Sequence of UD15_HUMAN
EC Number:2.4.1.17
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
Other sequences found for EC No. 2.4.1.17
General information:
Sequence
0 MATGLQVPLP QLATGLLLLL SVQPWAESGK VLVVPTDGSH WLSMREALRD LHARGHQVVV
60 LTLEVNMYIK EENFFTLTTY AISWTQDEFD RLLLGHTQSF FETEHLLMKF SRRMAIMNNM
120 SLIIHRSCVE LLHNEALIRH LHATSFDVVL TDPFHLCAAV LAKYLSIPAV FFLRNIPCDL
180 DFKGTQCPNP SSYIPRLLTT NSDHMTFLQR VKNMLYPLAL SYLCHAVSAP YASLASELFQ
240 REVSVVDLVS HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE
300 HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND
360 LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT
420 SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH
480 DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
498031
Ritter J.K.,Chen F.,Sheen Y.Y.,Tran H.M.,Kimura S.,Yeatman M.T.,Owens I.S.
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.
J. Biol. Chem.
267
3257-3261
1992
498032
Gong Q.H.,Cho J.W.,Huang T.,Potter C.,Gholami N.,Basu N.K.,Kubota S.,Carvalho S.,Pennington M.W.,Owens I.S.,Popescu N.C.
Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.
Pharmacogenetics
11
357-368
2001
498033
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
498035
Girard H.,Levesque E.,Bellemare J.,Journault K.,Caillier B.,Guillemette C.
Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.
Pharmacogenet. Genomics
17
1077-1089
2007
498036
Alonen A.,Finel M.,Kostiainen R.
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan.
Biochem. Pharmacol.
76
763-772
2008
