Sequence of XECC_XANP2
EC Number:1.8.1.5
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2-oxopropyl-CoM reductase (carboxylating)
Q56839
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
523
57348
Reaction
2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
Other sequences found for EC No. 1.8.1.5
General information:
Sequence
0 MKVWNARNDH LTINQWATRI DEILEAPDGG EVIYNVDEND PREYDAIFIG GGAAGRFGSA
60 YLRAMGGRQL IVDRWPFLGG SCPHNACVPH HLFSDCAAEL MLARTFSGQY WFPDMTEKVV
120 GIKEVVDLFR AGRNGPHGIM NFQSKEQLNL EYILNCPAKV IDNHTVEAAG KVFKAKNLIL
180 AVGAGPGTLD VPGVNAKGVF DHATLVEELD YEPGSTVVVV GGSKTAVEYG CFFNATGRRT
240 VMLVRTEPLK LIKDNETRAY VLDRMKEQGM EIISGSNVTR IEEDANGRVQ AVVAMTPNGE
300 MRIETDFVFL GLGEQPRSAE LAKILGLDLG PKGEVLVNEY LQTSVPNVYA VGDLIGGPME
360 MFKARKSGCY AARNVMGEKI SYTPKNYPDF LHTHYEVSFL GMGEEEARAA GHEIVTIKMP
420 PDTENGLNVA LPASDRTMLY AFGKGTAHMS GFQKIVIDAK TRKVLGAHHV GYGAKDAFQY
480 LNVLIKQGLT VDELGDMDEL FLNPTHFIQL SRLRAGSKNL VSL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
251273
Swaving J.,Weijers C.A.G.M.,van Ooyen A.J.J.,de Bont J.A.M.
Complementation of Xanthobacter Py2 mutants in epoxyalkane degradation; expression and nucleotide sequence of the complementing DNA fragment.
Microbiology
141
477-484
1995
251275
Allen J.R.,Ensign S.A.
Characterization of three protein components required for functional reconstitution of the epoxide carboxylase multienzyme complex from Xanthobacter strain Py2.
J. Bacteriol.
179
3110-3115
1997
251276
Allen J.R.,Clark D.D.,Krum J.G.,Ensign S.A.
A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation.
Proc. Natl. Acad. Sci. U.S.A.
96
8432-8437
1999
251277
Boyd J.M.,Clark D.D.,Kofoed M.A.,Ensign S.A.
Mechanism of inhibition of aliphatic epoxide carboxylation by the coenzyme M analog 2-bromoethanesulfonate.
J. Biol. Chem.
285
25232-25242
2010
251279
Nocek B.,Jang S.B.,Jeong M.S.,Clark D.D.,Ensign S.A.,Peters J.W.
Structural basis for CO2 fixation by a novel member of the disulfide oxidoreductase family of enzymes, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase.
Biochemistry
41
12907-12913
2002
251280
Pandey A.S.,Nocek B.,Clark D.D.,Ensign S.A.,Peters J.W.
Mechanistic implications of the structure of the mixed-disulfide intermediate of the disulfide oxidoreductase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase.
Biochemistry
45
113-120
2006
251281
Pandey A.S.,Mulder D.W.,Ensign S.A.,Peters J.W.
Structural basis for carbon dioxide binding by 2-ketopropyl coenzyme M oxidoreductase/carboxylase.
FEBS Lett.
585
459-464
2011
