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EC Number	Protein Variants	Commentary	Reference
2.1.1.45	A17T/D116A/D254E	the mutant shows decreased sensitivity towards 5-fluorodeoxyuridine compared to the wild type enzyme	703950
2.1.1.45	A191K	inactive. Mutant has large areas of hydrophobic region exposed to solvent and exposes the hydrophobic beta-sheets in the dimer interface	757176
2.1.1.45	A191K	the mutant enzyme displays a kcat value of 6fold lower than wild type	706625
2.1.1.45	A191K	the mutant exhibits about 25% of the catalytic activity of the wild type enzyme. The mutant exhibits nonhyperbolic behavior with respect to dUMP and inhibition of catalysis is reversed by substrate saturation	720995
2.1.1.45	C490A	inactive	720420
2.1.1.45	C506A	inactive	720420
2.1.1.45	C506D	inactive	720420
2.1.1.45	C506F	inactive	720420
2.1.1.45	C506P	inactive	720420
2.1.1.45	C506Y	inactive	720420

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Release 2023.1 (January 2023)