EC Number   |
General Information |
Reference |
|---|
   3.4.21.73 | evolution |
biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors. The binding interfaces of uPA:plasminogen and uPA:PAI-1 may have coevolved to maintain tight interactions |
754184 |
| 3.4.21.73 | evolution |
the enzyme belongs to the trypsin superfamily of enzymes |
731429 |
| 3.4.21.73 | malfunction |
a wide variety of disorders are associated with an imbalance in the plasminogen activator system, including inflammatory diseases, atherosclerosis, intimal hyperplasia, the response mechanism to vascular injury, and restenosis. uPA is implicated in the stimulation of angiogenesis, detailed overview |
707951 |
| 3.4.21.73 | malfunction |
at pathophysiological concentrations above 20 nM, uPA inhibits contractility and increases vascular permeability |
717076 |
| 3.4.21.73 | malfunction |
binding of urokinase-type plasminogen activator, uPA, to the uPA receptor, uPAR, existing on the surface of cancer cell is considered to be a trigger for cancer invasions |
709570 |
| 3.4.21.73 | malfunction |
both C57/black 6J, and AlbPLG1 mice expressing the human plasminogen transgene, are significantly more susceptible to invasive Group A Streptococcus strain 5448 disease than enzyme-deficient uPA-/- mice. The observed decrease in virulence in uPA-/- mice correlates directly with a decrease in bacterial dissemination and reduced cell surface plasmin accumulation by Group A Streptococci |
732801 |
| 3.4.21.73 | malfunction |
enzyme receptor defciient mice show no lipid droplets in their livers compared to wild-type C57BL/6 mice and the triglyceride levels are significantly lower, phenotype, overview |
-, 731239 |
| 3.4.21.73 | malfunction |
excessive fibrinolysis in monoclonal antibody light chain-amyloidosis is induced by urokinae-type plasminogen activator from bone marrow plasma cells, uPA expression analysis, overview |
707096 |
| 3.4.21.73 | malfunction |
genetic deficiency of enzyme or urokinase plasminogen activator receptor abrogates functional recovery after acute ischemic stroke |
-, 732371 |
| 3.4.21.73 | malfunction |
in enzyme knockout mice, the number of peritoneal macrophages is lower by 30% than the peritoneal macrophages harvested from wild-type C57BL/6 mice |
-, 731237 |
