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EC Number
pH Minimum
pH Maximum
Commentary
Reference
3.1.4.12
-999
-
neutral pH required for activity
649563
3.1.4.12
3
10
activity range
714926
3.1.4.12
3.5
6.5
-
135185
3.1.4.12
3.5
6.5
natural substrate
135168
3.1.4.12
4.5
9
approx. 5% of maximal activity at pH 4.5, approx. 15% of maximal activity at pH 9.0
653652
3.1.4.12
4.5
10
T-mSMase alpha, approx. 50% of maximal activity at pH 4.5, T-mSMase isoforms beta, gamma and delta, approx. 25% of maximal activity at pH 4.5, T-mSMase isoforms alpha, beta, gamma and delta, almost no activity at pH 10.0
652972
3.1.4.12
5
7.5
lysosomal enzyme stimulated by different divalent cations
135163
3.1.4.12
5
8
-
135147
,
135148
3.1.4.12
5
8.5
plasma membranes
135163
3.1.4.12
5
10
-
663974
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