.243

carbamazepine

4 entries

0.006 - 0.02

clomipramine

3 entries

1.1

codeine

Rattus norvegicus

competitive with morphine glucuronidation

488762

0.08

cyproheptadine

Rattus norvegicus

morphine-UDPGT

488768

0.111 - 0.458

desipramine

3 entries

desmethylcycloheptadine

Rattus norvegicus

488768

0.009 - 0.047

diazepam

2 entries

0.008 - 0.024

diclofenac

3 entries

0.005 - 0.26

estradiol

2 entries

0.022 - 0.808

flunitrazepam

9 entries

1.3

FNZ

Rattus norvegicus

488768

0.0164 - 0.0342

gossypol

2 entries

0.0039

hecogenin

Homo sapiens

pH 7.4, 37°C, substrate senecionine

719347

0.033 - 0.38

imipramine

4 entries

0.0479

indinavir

Homo sapiens

pH 7.5, 37°C, UGT1A1

673288

0.000023

isolongifolol

Homo sapiens

691811

0.0099 - 0.0623

kaempferol

6 entries

0.000026

longifolol

Homo sapiens

691811

0.017 - 0.239

lorazepam

4 entries

0.088 - 9

morphine

3 entries

0.296 - 0.713

mycophenolate

2 entries

0.518 - 1.298

naloxone

2 entries

0.196 - 0.266

olanzapine

2 entries

0.041 - 0.519

oxazepam

3 entries

0.002 - 0.1132

quercetin

6 entries

0.046 - 0.347

tacrolimus

4 entries

0.0046 - 0.081

tamoxifen

3 entries

0.059 - 2.2

testosterone

3 entries

0.514

trans-androsterone

Homo sapiens

isoform UGT1A4, pH 7.4, 37°C

719346

additional information

8 entries

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0.214

(-)-nicotine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0004

(1R)-1-cyclopropyl-2-methylpropan-1-ol

Homo sapiens

IC50: 0.0004 mM

675319

0.0004 - 0.0009

(1R)-1-cyclopropylbut-3-en-1-ol

2 entries

0.0004

(1R)-1-cyclopropylbut-3-ene-1,3-diol

Homo sapiens

IC50: 0.0004 mM

675319

0.0005

(1R)-1-cyclopropylethanol

Homo sapiens

IC50: 0.0005 mM

675319

0.0003

(1R)-1-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0003 mM

675319

0.0002

(1R)-1-cyclopropylpropan-1-ol

Homo sapiens

IC50: 0.0002 mM

675319

0.0002

(1R)-1-cyclopropylpropane-1,3-diol

Homo sapiens

IC50: 0.0002 mM

675319

0.0002

(1R)-2-chloro-1-cyclopropylethanol

Homo sapiens

IC50: 0.0002 mM

675319

0.0002

(1S)-1-cyclopropyl-2,2-dimethylpropan-1-ol

Homo sapiens

IC50: 0.0002 mM

675319

0.0004

(1S)-1-cyclopropyl-2-methylpropan-1-ol

Homo sapiens

IC50: 0.0004 mM

675319

0.0002

(1S)-1-cyclopropylbut-3-en-1-ol

Homo sapiens

IC50: 0.0002 mM

675319

0.0007

(1S)-1-cyclopropylethanol

Homo sapiens

IC50: 0.0007 mM

675319

0.0006

(1S)-1-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0006 mM

675319

0.0005

(1S)-1-cyclopropylpropan-1-ol

Homo sapiens

IC50: 0.0005 mM

675319

0.0003

(1S)-1-cyclopropylpropane-1,3-diol

Homo sapiens

IC50: 0.0003 mM

675319

0.012

(2-cyclopropylethyl)phosphonic acid

Homo sapiens

IC50: 0.012 mM

675319

0.003

(2E)-3-cyclopropylacrylic acid

Homo sapiens

IC50: 0.003 mM

675319

0.0008

(2E)-3-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0008 mM

675319

0.003

(2Z)-3-cyclopropylacrylic acid

Homo sapiens

IC50: 0.003 mM

675319

0.0007

(2Z)-3-cyclopropylprop-2-en-1-ol

Homo sapiens

IC50: 0.0007 mM

675319

0.032

(3-cyclopropylpropyl)phosphonic acid

Homo sapiens

IC50: 0.032 mM

675319

0.001

(3S)-3-cyclopropyl-3-hydroxypropanoic acid

Homo sapiens

IC50: 0.001 mM

675319

0.412 - 0.429

(5alpha)-17-allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one

2 entries

0.333

(R)-7-hydroxywarfarin

Homo sapiens

isoform UGT1A10, substrate (S)-7-hydroxywarfarin, pH 7.6, 37°C

720303

0.401

(R)-8-hydroxywarfarin

Homo sapiens

isoform UGT1A10, substrate (S)-6-hydroxywarfarin, pH 7.6, 37°C

720303

0.0002

(R)-chloro(cyclopropyl)methanol

Homo sapiens

IC50: 0.0002 mM

675319

0.00007

(R)-cyclopropyl(phenyl)methanol

Homo sapiens

IC50: 0.00007 mM

675319

0.344

(S)-8-hydroxywarfarin

Homo sapiens

isoform UGT1A10, substrate (R)-8-hydroxywarfarin, pH 7.6, 37°C

720303

0.0009

(S)-cyclopropyl(phenyl)methanol

Homo sapiens

IC50: 0.0009 mM

675319

0.0008

1-cyclopropyl-2,2-dimethylpropan-1-ol

Homo sapiens

IC50: 0.0008 mM

675319

0.042 - 0.21

17alpha-ethinylestradiol

3 entries

0.0086

17alpha-ethynylestradiol

Homo sapiens

pH 7.5, 37°C, inhibition of glucuronidation of 4-methylumbelliferone by isozyme UGT1A1

690683

0.005

2-cyclopropyl-N,N-dimethylethanamine

Homo sapiens

IC50: 0.005 mM

675319

0.0005

2-cyclopropylethanol

Homo sapiens

IC50: 0.0005 mM

675319

0.023 - 0.149

2-phenyl-4H-benzo[h]chromen-4-one

4 entries

0.0009

3-cyclopropylpropan-1-ol

Homo sapiens

IC50: 0.0009 mM

675319

0.002

3-cyclopropylpropanoic acid

Homo sapiens

IC50: 0.002 mM

675319

0.003

4-cyclopropylbutan-1-ol

Homo sapiens

IC50: 0.003 mM

675319

0.016

4-cyclopropylbutanoic acid

Homo sapiens

IC50: 0.016 mM

675319

0.0259 - 0.0774

ADP

3 entries

0.00645 - 0.159

amitriptyline

3 entries

0.031

AMP

Rattus norvegicus

pH 7.1, 37°C, inhibition of estradiol 17-glucuronidation activity

691045

0.0271

androsterone

Homo sapiens

pH 7.5, 37°C, recombinant isozyme UGT1A9

692038

0.0558

aripiprazole

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0117 - 0.0352

ATP

3 entries

0.068 - 0.086

beta-estradiol

Homo sapiens

exhibits strong inhibition on etoposide phenolic glucuronide (IC50: 0.068 mM) and etoposide alcoholic glucuronide EAG2 (IC50: 0.086 mM). The inhibitory effect of beta-estradiol on the formation of etoposide alcoholic glucuronide EAG1 is not so significant

673305

0.054 - 0.14

bilirubin

4 entries

0.0425 - 0.163

bisphenol A

4 entries

0.088 - 0.152

bupropion

2 entries

0.431 - 0.456

carbamazepine

2 entries

0.079

chlorpromazine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.026 - 0.04

clomipramine

3 entries

0.0059 - 0.0558

CTP

3 entries

0.001

cyclopropanecarboxylic acid

Homo sapiens

IC50: 0.001 mM

675319

0.023 - 0.048

cyclosporine A

2 entries

0.0341

desipramine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.00386

desloratadine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0437

desmethylnortriptyline

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.44

desvenlafaxine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.062 - 0.089

dextromethorphan

2 entries

0.053 - 0.057

diazepam

2 entries

0.031 - 0.192

diclofenac

4 entries

0.0362

didesmethylimipramine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.01

diethyl [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonate

Homo sapiens

IC50: 0.01 mM

675319

0.005

diethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate

Homo sapiens

IC50: 0.005 mM

675319

0.004

diethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate

Homo sapiens

IC50: 0.004 mM

675319

0.01

diethyl [(R)-cyclopropyl(hydroxy)methyl]phosphonate

Homo sapiens

IC50: 0.01 mM

675319

0.003

dimethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate

Homo sapiens

IC50: 0.003 mM

675319

0.004

dimethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate

Homo sapiens

IC50: 0.004 mM

675319

0.00364

doxepin

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0812

duloxetine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0003

ethyl (3S)-3-cyclopropyl-3-hydroxypropanoate

Homo sapiens

IC50: 0.0003 mM

675319

0.98 - 1.136

fluconazole

2 entries

0.0724

fluoxetine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0535

fluphenazine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.224

fluvoxamine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.108 - 0.227

GTP

3 entries

0.0614 - 0.102

hyodeoxycholic acid

2 entries

0.0428 - 0.129

imipramine

3 entries

0.0001

isolongifolol

Homo sapiens

IC50: 0.0001 mM

675319

0.0104 - 0.0385

kaempferol

6 entries

0.0041 - 0.06

ketoconazole

6 entries

0.056 - 0.065

lorazepam

2 entries

0.036

loxapine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.00224

mianserin

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.023 - 0.147

midazolam

4 entries

0.031

mirtazapine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.341 - 0.389

mycophenolate

2 entries

0.009 - 0.0321

NAD+

3 entries

0.008 - 0.0252

NADP+

3 entries

0.168

niflumic acid

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0508

norclomipramine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0453

nortriptyline

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.218

oitalopram

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.276 - 0.368

olanzapine

2 entries

0.044 - 0.272

oleandomycin

3 entries

0.0613

olozapine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.056 - 0.185

Omeprazole

2 entries

0.00218

oratadine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.109 - 0.119

oxazepam

2 entries

0.0049 - 0.074

paclitaxel

3 entries

0.0635

paroxetine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0662

perphenazine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0942

Phenelzine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0455 - 0.22

Phenylbutazone

3 entries

0.059 - 0.228

propofol

6 entries

0.0343

protriptyline

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.003 - 0.1526

quercetin

5 entries

0.0439

quetiapine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.166

quinidine

Homo sapiens

isoform UGT1A4, substrate midazolam, pH 7.4, 37°C

720115

0.0672

selegiline

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.0927

sertraline

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.384 - 0.488

tacrolimus

3 entries

0.093 - 0.107

tamoxifen

2 entries

0.043 - 0.165

testosterone

2 entries

0.0713

thioridazine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.281

Tolbutamide

Homo sapiens

isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C

720115

0.0326

trimipramine

Homo sapiens

P36537

pH 7.4, 37°C

736012

0.007 - 0.047

UDP

2 entries

2.54 - 3.59

zidovudine

2 entries

0.041

[(1E)-3-cyclopropylprop-1-en-1-yl]phosphonic acid

Homo sapiens

IC50: 0.041 mM

675319

0.013

[(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonic acid

Homo sapiens

IC50: 0.013 mM

675319

0.028

[(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid

Homo sapiens

IC50: 0.028 mM

675319

0.018

[(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid

Homo sapiens

IC50: 0.018 mM

675319

0.008

[(E)-2-cyclopropylvinyl]phosphonic acid

Homo sapiens

IC50: 0.008 mM

675319

0.018

[(R)-cyclopropyl(hydroxy)methyl]phosphonic acid

Homo sapiens

IC50: 0.018 mM

675319

additional information

Homo sapiens

inhibition of isozyme UGT2B7 at several different concentration of inhibitor compounds

691812

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0.000008

Homo sapiens

microsomes, substrate codeine

657879

0.000009

Canis lupus familiaris

Q6K1J1

microsomes, substrate ketoprofen

657879

0.000011

Canis lupus familiaris

Q6K1J1

microsomes, substrate naproxen

657879

0.000013

Homo sapiens

microsomes, substrate naproxen

657879

0.000028

Canis lupus familiaris

Q6K1J1

microsomes, substrate morphine 3-glucuronide

657879

0.000032

Canis lupus familiaris

Q6K1J1

microsomes, substrate 4-nitrophenol

657879

0.0000329

Homo sapiens

P22310

25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by liver microsomes

690850

0.0000337

Homo sapiens

P22310

25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by UGT1A4 supersomes

690850

0.000037

Canis lupus familiaris

Q6K1J1

microsomes, substrate androstanediol

657879

0.000045

Homo sapiens

substrate curcumin in liver microsomes

694249

0.000058

Homo sapiens

microsomes, substrates hydromorphone and morphine 3-glucuronide

657879

0.00006

2 entries

0.00007

Canis lupus familiaris

Q6K1J1

microsomes, substrate ethylphenol; microsomes, substrate gemfibrozil

657879

0.000075

Canis lupus familiaris

Q6K1J1

microsomes, substrate 4-methylumbelliferone

657879

0.00008

Canis lupus familiaris

Q6K1J1

microsomes, substrate 1-naphthol

657879

0.000082

Canis lupus familiaris

Q6K1J1

microsomes, substrate eugenol

657879

0.000102

Homo sapiens

microsomes, substrate valproic acid

657879

0.000105

Homo sapiens

microsomes, substrate ibuprofen

657879

0.000128

Homo sapiens

substrate propofol in liver microsomes

694249

0.0002

2 entries

0.000215

Homo sapiens

microsomes, substrate 4-methylumbelliferone

657879

0.00022

Homo sapiens

microsomes, substrate androstanediol

657879

0.00023

Homo sapiens

microsomes, substrate 1-naphthol

657879

0.00027

Homo sapiens

microsomes, substrate gemfibrozil

657879

0.00028

Homo sapiens

microsomes, substrate diclofenac

657879

0.0004

Homo sapiens

microsomes, substrate 4-nitrophenol

657879

0.0005

Homo sapiens

O75795

recombinant isozyme UGT2B4, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.0007

Homo sapiens

O75795

recombinant isozyme UGT1A8, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.00077 - 0.033

Homo sapiens

liver UGT1A6 of different individuals, microsomes

658518

0.00103

Homo sapiens

microsomes, substrate eugenol

657879

0.00124

Homo sapiens

microsomes, substrate hyodeoxycholic acid

657879

0.0014

Homo sapiens

O75795

recombinant isozyme UGT1A4, substrate trifluoperazine, pH 7.5, 37°C

658529

0.0015

Homo sapiens

O75795

recombinant isozyme UGT1A1, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.0016

Homo sapiens

P19224

liver microsomes, substrate morphine 3-glucuronide

658527

0.0022

Homo sapiens

O75795

recombinant isozyme UGT1A3, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.0037

Homo sapiens

O75795

recombinant isozyme UGT2B15, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; recombinant isozyme UGT2B7, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

0.0044

0.0052

liver microsomes, substrate N-acetylserotonin

658527

0.0065

Homo sapiens

O75795

recombinant isozyme UGT1A9, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.0072

Homo sapiens

P19224

liver microsomes, substrate 6-hydroxymelatonin

658527

0.008 - 4

Homo sapiens

P19224

liver microsomes, substrate 5-hydroxytryptophol

658527

0.0126

Homo sapiens

O75795

recombinant isozyme UGT1A7, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.0158

Homo sapiens

recombinant UGT1A6 from lymphoblasts or insect cells, microsomes

658518

0.0191

Homo sapiens

O75795

jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.028

Rattus norvegicus

4-nitrophenol as substrate, using Wistar strain liver microsomes

488695

0.032

Oryctolagus cuniculus

estrone

488775

0.0622

Homo sapiens

O75795

liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C; liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C

658529

0.075

Rattus norvegicus

7,7,7-triphenylheptanoic acid as substrate

488703

0.092

Rattus norvegicus

4-hydroxybiphenyl as substrate, enzyme induced by 3-methylcholanthrene

488715

0.142

Rattus norvegicus

bilirubin as substrate, non-treated Wistar strain

488703

0.168

Rattus norvegicus

chenodeoxycholic acid, Sprague-Dawley rat treated with phenobarbital

488727

0.45

Homo sapiens

purified recombinant GlcAT-S with substrate asialo-orosomucoid

660431

0.67

Rattus norvegicus

morphine as substrate, Wistar strain treated with phenobarbital

488698

0.682

Oryctolagus cuniculus

4-nitrophenol

488775

0.983

Rattus norvegicus

testosterone, Sprague-Dawley rat treated with phenobarbital

488727

1.11

Homo sapiens

purified recombinant GlcAT-P with substrate asialo-orosomucoid

660431

1.7

Rattus norvegicus

5-hydroxytryptamine, enzyme induced by 3-methylcholanthrene

488715

1.8

Rattus norvegicus

eugenol as substrate, enzyme induced by 3-methylcholanthrene

488715

Rattus norvegicus

1-naphthol as substrate, Wistar strain treated with 3-methylcholanthrene

488715

Rattus norvegicus

4-nitrophenol as substrate, Wistar strain treated with 3-methylcholanthrene

488715

5.35

Rattus norvegicus

1-naphthol as substrate, Wistar strain treated with phenobarbital

488698

6.06

Rattus norvegicus

1-naphthol as substrate, Wistar strain treated with 3-methylcholanthrene

488698

999

Homo sapiens

659973

additional information

62 entries

O60656

hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes; hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes; hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes; hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes; hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes

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Homo sapiens

substrate: eugenol, wild-type enzyme

676792

6.4 - 7.6

2 entries

6.4

Homo sapiens

substrate: eugenol, mutant enzyme S432G; substrate: eugenol, mutant enzyme S432G

676792

6.5

2 entries

6.7

Homo sapiens

chenodeoxycholic acid

7.1 - 7.4

assay at

7.1

assay at

7.3 - 7.8

4-thionitrophenol, thiophenol and 4-nitrophenol as substrates

7.3 - 8.7

estrone

7.4

7.5

7.6

7.7

7.8

8 - 8.8

glucuronidation of bilirubin

488699

Macaca fascicularis

488786

8 - 9

Oryctolagus cuniculus

estrone

bilirubin

8.1

conversion of bilirubin monoglucuronide to bilirubin diglucuronide, second optimum at pH 6.5

8.4

assay at

8.5

substrate: eugenol, wild-type enzyme

676792

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6 - 8

Homo sapiens

substrate chenodeoxycholic acid

6.4 - 7.6

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activity increases with rise in incubation temperature

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2 - 45

Sus scrofa

linear estrone glucuronide formation

488742

Sus scrofa

increase of activity up to 50°C, half-life at 50°C: 15 min

488755

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O60656, P22309, Q9HAW7, Q9HAW9

isozyme UGT1A8; isozyme UGT1A8

commercial preparation

gastrointestinal tract

4 entries

Hep-G2 cell

Homo sapiens

low-level UGT1A5 expression

675594

hepatocellular carcinoma cell

Homo sapiens

O60656, P16662, P22309, P22310

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

;

735649

oral squamous cell carcinoma cell line

;

isozyme UGT2B15, immunohistochemic analysis of isozyme distribution, UGT2B15 occurs in luminal epithelial cells, overview; isozyme UGT2B17, immunohistochemic analysis of isozyme distribution, overview

;

prostate epithelium cell line

Homo sapiens

androgens do not only affect their own inactivation but also influence the levels of monohydroxy-fatty acids by regulating the expression of UGT2B enzymes in an isoform-specific manner; androgens do not only affect their own inactivation but also influence the levels of monohydroxy-fatty acids by regulating the expression of UGT2B enzymes in an isoform-specific manner

O60656, P22309, Q9HAW7, Q9HAW9

isozyme UGT1A9

proximal, epithelial cells

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

O60656, P22309, Q9HAW7, Q9HAW9

isozyme UGT1A7; isozyme UGT1A7

659315

tonsil

Homo sapiens

isoform UGT2A1 is expressed in aerodigestive tract tissues including trachea, larynx and tonsil, and is also expressed in lung and colon. Isoform UGT2A1 exhibits highest expression in the lung, followed in decreasing order by trachea, tonsil, larynx, colon, olfactory tissue

isozyme UGT2B7

additional information

12 entries

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endoplasmic reticulum

4 entries

endoplasmic reticulum membrane

8 entries

Golgi membrane

Rattus norvegicus

low activity

139

mitochondrial outer membrane

rough endoplasmic reticulum

Rattus norvegicus

highest activity

5791

488773

smooth endoplasmic reticulum

highest activity

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2o6l, download, 3D-view

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22600

Sphingomonas paucimobilis

carboxyl region of the GelK protein

488796

26800

Sphingomonas paucimobilis

amino region of the GelK protein

488796

32000

Homo sapiens

x * 32000, recombinant GlcAT-P and GlcAT-S, SDS-PAGE

660431

41500

Rattus norvegicus

bilirubin monoglucuronide forming enzyme, monomeric, radiation inactivation

488721

41900

Sphingomonas paucimobilis

GelK by SDS-PAGE

50000

51000

x * 51000

52000

52500

x * 52500

53000

54000

55000 - 56000

phenol-UDPGT

55000

56000

57000

58500

x * 58500, deduced from cDNA sequence, higher value than that obtained from SDS-PAGE electrophoresis

488709

59000

Rattus norvegicus

x * 59000, SDS-polyacrylamide gel electrophoresis

488738

73500

Rattus norvegicus

estrone UDP-glucuronyltransferase, dimeric enzyme, radiation inactivation

488721

86000

Homo sapiens

x * 86000, CFP-tagged recombinant UGT1A10, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A10, SDS-PAGE; x * 86000, CFP-tagged recombinant UGT1A1, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A1, SDS-PAGE; x * 86000, CFP-tagged recombinant UGT1A3, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A3, SDS-PAGE; x * 86000, CFP-tagged recombinant UGT1A6, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A6, SDS-PAGE; x * 86000, CFP-tagged recombinant UGT1A7, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A7, SDS-PAGE; x * 86000, CFP-tagged recombinant UGT1A8, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A8, SDS-PAGE; x * 86000, CFP-tagged recombinant UGT1A9, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A9, SDS-PAGE; x * 86000, CFP-tagged recombinant UGT1A enzyme, SDS-PAGE, x * 56000, HA-tagged recombinant UGT1A enzyme, SDS-PAGE

693020

109000

Rattus norvegicus

4-nitrophenol UDP-glucuronyltransferase, dimeric or trimeric enzyme, radiation inactivation

488721

142000

Rattus norvegicus

testosterone UDP-glucuronyltransferase, trimeric or tetrameric enzyme, radiation inactivation

488721

159000

Rattus norvegicus

phenolphthalein UDP-glucuronyltransferase, tetrameric enzyme, radiation inactivation

488721

175000

Rattus norvegicus

formation of bilirubin diglucuronide from bilirubin monoglucuronide, tetrameric enzyme, radiation inactivation

488721

230000

Oryctolagus cuniculus

gel filtration

488728

316000 - 318000

Rattus norvegicus

gel filtration, polyacrylamide gradient slab gel electrophoresis

488727

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dimer

monomer

tetramer

additional information

10 entries

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glycoprotein

7 entries

phospholipoprotein

5 entries

phosphoprotein

2 entries

additional information

Rattus norvegicus

Gunn rat strain, inducible phenol-UGT synthesized in the truncated form is not the result of a posttranslational modification

488777

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construction of three-dimensional structure by homology modeling using a crystal structure of TDP-epi-vancosaminyltransferase as template. Amino acid residues Arg42, Lys91, Ala92, Tyr106, Gly111, Tyr113, Asp115, Asn152, Leu173, Leu219, His221, Arg222, and Glu241 are unique to UGT1A9 as compared with UGT1A7, UGT1A8 and UGT1A10. Molecular dynamics simulation of the structures revealed that Arg42, Leu173, Leu219, His221 and Arg222 as well as residues Lys91, Ala92, Tyr106, Gly111, Tyr113, Asp115, and Glu241 are responsible for the thermal stability

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11.1

Sus scrofa

unstable above

488708

additional information

Rattus norvegicus

UGT1A6 mutants activity reduced at acidic pH

488787

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-60

Rattus norvegicus

as pellets with a 1.15% KCl overlay, no apparent loss of activity for three months

488725

-20

Rattus norvegicus

rapid loss of activity

488698

Sus scrofa

mixtures of enzyme and lipid, under stream of argon, stable at least 8 hours

488726

Mus musculus

1 d, more than 50% loss of activity

488722

Sus scrofa

15 min, absence of substrates, slight inactivation

488742

Sus scrofa

reversible change from active to inactive form, this transition temperature is lowered by cholesterol in phosphatidylcholine bilayers

irreversible inactivation, stabilization by cholesterol in phosphatidylcholine bilayers

488705

Rattus norvegicus

3 min, 80% reduced activity

488749

Sus scrofa

15 min, 50% loss of activity

half-life 15 min

complete inactivation

488755

Sus scrofa

15 min, complete inactivation

488742

additional information

Homo sapiens

O60656

isoform UGT1A9 is rather stable against heat treatment. Molecular dynamics simulation of the structures revealed that Arg42, Leu173, Leu219, His221 and Arg222 as well as residues Lys91, Ala92, Tyr106, Gly111, Tyr113, Asp115, and Glu241 are responsible for the thermal stability

703427

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extremely unstable during purification

Homo sapiens

488767

phosphatidylcholine stabilizes the detergent treated enzyme

Rattus norvegicus

691045

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-20°C, 20% w/v glycerol, complete loss of activity

Rattus norvegicus

488730, 488737

-20°C, at least 1 month

Rattus norvegicus

488727

-20°C, microsomal preparation, more than 4 months

Sus scrofa

488742

-20°C, several months

-20°C, stable

-20ºC, completely stable for 3.5 months

Rattus norvegicus

488738

0-4°C, 0.1 mg/ml lysophosphatidylcholine, 1 mM EDTA, 11% loss of activity in 6 days, 20% loss of activity in 12 days

Rattus norvegicus

488698

0°C, 14 days, 80% loss of activity

Sus scrofa

488755

0°C, 30 days, 4-nitrophenol UDP-glucuronosyltransferase loses 11% of activity, 2-aminophenol UDP-glucuronosyltransferase loses 19% of activity

Rattus norvegicus

488740

0°C, half-life 18-20 days

2 entries

22°C, lyophilized microsomes, 15 days

4°C, at least 2 days

4°C, at least 6 days

4°C, bilirubin glucuronosyltransferases: isozyme F1 3 weeks stable, isozyme F3 inactivation in 1 week

Rattus norvegicus

488717

4°C, microsomal preparation: increase of activity towards 4-nitrophenol, maximum of activation at 3 days storage

Mus musculus

488746

4°C, solubilized enzyme stable for 7 days, concentrated form loses 12% of activity

Rattus norvegicus

488749

4ºC, purified GT1 with addition of egg lecithin, stable for 4 weeks, with loss of 25% of activity

Rattus norvegicus

488733

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4 entries

ammonium sulfate fractionation and affinity chromatography with UDP-hexanolamine Sepharose, several isoforms are isolated

Pleuronectes platessa

488702

ammonium sulfate precipitation and chromatography on DEAE-cellulose and DEAE-sephadex, 98% delipidation by hydroxyapatite chromatography caused 91-99% inactivation

Cavia porcellus

488729

ammonium sulfate precipitation, chromatography on DEAE-cellulose and affinity chromatography on UDP-hexanolamine sepharose

Oryctolagus cuniculus

488728, 488731

chromatofocusing and affinity chromatography on UDP-hexanolamine sepharose, three isoenzymes

Rattus norvegicus

488725

comparisson between DEAE-Sepharose and chromatofocusing methods

Rattus norvegicus

488758

fractionation of the mitochondria by isopynic centrifugation and separation of outer and inner membranes

Sus scrofa

488754

HA-tagged UGT2B7 wild-type and mutant allozymes in Spodoptera frugiperda Sf9 cells by hemagglutinin immunoaffinity chromatography

Homo sapiens

735648

His-tagged UGT1A9 purified by immobilized metal-chelating chromatography

Homo sapiens

488801

method

2 entries

microsome preparation of HEK 293 cells expressing recombinant isozymes

Homo sapiens

658515

native enzyme partially by microsome preparation

overview procedures

overview procedures, two forms: GT1P and GT2P

Sus scrofa

488726

purification of recombinant His-tagged isozymes UGT1A10 or UGT1A7 about 200fold from the 60000 x g supernatant by nickel affinity chromatography, binding analysis on affinity ligand 5-azidouridine-diphosphoglucuronic acid, which possesses high- and low-affinity binding sites, determination and analysis, overview

Homo sapiens

690975

purification of two isozymes inducibles by 3-methylcholanthrene or phenobarbital using sodium cholate solubilization, chromatography on Bio Gel A 1.5 m, DEAE-cellulose and UDP-hexanolamine Sepharose 4B

Rattus norvegicus

488698

recombinant His-tagged isozyme UGT1A9 by nickel affinity chromatography; recombinant isozyme UGT1A6 mutant Y485D with isozyme UGT1A4, after co-expression, by affinity chromatography; recombinant isozyme UGT1A6 mutant Y485D with isozyme UGT1A4, after co-expression, by affinity chromatography, recombinant His-tagged isozyme UGT1A6 by nickel affinity chromatography

Homo sapiens

691935

recombinant His-tagged isozyme UGT1A9 mutant from insect cells by nickel affinity chromatogaphy

Homo sapiens

659971

several methods including chromatofocusing, combined with anion exchange chromatography and/or affinity chromatography of UDP-hexanolamine Sepharose

Rattus norvegicus

488730, 488734, 488767

soluble recombinant FLAG-tagged enzymes GlcAT-P and GlcAT-S, 1233fold and 7511fold, respectively, from Escherichia coli by affinity chromatographic steps

two isozymes

two isozymes by a combination of ion-exchange chromatography, gel filtration and affinity chromatography on UDP-hexanolamine Sepharose

Rattus norvegicus

488760

two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography

Homo sapiens

488761, 488767, 488768

two isozymes separated by a method that includes chromatography on DEAE-cellulose DE-52

Oryctolagus cuniculus

488775

Wistar strain purified from microsomes by solubilization with CHAPS, and sequential chromatography on Red-Toyopearl, hydroxyapatite, heparin-Toyopearl and UDP-hexanolamine-agarose

Rattus norvegicus

488779

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Homo sapiens

703404, 703415, 703416, 719348, 720115, 720303, 720334

2 bilirubin UDP-glucuronyltransferases, expression in COS-1 cells

Homo sapiens

488770

8 different UGT's expressed in baculovirus-infected cells as His-tagged proteins

Homo sapiens

488801

co-expression of His-tagged and HA-tagged isozymes UGT1A6 and UGT1A9 in baculovrisu-infected insect cells; co-expression of isozyme UGT1A6 mutant Y485D with His-tagged isozyme UGT2B7; co-expression of isozyme UGT1A6 mutant Y485D with His-tagged isozyme UGT2B7, co-expression of isozyme UGT1A6 mutant Y485D with isozyme UGT1A4 showing high protein-protein interactions, co-expression of His-tagged and HA-tagged isozymes UGT1A6 and UGT1A9 in baculovirus-infected insect cells; co-expression of isozyme UGT1A6 mutant Y485D with isozyme UGT1A4 showing high protein-protein interactions

Homo sapiens

691935

coexpression of isozyme UGT2B7 with either CYP3A4, CYP1A2 or CYP2C9 cytochrome P450 enzymes in COS-1 cells, coexpression alters the kinetic properties of isozyme UGT2B7

Homo sapiens

659973

different isozymes expressed in COS-7

Homo sapiens

488768, 488790

DNA and amino acid sequence determination and analyis of wild-type isozyme UGT1A10, expression of wild-type and mutant isozymes UGT1A10 in COS-1 cells

Homo sapiens

658519

DNA and amino acid sequence determination and analysis, expression in chinese hamster lung fibroblast V79 cells, sequence comparison, phylogenetic analysis

Homo sapiens

657879

DNA and amino acid sequence determination and analysis, screening of dog cDNA library, expression in chinese hamster lung fibroblast V79 cells, sequence comparison, phylogenetic analysis

Canis lupus familiaris

Q6K1J1

657879

DNA and amino acid sequence determination, realtime RT-PCR analysis; DNA and amino acid sequence determination, realtime RT-PCR analysis; DNA and amino acid sequence determination, realtime RT-PCR analysis

Macaca fascicularis

Q9TSL7, Q9TSL9, Q9TSM0

692053

effect of female hormones progesterone, oestradiol, oestriol, or oestrone on the promoter activities of relevant UGTs in HepG2 cells, real-time reverse transcription-PCR analysis, overview; effect of female hormones progesterone, oestradiol, oestriol, or oestrone on the promoter activities of relevant UGTs in HepG2 cells, real-time reverse transcription-PCR analysis, overview; effect of female hormones progesterone, oestradiol, oestriol, or oestrone on the promoter activities of relevant UGTs in HepG2 cells, real-time reverse transcription-PCR analysis, overview; effect of female hormones progesterone, oestradiol, oestriol, or oestrone on the promoter activities of relevant UGTs in HepG2 cells, real-time reverse transcription-PCR analysis, overview; effect of female hormones progesterone, oestradiol, oestriol, or oestrone on the promoter activities of relevant UGTs in Hep-G2 cells, real-time reverse transcription-PCR analysis, transcriptional regulation of isozyme UGT1A1, overview; effect of female hormones progesterone, oestradiol, oestriol, or oestrone on the promoter activities of relevant UGTs in HepG2 cells, real-time reverse transcription-PCR analysis, transcriptional regulation of isozyme UGT2B7, overview

Homo sapiens

P06133

695271

estriol UDPGT, isozyme with pI 7.4

Homo sapiens

488709

expressed in baculovirus-infected insect cells

Homo sapiens

671611

expressed in baculovirus-infected insect cells and human B-lymphoblastoid cells

Homo sapiens

488792

expressed in Chinese hamster V-79 cells

Homo sapiens

488788

expressed in COS-7 cells

Rattus norvegicus

488767, 488777

expressed in COS-7-H25 and HP1 cells

Homo sapiens

488767

expressed in Escherichia coli BL21-DE3 cells

Sphingomonas paucimobilis

488796

expressed in HEK293 cells; expressed in HEK293 cells

Homo sapiens

692032

expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; expressed in HEK293 cells; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview; UGT1 gene locus, exon organization, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293 cells, overview

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

676313

expressed in HK293 cells

Homo sapiens

488785

expressed in yeast AH22 cells

Rattus norvegicus

488787

expression in baculovirus-infected insect cells

Homo sapiens

703407

expression in Cos-1 cells; expression in Cos-1 cells

Homo sapiens

676792

expression in COS7 cells

Homo sapiens

671843

expression in HEK cells; expression in HEK cells

Rattus norvegicus

P70624

673292

expression in HEK-293 cell

Homo sapiens

703410

expression in HEK-293 cell; expression in HEK-293 cell; expression in HEK-293 cell; expression in HEK-293 cell; expression in HEK-293 cell; expression in HEK-293 cell; expression in HEK-293 cell; expression in HEK-293 cell

Papio anubis

D2SML9, D2SMM0, D2SMM1, D2SMM2, D2SMM3, D2SMM4, D2SMM5, D2SMM6

703422

expression in HEK-293 cell; expression in insect cell; expression of wild-type isozyme UGT1A10 in insect cells, overview; expression of wild-type isozyme UGT1A7 in insect cells, overview; expression of wild-type isozyme UGT1A8 in insect cells, overview; expression of wild-type isozyme UGT1A9 and mutants in HEK-293 cells, expression of wild-type isozyme UGT1A9 in insect cells, expression levels, overview

Homo sapiens

692047

expression in HEK-293 cells; expression in HEK-293 cells; expression in HEK-293 cells; expression in HEK-293 cells; expression in HEK-293 cells; expression in HEK-293 cells; expression in HEK-293 cells

Homo sapiens

672823

expression in insect cell

2 entries

expression in yeast strain AH22; expression in yeast strain AH22; expression in yeast strain AH22; expression in yeast strain AH22; expression in yeast strain AH22; expression in yeast strain AH22; expression in yeast strain AH22; expression in yeast strain AH22

Rattus norvegicus

P08542, Q64633

673287

expression of diverse isozymes in a lymphoblast expression system, overview

Homo sapiens

P19224

658527

expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells; expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells; expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells; expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells; expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells; expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells

Homo sapiens

672123

expression of His-tagged isozymes UGT1A10 or UGT1A7, and of mutant constructurs in COS-1 cells

Homo sapiens

690975

expression of isoform UGT1A4 in HEK-293 cell

Homo sapiens

719346

expression of isozyme UGT1A1 in baculovirus-infected insect cells; expression of isozyme UGT1A8 in baculovirus-infected insect cells

Homo sapiens

692045

expression of isozyme UGT1A10 as HA-tagged or CFP-fusion protein in COS cells; expression of UGT1A1 isozyme as HA-tagged or CFP-fusion protein in COS cells; expression of UGT1A3 as HA-tagged or CFP-fusion protein in COS cells; expression of UGT1A4 as HA-tagged or CFP-fusion protein in COS cells; expression of UGT1A6 as HA-tagged or CFP-fusion protein in COS cells; expression of UGT1A7 as HA-tagged or CFP-fusion protein in COS cells; expression of UGT1A8 as HA-tagged or CFP-fusion protein in COS cells; expression of UGT1A9 isozyme as HA-tagged or CFP-fusion protein in COS cells

Homo sapiens

693020

expression of isozyme UGT1A10 in insect cells using the baculovirus infection system; expression of isozyme UGT1A1 in insect cells using the baculovirus infection system; expression of isozyme UGT1A3 in insect cells using the baculovirus infection system; expression of isozyme UGT1A4 in insect cells using the baculovirus infection system; expression of isozyme UGT1A6 in insect cells using the baculovirus infection system; expression of isozyme UGT1A7 in insect cells using the baculovirus infection system; expression of isozyme UGT1A8 in insect cells using the baculovirus infection system; expression of isozyme UGT1A9 in insect cells using the baculovirus infection system; expression of isozyme UGT2B15 in insect cells using the baculovirus infection system; expression of isozyme UGT2B17 in insect cells using the baculovirus infection system; expression of isozyme UGT2B4 in insect cells using the baculovirus infection system; expression of isozyme UGT2B7 in insect cells using the baculovirus infection system

Homo sapiens

O75795

658529

expression of isozyme UGT1A4 in Spodoptera frugiperda Sf9 cell microsomal membranes, expression analysis, overview; expression of isozyme UGT2B10 in Spodoptera frugiperda Sf9 cell microsomal membranes, expression analysis, overview

Homo sapiens

P36537

694256

expression of isozyme UGT1A9 lacking 45 residues of the C-terminus including the trans-membrane helix, enzyme mutant is His6-tagged at the shortened C-terminus, detergent-free expression as soluble protein in insect cells

Homo sapiens

659971

expression of isozyme UGT2B7 as a His-tagged protein in baculovirus-infected insect cells

Homo sapiens

691811

expression of isozymes in COS-1 cells; expression of isozymes in COS-1 cells; expression of isozymes in COS-1 cells; expression of isozymes in COS-1 cells, DNA sequence determination and analysis of isozyme UGT1A9

Homo sapiens

O60656, P22309, Q9HAW7, Q9HAW9

659315

expression of isozymes UGT1A1, UGT1A6, and UGT1A9 in HEK-293 cells

Homo sapiens

O60656

692035

expression of several human isozymes in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method

Homo sapiens

694249

expression of theUGT 1 locus in transgenic mice provides only a unique opportunity to examine the regulatory properties that control the tissue-specific and xenobiotic receptor-elicited expression patterns of the individual UGT1A genes and also enriches an understanding of how the UGT1 locus may be regulated at times where changes are apparent in the physiological levels of circulating hormones; expression of theUGT1 locus in transgenic mice provides only a unique opportunity to examine the regulatory properties that control the tissue-specific and xenobiotic receptor-elicited expression patterns of the individual UGT1A genes and also enriches an understanding of how the UGT1 locus may be regulated at times where changes are apparent in the physiological levels of circulating hormones; expression of theUGT1 locus in transgenic mice provides only a unique opportunity to examine the regulatory properties that control the tissue-specific and xenobiotic receptor-elicited expression patterns of the individual UGT1A genes and also enriches an understanding of how the UGT1 locus may be regulated at times where changes are apparent in the physiological levels of circulating hormones

Homo sapiens

674497

expression of UGT isozymes in COS-1 cells with co-localization of isozyme UGT1A7His and PKCepsilon and of isoyzme UGT1A10His andPKCalpha orPKCgamma

Homo sapiens

693111

expression of UGT1A and UGT2B isozymes in HEK293 cells

Homo sapiens

659571

expression of UGT1A10 in baculovirus-infected Sf9 insect cells as His-tagged protein

Homo sapiens

677147

expression of wild-type and mutant D256N enzymes in COS-1 cells

Homo sapiens

O60656

659783

expression of wild-type and mutant isozymes as C-terminal Histagged fusion proteins in baculovirus-infected insect cells, expression levels, overview

Homo sapiens

694254

expression of wild-type and mutant isozymes in Pichia pastoris; expression of wild-type and mutant isozymes in Pichia pastoris; expression of wild-type and mutant isozymes in Pichia pastoris; expression of wild-type and mutant isozymes in Pichia pastoris

Homo sapiens

P19224, P22310

693017

expression of wild-type isozyme UGR2B15, and of chimeric mutants in HEK-293 cells; expression of wild-type isozyme UGT2B7, and of chimeric mutants in HEK-293 cells

Homo sapiens

P54855

690847

functional expression of FLAG-tagged enzymes GlcAT-P and GlcAT-S in Escherichia coli strain BL21 as soluble proteins

Homo sapiens

660431

gene UGT1A1, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview; gene UGT1A4, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview; gene UGT1A9, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview; gene UGT2B7, expression analysis and mRNA levels in healthy and hepatitis B virus-positive liver microsomes, overview

Homo sapiens

O60656, P16662, P22309, P22310

737080

gene UGT1A10, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A1, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A3, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A4, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A5, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A6, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A7, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A8, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As; gene UGT1A9, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As

Homo sapiens

736010

gene UGT1A10, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A11, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A1, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A2, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A3, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A4, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A6, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A7, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A8, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As; gene UGT1A9, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As

Canis lupus familiaris

F1PJF0, P56592, Q29476, Q95M37, Q9N280

736010

gene UGT1A3, recombinant expression of His-tagged enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection; gene UGT1A4, recombinant expression of His-tagged enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection; gene UGT2B10, recombinant expression of His-tagged enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection

Homo sapiens

736005

gene UGT2A1, recombinant expression of C-terminally His-tagged enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection; gene UGT2A1, recombinant expression of C-terminally His-tagged enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection; gene UGT2A1, recombinant expression of C-terminally His-tagged enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection

Homo sapiens

Q6UWM9, Q9Y4X1

736006

gene UGT2A3, located on chromosome 4q13, DNA and amino acid sequence determination and analysis, the UGT2A3 proximal promoter contains putative HNF1alpha, CDX2, PXR, and GR consensus elements, sequence comparisons, expression of UGT2A3 in Spodoptera frugiperda SF21 cells using the baculovirus transfection system

Homo sapiens

Q6UWM9

694264

gene UGT2B10, recombinant expressin in HEK-293T cells

Homo sapiens

P36537

736012

gene UGT2B7, DNA and amino acid sequence determination and analysis, genotyping, three non-synonymous single nucleotide polymorphisms are identified, expression of CFP-tagged, YFP-tagged and HA-tagged UGT2B7 wild-type and mutant allozymes in Spodoptera frugiperda Sf9 cells via baculovirus transfection

Homo sapiens

735648

heterologous expression in insect Sf9 cells; heterologous expression in insect Sf9 cells

Homo sapiens

673582

heterologously expression in Saccharomyces cerevisiae

2 entries

isoform UGT1A, expression in HEK-293T cell

Homo sapiens

718805

isoform UGT1A10, expression in insect cell; isoform UGT1A6, expression in insect cell

Homo sapiens

702016

isozyme UGT1A10, realtime expression analysis in healthy and malignant breast tissue samples from African American and Caucasian women, overview; isozyme UGT2B7, realtime expression analysis in healthy and malignant breast tissue samples from African American and Caucasian women, overview

Homo sapiens

P36537

695149

isozyme UGT1A3, DNA and amino acid sequence determination and analysis, overexpression of isozymes UGT1A3 and UGT1A8 in HEK-293 cells; isozyme UGT1A3, DNA and amino acid sequence determination and analysis, overexpression of isozymes UGT1A3 and UGT1A8 in HEK-293 cells; isozyme UGT1A3, DNA and amino acid sequence determination and analysis, overexpression of isozyme UGT1A3 in HEK-293 cells; overexpression of isozyme UGT1A8 in HEK-293 cells

Homo sapiens

P22309, Q9HAW9

692033

isozyme UGT1A4, DNA and amino acid sequence determination and analysis, expression of isozyme UGT1A4 in COS-7 cells, analysis of polymorphisms naturally occuring in a Japanese population

Homo sapiens

658530

isozyme UGT2B15, sequence comparisons, realtime PCR expression analysis; isozyme UGT2B17, sequence comparisons, realtime PCR expression analysis

Homo sapiens

693011

phylogenetic tree of the 18 human UDP-glucuronosyltransferases; phylogenetic tree of the 18 human UDP-glucuronosyltransferases; phylogenetic tree of the 18 human UDP-glucuronosyltransferases

Homo sapiens

693883

realtime RT-PCR analysis

Homo sapiens

692053

recombinant UGT1A5, expressed in baculovirusinfected insect cells

Homo sapiens

675594

rhesus UGT1A1 expressed in HK-293 cells

Macaca mulatta

488797

several UGT cloned. Persistently increased expression of phenol-UGT in rat hepatocyte nodules, hepatoma H4IIE cells and various rat liver epithelial cell lines. Expressed in human lung carcinoma A549 cells and human breast cancer MCF7 cells

Homo sapiens

488777

stable expression in HEK293 cells, 2 allelic variants UGT2B7H268 and UGT2B7Y268

Homo sapiens

P16662

658558

stable expression of isozyme UGT2B7 Tyr268 variant in HEK-293 cells

Homo sapiens

694261

stable expression of isozymes UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, UGT2B15, UGT2B17, and UGT2B28 in HEK-293 cells

Homo sapiens

690855

stable expression of isozymes UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT1A10, and UGT2B7 in HEK 293 cells, isozymes UGT2B4, UGT2B7, UGT2B10, and UGT2B15 are inactivated during cell lysis for microsome preparation

Homo sapiens

658515

stable HEK293 cell lines overexpressing either the UGT1A10139Glu or UGT1A10139Lys isoforms are created

Homo sapiens

O75795, P54855

673300

the largest subfamily UGT2B is encoded by genes clustered on chromosome 4, most isozymes show genetic polymorphisms

Homo sapiens

P22309

691934

transiently expressed in COS-7 cells and stably expressed in V-79 Chinese hamster lung fibroblasts. 7 human liver UDG-GT cDNA clones isolated

Homo sapiens

488778

Ugt1a enzymes expression analysis in blastocysts, overview

Mus musculus

Q64435

736008

UGT1A1 expressed in HK-293 cells

Platyrrhini

488795

UGT1A1 expressed in HK293 cells

Homo sapiens

488795

UGT1A1 that contains the Y486D mutation (1A1 numbering) is expressed as His-tagged protein in thebaculovirus-infected insect cells; UGT1A6 that contains the Y485D is expressed as His-tagged protein in thebaculovirus-infected insect cells

Homo sapiens

676314

UGT1A3 expressed in COS-7 cells

Homo sapiens

488781

UGT1A71, UGT1a6 and UGT1A4 expressed in COS-1 cells

Oryctolagus cuniculus

488782

UGT2B7 expressed in COS-1 and COS-7 cells. UGT from both UGT1A and UGT1B families expressed in colon carcinoma cells Caco-2

Homo sapiens

488794

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all-trans-retinoic acid appears to downregulate UGT2B7 expression

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. Induction of UGT1A1 in keratinocytes by UV radiation-generated 6-formylindolo[3,2-b]carbazole, which is a potent activator of AhR transcription factor. Induction of UGT1A1 in the neonatal period is controlled in part by a cluster of 6 transcription factor response elements, termed gtPBREM (phenobarbital-responsive enhancer module) binding CAR, PXR, AhR, NRF2, PPARa and glucocorticoid receptor; bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. Intestinal UGT1A6 expression and serotonin glucuronidation is induced by activation of the AhR and Nrf2, the genetically-linked master regulator of the antioxidant response

Homo sapiens

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

735649

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A71S

Homo sapiens

naturally occuring mutation, non-synonymous single nucleotide polymorphism

735648

C127C

Homo sapiens

mutation results in loss of UGT1A1 activity

671843

C156R

Homo sapiens

mutation results in loss of UGT1A1 activity

671843

C177Y

Homo sapiens

mutation results in loss of UGT1A1 activity

671843

C186C

Homo sapiens

although the activity of the C186Y mutant UGT1A1 is reduced to 50% of normal, the enzyme activity increases proportionately in the presence of UDPGlcNAc

671843

C186Y

Homo sapiens

45% of wild-type activity with bilirubin as substrate

671843

C223Y

Homo sapiens

mutation results in loss of UGT1A1 activity

671843

C280Y

Homo sapiens

mutation results in loss of UGT1A1 activity

671843

C384Y

Homo sapiens

mutation results in loss of UGT1A1 activity

671843

C509Y

Homo sapiens

75% of wild-type activity with bilirubin as substrate

671843

C510Y

Homo sapiens

80% of wild-type activity with bilirubin as substrate

671843

C517Y

Homo sapiens

85% of wild-type activity with bilirubin as substrate

671843

D143A

Homo sapiens

increase in substrate inhibition with 4-methylumbelliferone, large decrease in Vmax

706582

D145A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

D148A

Homo sapiens

large decrease in Vmax

706582

D150A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6, inactive mutant

693017

D152A

Homo sapiens

site-directed mutagenesis, exchange of a conserved residue from isozyme UGT1A9 for the corresponding residue in isozyme UGT1A8, the mutant shows altered substrate specificity compared to wild-type isozyme UGT1A9, the mutant is active with the substrate 3-hydroxydesloratadine specific for isozyme UGT1A8

692047

D357A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

D394A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to slightly reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

D396A

Homo sapiens

mutation in isoform UGT1A10, activity toward substrates 5-diethylaminoethylamino-8-hydroxyimidazoacridinone and 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone is decreased by 30% and increased by 25%, respectively

719349

D397A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

D398N

Homo sapiens

naturally occuring mutation, non-synonymous single nucleotide polymorphism

735648

D420A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

D447A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to highly reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

D454A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

D488A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6, inactive mutant

693017

D85Y

Homo sapiens

naturally occuring polymorphism in UGT2B15 gene, Vmax of the Y allele is approximately twofold greater than the enzyme resulting from the D allele

693883

E139K

Homo sapiens

O75795, P54855

the nonconservative amino change of Glu to Lys at codon 139 renders UGT1A10 less active

673300

E241A

Homo sapiens

replacement of amino acid to corresponding residue of isoform UGT1A8; site-directed mutagenesis, exchange of a conserved residue from isozyme UGT1A9 for the corresponding residue in isozyme UGT1A8, the mutant shows altered substrate specificity compared to wild-type isozyme UGT1A9

692047

E287A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to 1.4fold reduced glucuronidation activity compared to the wild-type enzyme

693017

E289A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to 3.2fold reduced glucuronidation activity compared to the wild-type enzyme

693017

E297A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to 2.0fold reduced glucuronidation activity compared to the wild-type enzyme

693017

E314A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to 7.0fold reduced glucuronidation activity compared to the wild-type enzyme

693017

E378A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to 150fold reduced glucuronidation activity compared to the wild-type enzyme

693017

E378D

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

E378S

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

E461A

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to 350fold reduced glucuronidation activity compared to the wild-type enzyme

693017

E461D

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

E461Q

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

E461S

Homo sapiens

P19224, P22310

site-directed mutagenesis, mutation of isozyme UGT1A6 leading to reduced glucuronidation activity and altered kinetics compared to the wild-type enzyme

693017

F33L

Homo sapiens

mutation suppresses the activity towards hyodeoxycholic acid, and impairs the glucuronidation of several substrates, including 4-hydroxyestrone and 17-epiestriol

673582

F33Y

Homo sapiens

activity is similar to wild-type UGT2B4. Tyrosine is found at position 33 of UGT2B7

673582

F83L

Homo sapiens

mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity

F90A

F90L

F93A

F93L

G71R

mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity

719760

H268Y

Homo sapiens

naturally occuring mutation, non-synonymous single nucleotide polymorphism

735648

H369A

Homo sapiens

site-directed mutagenesis of isozyme UGT1A9, the Km values for scopoletin and UDP-D-glucuronate are increased compared to the wild-type isozyme, the mutant shows impaired cosubstrate binding

694254

H371A

Homo sapiens

site-directed mutagenesis of isozyme UGT1A6, the Km values for scopoletin and UDP-D-glucuronate are increased by 4 and 11fold, respectively, compared to the wild-type isozyme, the mutant shows severely impaired cosubstrate binding

694254

H377A

Homo sapiens

site-directed mutagenesis of isozyme UGT1A9, inactive mutant

694254

H379A

Homo sapiens

site-directed mutagenesis of isozyme UGT1A6, the Km values for scopoletin and UDP-D-glucuronate are increased compared to the wild-type isozyme, the mutant shows severely impaired cosubstrate binding

694254

H37A

Homo sapiens

H37 is not critical in N-glucuronidation, but in O-glucuronidation. 99% decrease in Vmax with substrate UDP-glucuronate

706582

H37D

Homo sapiens

H37 is not critical in N-glucuronidation, but in O-glucuronidation

706582

H37L

Homo sapiens

mutant of isoform UGT1A9, abolishes activity towards all substrates tested except retigabine

718805

H37P

2 entries

H37Q

Homo sapiens

mutant of isoform UGT1A9, abolishes activity towards all substrates tested except retigabine

718805

H38P

Homo sapiens

isoform UGT1A6, mutant lacks the ability to metabolize 4-methylumbeliferone, 1-naphthol, and naproxen

H39P

H40P

site-directed mutagenesis, replacing of His40 residue of isozyme UGT1A3 with proline shifts the substrate specificity toward that of isozyme UGT1A4 with loss of glucuronidation of phenolic substrates

693017

I294T

Homo sapiens

mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity

719760

I96R

Homo sapiens

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

I96R/T98I

Homo sapiens

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

I98T

Homo sapiens

UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

K75R

Homo sapiens

single nucleotide polymorphism, about 25% decrease in glucuronidation activity

720625

K91M/A92D

Homo sapiens

replacement of amino acid to corresponding residue of isoform UGT1A8; site-directed mutagenesis, exchange of conserved residues from isozyme UGT1A9 for the corresponding residues in isozyme UGT1A8, the mutant shows altered substrate specificity compared to wild-type isozyme UGT1A9

L173A

L219F/H221Q/R222Y

L48V

naturally occuring polymorphism, increased activity with trans-androsterone, imipramine, and cyproheptadine, less active with tigogenin as compared to the wild-type enzyme

658530

L93I

Homo sapiens

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

M33I

Homo sapiens

mutant of isoform UGT1A9, increase in both Km and Vmax value

718805

M33Q

Homo sapiens

mutant of isoform UGT1A9, increase in both Km and Vmax value

718805

M33T

Homo sapiens

mutant of isoform UGT1A9, increase in both Km and Vmax value

718805

M33V

Homo sapiens

mutant of isoform UGT1A9, increase in both Km and Vmax value

718805

M59I

Homo sapiens

mutation in isozyme UGT1A10, site-directed mutagenesis, activity similar to the wild-type enzyme

658519

N152A

Homo sapiens

replacement of amino acid to corresponding residue of isoform UGT1A8, increase in Km and Vmax values for substrates 4-methylumbelliferone and 4-nitrophenol. Active against substrate 3-hydroxydesloratadine, specifc substrate of isoform UGT1A8

692047

N400D

Homo sapiens

mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity

719760

P40H

Homo sapiens

P19224, P22310

site-directed mutagenesis, replacing Pro-40 of isozyme UGT1A4 by histidine expands the glucuronidation activity of the enzyme to phenolic and carboxylic compounds, therefore, leading to UGT1A3-type isoform in terms of substrate specificity

693017

Q357R

Homo sapiens

mutation results in loss of UGT1A1 activity

671843

R336L

Homo sapiens

mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity

719760

R42Q

Homo sapiens

replacement of amino acid to corresponding residue of isoform UGT1A8, increase in Km value for substrates 4-methylumbelliferone and 4-nitrophenol; site-directed mutagenesis, exchange of a conserved residue from isozyme UGT1A9 for the corresponding residue in isozyme UGT1A8, the mutant shows altered substrate specificity compared to wild-type isozyme UGT1A9

692047

R96I

Homo sapiens

UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

R96I/I98T

Homo sapiens

UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

S100G

Homo sapiens

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

S132A

Homo sapiens

protein kinase C-site mutant, activity similar to wild-type

702049

S132A/S437A

Homo sapiens

protein kinase C-site mutant, activity similar to wild-type

702049

S432G

Homo sapiens

mutant enzyme retains full activity, shift in pH-optimum for glucuronidation of eugenol from pH 6.0 for wild-type enzyme to 6.4 for mutant enzyme S432G; shift in pH-optimum for glucuronidation of eugenol from pH 8.5 for wild-type enzyme to 6.4 for mutant enzyme S432G. S432G-UGT1A7, but not wild-type UGT1A7, metabolizes new substrates, 17beta-estradiol, flurbiprofen, and estriol

676792

S437A

Homo sapiens

protein kinase C-site mutant, activity similar to wild-type

702049

T123A

Homo sapiens

protein kinase C-site mutant, activity similar to wild-type

702049

T123A/S132A

Homo sapiens

protein kinase C-site mutant, activity similar to wild-type

702049

T123A/S132A/S437A

Homo sapiens

protein kinase C-site mutant, activity similar to wild-type

702049

T123A/S437A

Homo sapiens

protein kinase C-site mutant, activity similar to wild-type

702049

T202A

Homo sapiens

inactive mutant enzyme; inactive mutant enzyme

676792

T202I

Homo sapiens

mutation in isozyme UGT1A10, site-directed mutagenesis, about 50% reduced activity compared to the wild-type enzyme

658519

T497A

Homo sapiens

Q6UWM9

naturally occuring polymorphism, approximately 10% of clones contains a A1489G nucleotide substitution, yielding proteins with a residue 497 alanine in UGT2A3.2 instead of a threonine in UGT2A3.1. The allele frequency of this polymorphism rs13128286 was 0.13 in a European-American population as determined by direct DNA sequencing, UGT2A3 allozymes vary in hyodeoxycholic acid glucuronidation kinetics, overview

694264

T73A

Homo sapiens

inactive mutant enzyme; inactive mutant enzyme

676792

T98I

Homo sapiens

UGT2B17 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone; UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

V92A

2 entries

W461R

Homo sapiens

mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity

719760

Y106F/G111S/D115G

Homo sapiens

replacement of amino acid to corresponding residue of isoform UGT1A8, increase in Vmax value for substrates 4-methylumbelliferone and 4-nitrophenol; site-directed mutagenesis, exchange of conserved residues from isozyme UGT1A9 for the corresponding residues in isozyme UGT1A8, the mutant shows altered substrate specificity compared to wild-type isozyme UGT1A9

692047

Y236F

Homo sapiens

tyrosine kinase-sites mutants, inactive

702049

Y33F

Homo sapiens

mutation exhibits similar or even somewhat higher activities than wild type UGT2B7. Phenylalanine is found at position 33 of UGT2B4

673582

Y33L

Homo sapiens

mutation strongly reduces the activity towards all the tested substrates, with the exception of 17-epiestriol

673582

Y438F

Homo sapiens

tyrosine kinase-sites mutants, inactive

702049

Y485D

Homo sapiens

mutation lowers the normalized glucuronidation rate to 6% when the aglycone substrate is 1-naphthol. Km of the mutant enzyme for UDP-glucuronic acid is about 50 times higher than in UGT1A6. Coexpression of UGT1A6(Y485D) with UGT1A4 lowers the Km for UDP-glucuronic acid to the level of UGT1A6

676314

Y486D

Homo sapiens

mutation lowers the normalized glucuronidation rate to 13% when the aglycone substrate is 1-naphthol

676314

A235V

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C704T, naturally occuring polymorphism of isozyme UGT1A4

676313

A26V

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C77T, naturally occuring polymorphism of isozyme UGT1A5B

676313

A432G

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A10A

676313

A483G

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A4

676313

A498T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

G1492A, naturally occuring polymorphism of isozyme UGT1A4

676313

A58V

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C173T, naturally occuring polymorphism of isozyme UGT1A2A

676313

A7G

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C20G, naturally occuring polymorphism of isozyme UGT1A6

676313

A966C

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A4; naturally occuring polymorphism of isozyme UGT1A5A

676313

C117T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A2A

676313

C1494T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A1; naturally occuring polymorphism of isozyme UGT1A1; naturally occuring polymorphism of isozyme UGT1A1

676313

C1497T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5A

676313

C1545T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5A

676313

C489T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A10A

676313

C639T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5A

676313

C663T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A9

676313

C702T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A4

676313

C966A

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5B

676313

G12C

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A6

676313

G1368T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5B

676313

G174A

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5A

676313

G399A

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A10A

676313

G720A

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A10A

676313

G804A

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A4

676313

H225D

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C673G, naturally occuring polymorphism of isozyme UGT1A5A

676313

K30N

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

G90C, naturally occuring polymorphism of isozyme UGT1A2A

676313

M214V

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

A640G, naturally occuring polymorphism of isozyme UGT1A5A

676313

N276S

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

A827G, naturally occuring polymorphism of isozyme UGT1A9

676313

P219T

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C655A, naturally occuring polymorphism of isozyme UGT1A6

676313

R516W

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C1546T, naturally occuring polymorphism of isozyme UGT1A4

676313

R51S

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

G153T, naturally occuring polymorphism of isozyme UGT1A7

676313

R91H

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

G272A, naturally occuring polymorphism of isozyme UGT1A4

676313

T1368G

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5A

676313

T1497C

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A4

676313

T1545C

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5B

676313

T646C

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5B

676313

T702C

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A5B

676313

T750C

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

naturally occuring polymorphism of isozyme UGT1A4; naturally occuring polymorphism of isozyme UGT1A5A

676313

V24G

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

T71G, naturally occuring polymorphism of isozyme UGT1A6

676313

V56F

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

G166T, naturally occuring polymorphism of isozyme UGT1A9

676313

W512R

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

C1534T, naturally occuring polymorphism of isozyme UGT1A10A

676313

Y216H

Papio anubis

Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6

T648C, naturally occuring polymorphism of isozyme UGT1A5B

676313

I96R

Platyrrhini

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

I96R/T98I

Platyrrhini

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

I98T

Platyrrhini

UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

L93I

Platyrrhini

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

R96I

Platyrrhini

UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

R96I/I98T

Platyrrhini

UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

488791

S100G

Platyrrhini

UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone

T98I

D446A

UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid

488787

D446E

Rattus norvegicus

UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid

488787

D446G

Rattus norvegicus

UGT1A6 activity not detected for 1-naphthol nor UDP-glucuronic acid

488787

D446K

Rattus norvegicus

UGT1A6 activity not detected for 1-naphthol nor UDP-glucuronic acid

488787

D446N

Rattus norvegicus

UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid

488787

D446q

Rattus norvegicus

UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid

488787

D446T

Rattus norvegicus

UGT1A6 activity retained for 1-naphthol nor UDP-glucuronic acid

488787

additional information

14 entries

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phospholipid required for reconstitution

Homo sapiens

488761

reactivation of lipid-depleted enzyme

Cavia porcellus

488729

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analysis

Homo sapiens

after infection of Sf9 insect cells with increasing amounts of recombinant baculovirus, encoding either UGT1A9 or UGT2B7, the correlation between glucuronidation rates and degree of infection follows different trends, depending on whether activity is the actual activity measured or is corrected for UDP-glucuronosyltransferase expression level. Above a certain low level of infection, further increases in infection ratios lead to a large decline in normalized activity, presumably due to the presence of full-length but inactive enzyme in the sample. Inaccuracies in comparison of normalized activity between different batches of a recombinant UDP-glucuronosyltransferase can be reduced by lowering the degree of infection of the insect cells, in combination with careful monitoring of UDP-glucuronosyltransferase expression. Poly-His-containing peptides, fused to the UDP-glucuronosyltransferase C-terminus, allow sensitive immunodetection of expressed enzymes with monoclonal antibodies. A minor increase in the Km values has been detected in the His-tagged UDP-glucuronosyltransferases, but no changes in parameters such as the kinetic model and the effects of albumin addition

719350

diagnostics

2 entries

drug development

Homo sapiens

drug development process aims to produce safe, effective drugs within a reasonable time and at a reasonable cost. Phase II metabolism (glucuronidation) can affect drug action and pharmacokinetics to a considerable extent. Extensive glucuronidation is an obstacle to oral bioavailability because the first-pass glucuronidation or premature clearance by UDP-glucuronosyltransferases of orally administered agents frequently results in poor oral bioavailability and lack of efficacy. Modeling of chemical entities/drugs for UGTs and their kinetic data can be useful in understanding the binding patterns to be used in the design of better molecules, analysis of first-pass glucuronidation by intestinal UGTs, including their topology, expression profile, and pharmacogenomics, and substrate selectivity at the binding pocket, structural requirements, and mechanism of enzyme actions, detailed overview

736015

medicine

6 entries

pharmacology

2 entries