EC Number   |
General Information |
Reference |
|---|
   3.4.25.1 | malfunction |
reduced proteasomal activity contributes to the accumulation of carbonylated proteins in chronic experimental autoimmune encephalomyelitis. Chymotrysin-like and caspase-like activities of the 20S proteasome are impaired in chronic experimental autoimmune encephalomyelitis, while the amount of proteasome is unchanged, determination of proteasome failure by the build-up of ubiquitinated proteins, mostly within astrocytes, diminished activity of the 20S proteasome is a major contributor to the accumulation of carbonylated proteins in astrocytes of chronic experimental autoimmune encephalomyelitis mice |
-, 720289 |
| 3.4.25.1 | malfunction |
T-DNA insertion mutation in RPN1a results in increased trichome branches on main stem, and trichome number on rosette leaves and the main stem compared with the wild type plant |
734942 |
| 3.4.25.1 | metabolism |
inhibition of the proteolytic activity of the proteasome induces apoptosis and suppresses essential functions of activated human CD4+ T cells, and proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells, detailed mechanisms of apoptosis, overview |
712549 |
| 3.4.25.1 | metabolism |
the expression of unstable proteins is regulated by transcriptional regulation and not by degradation of the unstable protein by the ubiquitin/proteasome system, overview |
712388 |
| 3.4.25.1 | metabolism |
the ubiquitin-proteasome pathway plays an important role in a variety of cellular functions, primarily via its proteolytic activity, and is one of the vital pathways in the cell that becomes dysfunctional as a result of chronic ethanol consumption. The inhibition of proteasome activity in the nucleus is therefore etiologically involved in the accumulation of damaged proteins in the nucleus, and in the deregulation of transcription |
713585 |
| 3.4.25.1 | more |
a decrease in proteasome activity induced by the injection of lactacystin in the corpus callosum in the remyelination process that normally occurs after cuprizone-induced demyelination markedly improves the remyelination process. It also attenuates the activation of NFkappaB and the recruitment of microglia and astrocytes, thus helping in the recovery of the mitochondrial respiratory chain activities that are affected by cuprizone treatment |
711942 |
| 3.4.25.1 | more |
activity and subunit composition of the 26 S proteasomes in plants, detailed overview. The 26 S proteasome is composed of two subparticles, the 20 S core protease that compartmentalizes the protease active sites and the 19 S regulatory particle that recognizes and translocates appropriate substrates into the core protease lumen for breakdown. A diverse and highly dynamic population of proteasomes is assembled in plants, which may expand the target specificity and functions of intracellular proteolysis, overview |
-, 719878 |
| 3.4.25.1 | more |
development of an integrated proteomic approach, QTAX, for quantitative analysis of tandem affinity purified in vivo cross-linked protein complexes to capture protein interactions of all natures in a single analysis, overview. Investigation of cell cycle specific proteasome interaction networks |
720331 |
| 3.4.25.1 | more |
development of SpliceMet: a method that combines combinatorial computations with mass spectrometric analyses of proteasome-generated spliced peptides, for analysis of peptides, presented by MHC class I molecules on the cell surface, in a manner independent of cytotoxic T lymphocytes, kinetics, detailed overview |
720802 |
| 3.4.25.1 | more |
inhibition of the proteasomes by gold complexes results in accumulation of ubiquitinated proteins and proteasome target proteins, and induction of cell death, but at significantly different levels |
712551 |
