Sequence of EIS_MYCTU
EC Number:2.3.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 2.3.1
EC Number:2.3.1.81
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
aminoglycoside 3-N-acetyltransferase
P9WFK7
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
402
43804
Reaction
acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic
Other sequences found for EC No. 2.3.1.81
EC Number:2.3.1.87
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
aralkylamine N-acetyltransferase
P9WFK7
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
402
43804
Reaction
acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine
Other sequences found for EC No. 2.3.1.87
General information:
Sequence
0 MTVTLCSPTE DDWPGMFLLA AASFTDFIGP ESATAWRTLV PTDGAVVVRD GAGPGSEVVG
60 MALYMDLRLT VPGEVVLPTA GLSFVAVAPT HRRRGLLRAM CAELHRRIAD SGYPVAALHA
120 SEGGIYGRFG YGPATTLHEL TVDRRFARFH ADAPGGGLGG SSVRLVRPTE HRGEFEAIYE
180 RWRQQVPGGL LRPQVLWDEL LAECKAAPGG DRESFALLHP DGYALYRVDR TDLKLARVSE
240 LRAVTADAHC ALWRALIGLD SMERISIITH PQDPLPHLLT DTRLARTTWR QDGLWLRIMN
300 VPAALEARGY AHEVGEFSTV LEVSDGGRFA LKIGDGRARC TPTDAAAEIE MDRDVLGSLY
360 LGAHRASTLA AANRLRTKDS QLLRRLDAAF ASDVPVQTAF EF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1182454
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
1182455
Wei J.,Dahl J.,Moulder J.W.,Roberts E.A.,O'Gaora P.,Young D.B.,Friedman R.L.
Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages.
J. Bacteriol.
182
377-384
2000
1182456
Dahl J.L.,Wei J.,Moulder J.W.,Laal S.,Friedman R.L.
Subcellular localization of the intracellular survival-enhancing Eis protein of Mycobacterium tuberculosis.
Infect. Immun.
69
4295-4302
2001
1182457
Lella R.K.,Sharma C.
Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells.
J. Biol. Chem.
282
18671-18675
2007
1182458
Samuel L.P.,Song C.H.,Wei J.,Roberts E.A.,Dahl J.L.,Barry C.E. III,Jo E.K.,Friedman R.L.
Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion.
Microbiology
153
529-540
2007
1182459
Zaunbrecher M.A.,Sikes R.D. Jr.,Metchock B.,Shinnick T.M.,Posey J.E.
Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.
Proc. Natl. Acad. Sci. U.S.A.
106
20004-20009
2009
1182460
Shin D.M.,Jeon B.Y.,Lee H.M.,Jin H.S.,Yuk J.M.,Song C.H.,Lee S.H.,Lee Z.W.,Cho S.N.,Kim J.M.,Friedman R.L.,Jo E.K.
Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling.
PLoS Pathog.
6
0-0
2010
1182461
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
1182462
Houghton J.L.,Green K.D.,Pricer R.E.,Mayhoub A.S.,Garneau-Tsodikova S.
Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.
J. Antimicrob. Chemother.
68
800-805
2013
1182463
Chen W.,Biswas T.,Porter V.R.,Tsodikov O.V.,Garneau-Tsodikova S.
Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.
Proc. Natl. Acad. Sci. U.S.A.
108
9804-9808
2011
1182464
Kim K.H.,An D.R.,Song J.,Yoon J.Y.,Kim H.S.,Yoon H.J.,Im H.N.,Kim J.,Kim do J.,Lee S.J.,Kim K.H.,Lee H.M.,Kim H.J.,Jo E.K.,Lee J.Y.,Suh S.W.
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.
Proc. Natl. Acad. Sci. U.S.A.
109
7729-7734
2012
1182465
Houghton J.L.,Biswas T.,Chen W.,Tsodikov O.V.,Garneau-Tsodikova S.
Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase Eis.
ChemBioChem
14
2127-2135
2013
1182466
Willby M.J.,Green K.D.,Gajadeera C.S.,Hou C.,Tsodikov O.V.,Posey J.E.,Garneau-Tsodikova S.
Potent inhibitors of acetyltransferase Eis overcome kanamycin resistance in Mycobacterium tuberculosis.
ACS Chem. Biol.
11
1639-1646
2016
