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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.B14more construction of 1092cl4 and 1092cl6, two parasite lines deficient in expressing PM4, by gene disruption, and of mutant lines 688cl2 and 688cl3. PM4 deficiency results in significantly less virulence than that for the parental parasite. Enzyme-deficient parasites fail to induce experimental cerebral malaria in susceptible mice, and resistant mice are able to clear infections. The mutant acts as vaccine, immunity through antibody-mediated parasite clearance in the spleen, virulence-attenuated phenotypes, overview 707051
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