EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
   3.4.24.15 | 0.00006 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-p-aminobenzoate |
IC50: 0.00006 mM, potent and specific inhibitor, unstable in vivo due to cleavage between the alanine and tyrosine residues by the enzyme nephrilysin. This cleavage generates a potent inhibitor of angiotensin converting enzyme, thereby limiting the use of |
650099 |
| 3.4.24.15 | 0.00012 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-(3-aminopropanoic acid) |
IC50: 0.00012 mM, complete degradation by nephrilysin |
650099 |
| 3.4.24.15 | 0.00066 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Pro-Tyr-(3-aminopropanoic acid) |
IC50: 0.00066 mM, no cleavage by nephrilysin |
650099 |
| 3.4.24.15 | 0.00079 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Pro-Phe-(3-aminopropanoic acid) |
IC50: 0.00079 mM, no cleavage by nephrilysin |
650099 |
| 3.4.24.15 | 0.0028 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-(3-amino-2-methylpropanoyl)-Phe-(3-aminopropanoic acid) |
IC50: 0.0028 mM, no cleavage by nephrilysin |
650099 |
| 3.4.24.15 | 0.0036 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-(3-aminopropanoic acid) |
IC50: 0.0036 mM, no cleavage by nephrilysin |
650099 |
| 3.4.24.15 | 0.0056 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-(3-aminopropanoyl)-Tyr-(3-aminopropanoic acid) |
IC50: 0.0056 mM, no cleavage by nephrilysin |
650099 |
| 3.4.24.15 | 0.0056 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-(piperidine-3-carboxyl)-Tyr-(3-aminopropanoic acid) |
IC50: 0.0056 mM, no cleavage by nephrilysin |
650099 |
| 3.4.24.15 | 0.0063 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-((3S)-pyrrolidine-3-carboxyl)-Phe-(3-aminopropanoic acid) |
IC50: 0.0063 mM, no cleavage by nephrilysin |
650099 |
| 3.4.24.15 | 0.0063 |
- |
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-(3-amino-2-methylpropanoyl)-Tyr-3-aminopropanoic acid |
IC50: 0.0063 mM, no cleavage by nephrilysin |
650099 |
