Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lactacystin | specific inhibitor of the proteasome, partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination, overview | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
oligodendroglial cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | Ala-Ala-Phe + 7-amino-4-methylcoumarin | - |
? | |
Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | Boc-Leu-Ser-Thr-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
proteasome | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | a decrease in proteasome activity induced by the injection of lactacystin in the corpus callosum in the remyelination process that normally occurs after cuprizone-induced demyelination markedly improves the remyelination process. It also attenuates the activation of NFkappaB and the recruitment of microglia and astrocytes, thus helping in the recovery of the mitochondrial respiratory chain activities that are affected by cuprizone treatment | Mus musculus |
physiological function | physiological effects of partial inhibition of proteolytic activities of the proteasome, overview | Mus musculus |