Sequence of PK3CD_MOUSE
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
EC Number:2.7.1.153
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153
General information:
Sequence
0 MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW HRAQYEPLFH
60 MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR LVAREGDRVK KLINSQISLL
120 IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA
180 GLLRVSNRAL LVNVKFEGSE ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA
240 LQVNGRHEYL YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR
300 AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK LVVQAGLFHG NEMLCKTVSS
360 SEVNVCSEPV WKQRLEFDIS VCDLPRMARL CFALYAVVEK AKKARSTKKK SKKADCPIAW
420 ANLMLFDYKD QLKTGERCLY MWPSVPDEKG ELLNPAGTVR GNPNTESAAA LVIYLPEVAP
480 HPVYFPALEK ILELGRHGER GRITEEELQL REILERRGSG ELYEHEKDLV WKMRHEVQEH
540 FPEALARLLL VTKWNKHEDV AQMLYLLCSW PELPVLSALE LLDFSFPDCY VGSFAIKSLR
600 KLTDDELFQY LLQLVQVLKY ESYLDCELTK FLLGRALANR KIGHFLFWHL RSEMHVPSVA
660 LRFGLIMEAY CRGSTHHMKV LMKQGEALSK LKALNDFVKV SSQKTTKPQT KEMMHMCMRQ
720 ETYMEALSHL QSPLDPSTLL EEVCVEQCTF MDSKMKPLWI MYSSEEAGSA GNVGIIFKNG
780 DDLRQDMLTL QMIQLMDVLW KQEGLDLRMT PYGCLPTGDR TGLIEVVLHS DTIANIQLNK
840 SNMAATAAFN KDALLNWLKS KNPGEALDRA IEEFTLSCAG YCVATYVLGI GDRHSDNIMI
900 RESGQLFHID FGHFLGNFKT KFGINRERVP FILTYDFVHV IQQGKTNNSE KFERFRGYCE
960 RAYTILRRHG LLFLHLFALM RAAGLPELSC SKDIQYLKDS LALGKTEEEA LKHFRVKFNE
1020 ALRESWKTKV NWLAHNVSKD NRQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
205840
Chantry D.,Vojtek A.,Kashishian A.,Holtzman D.A.,Wood C.,Gray P.W.,Cooper J.A.,Hoekstra M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
J. Biol. Chem.
272
19236-19241
1997
205841
Okkenhaug K.,Bilancio A.,Farjot G.,Priddle H.,Sancho S.,Peskett E.,Pearce W.,Meek S.E.,Salpekar A.,Waterfield M.D.,Smith A.J.,Vanhaesebroeck B.
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.
Science
297
1031-1034
2002
205842
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
205844
Clayton E.,Bardi G.,Bell S.E.,Chantry D.,Downes C.P.,Gray A.,Humphries L.A.,Rawlings D.,Reynolds H.,Vigorito E.,Turner M.
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.
J. Exp. Med.
196
753-763
2002
205845
Takahashi K.,Mitsui K.,Yamanaka S.
Role of Eras in promoting tumor-like properties in mouse embryonic stem cells.
Nature
423
541-545
2003
205846
Ali K.,Bilancio A.,Thomas M.,Pearce W.,Gilfillan A.M.,Tkaczyk C.,Kuehn N.,Gray A.,Giddings J.,Peskett E.,Fox R.,Bruce I.,Walker C.,Sawyer C.,Okkenhaug K.,Finan P.,Vanhaesebroeck B.
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.
Nature
431
1007-1011
2004
205847
Webb L.M.C.,Vigorito E.,Wymann M.P.,Hirsch E.,Turner M.
T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.
J. Immunol.
175
2783-2787
2005
205848
Jarmin S.J.,David R.,Ma L.,Chai J.-G.,Dewchand H.,Takesono A.,Ridley A.J.,Okkenhaug K.,Marelli-Berg F.M.
T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.
J. Clin. Invest.
118
1154-1164
2008
205849
Guo H.,Samarakoon A.,Vanhaesebroeck B.,Malarkannan S.
The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation.
J. Exp. Med.
205
2419-2435
2008
205850
Saudemont A.,Garcon F.,Yadi H.,Roche-Molina M.,Kim N.,Segonds-Pichon A.,Martin-Fontecha A.,Okkenhaug K.,Colucci F.
p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.
Proc. Natl. Acad. Sci. U.S.A.
106
5795-5800
2009
205851
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
205852
Fransson S.,Uv A.,Eriksson H.,Andersson M.K.,Wettergren Y.,Bergo M.,Ejeskar K.
p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors.
Oncogene
31
3277-3286
2012
205853
Berndt A.,Miller S.,Williams O.,Le D.D.,Houseman B.T.,Pacold J.I.,Gorrec F.,Hon W.-C.,Liu Y.,Rommel C.,Gaillard P.,Ruckle T.,Schwarz M.K.,Shokat K.M.,Shaw J.P.,Williams R.L.
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Nat. Chem. Biol.
6
117-124
2010
