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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35E402A inactive 709635
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35E402A no enzymic activity, competition with isolated collagen-binding domain and with matrix metalloproteinase MMP-2 binding to native and denatured type I collagen 667516
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35E402A site-directed mutagenesis of the catalytic Glu402 results in an inactive enzyme 683170
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35E402H/H411E site-directed mutagenesis, proteolytic inactive MMP-9 mutant, application of the MMP-9 mutant decreases portal and periportal accumulation of collagen and inhibits fibrogenesis induced by CCl4 in mice -, 683450
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35E402Q site-directed mutagenesis, proteolytic inactive MMP-9 mutant, application of the MMP-9 mutant decreases portal and periportal accumulation of collagen and inhibits fibrogenesis induced by CCl4 in mice, the MMP-9 mutant suppresses transdifferentiation of hepatic stellate cells to the myofibroblast-like phenotype in vitro and in vivo. Adenoviral application of the mutant leads to increased apoptosis of activated hepatic stellate cells -, 683450
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35E412D site-directed mutagenesis 652384
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35H401A site-directed mutagenesis, proteolytic inactive MMP-9 mutant, application of the MMP-9 mutant decreases portal and periportal accumulation of collagen and inhibits fibrogenesis induced by CCl4 in mice, the MMP-9 mutant suppresses transdifferentiation of hepatic stellate cells to the myofibroblast-like phenotype in vitro and in vivo. Adenoviral application of the mutant leads to increased apoptosis of activated hepatic stellate cells -, 683450
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35more construction of proteolytically inactive truncated MMP-9 mutant: MMP-9DELTAHem, lacking the hemopexin domain, MMP-9DELTAOG, lacking the OG domain, and MMP-9DELTAOGHem, lacking both the hemopexin and the OG domain 683170
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35more enzyme-deficient MPP-9-/- mice show impaired neutrophil infiltration during zymosan peritonitis, overview -, 683525
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.35more generation of a mutant version lacking the O-glycosylated linker region and hemopexin domains and containing only the protease domain, residues 1-447 718355
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