Sequence of HCHL_PSEFL
EC Number:4.1.2.61
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA
Other sequences found for EC No. 4.1.2.61
EC Number:4.1.2.61
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA
Other sequences found for EC No. 4.1.2.61
General information:
Sequence
0 MSTYEGRWKT VKVEIEDGIA FVILNRPEKR NAMSPTLNRE MIDVLETLEQ DPAAGVLVLT
60 GAGEAWTAGM DLKEYFREVD AGPEILQEKI RREASQWQWK LLRMYAKPTI AMVNGWCFGG
120 GFSPLVACDL AICADEATFG LSEINWGIPP GNLVSKAMAD TVGHRQSLYY IMTGKTFGGQ
180 KAAEMGLVNE SVPLAQLREV TIELARNLLE KNPVVLRAAK HGFKRCRELT WEQNEDYLYA
240 KLDQSRLLDT EGGREQGMKQ FLDDKSIKPG LQAYKR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
936619
Gasson M.J.,Kitamura Y.,McLauchlan W.R.,Narbad A.,Parr A.J.,Parsons E.L.,Payne J.,Rhodes M.J.,Walton N.J.
Metabolism of ferulic acid to vanillin. A bacterial gene of the enoyl-SCoA hydratase/isomerase superfamily encodes an enzyme for the hydration and cleavage of a hydroxycinnamic acid SCoA thioester.
J. Biol. Chem.
273
4163-4170
1998
936620
Mitra A.,Kitamura Y.,Gasson M.J.,Narbad A.,Parr A.J.,Payne J.,Rhodes M.J.,Sewter C.,Walton N.J.
4-hydroxycinnamoyl-CoA hydratase/lyase (HCHL)--An enzyme of phenylpropanoid chain cleavage from Pseudomonas.
Arch. Biochem. Biophys.
365
10-16
1999
936621
Leonard P.M.,Brzozowski A.M.,Lebedev A.,Marshall C.M.,Smith D.J.,Verma C.S.,Walton N.J.,Grogan G.
The 1.8 A resolution structure of hydroxycinnamoyl-coenzyme A hydratase-lyase (HCHL) from Pseudomonas fluorescens, an enzyme that catalyses the transformation of feruloyl-coenzyme A to vanillin.
Acta Crystallogr. D
62
1494-1501
2006
936622
Bennett J.P.,Bertin L.,Moulton B.,Fairlamb I.J.,Brzozowski A.M.,Walton N.J.,Grogan G.
A ternary complex of hydroxycinnamoyl-CoA hydratase-lyase (HCHL) with acetyl-CoA and vanillin gives insights into substrate specificity and mechanism.
Biochem. J.
414
281-289
2008
