Sequence of HDAC1_MOUSE
EC Number:3.5.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Other sequences found for EC No. 3.5.1.98
General information:
Sequence
0 MAQTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN
60 AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS
120 AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG
180 DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI
240 FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
300 GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE
360 KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED PDKRISICSS DKRIACEEEF
420 SDSDEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK
480 LA
Download this sequence
in fasta formatDownload all sequences for 3.5.1.98
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1067372
Bartl S.,Taplick J.,Lagger G.,Khier H.,Kuchler K.,Seiser C.
Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.
Mol. Cell. Biol.
17
5033-5043
1997
1067374
Laherty C.D.,Billin A.N.,Lavinsky R.M.,Yochum G.S.,Bush A.C.,Sun J.-M.,Mullen T.-M.,Davie J.R.,Rose D.W.,Glass C.K.,Rosenfeld M.G.,Ayer D.E.,Eisenman R.N.
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.
Mol. Cell
2
33-42
1998
1067375
Fuks F.,Burgers W.A.,Brehm A.,Hughes-Davies L.,Kouzarides T.
DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
Nat. Genet.
24
88-91
2000
1067376
Downes M.,Ordentlich P.,Kao H.-Y.,Alvarez J.G.A.,Evans R.M.
Identification of a nuclear domain with deacetylase activity.
Proc. Natl. Acad. Sci. U.S.A.
97
10330-10335
2000
1067377
Zhang C.L.,McKinsey T.A.,Lu J.R.,Olson E.N.
Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.
J. Biol. Chem.
276
35-39
2001
1067378
Amann J.M.,Nip J.,Strom D.K.,Lutterbach B.,Harada H.,Lenny N.,Downing J.R.,Meyers S.,Hiebert S.W.
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Mol. Cell. Biol.
21
6470-6483
2001
1067379
Zhou Y.,Santoro R.,Grummt I.
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.
EMBO J.
21
4632-4640
2002
1067380
Alland L.,David G.,Shen-Li H.,Potes J.,Muhle R.,Lee H.-C.,Hou H. Jr.,Chen K.,DePinho R.A.
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.
Mol. Cell. Biol.
22
2743-2750
2002
1067381
Vaute O.,Nicolas E.,Vandel L.,Trouche D.
Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.
Nucleic Acids Res.
30
475-481
2002
1067382
Yang L.,Mei Q.,Zielinska-Kwiatkowska A.,Matsui Y.,Blackburn M.L.,Benedetti D.,Krumm A.A.,Taborsky G.J. Jr.,Chansky H.A.
An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.
Biochem. J.
369
651-657
2003
1067383
Datta J.,Ghoshal K.,Sharma S.M.,Tajima S.,Jacob S.T.
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.
J. Cell. Biochem.
88
855-864
2003
1067384
Zoltewicz J.S.,Stewart N.J.,Leung R.,Peterson A.S.
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.
Development
131
3-14
2004
1067385
Kurtev V.,Margueron R.,Kroboth K.,Ogris E.,Cavailles V.,Seiser C.
Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.
J. Biol. Chem.
279
24834-24843
2004
1067386
Naruse Y.,Oh-hashi K.,Iijima N.,Naruse M.,Yoshioka H.,Tanaka M.
Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation.
Mol. Cell. Biol.
24
6278-6287
2004
1067387
Chen X.,Bieker J.J.
Stage-specific repression by the EKLF transcriptional activator.
Mol. Cell. Biol.
24
10416-10424
2004
1067388
Castet A.,Boulahtouf A.,Versini G.,Bonnet S.,Augereau P.,Vignon F.,Khochbin S.,Jalaguier S.,Cavailles V.
Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.
Nucleic Acids Res.
32
1957-1966
2004
1067389
Zhou Y.,Grummt I.
The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
Curr. Biol.
15
1434-1438
2005
1067390
Chakravarthy S.,Gundimella S.K.,Caron C.,Perche P.-Y.,Pehrson J.R.,Khochbin S.,Luger K.
Structural characterization of the histone variant macroH2A.
Mol. Cell. Biol.
25
7616-7624
2005
1067391
Rampalli S.,Pavithra L.,Bhatt A.,Kundu T.K.,Chattopadhyay S.
Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.
Mol. Cell. Biol.
25
8415-8429
2005
1067392
Mejat A.,Ramond F.,Bassel-Duby R.,Khochbin S.,Olson E.N.,Schaeffer L.
Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.
Nat. Neurosci.
8
313-321
2005
1067393
Brown M.A.,Sims R.J. III,Gottlieb P.D.,Tucker P.W.
Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.
Mol. Cancer
5
26-26
2006
1067394
Davis C.A.,Haberland M.,Arnold M.A.,Sutherland L.B.,McDonald O.G.,Richardson J.A.,Childs G.,Harris S.,Owens G.K.,Olson E.N.
PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.
Mol. Cell. Biol.
26
2626-2636
2006
1067395
Morrison B.E.,Majdzadeh N.,Zhang X.,Lyles A.,Bassel-Duby R.,Olson E.N.,D'Mello S.R.
Neuroprotection by histone deacetylase-related protein.
Mol. Cell. Biol.
26
3550-3564
2006
1067396
Saleque S.,Kim J.,Rooke H.M.,Orkin S.H.
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.
Mol. Cell
27
562-572
2007
1067397
Choi E.,Han C.,Park I.,Lee B.,Jin S.,Choi H.,Kim do H.,Park Z.Y.,Eddy E.M.,Cho C.
A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis.
J. Biol. Chem.
283
35283-35294
2008
1067398
Jacobs F.M.,van Erp S.,van der Linden A.J.,von Oerthel L.,Burbach J.P.,Smidt M.P.
Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.
Development
136
531-540
2009
1067399
Nimura K.,Ura K.,Shiratori H.,Ikawa M.,Okabe M.,Schwartz R.J.,Kaneda Y.
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
Nature
460
287-291
2009
1067400
Brandt S.,Ellwanger K.,Beuter-Gunia C.,Schuster M.,Hausser A.,Schmitz I.,Beer-Hammer S.
SLy2 targets the nuclear SAP30/HDAC1 complex.
Int. J. Biochem. Cell Biol.
42
1472-1481
2010
1067401
Bruscoli S.,Donato V.,Velardi E.,Di Sante M.,Migliorati G.,Donato R.,Riccardi C.
Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids.
J. Biol. Chem.
285
10385-10396
2010
1067402
Yan W.,Si Y.,Slaymaker S.,Li J.,Zheng H.,Young D.L.,Aslanian A.,Saunders L.,Verdin E.,Charo I.F.
Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.
J. Biol. Chem.
285
31418-31426
2010
1067403
Li Z.,Zhang Q.,Mao J.H.,Weise A.,Mrasek K.,Fan X.,Zhang X.,Liehr T.,Lu K.H.,Balmain A.,Cai W.W.
An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis.
Oncogene
29
2659-2671
2010
1067404
Alter J.,Bengal E.
Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation.
PLoS ONE
6
0-0
2011
1067405
He Z.,Cai J.,Lim J.W.,Kroll K.,Ma L.
A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.
J. Biol. Chem.
286
7279-7289
2011
1067406
Lu P.,Hankel I.L.,Hostager B.S.,Swartzendruber J.A.,Friedman A.D.,Brenton J.L.,Rothman P.B.,Colgan J.D.
The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.
J. Biol. Chem.
286
18311-18319
2011
1067407
DiTacchio L.,Le H.D.,Vollmers C.,Hatori M.,Witcher M.,Secombe J.,Panda S.
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
Science
333
1881-1885
2011
1067408
Welcker J.E.,Hernandez-Miranda L.R.,Paul F.E.,Jia S.,Ivanov A.,Selbach M.,Birchmeier C.
Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.
Development
140
4947-4958
2013
1067409
Duong H.A.,Weitz C.J.
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes.
Nat. Struct. Mol. Biol.
21
126-132
2014
1067410
Goriki A.,Hatanaka F.,Myung J.,Kim J.K.,Yoritaka T.,Tanoue S.,Abe T.,Kiyonari H.,Fujimoto K.,Kato Y.,Todo T.,Matsubara A.,Forger D.,Takumi T.
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
PLoS Biol.
12
0-0
2014
1067411
Streubel G.,Fitzpatrick D.J.,Oliviero G.,Scelfo A.,Moran B.,Das S.,Munawar N.,Watson A.,Wynne K.,Negri G.L.,Dillon E.T.,Jammula S.,Hokamp K.,O'Connor D.P.,Pasini D.,Cagney G.,Bracken A.P.
Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.
EMBO J.
36
2216-2232
2017
1067412
Kelly R.D.W.,Chandru A.,Watson P.J.,Song Y.,Blades M.,Robertson N.S.,Jamieson A.G.,Schwabe J.W.R.,Cowley S.M.
Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.
Sci. Rep.
8
14690-14690
2018
1067413
Zhang T.,Wei G.,Millard C.J.,Fischer R.,Konietzny R.,Kessler B.M.,Schwabe J.W.R.,Brockdorff N.
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.
Nat. Commun.
9
3798-3798
2018
1067414
Yan L.,Jin W.,Zhao Q.,Cui X.,Shi T.,Xu Y.,Li F.,Jin W.,Zhang Z.,Zhang Z.,Tang Q.Q.,Pan D.
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Adv. Sci.
8
0-0
2021
1067415
Zheng S.,Matthews A.J.,Rahman N.,Herrick-Reynolds K.,Sible E.,Choi J.E.,Wishnie A.,Ng Y.K.,Rhodes D.,Elledge S.J.,Vuong B.Q.
The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.
J. Biol. Chem.
296
100625-100625
2021
