Information on EC 2.4.1.17 - glucuronosyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.4.1.17
-
RECOMMENDED NAME
GeneOntology No.
glucuronosyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
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-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Ascorbate and aldarate metabolism
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Drug metabolism - cytochrome P450
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Drug metabolism - other enzymes
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-
melatonin degradation I
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Metabolic pathways
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Metabolism of xenobiotics by cytochrome P450
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nicotine degradation IV
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nicotine degradation V
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Pentose and glucuronate interconversions
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Porphyrin and chlorophyll metabolism
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Retinol metabolism
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saponin biosynthesis II
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serotonin degradation
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Starch and sucrose metabolism
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Steroid hormone biosynthesis
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thyroid hormone metabolism II (via conjugation and/or degradation)
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-
SYSTEMATIC NAME
IUBMB Comments
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
CAS REGISTRY NUMBER
COMMENTARY hide
37205-52-0
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37277-52-4
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37277-66-0
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61969-98-0
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62213-43-8
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62213-47-2
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9030-08-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
domestic guinea pig
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
rhesus monkey
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Manually annotated by BRENDA team
overview
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Manually annotated by BRENDA team
rainbow trout
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
R/A Pfd strain
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Manually annotated by BRENDA team
produces gellan gum
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
substrate for isoforms UGT1A9 and UGT1A10
-
-
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10
-
-
?
(-)-borneol + UDP-glucuronate
UDP + (-)-borneol-O-alpha-D-glucuronide
show the reaction diagram
-
-
-
?
(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(R)-propanolol + UDP-glucuronate
UDP + (R)-propanolol O-glucuronide
show the reaction diagram
-
-
-
-
?
(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
(S)-naproxen D-glucuronide
show the reaction diagram
-
-
-
-
?
(S)-propanolol + UDP-glucuronate
UDP + (S)-propanolol O-glucuronide
show the reaction diagram
-
-
-
-
?
1-hydroxy-benzo(a)pyrene + UDP-glucuronate
1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
1-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
1-hydroxypyrene 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
1-hydroxy[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide
show the reaction diagram
-
-
-
-
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl O-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl-O-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
1-naphthol + UDP-glucuronate
1-naphthyl 1-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
1-naphthol + UDP-glucuronate
1-naphthyl-O-glucuronide + UDP
show the reaction diagram
-
-
-
?
1-naphthol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
show the reaction diagram
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
show the reaction diagram
10-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-10-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
11-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-11-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-alpha-D-glucuronate
show the reaction diagram
-
-
-
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
show the reaction diagram
12-hydroxyeicosatetraenoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
13-hydroxyoctadecadienoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
show the reaction diagram
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-alpha-D-glucuronate
show the reaction diagram
UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprogesteron-16-O-alpha-D-glucuronate
show the reaction diagram
-
-
-
?
17-epiestriol + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
17-epiestriol + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
17alpha-estradiol + UDP-alpha-D-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
17alpha-ethynylestradiol + UDP-glucuronate
UDP + 17alpha-ethynylestradiol 3-O-beta-D-glucuronide
show the reaction diagram
-
-
-
?
17beta-estradiol + UDP-alpha-D-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
17beta-estradiol + UDP-glucuronate
?
show the reaction diagram
17beta-ethynylestradiol + UDPglucuronate
?
show the reaction diagram
-
-
-
?
17beta-hydroxy-5alpha-androstan-3-one + UDPglucuronate
UDP + 17beta-hydroxy-5alpha-androstan-3-one 17O-glucuronide
show the reaction diagram
-
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
2',4,4'-trihydroxychalcone + UDP-glucuronate
UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside
show the reaction diagram
-
i.e. isoliquiritigenin
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
show the reaction diagram
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
show the reaction diagram
-
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
-
-
?
2-aminobenzoate + UDPglucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
2-aminobiphenyl + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
show the reaction diagram
2-hydroxy-2',3',4',5'-tetrachlorobiphenyl + UDPglucuronate
UDP + 2',3',4',5'-tetrachlorobiphenyl 2-O-glucuronate
show the reaction diagram
-
-
-
?
2-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-2-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
2-hydroxyestradiol + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
show the reaction diagram
2-hydroxyestrone + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
show the reaction diagram
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate
UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
show the reaction diagram
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-alpha-D-glucuronate
show the reaction diagram
-
-
-
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
show the reaction diagram
-
substrate of isoform UGT2B7
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
show the reaction diagram
3,5-dinitrocatechol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
3-azido-4-chlorobenzoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
3-azidobenzoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
3-hydroxy-benzo(a)pyrene + UDP-glucuronate
3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
3-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-3-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
show the reaction diagram
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
show the reaction diagram
4-aminobiphenyl + UDP-glucuronate
UDP + 4-aminobiphenyl N-glucuronide
show the reaction diagram
-
-
-
-
?
4-aminobiphenyl + UDPglucuronate
UDP + ?
show the reaction diagram
-
catalyzed by isozyme 1 but not by isozyme 2
-
-
?
4-azido-2-hydroxybenzoic acid + UDPglucuronate
?
show the reaction diagram
-
-
-
?
4-azidobenzoic acid + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl + UDPglucuronate
UDP + 2,3,3',4',5'-pentachlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxy-2',3,3',4',5,5'-heptachlorobiphenyl + UDPglucuronate
UDP + 2',3,3',4',5,5'-hexachlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl + UDPglucuronate
UDP + 2',3,4',5,6'-pentachlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxy-2',3,4',6'-tetrachlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxy-2',4',6'-trichlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
show the reaction diagram
-
-
-
?
4-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-4-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
show the reaction diagram
4-hydroxybiphenyl + UDPglucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
show the reaction diagram
4-hydroxyestradiol + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
show the reaction diagram
4-hydroxyestrone + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
show the reaction diagram
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
4-methylumbeliferone + UDP-alpha-D-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
show the reaction diagram
-
-
-
-
?
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
show the reaction diagram
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-beta-D-glucuronide
show the reaction diagram
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
show the reaction diagram
4-n-octylgallate + UDPglucuronate
UDP + 4-n-octylgallate 3-O-glucuronide
show the reaction diagram
-
highly specific for UGT1A71
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
show the reaction diagram
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
show the reaction diagram
5-diethylaminoethylamino-8-hydroxyimidazoacridinone + UDP-alpha-D-glucuronate
5-{[2-(diethylamino)ethyl]amino}-6-oxo-6H-imidazo[4,5,1-de]acridin-8-yl beta-D-glucuronide + UDP
show the reaction diagram
-
i.e. antitumor agent C-1311, NSC-645809
-
-
?
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone + UDP-alpha-D-glucuronate
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone-8-D-glucuronide + UDP
show the reaction diagram
-
i.e. antitumor agent C-1305
-
-
?
5-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-5-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
5-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 5-hydroxybenzo[a]pyrene O-glucuronide
show the reaction diagram
-
glucuronidated by UGT1A3
-
?
5-methylchrysene-1,2-diol + UDP-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
show the reaction diagram
5beta-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5beta-androstane-3alpha,17beta-diol O-glucuronide
show the reaction diagram
-
-
-
?
6-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-6-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
6-hydroxywarfarin + UDP-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
6alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
show the reaction diagram
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
show the reaction diagram
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
show the reaction diagram
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
show the reaction diagram
7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate
7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP
show the reaction diagram
7-hydroxy benzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
7-hydroxy-4-(trifluoromethyl)-coumarin + UDPglucuronate
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
show the reaction diagram
-
-
-
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate
7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP
show the reaction diagram
7-hydroxy-benzo(a)pyrene + UDP-glucuronate
7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
7-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-7-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
7-hydroxycoumarin + UDP-glucuronate
UDP + coumarin-7-yl-alpha-D-glucuronide
show the reaction diagram
-
-
-
?
7-hydroxywarfarin + UDP-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
8-hydroxy-benzo(a)pyrene + UDP-glucuronate
8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
8-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-8-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
8-hydroxyquinoline + UDPglucuronate
UDP + 8-hydroxyquinoline 8-O-glucuronide
show the reaction diagram
-
-
-
?
8-hydroxywarfarin + UDP-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
9-hydroxybenzo(a)pyrene + UDP-glucuronate
?
show the reaction diagram
9-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-9-yl-beta-D-glucuronide
show the reaction diagram
-
-
-
?
acetaminophen + UDP-glucuronate
?
show the reaction diagram
alpha-naphthylamine + UDPglucuronate
UDP + ?
show the reaction diagram
alprazolam + UDP-alpha-D-glucuronate
alprazolam D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
amitriptyline + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
androstane-3alpha,17beta diol + UDPglucuronate
UDP + androstane-3alpha,17beta diol O-glucuronide
show the reaction diagram
-
-
-
?
androsterone + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
show the reaction diagram
anthraflavic acid + UDPglucuronate
UDP + ?
show the reaction diagram
apigenin + UDPglucuronate
UDP + apigenin O-glucuronide
show the reaction diagram
benzo(a)pyrene-7,8-diol + UDP-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
benzo[a]pyrene 3,6-diphenol + UDP-glucuronate
?
show the reaction diagram
-
converted readily to mono- and diglucuronides
-
-
?
benzo[a]pyrene 3,6-quinone + UDPglucuronate
benzo[a]pyrene 3,6-quinol glucuronide + UDP
show the reaction diagram
-
-
no information to which positions 3-, 6-, or both the glucuronate is attached
?
benzo[a]pyrene-3,6-quinol + UDPglucuronate
benzo[a]pyrene 3,6-quinol mono- and diglucuronide + UDP
show the reaction diagram
-
-
-
?
benzo[a]pyrene-7,8(+)-diol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
benzo[a]pyrene-7,8(-)diol + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
beta-estradiol + UDP-alpha-D-glucuronate
beta-estradiol-3-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
show the reaction diagram
bifonazole + UDP-alpha-D-glucuronate
bifonazole D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
bilirubin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
bilirubin + UDP-glucuronate
bilirubin D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
bilirubin + UDP-glucuronate
bilirubin glucuronoside + UDP
show the reaction diagram
-
UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein)
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
show the reaction diagram
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
show the reaction diagram
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
show the reaction diagram
bisphenol A + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
borneol + UDPglucuronate
UDP + borneol O-glucuronide
show the reaction diagram
buprenorphine + UDPglucuronate
UDP + buprenorphine O-glucuronide
show the reaction diagram
cannabinol + UDP-glucuronate
? + UDP
show the reaction diagram
-
substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10
-
-
?
carvacrol + UDP-glucuronate
caervcrol O-glucuronate + UDP
show the reaction diagram
-
isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes
-
-
?
chenodeoxycholic acid + UDP-glucuronate
UDP + ?
show the reaction diagram
chenodeoxycholic acid + UDPgalacturonate
UDP + chenodeoxycholic acid O-galacturonide
show the reaction diagram
-
-
-
?
chloramphenicol + UDPglucuronate
UDP + chloramphenicol O-glucuronide
show the reaction diagram
cholic acid + UDPglucuronate
cholic acid O-glucuronide
show the reaction diagram
-
-
-
?
chrysin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
clofibrate + UDPglucuronate
UDP + ?
show the reaction diagram
codeine + UDPglucuronate
codeine-6-glucuronide + UDP
show the reaction diagram
-
glucuronidated by HGT2B7H and HGT2B7Y
-
-
deferiprone + UDP-glucuronate
deferiprone 3-O-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
deoxycholic acid + UDPglucuronate
UDP + deoxycholic acid O-glucuronide
show the reaction diagram
-
-
-
?
dibenzo(a,l)pyrene-11,12-diol + UDP-glucuronate
? + UDP
show the reaction diagram
-
-
-
-
?
diclofenac + UDP-alpha-D-glucuronate
diclofenac D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
diclofenac + UDPglucuronate
UDP + ?
show the reaction diagram
digitoxigenin + UDPglucuronate
UDP + digitoxigenin O-glucuronide
show the reaction diagram
-
-
-
?
dihydromorphine + UDPglucuronate
UDP + dihydromorphine O-glucuronide
show the reaction diagram
-
-
-
?
dihydromorphone + UDPglucuronate
UDP + dihydromorphone O-glucuronide
show the reaction diagram
-
-
-
?
dihydrotestosterone + UDP-alpha-D-glucuronate
dihydrotestosterone D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
dihydrotestosterone + UDPglucuronate
UDP + dihydrotestosterone O-glucuronide
show the reaction diagram
-
-
-
?
econazole + UDP-alpha-D-glucuronate
econazole D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
edaravone + UDP-alpha-D-glucuronate
edaravone beta-D-glucuronate + UDP
show the reaction diagram
-
i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7
-
-
?
epicatechin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
show the reaction diagram
epitestosterone + UDP-glucuronate
UDP + epitestosterone O-glucuronide
show the reaction diagram
-
glucuronidated by HGT2B7H and HGT2B7Y
-
?
estradiol + UDP-alpha-D-glucuronate
estradiol 3-O-glucuronate + UDP
show the reaction diagram
sigmoidal kinetics with n of 1.7
-
-
?
estradiol + UDP-alpha-D-glucuronate
UDP + estradiol 3-O-glucuronide
show the reaction diagram
-
substrate of isoform UGT1A1
-
-
?
estradiol + UDP-glucuronate
?
show the reaction diagram
estradiol + UDP-glucuronate
estradiol 3-O-glucuronate + UDP
show the reaction diagram
sigmoidal kinetics with n of 1.7
-
-
?
estradiol + UDPglucuronate
UDP + estradiol O-glucuronide
show the reaction diagram
-
-
-
?
estradiol-17alpha + UDPglucuronate
UDP + 17-alpha-estradiol O-glucuronide
show the reaction diagram
-
-
-
?
estradiol-17beta + UDPglucuronate
estradiol-17beta-3-monoglucuronide + UDP
show the reaction diagram
estriol + UDP-glucuronate
?
show the reaction diagram
estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
show the reaction diagram
estrogen + UDP-glucuronate
?
show the reaction diagram
estrone + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
show the reaction diagram
ethinylestradiol + UDPglucuronate
UDP + ethinylestradiol-3-glucuronide
show the reaction diagram
-
-
-
?
etiocholanone + UDPglucuronate
UDP + etiocholanone O-glucuronide
show the reaction diagram
etoposide + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
show the reaction diagram
eugenol + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
eugenol + UDP-glucuronate
UDP + eugenol-O-alpha-D-glucuronide
show the reaction diagram
-
-
-
-
?
fluconazole + UDP-alpha-D-glucuronate
fluconazole D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
flurbiprofen + UDP-glucuronate
?
show the reaction diagram
-
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
-
-
?
frusemide + UDP-alpha-D-glucuronate
frusemide D-glucuronide
show the reaction diagram
-
-
-
-
?
glycolithocholic acid + UDPglucuronate
UDP + glycolithocholic acid O-glucuronide
show the reaction diagram
-
lowest activity among five bile acids studied
-
?
hyodeoxycholic acid + UDP-glucuronate
?
show the reaction diagram
hyodeoxycholic acid + UDPglucuronate
UDP + hyodeoxycholic acid O-glucuronide
show the reaction diagram
ibuprofen + UDPglucuronate
UDP + ?
show the reaction diagram
imipramine + UDPglucuronate
UDP + ?
show the reaction diagram
itraconazole + UDP-alpha-D-glucuronate
?
show the reaction diagram
-
-
-
-
?
ketoconazole + UDP-alpha-D-glucuronate
?
show the reaction diagram
-
-
-
-
?
lamotrigine + UDP-alpha-D-glucuronate
lamotrigine D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
lamotrigine + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
lithocholic acid + UDPglucuronate
UDP + ?
show the reaction diagram
lorazepam + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
miconazole + UDP-alpha-D-glucuronate
miconazole D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
midazolam + UDP-alpha-D-glucuronate
midazolam D-glucuronide + UDP
show the reaction diagram
-
-
-
-
?
milnacipran + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
morphine + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
show the reaction diagram
morphine + UDP-glucuronate
UDP + morphine 3-glucuronide + morphine 6-glucuronide
show the reaction diagram
-
-
-
-
?
mycophenolate + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
mycophenolic acid + UDP-alpha-D-glucuronate
mycophenolic acid D-glucuronide
show the reaction diagram
-
-
-
-
?
N-hydroxy-2-acetylaminofluorene + UDPglucuronate
UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide
show the reaction diagram
-
glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives
-
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
show the reaction diagram
nalorphine + UDPglucuronate
UDP + nalorphine O-glucuronate
show the reaction diagram
-
-
-
?
naloxone + UDPglucuronate
UDP + naloxone O-glucuronide
show the reaction diagram
-
-
-
?
naltrexone + UDPglucuronate
UDP + naltrexone O-glucuronide
show the reaction diagram
-
-
-
?
naproxen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
octylgallate + UDPglucuronate
?
show the reaction diagram
-
-
-
?
olanzapine + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
opiates + UDPglucuronate
opiates 6-O-glucuronides + UDP
show the reaction diagram
-
substrate for UGT2B7
-
-
oxazepam + UDP-glucuronate
?
show the reaction diagram
-
-
-
-
?
oxymorphone + UDPglucuronate
UDP + oxymorphone O-glucuronide
show the reaction diagram
-
-
-
?
p,p'-biphenyl + UDPglucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
p-ethoxyphenylurea + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
show the reaction diagram
planar phenols + UDPglucuronate
UDP + phenylglucuronides
show the reaction diagram
-
expressed before birth
-
-
-
profen + UDPglucuronate
UDP + ?
show the reaction diagram
propofol + UDP-alpha-D-glucuronate
propofol D-glucuronide
show the reaction diagram
-
-
-
-
?
propofol + UDP-alpha-D-glucuronate
UDP + estradiol O-glucuronide
show the reaction diagram
-
substrate of isoform UGT1A9
-
-
?
propofol + UDP-glucuronate
UDP + propofyl beta-D-glucuronide
show the reaction diagram
-
-
-
?
quercetin + UDPglucuronate
UDP + quercetin O-glucuronide
show the reaction diagram
retigabine + UDP-alpha-D-glucuronate
retigabine D-glucuronide
show the reaction diagram
-
-
-
-
?
retigabine + UDP-glucuronate
UDP + retigabine N-glucuronide
show the reaction diagram
-
-
-
-
?
scopoletin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
scopoletin + UDP-glucuronate
UDP + scopoletin O-glucoside
show the reaction diagram
very low rate of glucuronidation
-
-
?
scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
show the reaction diagram
-
-
-
-
?
scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
show the reaction diagram
senecionine + UDP-alpha-D-glucuronate
senecionine N-glucuronide + UDP
show the reaction diagram
-
senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics
-
-
?
serotonin + UDP-glucuronate
?
show the reaction diagram
-
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
show the reaction diagram
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
show the reaction diagram
sulconazole + UDP-alpha-D-glucuronate
sulconazole D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
sulfinpyrazone + UDP-alpha-D-glucuronate
sulfinpyrazone D-glucuronide
show the reaction diagram
-
-
-
-
?
tamoxifen + UDP-alpha-D-glucuronate
tamoxifen-N-glucuronate + UDP
show the reaction diagram
-
-
-
-
-
tamoxifen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
testosterone + UDP-glucuronate
?
show the reaction diagram
testosterone + UDP-glucuronate
UDP + testosterone 17-O-glucuronide
show the reaction diagram
-
isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone-17-O-alpha-D-glucuronate
show the reaction diagram
-
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone-17alpha-glucuronide
show the reaction diagram
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
show the reaction diagram
thiophenol + UDPglucuronate
thiophenyl thio-beta-D-glucuronide + UDP
show the reaction diagram
tioconazole + UDP-alpha-D-glucuronate
tioconazole D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
tranilast + UDP-glucuronate
tranilast glucuronoside + UDP
show the reaction diagram
-
-
-
-
?
trans-4-hydroxytamoxifen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
trans-androsterone + UDP-alpha-D-glucuronate
trans-androsterone D-glucuronate + UDP
show the reaction diagram
-
-
-
-
?
trans-endoxifen + UDP-glucuronate
UDP + ?
show the reaction diagram
-
-
-
-
?
trifluoperazine + UDP-glucuronate
UDP + ?
show the reaction diagram
-
substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P
-
-
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
show the reaction diagram
UDP-alpha-D-glucuronate + 3-hydroxyflavone
UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
show the reaction diagram
isozyme UGT1A1
-
-
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid
show the reaction diagram
-
substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
-
-
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid
show the reaction diagram
-
-
substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
-
?
UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 11alpha-hydroxyprogesterone
UDP + 11alpha-hydroxyprogesterone 11-O-beta-D-glucuronoside
show the reaction diagram
an UGT2B7 substrate
-
-
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol-3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3
UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside
show the reaction diagram
among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview
-
-
?
UDP-D-glucuronate + 2-hydroxyestradiol
UDP + 2-hydroxyestradiol beta-D-glucuronoside
show the reaction diagram
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronoside
show the reaction diagram
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 2-naphthol
UDP + 2-naphthyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine 5'-O-beta-D-glucuronoside
show the reaction diagram
model substrate for determination of glucuronidation with respect to specificity, linearity, detection limit, recovery, stability, precision and accuracy, method development and validation for assay and chromatographic determination of reaction products, overview
-
-
?
UDP-D-glucuronate + 3-hydroxydesloratadine
UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside
show the reaction diagram
-
specific substrate of isozyme UGT1A8
-
-
?
UDP-D-glucuronate + 4'-hydroxy-warfarin
UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
substrate of isozyme UGT1A10
-
-
?
UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone
UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferonyl beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-O-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-O-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + acacetin
UDP + acacetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + anthraflavic acid
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + apigenin
UDP + apigenin 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + beta-D-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + bilirubin
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
show the reaction diagram
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + bisdemethoxy-curcumin
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + candesartan
UDP + candesartan beta-D-glucuronoside
show the reaction diagram
-
isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, also isozyme UGT2B7 glucuronidates candesartan at the tetrazole-N2 position, whereas isozymes UGT1A7, UGT1A8, UGT1A9, and UGT1A10 mainly yield candesartan O-glucuronide
-
-
?
UDP-D-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + chenodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + cotinine
UDP + ?
show the reaction diagram
UDP-D-glucuronate + curcumin
UDP + curcumin beta-D-glucuronoside
show the reaction diagram
-
low activity, can reverse the inhibtory effect of curcumin on UGTs
-
-
?
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + demethoxy-curcumin
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + deoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + eriodictyol
UDP + eriodictyol 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + estriol
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + estriol
UDP + estriol 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + estriol
UDP + estriol glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + eugenol
UDP + eugenol beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + flurbiprofen
UDP + flurbiprofen beta-D-glucuronoside
show the reaction diagram
-
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + frusemide
UDP + frusemide beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + hesperetin
UDP + hesperetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + homoeriodictyol
UDP + homoeriodictyol 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24-carboxy-glucuronoside
show the reaction diagram
recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
product formation depends on the isozyme, overview
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 3-O-glucuronoside
show the reaction diagram
recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
product formation depends on the isozyme, overview
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
UDP-D-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
show the reaction diagram
-
reaction of isozyme UGT1A4
-
-
?
UDP-D-glucuronate + isolongifolol
UDP + isolongifolol beta-D-glucuronoside
show the reaction diagram
-
the compound is substrate and competitive inhibitor
-
-
?
UDP-D-glucuronate + kaempferol
UDP + kaempferol 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + labetalol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + longifolol
UDP + longifolol beta-D-glucuronoside
show the reaction diagram
-
the compound is substrate and competitive inhibitor
-
-
?
UDP-D-glucuronate + losartan
UDP + losartan beta-D-glucuronoside
show the reaction diagram
-
no O-glucuronide is generated by any isozyme, while isozymes UGT1A1, UGT1A3, 1A10, UGT2B7, and UGT2B17 glucuronidate losartan at the tetrazole-N2, isozyme UGT1A10 also yields the respective N1-glucuronide, isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring
-
-
?
UDP-D-glucuronate + luteolin
UDP + luteolin 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + menadiol
UDP + mendadiol 1-O-beta-D-glucuronoside
show the reaction diagram
-
-
isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1
-
?
UDP-D-glucuronate + menadiol
UDP + mendadiol 4-O-beta-D-glucuronoside
show the reaction diagram
-
-
isoform UGT1A10, preferential formation of 4-menadiol glucuronoside, isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
show the reaction diagram
-
activity of isozyme UGT1A8
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 6-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + mycophenolate
UDP + ?
show the reaction diagram
UDP-D-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
show the reaction diagram
-
K314 and K404m are determined binding sites required for UDP-glcA binding to isozyme UGT1A10, overview
-
-
?
UDP-D-glucuronate + myricetin
UDP + myricetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + naringenin
UDP + naringenin 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + nicotine
UDP + ?
show the reaction diagram
UDP-D-glucuronate + octylgallate
UDP + octylgallate beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-glucuronoside
show the reaction diagram
an UGT2B15 substrate
-
-
?
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-monoglucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + phloretin
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + protocatechuic aldehyde
UDP + ?
show the reaction diagram
UDP-D-glucuronate + quercetin
UDP + quercetin 7-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + S-naproxen
UDP + S-naproxen beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
show the reaction diagram
isozyme UGT1A6
-
-
?
UDP-D-glucuronate + serotonin
UDP + serotonin O-beta-D-glucuronoside
show the reaction diagram
-
reaction of isozyme UGT1A6
-
-
?
UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + testosterone
UDP + testosterone 17-O-beta-D-glucuronoside
show the reaction diagram
an UGT2B15 substrate
-
-
?
UDP-D-glucuronate + thyroxine
UDP + thyroxine beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + umbelliferone
UDP + umbelliferyl beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + ursodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + zolarsartan
UDP + zolarsartan beta-D-glucuronoside
show the reaction diagram
-
isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, the tetrazole-N1 of this aglycone is accessible to other enzymes, including isozyme UGT1A5, zolarsartan O-glucuronide is mainly produced by isozyme UGT1A10 and isozyme UGT2B7
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
show the reaction diagram
UDP-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 17beta-estradiol
UDP + estradiol 17-beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone
?
show the reaction diagram
UDP-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 2-methoxyestrone
UDP + 2-methoxyestrone beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide
show the reaction diagram
-
isozymes UGT2B4, UGT2B7, and UGT2B17
-
-
?
UDP-glucuronate + 3,17-estradiol
UDP + 17-estradiol 3-O-glucuronide
show the reaction diagram
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + 3,17-estradiol
UDP + 3-estradiol 17-O-glucuronide
show the reaction diagram
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone
UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide
show the reaction diagram
high activity
-
-
?
UDP-glucuronate + 4-aminobiphenyl
?
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
show the reaction diagram
UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
-
-
?
UDP-glucuronate + 4-methoxyestrone
UDP + 4-methoxyestrone beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronide
show the reaction diagram
-
all isozymes, nonselective substrate
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
show the reaction diagram
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenol beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
show the reaction diagram
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronide
show the reaction diagram
isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity
-
-
?
UDP-glucuronate + 5alpha-dihydroaldosterone
UDP + 5alpha-dihydroaldosterone beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 5alpha-tetrahydrocortisone
UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 5beta-tetrahydrocortisone
UDP + 5beta-tetrahydrocortisone beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 6-hydroxymelatonin
UDP + 6-hydroxymelatonin beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxycampothecin
UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide
show the reaction diagram
i.e. SN-38, isozymes UGT1A1, UGT1A7, and UGT1A9
-
-
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + 8-hydroxyquinoline
UDP + 8-hydroxyquinoline beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UGT1A10 is an important detoxifier of polycyclic aromatic hydrocarbons
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
show the reaction diagram
UDP-glucuronate + aldosterone
UDP + aldosterone beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + Aloe-emodin
UDP + Aloe-emodin beta-D-glucuronide
show the reaction diagram
isozyme UGT1A7
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + androstane-3,17-diol 17-O-beta-D-glucuronide
show the reaction diagram
-
isozyme UGT2B15
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
show the reaction diagram
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-glucuronide
show the reaction diagram
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-O-beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + apigenin
UDP + apigenin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + asialo-orosomucoid
UDP + asialo-orosomucoid beta-D-glucuronide
show the reaction diagram
-
acceptor is a glycoprotein, preferred substrate
-
-
?
UDP-glucuronate + beta-estradiol
UDP + estradiol 3-beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + bilirubin
?
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + biochanin A
UDP + biochanin A beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + buprenorphine
UDP + buprenorphine glucuronide
show the reaction diagram
UDP-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + clozapine
UDP + clozapine beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + codeine
UDP + beta-D-glucuronosyl-codeine
show the reaction diagram
-
low activity
-
-
?
UDP-glucuronate + codeine
UDP + codeine beta-D-glucuronide
show the reaction diagram
-
isozymes UGT2B4 and UGT2B7
-
-
?
UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + cyproheptadine
UDP + cyproheptadine beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + desmethylnaproxen
?
show the reaction diagram
UDP-glucuronate + diclofenac
UDP + beta-D-glucuronosyl-diclofenac
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol glucuronide
show the reaction diagram
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronide
show the reaction diagram
isozyme UGT1A1 is specific for etoposide
-
-
?
UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
show the reaction diagram
UDP-glucuronate + eugenol
UDP + eugenol beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + flufenamic acid
?
show the reaction diagram
-
-
-
?
UDP-glucuronate + gemfibrozil
UDP + beta-D-glucuronosyl-gemfibrozil
show the reaction diagram
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + hydromorphone
UDP + beta-D-glucuronosyl-hydromorphone
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + hyodeoxycholic acid
UDP + beta-D-glucuronosyl-hyodeoxycholic acid
show the reaction diagram
-
high activity
-
-
?
UDP-glucuronate + ibuprofen
UDP + beta-D-glucuronosyl-ibuprofen
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + ketoprofen
UDP + beta-D-glucuronosyl-ketoprofen
show the reaction diagram
UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + lorazepam
UDP + beta-D-glucuronosyl-lorazepam
show the reaction diagram
-
-
-
?
UDP-glucuronate + mefenamic acid
?
show the reaction diagram
-
-
-
?
UDP-glucuronate + morphine
UDP + morphine 3-glucuronide
show the reaction diagram
UDP-glucuronate + morphine
UDP + morphine 6-glucuronide
show the reaction diagram
UDP-glucuronate + morphine 3-glucuronide
UDP + ?
show the reaction diagram
-
-
-
?
UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
show the reaction diagram
UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
show the reaction diagram
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
show the reaction diagram
UDP-glucuronate + N-acetylserotonin
UDP + N-acetylserotonin beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + naphthol
UDP + naphthol glucuronide
show the reaction diagram
-
isozyme UGT1A6
-
-
?
UDP-glucuronate + naproxen
?
show the reaction diagram
UDP-glucuronate + naproxen
UDP + beta-D-glucuronosyl-naproxen
show the reaction diagram
UDP-glucuronate + naringenin
UDP + naringenin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + niflumic acid
?
show the reaction diagram
-
-
-
?
UDP-glucuronate + p-nitrophenol
UDP + 4-nitrophenyl-alpha-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + paragloboside
UDP + paragloboside beta-D-glucuronide
show the reaction diagram
-
acceptor is a glycolipid, activity requires phosphatidylinositol
-
-
?
UDP-glucuronate + phenylbutazone
?
show the reaction diagram
among 16 UDP-glucuronosyltransferase isoforms investigated, only UGT1A9 catalyzes PB C-glucuronidation
-
-
?
UDP-glucuronate + phloretin
UDP + phloretin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + propofol
UDP + propofol alpha-D-glucuronide
show the reaction diagram
-
isozyme UGT1A9
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + quinazarin
UDP + quinazarin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + quinizarin
UDP + quinizarin beta-D-glucuronide
show the reaction diagram
isozyme UGT1A7
-
-
?
UDP-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + serotonin
?
show the reaction diagram
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + serotonin
UDP + serotonin beta-glucuronoside
show the reaction diagram
isozyme UGT2B7
-
-
?
UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + tigogenin
UDP + tigogenin beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + tolcapone
UDP + tolcapone beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + trans-androsterone
UDP + trans-androsterone beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronide
show the reaction diagram
isozyme UGT1A4
-
-
?
UDP-glucuronate + trifluoroperazine
UDP + trifluoroperazine beta-D-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + umbelliferone
UDP + umbelliferone beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + valproic acid
UDP + beta-D-glucuronosyl-valproic acid
show the reaction diagram
-
-
-
-
?
UDP-glucuronic acid + 7-hydroxy-4-(trifluoromethyl)-coumarin
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
show the reaction diagram
-
UGT1A6, UGT1A9, and UGT2B7
-
-
?
UDP-glucuronic acid + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronide
show the reaction diagram
-
UGT1A3
-
-
?
UDP-glucuronic acid + bilirubin
bilirubin glucuronoside + UDP
show the reaction diagram
-
-
-
?
UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
show the reaction diagram
UDP-glucuronic acid + diclofenac
UDP + diclofenac O-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronic acid + imipramine
UDP + imipramine N-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronic acid + serotonin
UDP + serotonin O-glucuronide
show the reaction diagram
-
-
-
-
?
UDP-glucuronic acid + trifluoperazine
UDP + ?
show the reaction diagram
-
UGT1A4
-
-
?
UDP-glucuronic acid + trifluoperazine
UDP + trifluoperazine N-glucuronide
show the reaction diagram
-
-
-
-
?
UDPglucuronate + bilirubin
?
show the reaction diagram
-
-
-
-
?
UDPglucuronate + naproxen
?
show the reaction diagram
-
UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
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ursodeoxycholic acid + UDPglucuronate
UDP + ursodeoxycholic acid O-glucuronide
show the reaction diagram
valproic acid + UDPglucuronate
UDP + ?
show the reaction diagram
vanillin + UDP-glucuronate
UDP + vanillin O-glucuronide
show the reaction diagram
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other 7 phenolic compounds show substrate activity on hUGT2A1
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?
voriconazole + UDP-alpha-D-glucuronate
voriconazole D-glucuronate + UDP
show the reaction diagram
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additional information
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