EC Number   |
|---|
   3.4.21.26 | - |
| 3.4.21.26 | D641A and D641N mutants are cocrystallized in presence of substrate benzyloxycarbonyl-Gly-Pro-4-nitroanilide |
| 3.4.21.26 | enzyme in complex with inhibitor benzyloxycarbonyl-Pro-Prolinal, X-ray diffraction structure determination at high resolution |
| 3.4.21.26 | enzyme in open conformation |
| 3.4.21.26 | enzyme with bound inhibitor |
| 3.4.21.26 | inhibitor (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one is co-crystallized within the catalytic site of a human chimeric POP protein which provides a more detailed understanding of how these inhibitors interact with the key residues within the catalytic pocket |
| 3.4.21.26 | peptides 2-aminobenzoyl-Gly-Phe-Arg-Pro-Phe(NO2)-Arg-Ala, 2-aminobenzoyl-Gly-Phe-Glu-Pro-Phe(NO2)-Arg-Ala or 2-aminobenzoyl-Glu-Phe-Ser-Pro-Phe(NO2)-Arg-Ala with prolyl oligopeptidase |
| 3.4.21.26 | S554A mutant enzyme cocrystallized with 2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 or benzyloxycarbonyl-Gly-Pro-beta-naphthylamide |
| 3.4.21.26 | wild type enzyme and mutant S477C, hanging drop vapor diffusion method, using 30% (w/v) PEG 8K and 100 mM Tris-HCl (pH 9.0) |
| 3.4.21.26 | wild-type enzyme, mutant enzyme Y473F, mutant enzyme Y473F + benzyloxcarbonyl-Pro-prolinal and mutant enzyme S554A + succinyl-Gly-Pro-OH |
