EC Number   |
General Information |
Reference |
|---|
    5.3.1.1 | malfunction |
TIM deficiency is the only human glycolytic deficiency disease which is lethal, usually in early childhood. The disease symptoms concern hemolytic anemia but also neurological disorders |
714686 |
| 5.3.1.1 | metabolism |
anaerobic fermentative metabolism of glycerol. Proteome analysis as well as enzyme assays performed in cell-free extracts demonstrate that glycerol is degraded via glyceraldehyde-3-phosphate, which is further metabolized through the lower part of glycolysis leading to formation of mainly ethanol and hydrogen |
748573 |
| 5.3.1.1 | metabolism |
the chloroplastic isoform participates in the Calvin-Benson cycle |
728349 |
| 5.3.1.1 | metabolism |
the dimeric enzyme functions in the glycolytic pathway. In the glycolysis, the catalyzed interconversion reaction is important in the thermodynamically uphill direction of the synthesis of D-glyceraldehyde 3-phosphate |
706663 |
| 5.3.1.1 | metabolism |
the enzyme is involved in glycolysis |
706845 |
| 5.3.1.1 | metabolism |
TPIs play a very important role in gluconeogenesis, fatty acid biosynthesis, pentosephosphate pathway |
704137 |
| 5.3.1.1 | metabolism |
triosephosphate isomerase is a ubiquitously distributed enzyme of the glycolysis pathway |
704030 |
| 5.3.1.1 | physiological function |
comparison of Saccharomyces cerevisiae and Moritella marina enzymes to evaluate the temperature dependence of the activation free energy for differently adapted triosephosphate isomerases. Moritella marina TpiA displays a shift in enthalpy-entropy balance characteristic for cold-adapted proteins, due to a few surface-exposed protein loops that show differential mobilities in the two enzymes |
-, 747127 |
| 5.3.1.1 | physiological function |
enzyme is involved in cytadherence of Mycoplasma gallisepticum |
-, 747796 |
| 5.3.1.1 | physiological function |
forced expression of TPI1 in hepatocellular carcinoma cells inhibits cell growth, migration, and invasion in vitro. Knockdown of TPI1 by shRNA promotes cell growth, migration and invasion. Overexpression of TPI1 leads to slowed tumor growth and decreased tumor weight in vivo. Cell cycle arrest is induced by TPI1 overexpression |
746982 |
