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Sequence of DDC_HUMAN

EC Number:4.1.1.28

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
aromatic-L-amino-acid decarboxylase
P20711
Homo sapiens
480
53926
Reaction
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2
Other sequences found for EC No. 4.1.1.28

General information:

Sequence
show sequence in fasta format
  0 MNASEFRRRG KEMVDYMANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP DTFEDIINDV
 60 EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD
120 WLGKMLELPK AFLNEKAGEG GGVIQGSASE ATLVALLAAR TKVIHRLQAA SPELTQAAIM
180 EKLVAYSSDQ AHSSVERAGL IGGVKLKAIP SDGNFAMRAS ALQEALERDK AAGLIPFFMV
240 ATLGTTTCCS FDNLLEVGPI CNKEDIWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN
300 PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP TYLKHSHQDS GLITDYRHWQ IPLGRRFRSL
360 KMWFVFRMYG VKGLQAYIRK HVQLSHEFES LVRQDPRFEI CVEVILGLVC FRLKGSNKVN
420 EALLQRINSA KKIHLVPCHL RDKFVLRFAI CSRTVESAHV QRAWEHIKEL AADVLRAERE
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
661781
Ichinose H.,Kurosawa Y.,Titani K.,Fujita K.,Nagatsu T.
Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase.
Biochem. Biophys. Res. Commun.
164
1024-1030
1989
661782
Scherer L.J.,McPherson J.D.,Wasmuth J.J.,Marsh L.J.
Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs.
Genomics
13
469-471
1992
661783
Sumi-Ichinose C.,Ichinose H.,Takahashi E.,Hori T.,Nagatsu T.
Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis.
Biochemistry
31
2229-2238
1992
661784
Vassilacopoulou D.S.,Sideris D.C.,Vassiliou A.G.,Fragoulis E.G.
Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA.
Neurochem. Res.
29
1817-1823
2004
661786
Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
The DNA sequence of human chromosome 7.
Nature
424
157-164
2003
661787
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
661788
Van Thai A.,Coste E.,Allen J.M.,Palmiter R.D.,Weber M.J.
Identification of a neuron-specific promoter of human aromatic L-amino acid decarboxylase gene.
Brain Res. Mol. Brain Res.
17
227-238
1993
661789
Craig S.P.,Thai A.L.,Weber M.,Craig I.W.
Localisation of the gene for human aromatic L-amino acid decarboxylase (DDC) to chromosome 7p13-->p11 by in situ hybridisation.
Cytogenet. Cell Genet.
61
114-116
1992
661790
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
661791
Giardina G.,Montioli R.,Gianni S.,Cellini B.,Paiardini A.,Voltattorni C.B.,Cutruzzola F.
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc. Natl. Acad. Sci. U.S.A.
108
20514-20519
2011
661793
Cargill M.,Altshuler D.,Ireland J.,Sklar P.,Ardlie K.,Patil N.,Shaw N.,Lane C.R.,Lim E.P.,Kalyanaraman N.,Nemesh J.,Ziaugra L.,Friedland L.,Rolfe A.,Warrington J.,Lipshutz R.,Daley G.Q.,Lander E.S.
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Nat. Genet.
22
231-238
1999
661795
Chang Y.T.,Sharma R.,Marsh J.L.,McPherson J.D.,Bedell J.A.,Knust A.,Braeutigam C.,Hoffmann G.F.,Hyland K.
Levodopa-responsive aromatic L-amino acid decarboxylase deficiency.
Ann. Neurol.
55
435-438
2004
661796
Pons R.,Ford B.,Chiriboga C.A.,Clayton P.T.,Hinton V.,Hyland K.,Sharma R.,De Vivo D.C.
Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis.
Neurology
62
1058-1065
2004