EC Number |
Protein Variants |
Reference |
---|
2.4.1.38 | C134S |
complete loss of activity |
489552 |
2.4.1.38 | C342S |
33fold increase in the apparent Km-value for UDPgalactose |
489552 |
2.4.1.38 | D254E |
0.01% of the activity of the wild-type enzyme |
489556 |
2.4.1.38 | D254N |
0.01% of the activity of the wild-type enzyme |
489556 |
2.4.1.38 | D320A |
when partially activated by Mn2+ binding to the primary site, can be further activated by Co2+ or inhibited by Ca2+, an effect that is the opposite of what is observed with the wild-type enzyme |
489556 |
2.4.1.38 | D320E |
when partially activated by Mn2+ binding to the primary site, can be further activated by Co2+ or inhibited by Ca2+, an effect that is the opposite of what is observed with the wild-type enzyme |
489556 |
2.4.1.38 | D320N |
when partially activated by Mn2+ binding to the primary site, can be further activated by Co2+ or inhibited by Ca2+, an effect that is the opposite of what is observed with the wild-type enzyme |
489556 |
2.4.1.38 | E317A |
when partially activated by Mn2+ binding to the primary site, can be further activated by Co2+ or inhibited by Ca2+, an effect that is the opposite of what is observed with the wild-type enzyme |
489556 |
2.4.1.38 | E317D |
when partially activated by Mn2+ binding to the primary site, can be further activated by Co2+ or inhibited by Ca2+, an effect that is the opposite of what is observed with the wild-type enzyme |
489556 |
2.4.1.38 | E317Q |
when partially activated by Mn2+ binding to the primary site, can be further activated by Co2+ or inhibited by Ca2+, an effect that is the opposite of what is observed with the wild-type enzyme |
489556 |