Sequence of OTCA_PYRFU
EC Number:2.1.3.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ornithine carbamoyltransferase
Q51742
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
315
35181
Reaction
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
Other sequences found for EC No. 2.1.3.3
General information:
Sequence
0 MVVSLAGRDL LCLQDYTAEE IWTILETAKM FKIWQKIGKP HRLLEGKTLA MIFQKPSTRT
60 RVSFEVAMAH LGGHALYLNA QDLQLRRGET IADTARVLSR YVDAIMARVY DHKDVEDLAK
120 YATVPVINGL SDFSHPCQAL ADYMTIWEKK GTIKGVKVVY VGDGNNVAHS LMIAGTKLGA
180 DVVVATPEGY EPDEKVIKWA EQNAAESGGS FELLHDPVKA VKDADVIYTD VWASMGQEAE
240 AEERRKIFRP FQVNKDLVKH AKPDYMFMHC LPAHRGEEVT DDVIDSPNSV VWDQAENRLH
300 AQKAVLALVM GGIKF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
708191
Roovers M.,Hetcke C.,Legrain C.,Thomm M.,Glansdorff N.
Isolation of the gene encoding Pyrococcus furiosus ornithine carbamoyltransferase and study of its expression profile in vivo and in vitro.
Eur. J. Biochem.
247
1038-1045
1997
708192
Maeder D.L.,Weiss R.B.,Dunn D.M.,Cherry J.L.,Gonzalez J.M.,DiRuggiero J.,Robb F.T.
Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences.
Genetics
152
1299-1305
1999
708193
Legrain C.,Villeret V.,Roovers M.,Gigot D.,Dideberg O.,Pierard A.,Glansdorff N.
Biochemical characterisation of ornithine carbamoyltransferase from Pyrococcus furiosus.
Eur. J. Biochem.
247
1046-1055
1997
708194
Massant J.,Verstreken P.,Durbecq V.,Kholti A.,Legrain C.,Beeckmans S.,Cornelis P.,Glansdorff N.
Metabolic channeling of carbamoyl phosphate, a thermolabile intermediate: evidence for physical interaction between carbamate kinase-like carbamoyl-phosphate synthetase and ornithine carbamoyltransferase from the hyperthermophile Pyrococcus furiosus.
J. Biol. Chem.
277
18517-18522
2002
708195
Roovers M.,Sanchez R.,Legrain C.,Glansdorff N.
Experimental evolution of enzyme temperature activity profile: selection in vivo and characterization of low-temperature-adapted mutants of Pyrococcus furiosus ornithine carbamoyltransferase.
J. Bacteriol.
183
1101-1105
2001
708196
Clantin B.,Tricot C.,Lonhienne T.,Stalon V.,Villeret V.
Probing the role of oligomerization in the high thermal stability of Pyrococcus furiosus ornithine carbamoyltransferase by site-specific mutants.
Eur. J. Biochem.
268
3937-3942
2001
708197
Villeret V.,Clantin B.,Tricot C.,Legrain C.,Roovers M.,Stalon V.,Glansdorff N.,van Beeumen J.
The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures.
Proc. Natl. Acad. Sci. U.S.A.
95
2801-2806
1998
708198
Massant J.,Wouters J.,Glansdorff N.
Refined structure of Pyrococcus furiosus ornithine carbamoyltransferase at 1.87 A.
Acta Crystallogr. D
59
2140-2149
2003
