Sequence of HDAC4_HUMAN
EC Number:3.5.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Other sequences found for EC No. 3.5.1.98
General information:
Sequence
0 MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP
60 VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA
120 MKHQQELLEH QRKLERHRQE QELEKQHREQ KLQQLKNKEK GKESAVASTE VKMKLQEFVL
180 NKKKALAHRN LNHCISSDPR YWYGKTQHSS LDQSSPPQSG VSTSYNHPVL GMYDAKDDFP
240 LRKTASEPNL KLRSRLKQKV AERRSSPLLR RKDGPVVTAL KKRPLDVTDS ACSSAPGSGP
300 SSPNNSSGSV SAENGIAPAV PSIPAETSLA HRLVAREGSA APLPLYTSPS LPNITLGLPA
360 TGPSAGTAGQ QDAERLTLPA LQQRLSLFPG THLTPYLSTS PLERDGGAAH SPLLQHMVLL
420 EQPPAQAPLV TGLGALPLHA QSLVGADRVS PSIHKLRQHR PLGRTQSAPL PQNAQALQHL
480 VIQQQHQQFL EKHKQQFQQQ QLQMNKIIPK PSEPARQPES HPEETEEELR EHQALLDEPY
540 LDRLPGQKEA HAQAGVQVKQ EPIESDEEEA EPPREVEPGQ RQPSEQELLF RQQALLLEQQ
600 RIHQLRNYQA SMEAAGIPVS FGGHRPLSRA QSSPASATFP VSVQEPPTKP RFTTGLVYDT
660 LMLKHQCTCG SSSSHPEHAG RIQSIWSRLQ ETGLRGKCEC IRGRKATLEE LQTVHSEAHT
720 LLYGTNPLNR QKLDSKKLLG SLASVFVRLP CGGVGVDSDT IWNEVHSAGA ARLAVGCVVE
780 LVFKVATGEL KNGFAVVRPP GHHAEESTPM GFCYFNSVAV AAKLLQQRLS VSKILIVDWD
840 VHHGNGTQQA FYSDPSVLYM SLHRYDDGNF FPGSGAPDEV GTGPGVGFNV NMAFTGGLDP
900 PMGDAEYLAA FRTVVMPIAS EFAPDVVLVS SGFDAVEGHP TPLGGYNLSA RCFGYLTKQL
960 MGLAGGRIVL ALEGGHDLTA ICDASEACVS ALLGNELDPL PEKVLQQRPN ANAVRSMEKV
1020 MEIHSKYWRC LQRTTSTAGR SLIEAQTCEN EEAETVTAMA SLSVGVKPAE KRPDEEPMEE
1080 EPPL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
426648
Grozinger C.M.,Hassig C.A.,Schreiber S.L.
Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Proc. Natl. Acad. Sci. U.S.A.
96
4868-4873
1999
426649
Ohara O.,Nagase T.,Ishikawa K.,Nakajima D.,Ohira M.,Seki N.,Nomura N.
Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.
DNA Res.
4
53-59
1997
426651
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
426653
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
426654
Miska E.A.,Karlsson C.,Langley E.,Nielsen S.J.,Pines J.,Kouzarides T.
HDAC4 deacetylase associates with and represses the MEF2 transcription factor.
EMBO J.
18
5099-5107
1999
426655
Wang A.H.,Bertos N.R.,Vezmar M.,Pelletier N.,Crosato M.,Heng H.H.,Th'ng J.,Han J.,Yang X.-J.
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.
Mol. Cell. Biol.
19
7816-7827
1999
426656
Wang A.H.,Kruhlak M.J.,Wu J.,Bertos N.R.,Vezmar M.,Posner B.I.,Bazett-Jones D.P.,Yang X.-J.
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins.
Mol. Cell. Biol.
20
6904-6912
2000
426657
Zhao X.,Ito A.,Kane C.D.,Liao T.-S.,Bolger T.A.,Lemrow S.M.,Means A.R.,Yao T.-P.
The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.
J. Biol. Chem.
276
35042-35048
2001
426658
McKinsey T.A.,Zhang C.-L.,Olson E.N.
Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.
Mol. Cell. Biol.
21
6312-6321
2001
426659
Franco P.J.,Farooqui M.,Seto E.,Wei L.-N.
The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases.
Mol. Endocrinol.
15
1318-1328
2001
426660
Kirsh O.,Seeler J.-S.,Pichler A.,Gast A.,Mueller S.,Miska E.,Mathieu M.,Harel-Bellan A.,Kouzarides T.,Melchior F.,Dejean A.
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
EMBO J.
21
2682-2691
2002
426661
Barrett A.,Santangelo S.,Tan K.,Catchpole S.,Roberts K.,Spencer-Dene B.,Hall D.,Scibetta A.,Burchell J.,Verdin E.,Freemont P.,Taylor-Papadimitriou J.
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.
Int. J. Cancer
121
265-275
2007
426662
Little G.H.,Bai Y.,Williams T.,Poizat C.
Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells.
J. Biol. Chem.
282
7219-7231
2007
426663
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
426664
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
426665
Williams S.R.,Aldred M.A.,Der Kaloustian V.M.,Halal F.,Gowans G.,McLeod D.R.,Zondag S.,Toriello H.V.,Magenis R.E.,Elsea S.H.
Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems.
Am. J. Hum. Genet.
87
219-228
2010
426666
Shao Y.,Li Y.,Zhang J.,Liu D.,Liu F.,Zhao Y.,Shen T.,Li F.
Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX.
Nucleic Acids Res.
38
2813-2824
2010
426667
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
426668
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
426669
Villavicencio-Lorini P.,Klopocki E.,Trimborn M.,Koll R.,Mundlos S.,Horn D.
Phenotypic variant of Brachydactyly-mental retardation syndrome in a family with an inherited interstitial 2q37.3 microdeletion including HDAC4.
Eur. J. Hum. Genet.
21
743-748
2013
426670
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
426671
Kang H.J.,Lee M.H.,Kang H.L.,Kim S.H.,Ahn J.R.,Na H.,Na T.Y.,Kim Y.N.,Seong J.K.,Lee M.O.
Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1.
Cancer Res.
74
1484-1494
2014
426672
Wheeler P.G.,Huang D.,Dai Z.
Haploinsufficiency of HDAC4 does not cause intellectual disability in all affected individuals.
Am. J. Med. Genet. A
164A
1826-1829
2014
426673
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
426674
Nie J.,Xu C.,Jin J.,Aka J.A.,Tempel W.,Nguyen V.,You L.,Weist R.,Min J.,Pawson T.,Yang X.J.
Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.
Structure
23
700-712
2015
426675
Seo J.H.,Park J.H.,Lee E.J.,Vo T.T.,Choi H.,Kim J.Y.,Jang J.K.,Wee H.J.,Lee H.S.,Jang S.H.,Park Z.Y.,Jeong J.,Lee K.J.,Seok S.H.,Park J.Y.,Lee B.J.,Lee M.N.,Oh G.T.,Kim K.W.
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
Nat. Commun.
7
12882-12882
2016
426676
Zhu Y.,Wang G.Z.,Cingoez O.,Goff S.P.
NP220 mediates silencing of unintegrated retroviral DNA.
Nature
564
278-282
2018
426677
Xu C.,Jin J.,Bian C.,Lam R.,Tian R.,Weist R.,You L.,Nie J.,Bochkarev A.,Tempel W.,Tan C.S.,Wasney G.A.,Vedadi M.,Gish G.D.,Arrowsmith C.H.,Pawson T.,Yang X.J.,Min J.
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
Sci. Signal.
5
0-0
2012
426678
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006
426679
Piton A.,Poquet H.,Redin C.,Masurel A.,Lauer J.,Muller J.,Thevenon J.,Herenger Y.,Chancenotte S.,Bonnet M.,Pinoit J.M.,Huet F.,Thauvin-Robinet C.,Jaeger A.S.,Le Gras S.,Jost B.,Gerard B.,Peoc'h K.,Launay J.M.,Faivre L.,Mandel J.L.
20 ans apres: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition.
Eur. J. Hum. Genet.
22
776-783
2014
