Sequence of TOR1_SCHPO
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphatidylinositol 3-kinase
O14356
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
2335
266184
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
O14356
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
2335
266184
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MEYFSDLKNK NESIQLAAAD QLKEFVHSST KELSGESLAR FNNDINRRIF ELIHSHDSHE
60 RFGGILAIGK LIEFESEGDV TNLSRYANYL RMTLPSTDWH SMELSAKVLG HLAASGGTLA
120 AEFVEFEVQR AFEWLQGDRQ EQKRMAAILI IKALAQNSPT LVYLYISEIF QNLWTGLRDP
180 KPLIRETAAD ALGASLDVVC QREAKVQLQC FNEVLLQAEH GLRQSSVEYL HGSLLAYKEL
240 FEKSGSFIRE HYTEFCDLAL RLREHRDNSI RRCIVFLLPT LSEYNPKKFQ QRYLDSFMVY
300 LLSHIRKDKE KSLAFEAIGR IAMAVNEAMI PYLQNILKVI RDTLTAKVRE KTQYEKPVFE
360 CIGMLAAAVK LELLEDSRSL LGLIFSCELS VHLRQALVKM AENIPPLLAP IQERLLNMVS
420 QILTGKNFEI RTNDTYTPSF TNIYSAREPD QRSKSTESII LALETLGTFN FTGYSLISFI
480 QESVLSYLEN DNSEIRIAAA RTCCQVFARD PICRKTNPLA VESVAEVLEK LLTLGIADSD
540 PKIRETVLSL LDERFDRHLA HPDNIRCLFI ALNDEVFSIR EIAIIIIGRL ALYNPAHVMP
600 SLRKTIIQLL SDMEYSGNSR QKEESAQLLK LLVSKARTLI KPYIQSIIHV ILPKAADTSP
660 GVSSAIISAL GELASVEGED MPVDVRGSFM KLILVNLQDQ SSTLKRLASL KCLRKLCGRS
720 GYVIQPYLDY PPLLGALIGI LQSEQPTPIR REVLRTLGVL GALDPYTYLT TEEVSDDLQS
780 SHNNAHGVPQ ISAAQYPSLE NYAMVAVVTL IGILKDSSLS MHHSSVVQAV MHICSQMGSK
840 STVFLPQVVP TFLQVMQSLS ASSAEFYFQQ LTTLTSIIGP NIRDYVSDIF NLSKVFWEST
900 TSLLLVILEL IDAIAIALQD EFKFYLPQIL SCMLKAFSLD NTSSRSVSYK VLQSFVIFGS
960 NIEEYMHLVL PVIIRSFERD TIPLGFRKSA LKCIAQLFQS VNFSDHASRI IHPLVRMLGK
1020 SNGDLRAVIM DTLCAIVSQL GYDYSIFIPM VNKVLVSHKI SHPAYELLVS RLLKGEPLPK
1080 DVVVKEFKPR PSTKPFSTQD EVLTKLPVDQ ASLKAAWESS QKLTRDDWQD WIRRISIELL
1140 KESPSSALRS CSTLAGIYHP LARDLFNVSF LSCWDELTES NKKNLVKSIE LAMNAPNISV
1200 EILQTLLNLA EYMEREDHTL PIPIKVISAH ASKCNVYAKA LHYTELQFVQ ETKEEVSIST
1260 IESLITINNH LQQSDAAVGM LQYTKEHKQF SLKETWYEKL HRWDDALAAY EHREREGDSS
1320 FEINIGKLRC YYALGDWDHL SELAQKAWVT SEQEHREAIA PLAAAAAWGL GQWNLISEYV
1380 SAMDRDPQDK EFFSAISAVH LGQYNKAYGH IERHRDILVN DLSSIIGESY NRAYGIMVKS
1440 QMLSELEEII DYKKNMQYEN NLDSLKKTWR KRLEGCQKNV DVWHNTLRFR ALVLSPQDSP
1500 EMWIKLADLC RRSDRLKLSN QCLTYLMGRD PSNAYPLDSL KLLNPHVVYT YLKYLWATDQ
1560 KNIAVSELEE FTSYLSSKHG YKMGDSSKLV DILASSSVSS EERSFLARCF HKLGKWKKSL
1620 QDSVNQESVR DILNCYFYAT LFDKSWYKAW HSWALANFEV VGYYEQTEHG VTQDMYEQYI
1680 VPAIKGFFHS SVLNQKNSLQ DILRLLNLWF KFGEHSDVAA AIVEGFSNVP MDTWLEVIPQ
1740 LIARIHTSSS SVRASVHQLL SDIGRVHPQA LVYSLTVSSK STNPQQKHSA KSIMDSMLSH
1800 SDTLVRQALL VSQELIRVAI LWHELWYEGL EEASQAYFSD HDISLMIDIV KPLHETLEKG
1860 PSTLSEISFA QTFGYDLRKA RSYWQKFLQD GDPTELNQSW DLYYQVFRRI QKQLPRIKHL
1920 ELQYVSPKLL DACDLELAVP GTYGHNKPVI RISHFHHTFE VISSKQRPRR LTIHGSDGKD
1980 YQYVLKGHED LRQDERVMQL FGLCNTLLTT DSETFKRRLN IERYTVIPLS PNSGLLGWVP
2040 HSDTLHFLIK EFRSKRNILL NLEHRMMLQM APDCDSLTLL QKLEVFEYVM ANTDGYDLYH
2100 VLWLKSRSSE AWLDRRTSYT QSLAVMSMVG YILGLGDRHP SNLMMDRYSG KIIHIDFGDC
2160 FEVAMHREKF PEKIPFRLTR MLINAMEVSG IQGTYKITCE LVMRVLRSNT ESLMAVLEAF
2220 VYDPLINWRL MTKSSFGAST TLRPTSSSVE EKGRSYTHRA RHADYAALSE TNGVNAEGLN
2280 ERSIQVLKRV SNKLTGKDFD LKEQLPVKAQ VEKLIQQATA PENLCRCYVG WCSFW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
242846
Wood V.,Gwilliam R.,Rajandream M.A.,Lyne M.H.,Lyne R.,Stewart A.,Sgouros J.G.,Peat N.,Hayles J.,Baker S.G.,Basham D.,Bowman S.,Brooks K.,Brown D.,Brown S.,Chillingworth T.,Churcher C.M.,Collins M.,Connor R.,Cronin A.,Davis P.,Feltwell T.,Fraser A.,Gentles S.,Goble A.,Hamlin N.,Harris D.E.,Hidalgo J.,Hodgson G.,Holroyd S.,Hornsby T.,Howarth S.,Huckle E.J.,Hunt S.,Jagels K.,James K.D.,Jones L.,Jones M.,Leather S.,McDonald S.,McLean J.,Mooney P.,Moule S.,Mungall K.L.,Murphy L.D.,Niblett D.,Odell C.,Oliver K.,O'Neil S.,Pearson D.,Quail M.A.,Rabbinowitsch E.,Rutherford K.M.,Rutter S.,Saunders D.,Seeger K.,Sharp S.,Skelton J.,Simmonds M.N.,Squares R.,Squares S.,Stevens K.,Taylor K.,Taylor R.G.,Tivey A.,Walsh S.V.,Warren T.,Whitehead S.,Woodward J.R.,Volckaert G.,Aert R.,Robben J.,Grymonprez B.,Weltjens I.,Vanstreels E.,Rieger M.,Schaefer M.,Mueller-Auer S.,Gabel C.,Fuchs M.,Duesterhoeft A.,Fritzc C.,Holzer E.,Moestl D.,Hilbert H.,Borzym K.,Langer I.,Beck A.,Lehrach H.,Reinhardt R.,Pohl T.M.,Eger P.,Zimmermann W.,Wedler H.,Wambutt R.,Purnelle B.,Goffeau A.,Cadieu E.,Dreano S.,Gloux S.,Lelaure V.,Mottier S.,Galibert F.,Aves S.J.,Xiang Z.,Hunt C.,Moore K.,Hurst S.M.,Lucas M.,Rochet M.,Gaillardin C.,Tallada V.A.,Garzon A.,Thode G.,Daga R.R.,Cruzado L.,Jimenez J.,Sanchez M.,del Rey F.,Benito J.,Dominguez A.,Revuelta J.L.,Moreno S.,Armstrong J.,Forsburg S.L.,Cerutti L.,Lowe T.,McCombie W.R.,Paulsen I.,Potashkin J.,Shpakovski G.V.,Ussery D.,Barrell B.G.,Nurse P.
The genome sequence of Schizosaccharomyces pombe.
Nature
415
871-880
2002
242847
Kawai M.,Nakashima A.,Ueno M.,Ushimaru T.,Aiba K.,Doi H.,Uritani M.
Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature.
Curr. Genet.
39
166-174
2001
242848
Weisman R.,Choder M.
The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.
J. Biol. Chem.
276
7027-7032
2001
242849
Matsuo T.,Kubo Y.,Watanabe Y.,Yamamoto M.
Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases.
EMBO J.
22
3073-3083
2003
242850
Weisman R.,Roitburg I.,Nahari T.,Kupiec M.
Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.
Genetics
169
539-550
2005
242851
Alvarez B.,Moreno S.
Fission yeast Tor2 promotes cell growth and represses cell differentiation.
J. Cell Sci.
119
4475-4485
2006
242852
Matsuyama A.,Arai R.,Yashiroda Y.,Shirai A.,Kamata A.,Sekido S.,Kobayashi Y.,Hashimoto A.,Hamamoto M.,Hiraoka Y.,Horinouchi S.,Yoshida M.
ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Nat. Biotechnol.
24
841-847
2006
242853
Hayashi T.,Hatanaka M.,Nagao K.,Nakaseko Y.,Kanoh J.,Kokubu A.,Ebe M.,Yanagida M.
Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Genes Cells
12
1357-1370
2007
242854
Weisman R.,Roitburg I.,Schonbrun M.,Harari R.,Kupiec M.
Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.
Genetics
175
1153-1162
2007
242855
Matsuo T.,Otsubo Y.,Urano J.,Tamanoi F.,Yamamoto M.
Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
Mol. Cell. Biol.
27
3154-3164
2007
242856
Halova L.,Du W.,Kirkham S.,Smith D.L.,Petersen J.
Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.
J. Cell Biol.
203
595-604
2013
