Information on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
2.7.1.153
-
RECOMMENDED NAME
GeneOntology No.
phosphatidylinositol-4,5-bisphosphate 3-kinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phospho-group transfer
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-
-
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PATHWAY
KEGG Link
MetaCyc Link
3-phosphoinositide biosynthesis
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Inositol phosphate metabolism
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SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
class I phosphoinositide 3-kinase
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class I PI3K
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class I PI3K
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class IA phosphatidylinositol 3-kinase
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CXCR2/phosphatidylinositol 3-kinase gamma
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p101-PI3K
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-
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p110delta
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-
-
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p110delta
O35904
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p110delta PI 3-kinase
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p110gamma/p101
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-
P120-PI3K
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-
-
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phosphatidylinositol (4,5)-bisphosphate 3-hydroxykinase
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phosphatidylinositol 3'-kinase
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phosphatidylinositol 3-hydroxyl kinase
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-
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phosphoinositide 3-kinase
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phosphoinositide 3-kinase p110delta
O35904
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PI 3-kinase
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PI 3-kinase
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PI 3-kinase
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PI-3K
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PI3-K
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PI3-kinase
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PI3K
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-
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PI3K
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PI3K p110delta
O35904
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PI3Kbeta
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-
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PI3Kdelta
O35904
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PI3Kgamma
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-
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PI3Kgamma
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PI3Kgamma
Q9JHG7
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PI3Kp110delta
O35904
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PIK3CA
P42336
gene name
Pik3r1
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PtdIns(4,5)P2 3-OH kinase
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PtdIns-3-kinase p101
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PtdIns-3-kinase p110
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PtdInsP 3-OH-kinase
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type I phosphoinositide 3-kinase
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kinase (phosphorylating), phosphatidylinositol 4,5-diphosphate 3-
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additional information
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cf. EC 2.7.1.37
additional information
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class I PI3Ks can be further subtyped depending on their associated catalytic subunit into class IA p110alpha, p110beta and p110delta and class IB p110gamma
CAS REGISTRY NUMBER
COMMENTARY
103843-30-7
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115926-52-8
cf. EC 2.7.1.137
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
catalytic subunit alpha isoform
SwissProt
Manually annotated by BRENDA team
catalytic subunit beta isoform
SwissProt
Manually annotated by BRENDA team
catalytic subunit delta isoform
SwissProt
Manually annotated by BRENDA team
catalytic subunit gamma isoform
SwissProt
Manually annotated by BRENDA team
catalytic subunit p110, alpha isoform
SwissProt
Manually annotated by BRENDA team
catalytic subunit p110, delta isoform
SwissProt
Manually annotated by BRENDA team
catalytic subunit p110, gamma isoform
SwissProt
Manually annotated by BRENDA team
gamma isoform
SwissProt
Manually annotated by BRENDA team
gene PIK3CA encoding for the catalytic subunit p110alpha of PI3K
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-
Manually annotated by BRENDA team
gene PIK3CA enocding the PI3K catalytic subunit alpha
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-
Manually annotated by BRENDA team
GFP-tag, expression in HEK cell
SwissProt
Manually annotated by BRENDA team
isoform p85/p110 phosphatidylinositol 3-kinase
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-
Manually annotated by BRENDA team
Korean population, women with polycystic ovary syndrome
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-
Manually annotated by BRENDA team
p110 catalytic subunit, gamma isoform
SwissProt
Manually annotated by BRENDA team
patients with acute myelogenous leukemia
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-
Manually annotated by BRENDA team
phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
SwissProt
Manually annotated by BRENDA team
regulatory subunit alpha
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
C57BL/6 mice, BALB/c mice, and CB-17/lcr-Prkdcscid/Crl, i.e. BALB/c SCID, mice
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-
Manually annotated by BRENDA team
expression in CHO-K1 cells
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-
Manually annotated by BRENDA team
K/BxN serum transfer model of arthritis, isoforms PI3Kdelta and PI3Kgamma
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-
Manually annotated by BRENDA team
recombinant enzyme
SwissProt
Manually annotated by BRENDA team
strain C57BL/6 mice
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-
Manually annotated by BRENDA team
two isozymes of the catalytic subunit, p110alpha and p110beta
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-
Manually annotated by BRENDA team
strain TU-1
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-
Manually annotated by BRENDA team
beta-isoform
Swissprot
Manually annotated by BRENDA team
Wistar-Kyoto rats and spontaneously hypertensive rats
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-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM