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Results 1 - 10 of 79 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19C36S/C118V/A152C/C160S/C197S/C257S/C293S/C204V introduction of a Cys residue in a mutant lacking all endogenous Cys residues. Mutant achieves maximum specific disulfide cross-linking efficiency. The resulting construct is active and, when mixed with a chemically modified RNA, yields crystals of an enzyme-RNA complex 721206
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19C36S/C118V/C160S/C197S/C257S/C293S/C204V mutation of all seven endogenous cysteine residues. Mutant is able to bind RNA at a level similar to that of wild-type, but no longer forms nonspecific disulfide cross-links with the modified RNA 721206
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D114A polyadenylation-defective mutant 761749
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D124A the mutant shows strongly reduced activity compared to the wild type enzyme 762055
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D126A the mutant shows strongly reduced activity compared to the wild type enzyme 762055
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D154A crystallization data, closed conformation with extensive interactions between substrates and all three polymerase domains 677164
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D154A the mutant has a nearly identical melting temperature as wild type PAP 677164
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D167N strong reduction of catalytic efficiency 662628
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D167N/N202A sharp decrease in catalytic efficiency 662628
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.19D167N/T317G sharp decrease in catalytic efficiency 662628
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